Publication Information

{'id': 'https://openalex.org/W2132198921', 'doi': 'https://doi.org/10.1158/1940-6207.capr-08-0205', 'title': 'Phase I-II Trial of Weekly Bicalutamide in Men with Elevated Prostate-Specific Antigen and Negative Prostate Biopsies', 'display_name': 'Phase I-II Trial of Weekly Bicalutamide in Men with Elevated Prostate-Specific Antigen and Negative Prostate Biopsies', 'publication_year': 2009, 'publication_date': '2009-04-01', 'ids': {'openalex': 'https://openalex.org/W2132198921', 'doi': 'https://doi.org/10.1158/1940-6207.capr-08-0205', 'mag': '2132198921', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19336728'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1940-6207.capr-08-0205', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S68240649', 'display_name': 'Cancer Prevention Research', 'issn_l': '1940-6215', 'issn': ['1940-6215', '1940-6207'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109231187', 'display_name': 'Silvia Zanardi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}, {'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Silvia Zanardi', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy", 'institution_ids': ['https://openalex.org/I83816512', 'https://openalex.org/I6141010']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011702331', 'display_name': 'Matteo Puntoni', 'orcid': 'https://orcid.org/0000-0002-7908-0626'}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}, {'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Matteo Puntoni', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy", 'institution_ids': ['https://openalex.org/I6141010', 'https://openalex.org/I83816512', 'https://openalex.org/I6141010', 'https://openalex.org/I83816512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044990634', 'display_name': 'Massimo Maffezzini', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}, {'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}, {'id': 'https://openalex.org/I4210156707', 'display_name': 'Fondazione IRCCS Istituto Nazionale dei Tumori', 'ror': 'https://ror.org/05dwj7825', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I4210156707']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Massimo Maffezzini', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy", 'Fondazione IRCCS Istituto Nazionale dei Tumori'], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy", 'institution_ids': ['https://openalex.org/I6141010', 'https://openalex.org/I83816512']}, {'raw_affiliation_string': 'Fondazione IRCCS Istituto Nazionale dei Tumori', 'institution_ids': ['https://openalex.org/I4210156707']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074289028', 'display_name': 'Roberto Bandelloni', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}, {'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Roberto Bandelloni', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy", 'institution_ids': ['https://openalex.org/I6141010', 'https://openalex.org/I83816512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064348643', 'display_name': 'Marco Mori', 'orcid': 'https://orcid.org/0000-0003-1231-8756'}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}, {'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Marco Mori', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy", 'institution_ids': ['https://openalex.org/I6141010', 'https://openalex.org/I83816512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051229924', 'display_name': 'Alessandra Argusti', 'orcid': 'https://orcid.org/0000-0003-0444-359X'}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}, {'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Alessandra Argusti', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy", 'institution_ids': ['https://openalex.org/I6141010', 'https://openalex.org/I83816512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035398376', 'display_name': 'Fabio Campodonico', 'orcid': 'https://orcid.org/0000-0001-7495-2424'}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}, {'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Fabio Campodonico', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy", 'institution_ids': ['https://openalex.org/I6141010', 'https://openalex.org/I83816512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004930669', 'display_name': 'Laura Turbino', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}, {'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Laura Turbino', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy", 'institution_ids': ['https://openalex.org/I6141010', 'https://openalex.org/I83816512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022458318', 'display_name': 'Daniela Branchi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}, {'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Daniela Branchi', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy", 'institution_ids': ['https://openalex.org/I6141010', 'https://openalex.org/I83816512']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055056275', 'display_name': 'Rodolfo Montironi', 'orcid': 'https://orcid.org/0000-0003-3938-610X'}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}, {'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Rodolfo Montironi', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy", 'institution_ids': ['https://openalex.org/I6141010', 'https://openalex.org/I83816512']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065678804', 'display_name': 'Andrea DeCensi', 'orcid': 'https://orcid.org/0000-0003-2635-4491'}, 'institutions': [{'id': 'https://openalex.org/I83816512', 'display_name': 'University of Genoa', 'ror': 'https://ror.org/0107c5v14', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I83816512']}, {'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Andrea Decensi', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081Medical Oncology Unit, 2Urology Unit, 3Pathology Unit, and 4Clinical Chemistry and Microbiology Laboratory, Galliera Hospital; 5Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy; 6Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy; and 7Division of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy", 'institution_ids': ['https://openalex.org/I83816512', 'https://openalex.org/I6141010', 'https://openalex.org/I83816512', 'https://openalex.org/I6141010']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.508, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.775581, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '2', 'issue': '4', 'first_page': '377', 'last_page': '384'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10124', 'display_name': 'Prostate Cancer Diagnosis and Treatment', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bicalutamide', 'display_name': 'Bicalutamide', 'score': 0.9790188}, {'id': 'https://openalex.org/keywords/flutamide', 'display_name': 'Flutamide', 'score': 0.52637845}], 'concepts': [{'id': 'https://openalex.org/C2780962315', 'wikidata': 'https://www.wikidata.org/wiki/Q1988832', 'display_name': 'Bicalutamide', 'level': 5, 'score': 0.9790188}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.78478277}, {'id': 'https://openalex.org/C2779322244', 'wikidata': 'https://www.wikidata.org/wiki/Q574820', 'display_name': 'Antiandrogen', 'level': 4, 'score': 0.74308044}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.6483894}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.6459707}, {'id': 'https://openalex.org/C2781406297', 'wikidata': 'https://www.wikidata.org/wiki/Q409450', 'display_name': 'Prostate-specific antigen', 'level': 4, 'score': 0.62001044}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.61434567}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.535576}, {'id': 'https://openalex.org/C2778313021', 'wikidata': 'https://www.wikidata.org/wiki/Q418669', 'display_name': 'Flutamide', 'level': 5, 'score': 0.52637845}, {'id': 'https://openalex.org/C2781172350', 'wikidata': 'https://www.wikidata.org/wiki/Q194520', 'display_name': 'Atrophy', 'level': 2, 'score': 0.4789696}, {'id': 'https://openalex.org/C2779279991', 'wikidata': 'https://www.wikidata.org/wiki/Q6058681', 'display_name': 'Testosterone (patch)', 'level': 2, 'score': 0.4390473}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.424542}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.30141488}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.21734968}], 'mesh': [{'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D019048', 'descriptor_name': 'Prostatic Intraepithelial Neoplasia', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D014105', 'descriptor_name': 'Tosyl Compounds', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D001706', 'descriptor_name': 'Biopsy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006177', 'descriptor_name': 'Gynecomastia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006177', 'descriptor_name': 'Gynecomastia', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019394', 'descriptor_name': 'Ki-67 Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019394', 'descriptor_name': 'Ki-67 Antigen', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019048', 'descriptor_name': 'Prostatic Intraepithelial Neoplasia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019048', 'descriptor_name': 'Prostatic Intraepithelial Neoplasia', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014105', 'descriptor_name': 'Tosyl Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014105', 'descriptor_name': 'Tosyl Compounds', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1940-6207.capr-08-0205', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S68240649', 'display_name': 'Cancer Prevention Research', 'issn_l': '1940-6215', 'issn': ['1940-6215', '1940-6207'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19336728', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.85, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1848388241', 'https://openalex.org/W1962516626', 'https://openalex.org/W1978782251', 'https://openalex.org/W1980248434', 'https://openalex.org/W1980800735', 'https://openalex.org/W2009948823', 'https://openalex.org/W2033284717', 'https://openalex.org/W2050673106', 'https://openalex.org/W2056367730', 'https://openalex.org/W2059389875', 'https://openalex.org/W2066396162', 'https://openalex.org/W2073300352', 'https://openalex.org/W2076371419', 'https://openalex.org/W2091279457', 'https://openalex.org/W2103429217', 'https://openalex.org/W2107505347', 'https://openalex.org/W2110065044', 'https://openalex.org/W2110105767', 'https://openalex.org/W2111417767', 'https://openalex.org/W2117299097', 'https://openalex.org/W2122680090', 'https://openalex.org/W2123449568', 'https://openalex.org/W2129302529', 'https://openalex.org/W2133929387', 'https://openalex.org/W2136314724', 'https://openalex.org/W2139024759', 'https://openalex.org/W2145145182', 'https://openalex.org/W2145847071', 'https://openalex.org/W2148180201', 'https://openalex.org/W2162922885', 'https://openalex.org/W2227970081', 'https://openalex.org/W3135529189', 'https://openalex.org/W4232547688', 'https://openalex.org/W90846558'], 'related_works': ['https://openalex.org/W4229984084', 'https://openalex.org/W3148026613', 'https://openalex.org/W2589605293', 'https://openalex.org/W2165611177', 'https://openalex.org/W2065112594', 'https://openalex.org/W2033996255', 'https://openalex.org/W2013301667', 'https://openalex.org/W2010412515', 'https://openalex.org/W1978560708', 'https://openalex.org/W1592598587'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'Men': [2], 'with': [3, 48, 181], 'elevated': [4], 'prostate-specific': [5], 'antigen': [6], '(PSA)': [7], 'and': [8, 52, 95, 98, 128, 213, 216, 241], 'negative': [9, 53, 264], 'prostate': [10, 16, 99], 'biopsies': [11, 100], 'are': [12], 'at': [13, 92, 259], 'risk': [14, 261], 'for': [15, 85], 'cancer.': [17], 'The': [18, 106], 'antiandrogen': [19], 'bicalutamide': [20, 45, 67, 153, 235], 'has': [21], 'a': [22, 39, 62], 'prolonged': [23], 'half-life,': [24], 'thus': [25], 'potentially': [26], 'allowing': [27], 'an': [28, 161, 243], 'intermittent': [29], 'administration': [30, 233], 'to': [31, 61, 65, 237], 'retain': [32], 'activity': [33, 247], 'while': [34], 'reducing': [35], 'toxicity.': [36], 'We': [37], 'conducted': [38], 'phase': [40], 'I-II': [41], 'trial': [42, 64], 'of': [43, 112, 163, 226, 234, 246, 254], 'weekly': [44, 232], 'in': [46, 136, 139, 154, 168, 210, 224, 257], 'men': [47, 258], 'PSA': [49, 207], '>4': [50], 'ng/mL': [51], 'biopsies.': [54], 'Methods:': [55], 'Eighty': [56], 'subjects': [57, 170], 'were': [58, 90, 101, 109], 'nonrandomly': [59], 'assigned': [60], 'three-arm': [63], 'either': [66], '50': [68], 'mg/wk': [69, 75], '(n': [70, 76, 82], '=': [71, 77, 83, 194], '26)': [72, 84], 'or': [73, 79], '100': [74], '28)': [78], 'no': [80, 175, 189], 'treatment': [81], '6': [86, 96, 104], 'months.': [87, 105], 'Blood': [88], 'samples': [89], 'obtained': [91], '0,': [93], '3,': [94], 'months,': [97], 'repeated': [102], 'after': [103], 'outcome': [107], 'measures': [108], '6-month': [110], 'changes': [111], 'tissue': [113, 141], 'Ki-67': [114, 132], '(primary': [115], 'end': [116], 'point),': [117], 'high-grade': [118], 'prostatic': [119], 'intraepithelial': [120], 'neoplasia': [121], '(HG-PIN),': [122], 'proliferative': [123], 'inflammatory': [124, 197], 'atrophy,': [125], 'circulating': [126], 'PSA,': [127], 'sex': [129], 'hormones.': [130], 'Results:': [131], 'expression': [133], 'was': [134, 149, 166, 200, 222], 'higher': [135], 'HG-PIN': [137, 164, 249], 'than': [138], 'normal': [140, 155], '(10%': [142], 'versus': [143], '3%;': [144], 'P': [145, 193], '<': [146], '0.01)': [147], 'but': [148], 'not': [150, 201], 'modulated': [151], 'by': [152, 203, 208], 'luminal': [156], 'cells.': [157], 'A': [158, 231], 'trend': [159], 'toward': [160], 'improvement': [162], 'status': [165], 'found': [167], 'treated': [169, 228], '(26%': [171], 'improved,': [172, 186], '60%': [173], 'had': [174, 188], 'change,': [176, 190], '15%': [177], 'worsened)': [178], 'as': [179], 'compared': [180], 'the': [182, 227, 263], 'no-treatment': [183], 'arm': [184], '(4%': [185], '83%': [187], '13%': [191], 'worsened;': [192], '0.07).': [195], 'Proliferative': [196], 'atrophy': [198], 'prevalence': [199], 'reduced': [202, 206], 'bicalutamide.': [204], 'Bicalutamide': [205], '50%': [209], 'both': [211], 'arms': [212], 'raised': [214], 'testosterone': [215], 'estradiol': [217], 'levels.': [218], 'Asymptomatic': [219], 'breast': [220], 'swelling': [221], 'noted': [223], '40%': [225], 'cases.': [229], 'Conclusions:': [230], 'seems': [236], 'be': [238], 'reasonably': [239], 'safe': [240], 'shows': [242], 'encouraging': [244], 'signal': [245], 'on': [248, 268], 'prevalence,': [250], 'supporting': [251], 'further': [252], 'studies': [253], 'this': [255], 'schedule': [256], 'high': [260], 'despite': [262], 'primary': [265], 'end-point': [266], 'findings': [267], 'Ki-67.': [269]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2132198921', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-09T04:48:35.269211', 'created_date': '2016-06-24'}