Publication Information

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280, 340, 487, 1145, 1553, 1861, 2620, 4047], 'chaperone': [5, 264], 'retinoids': [6, 265, 1147], 'to': [7, 134, 163, 222, 266, 393, 422, 481, 524, 636, 944, 951, 1011, 1051, 1505, 1605, 1836, 1843, 1866, 1974, 1992, 2011, 2142, 2150, 2253, 2407, 2480, 2918, 3357, 3634, 3820, 3843, 3850, 3875, 4008, 4069, 4086, 4106, 4174, 4182, 4193, 4214, 4218, 4285, 4410], 'manage': [8, 267], 'their': [9, 253, 268, 512, 1606, 1615, 1825, 1936, 3565, 4299, 4309], 'transport': [10, 269], 'and': [11, 22, 43, 84, 86, 100, 123, 190, 194, 229, 234, 248, 270, 281, 302, 343, 345, 359, 382, 449, 453, 488, 493, 507, 539, 667, 672, 674, 811, 835, 1061, 1306, 1373, 1510, 1554, 1572, 1598, 1669, 1709, 1868, 1870, 1882, 1897, 1935, 1947, 1972, 1978, 2006, 2008, 2018, 2024, 2028, 2030, 2033, 2043, 2055, 2077, 2110, 2128, 2153, 2159, 2203, 2222, 2240, 2260, 2262, 2271, 2273, 2282, 2309, 2358, 2411, 2418, 2444, 2508, 2510, 2542, 2577, 2637, 2641, 2663, 2694, 2718, 2785, 2824, 2868, 2901, 2907, 3091, 3175, 3289, 3299, 3363, 3373, 3388, 3394, 3483, 3492, 3506, 3645, 3665, 3683, 3690, 3715, 3739, 3750, 3756, 3779, 3789, 3793, 3799, 3803, 3832, 3864, 3888, 3897, 3901, 3909, 3936, 3967, 3970, 3978, 3996, 3999, 4019, 4036, 4130, 4144, 4176, 4216, 4306, 4417, 4420], 'metabolism.': [12, 271], 'Proposing': [13, 272, 1544], 'mechanisms': [14, 273], 'of': [15, 36, 54, 60, 107, 111, 154, 176, 206, 274, 295, 313, 319, 366, 370, 413, 435, 465, 530, 630, 660, 818, 822, 827, 832, 871, 879, 913, 1014, 1075, 1140, 1304, 1380, 1419, 1547, 1561, 1577, 1581, 1601, 1627, 1681, 1802, 1813, 1832, 1849, 1980, 2102, 2121, 2148, 2170, 2181, 2196, 2215, 2322, 2328, 2343, 2387, 2452, 2539, 2566, 2588, 2618, 2633, 2644, 2699, 2726, 2729, 2742, 2747, 2777, 2788, 3113, 3156, 3335, 3339, 3557, 3561, 3629, 3656, 3681, 3763, 3776, 3869, 3949, 3962, 3973, 4033, 4044, 4067, 4128, 4170, 4191, 4225, 4276, 4282, 4289], 'retinoid': [16, 275, 1076, 1548, 1877], 'transfer': [17, 276, 1549], 'between': [18, 277, 1550], 'these': [19, 278, 1551, 1806, 1819, 3660, 4082], 'membrane-associated': [23, 282, 1566], 'retinoid-metabolizing': [24, 283, 1555], 'enzymes': [25, 284, 938, 1556, 3383], 'requires': [26, 285, 519, 1557], 'insight': [27, 217, 286, 476], 'into': [28, 211, 218, 287, 470, 477, 521, 642, 1774, 1954, 2166, 2177, 2673, 4265, 4319], 'enzyme': [29, 288], 'topology.': [30, 143, 289, 402, 1883], 'We': [31, 290, 3477, 3839], 'therefore': [32, 291], 'determined': [33, 292, 3484, 4041], 'the': [34, 51, 75, 126, 130, 137, 151, 155, 167, 173, 177, 181, 185, 203, 212, 219, 257, 293, 310, 334, 385, 389, 396, 410, 414, 426, 432, 436, 440, 444, 462, 471, 478, 516, 526, 626, 661, 816, 825, 839, 844, 848, 854, 872, 945, 953, 1230, 1291, 1420, 1429, 1559, 1562, 1586, 1618, 1628, 1633, 1675, 1679, 1682, 1685, 1710, 1759, 1765, 1775, 1795, 1800, 1803, 1814, 1839, 1844, 1847, 1871, 1894, 1904, 1907, 1968, 1976, 1994, 2013, 2046, 2069, 2082, 2088, 2096, 2136, 2143, 2167, 2178, 2192, 2212, 2243, 2274, 2408, 2445, 2532, 2567, 2754, 2902, 2996, 3329, 3367, 3504, 3548, 3630, 3635, 3639, 3643, 3651, 3712, 3723, 3761, 3777, 3821, 3861, 3876, 3882, 3934, 3942, 3956, 3959, 3975, 3979, 3992, 4002, 4009, 4011, 4031, 4034, 4042, 4058, 4063, 4094, 4100, 4114, 4131, 4152, 4159, 4165, 4178, 4183, 4187, 4209, 4262, 4277, 4286, 4320, 4323, 4411], 'topology': [35, 294, 1560, 1848], 'mouse': [37, 249, 296, 508, 582, 597, 665], 'retinol': [38, 297, 598, 632, 662, 810, 823, 852, 1016, 1024, 1052], 'dehydrogenase': [39, 46, 73, 298, 305, 332, 584, 599, 956, 1009, 1049, 1665, 1712, 1878, 3159, 3254], 'type': [40, 47, 224, 299, 306, 483, 579, 585, 591, 600, 1235, 1750, 3160], '1': [41, 48, 300, 307, 2402, 2458, 2575, 2655, 2778, 2848, 2976, 3030, 3896, 3966, 3995], '(Rdh1)': [42, 301], 'cis-retinoid': [44, 303], 'androgen': [45, 304], '(Crad1)': [49, 308], 'in': [50, 116, 125, 136, 309, 375, 384, 395, 815, 824, 838, 903, 962, 1017, 1029, 1148, 1229, 1255, 1290, 1308, 1361, 1413, 1764, 1811, 1824, 1855, 1893, 2295, 2340, 2556, 2580, 2677, 2692, 2712, 2731, 2751, 2844, 2855, 2873, 2909, 2927, 2938, 2961, 2993, 3076, 3382, 3480, 3487, 3493, 3503, 3547, 3641, 3686, 3695, 3881, 3890, 3892, 3932, 3941, 3991, 4151, 4196, 4253], 'endoplasmic': [52, 127, 311, 386, 594], 'reticulum': [53, 128, 312, 387], 'intact': [55, 314, 1018, 1856, 3494, 3657, 3687, 3893], 'mammalian': [56, 315], 'cells.': [57, 316, 3688], 'The': [58, 317, 657, 1138, 1564, 1706, 1830, 1982, 2114, 2226, 2365, 2378, 2414, 2432, 2486, 2526, 2551, 2559, 3150, 3345, 3627, 3704, 3727, 3769, 3814, 3925, 4125], 'properties': [59, 318], 'Rdh1': [61, 122, 193, 207, 320, 381, 452, 466, 666, 1840, 1850, 1908, 1955, 2071, 2122, 2149, 2162, 2197, 3336, 3479, 3502, 3631, 3667, 3682, 3689, 3819, 4007, 4068, 4134, 4171, 4185, 4194, 4263, 4401], 'were': [62, 321, 1835, 1886, 1898, 1952, 1985, 2057, 2079, 2164, 2175, 2229, 2287, 2317, 2338, 2367, 2421, 2590, 2596, 2658, 2671, 2688, 2710, 2737, 2758, 2807, 2832, 2842, 2851, 2884, 2904, 2925, 2949, 2981, 3059, 3074, 3693, 3783], 'compared': [63, 322], 'with': [64, 67, 188, 252, 323, 326, 447, 511, 634, 805, 808, 830, 881, 1036, 1428, 1617, 1666, 1678, 1758, 1799, 1858, 1989, 2002, 2039, 2059, 2063, 2081, 2107, 2112, 2125, 2130, 2155, 2200, 2205, 2219, 2224, 2234, 2238, 2242, 2257, 2268, 2292, 2301, 2319, 2391, 2401, 2449, 2496, 2516, 2536, 2598, 2610, 2629, 2680, 2696, 2716, 2739, 2761, 2834, 2870, 2892, 2951, 2989, 3093, 3105, 3163, 3510, 3555, 3669, 3678, 3700, 3760, 3785, 3885, 4075, 4098, 4147, 4200, 4258, 4267, 4399], 'a': [65, 68, 112, 117, 199, 324, 327, 371, 376, 458, 858, 910, 940, 1252, 1749, 1770, 2091, 2188, 2388, 2392, 2482, 2497, 2502, 3084, 3340, 3352, 3359, 3540, 3664, 3773, 3788, 3986, 4025, 4053, 4073, 4109, 4141, 4268, 4274, 4294, 4416], 'chimera': [66, 325, 4275], 'luminal': [69, 328, 1720, 1859, 4269], 'signaling': [70, 87, 105, 138, 156, 178, 242, 329, 346, 364, 397, 415, 437, 501, 1761, 1828, 3343, 3380, 4004, 4295], 'sequence': [71, 88, 106, 139, 157, 330, 347, 365, 398, 416, 1762, 2133, 3121, 4005], '(11β-hydroxysteroid': [72, 331], '(11β-HSD1)(1-41)/Rdh1(23-317);': [74, 333], 'green': [76, 335, 610], 'fluorescent': [77, 336, 611], 'protein': [78, 337, 590, 837, 1234, 1297, 1500, 1683, 1757, 2589, 3515, 3559, 3987, 4074, 4096, 4127, 4180], '(GFP)': [79, 338], 'fusion': [80, 339, 4046, 4095, 4126], 'Rdh1(1-22)/GFP,': [82, 341], 'Crad1(1-22)/GFP,': [83, 342], '11β-HSD1(1-41)/GFP;': [85, 344], 'charge': [89, 170, 348, 429], 'difference': [90, 349], 'mutants': [91, 350, 1909, 2017, 2163, 3685, 3692, 3842], 'using': [92, 351, 1967, 2045, 2325, 2817, 3116, 3709], 'confocal': [93, 352, 3089], 'immunofluorescence,': [94, 353], 'antibody': [95, 354, 3002, 3037, 3714, 3725], 'access,': [96, 355], 'proteinase': [97, 356, 1863, 2762], 'K': [98, 357, 2763], 'sensitivity,': [99, 358, 1864], 'deglycosylation': [101, 360], 'assays.': [102, 361], 'An': [103, 362, 1620, 2395], 'N-terminal': [104, 241, 363, 500, 1578, 1760, 1827, 3379, 3815, 3977, 4003, 4103, 4161, 4280], '22': [108, 367, 2194, 4065, 4160], 'residues,': [109, 368, 3982, 4137, 4162, 4169, 4315], 'consisting': [110, 369], 'hydrophobic': [113, 200, 372, 459, 1579, 1594, 1599, 1630, 1671, 3353, 3824, 4013, 4038], 'helix': [114, 373, 1797, 3354, 4014], 'ending': [115, 374], 'net': [118, 168, 377, 427, 1590], 'positive': [119, 169, 378, 428, 1591], 'charge,': [120, 379], 'anchors': [121, 380], 'Crad1': [124, 383, 1708], 'facing': [129, 256, 388, 515, 1684, 1721, 1860, 4270, 4322], 'cytoplasm.': [131, 213, 258, 390, 472, 517], 'Mutating': [132, 391], 'arginine': [133, 148, 392, 407, 2065], 'glutamine': [135, 394], 'did': [140, 399, 1042, 3675, 3872], 'not': [141, 400, 959, 1033, 1043, 3676, 3873, 3919, 4023, 4120, 4164], 'affect': [142, 401], 'Inserting': [144, 403], 'one': [145, 404, 1418, 3846], 'or': [146, 405, 1078, 2145, 2744, 2819, 2929, 3006, 3019, 3051, 3063, 3741, 3847, 3857, 4203, 4402], 'two': [147, 406, 873, 2227, 4303, 4313], 'residues': [149, 408, 1583, 1603, 2101, 2195, 3350, 3370, 3868, 3907, 3910, 4066, 4083, 4104, 4117, 4281, 4292, 4305], 'near': [150, 202, 409, 461, 3833, 4298], 'N': [152, 411, 2144, 3333, 3828, 4287, 4300], 'terminus': [153, 175, 205, 412, 434, 464, 1588, 3334, 3829, 3836, 4288, 4301, 4311], 'caused': [158, 417], '28-95%': [159, 418], 'inversion': [160, 419], 'from': [161, 420, 1238, 1376, 1439, 2531, 3056], 'cytoplasmic': [162, 421, 4143], 'luminal,': [164, 423], 'depending': [165, 424], 'on': [166, 425, 1585, 2314, 2360, 2501, 2830, 3110, 3153, 4308], 'remaining': [171, 430], 'at': [172, 431, 1962, 2289, 2372, 2425, 2437, 2473, 2512, 2523, 2544, 2570, 2651, 2705, 2766, 2875, 2889, 2915, 2943, 2958, 2983, 3826], 'C': [174, 204, 433, 463, 1587, 1607, 2146, 3835, 4310], 'sequence;': [179, 438], 'e.g.': [180, 439, 799, 1172], 'mutant': [182, 441, 1995, 1998, 2014, 2048, 2255, 3927, 3983], 'L3R,L5R,R16Q,R19Q,R21Q': [183, 442], 'faced': [184, 443], 'lumen.': [186, 445], 'Experiments': [187, 446], 'N-': [189, 448, 1668, 4035], 'C-terminal': [191, 450, 1670, 1796, 3981, 4037, 4168], 'epitope-tagged': [192, 451], 'molecular': [195, 454, 1872, 3101], 'modeling': [196, 455], 'indicated': [197, 456], 'that': [198, 231, 457, 490, 534, 843, 898, 1624, 1874, 3649, 3906, 3988, 4081, 4113, 4158, 4316], 'helix-turn-helix': [201, 460], '(residues': [208, 467, 3830, 3837], '289-311)': [209, 468], 'projects': [210, 469], 'These': [214, 473, 3551, 3903, 4155, 4291], 'data': [215, 474, 3904, 4156], 'provide': [216, 475, 1044], 'features': [220, 479, 1873], 'necessary': [221, 480, 3913], 'orient': [223, 251, 482, 510], 'III': [225, 484, 1751], '(reverse': [226, 485], 'signal-anchor)': [227, 486, 1756], 'demonstrate': [230, 489, 3920], 'Rdh1,': [232, 491, 596, 1570, 3870], 'Crad1,': [233, 492, 581], 'other': [235, 494], 'short-chain': [236, 495, 574], 'dehydrogenases/reductases,': [237, 496], 'which': [238, 497, 863, 1415, 3765, 3859], 'share': [239, 498], 'similar': [240, 499], 'sequences': [243, 502, 3381], 'such': [244, 503, 3390], 'as': [245, 504, 1417, 1719, 1748, 1754, 1769, 1903, 1987, 2050, 2814, 3061, 3123, 3391, 3711, 3722, 3754], 'human': [246, 505, 675, 2103, 3157], 'Rdh5': [247, 506], 'Rdh4,': [250, 509], 'catalytic': [254, 513], 'domains': [255, 514], 'Retinol': [518], 'conversion': [520, 641], 'all-trans-retinoic': [522, 643], 'acid': [523, 644, 1069, 1816, 2100, 3120, 3349, 3867, 4136], 'fulfill': [525], 'vitamin': [527, 1239, 1256], 'A': [528, 1240, 1257, 1660, 2132, 2207, 2616], 'function': [529, 4032], 'regulating': [531], 'gene': [532, 1039, 1154], 'expression': [533, 1880, 3964, 4078], 'begins': [535], 'shortly': [536], 'after': [537, 1245, 2068, 3564], 'conception': [538], 'continues': [540], 'throughout': [541, 4057], 'vertebrate': [542], 'life': [543], '(1Wolf': [544], 'G.': [545, 730, 1090, 1122, 3401, 3422, 3452, 3577, 3607], 'Physiol.': [546], 'Rev.': [547], '1984;': [548], '64:': [549], '873-938Crossref': [550], 'PubMed': [551, 652, 696, 720, 744, 793, 930, 979, 1102, 1133, 1164, 1222, 1283, 1325, 1355, 1407, 1460, 1493, 1539, 1703, 1739, 1787, 1929, 3145, 3202, 3225, 3248, 3414, 3442, 3472, 3533, 3597, 3622, 4244, 4338, 4364, 4390], 'Scopus': [552, 653, 697, 721, 745, 769, 794, 892, 931, 980, 1003, 1103, 1134, 1165, 1223, 1284, 1326, 1356, 1408, 1461, 1494, 1540, 1656, 1740, 1788, 1930, 3146, 3203, 3226, 3249, 3285, 3324, 3415, 3443, 3473, 3534, 3598, 3623, 4245, 4339, 4365, 4391], '(299)': [553], 'Google': [554, 565, 655, 699, 723, 747, 771, 796, 894, 933, 982, 1005, 1105, 1136, 1167, 1225, 1286, 1328, 1358, 1410, 1463, 1496, 1542, 1658, 1704, 1742, 1790, 1932, 3148, 3205, 3228, 3251, 3287, 3326, 3417, 3445, 3475, 3536, 3600, 3625, 4247, 4341, 4367, 4393], 'Scholar,': [555, 700, 724, 748, 772, 983, 1106, 1329, 1464, 3206, 3229, 3418, 3446, 3601, 4342, 4368], '2De': [556], 'Luca': [557], 'L.M.': [558], 'Basic': [559], 'Life': [560], 'Sci.': [561, 1126, 1699, 3278, 3526], '1993;': [562], '61:': [563], '17-25PubMed': [564], 'Scholar).': [566, 656, 797, 895, 934, 1006, 1137, 1168, 1226, 1287, 1359, 1411, 1497, 1543, 1659, 1705, 1743, 1791, 1933, 3149, 3327, 3476, 3537, 3626, 4248, 4394], 'Retinoid-active': [567], 'SDRs': [568, 1822], '1The': [569], 'abbreviations': [570], 'used': [571, 1902, 1986, 2010, 2252, 3041, 3060, 3069], 'are:': [572], 'SDR,': [573, 952, 3115, 4271], 'dehydrogenase/reductase;': [575], '11β-HSD1,': [576], '11β-hydroxysteroid': [577], 'dehydrogenase,': [578], '1;': [580, 586, 601], 'cis-retinol/androgen': [583], 'CRBP,': [587, 635], 'cellular': [588, 1232, 1367], 'retinol-binding': [589, 1233, 1499], 'I;': [592], 'ER,': [593, 4010], 'reticulum;': [595], 'SLO,': [602, 4201], 'streptolysin': [603], 'O;': [604], 'SRP,': [605], 'signal': [606, 3632, 3637, 3961, 4146], 'recognition': [607], 'particle;': [608], 'GFP,': [609, 4107], 'protein;': [612], 'PNGase': [613, 2611, 2645], 'F,': [614], 'peptide-N-glycosidase': [615], 'F;': [616], 'PBS,': [617, 2713, 2717], 'phosphate-buffered': [618], 'saline;': [619], 'ConA,': [620, 3670], 'concanavalin': [621], 'A;': [622], 'DAPI,': [623], '4,6-diamidino-2-phenylindole.': [624], 'recognize': [625, 899, 960], 'major': [627], 'physiological': [628, 1012], 'form': [629, 3351], 'retinol,': [631], 'bound': [633], 'generate': [637, 2151, 2254, 4024], 'retinal': [638, 813, 1292, 1363, 1421], 'for': [639, 1046, 1302, 1614, 1862, 1906, 2095, 2135, 2362, 2429, 2441, 2477, 2520, 2548, 2574, 2654, 2702, 2769, 2847, 2878, 2886, 2912, 2940, 2955, 2986, 3028, 3042, 3070, 3914, 4122], 'irreversible': [640], '(3Napoli': [645], 'J.L.': [646, 684, 708, 732, 784, 887, 918, 967, 1782, 1917, 3133], 'FASEB': [647], 'J.': [648, 685, 709, 733, 758, 782, 919, 968, 1091, 1118, 1160, 1218, 1263, 1272, 1341, 1344, 1393, 1482, 1535, 1645, 1697, 1728, 1778, 1918, 3134, 3405, 3408, 3431, 3461, 3613, 3616, 4326, 4327, 4353, 4376, 4379], '1996;': [649, 889, 922, 971, 3222, 3240, 3282], '10:': [650], '993-1001Crossref': [651], '(329)': [654], 'most': [658], 'active': [659], 'dehydrogenases': [663], 'include': [664], 'its': [668, 1667, 1853, 3485, 3827, 3834], 'orthologs,': [669], 'rat': [670], 'Rodh1': [671], '-2': [673], 'RDH-E/RoDH4': [676], '(4Zhang': [677, 1910], 'M.': [678, 786, 1196, 1212, 1385, 1911, 3131, 3270, 3302, 3581, 4229, 4237], 'Chen': [679, 1912, 3128], 'W.': [680, 1913, 3129, 3188, 3306, 3428], 'Smith': [681, 1914], 'S.M.': [682, 1915], 'Napoli': [683, 707, 731, 783, 886, 917, 966, 1781, 1916, 3132], 'Biol.': [686, 710, 734, 759, 920, 969, 1092, 1273, 1345, 1483, 1646, 1729, 1919, 3135, 3221, 3410, 3432, 3462, 3618, 4328, 4354, 4380], 'Chem.': [687, 711, 735, 760, 921, 970, 1093, 1274, 1346, 1484, 1647, 1730, 1920, 3136, 3433, 3463, 4329, 4355, 4381], '2001;': [688, 1399, 1485, 1731, 1784, 1921], '276:': [689, 1486, 1732, 1922], '44083-44090Abstract': [690, 1923], 'Full': [691, 693, 715, 717, 739, 741, 764, 766, 925, 927, 974, 976, 1097, 1099, 1278, 1280, 1350, 1352, 1402, 1404, 1488, 1490, 1651, 1653, 1734, 1736, 1924, 1926, 3140, 3142, 3197, 3199, 3243, 3245, 3319, 3321, 3437, 3439, 3467, 3469, 3530, 3592, 3594, 4333, 4335, 4359, 4361, 4385, 4387], 'Text': [692, 694, 716, 718, 740, 742, 765, 767, 926, 928, 975, 977, 1098, 1100, 1279, 1281, 1351, 1353, 1403, 1405, 1489, 1491, 1652, 1654, 1735, 1737, 1925, 1927, 3141, 3143, 3198, 3200, 3244, 3246, 3320, 3322, 3438, 3440, 3468, 3470, 3531, 3593, 3595, 4334, 4336, 4360, 4362, 4386, 4388], 'PDF': [695, 719, 743, 768, 929, 978, 1101, 1282, 1354, 1406, 1492, 1655, 1738, 1928, 3144, 3201, 3247, 3323, 3441, 3471, 3532, 3596, 4337, 4363, 4389], '(48)': [698, 1004, 1931, 4392], '5Chai': [701], 'X.': [702, 726, 1110, 1120, 1259], 'Boerman': [703], 'M.H.E.M.': [704, 885, 916, 965], 'Zhai': [705, 727], 'Y.': [706, 728], '1995;': [712, 736, 3194, 4330], '270:': [713, 737, 4331], '3900-3904Abstract': [714], '(132)': [722], '6Chai': [725], 'Popescu': [729], '28408-28412Abstract': [738], '(89)': [746, 3325], '7Gough': [749], 'W.H.': [750, 987, 1637], 'Van': [751, 1467, 1638], 'Ooteghem': [752, 1639], 'S.': [753, 991, 1116, 1128, 1214, 1521, 1527, 1640, 3280, 3397, 3426, 4239], 'Sint': [754, 1641], 'T.': [755, 1642, 3573, 3609], 'Kedishvili': [756, 1643], 'N.Y.': [757, 985, 1644], '1998;': [761, 1000, 1648, 4241], '272:': [762, 1649], '19778-19785Abstract': [763, 1650], '(110)': [770, 1657], '8Jurukovski': [773], 'V.': [774, 1194, 1210, 1471, 1531], 'Markova': [775], 'N.G.': [776, 3407, 3430, 3460], 'Karaman-Jurukovska': [777], 'N.': [778, 1158], 'Randolph': [779], 'R.K.': [780], 'Su': [781], 'Simon': [785, 1445], 'Mol.': [787], 'Genet.': [788, 1456], 'Metab.': [789], '1999;': [790, 1219, 1457, 1536, 1700, 3434, 4356], '67:': [791], '62-73Crossref': [792], '(51)': [795], 'rRodh2': [798], 'has': [800, 857, 874, 1025, 1150, 3337, 3823], 'lower': [801], 'apparent': [802], 'Km': [803], 'values': [804], 'holo-CRBP': [806, 880, 900], 'than': [807, 1182], 'unbound': [809, 867, 1015], 'catalyzes': [812], 'synthesis': [814], 'presence': [817, 826], 'excess': [819, 828, 912], 'apoCRBP.': [820], 'Dehydrogenation': [821], 'CRBP': [829, 1169], 'concentrations': [831], 'both': [833, 3642, 3848, 3879, 3933, 3974, 4021], 'ligand': [834], 'micromolar': [840], 'range': [841], 'indicates': [842], 'reaction': [845], 'proceeds': [846], 'through': [847, 1153, 1674], 'SDR': [849, 1707, 1772], 'accessing': [850], 'CRBP-bound': [851], 'because': [853, 1023, 1057], 'CRBP-retinol': [855, 961], 'complex': [856], 'Kd': [859], 'value': [860], '∼0.1': [861], 'nm,': [862, 4222], 'would': [864], 'virtually': [865], 'eliminate': [866, 1177], 'retinol.': [868], 'Close': [869], 'approach': [870], 'been': [875, 1151, 1612, 1717], 'confirmed': [876, 3659, 3945], 'by': [877, 909, 1249, 1589, 1851, 1888, 1956, 2369, 2383, 2423, 2492, 2564, 2592, 2660, 2665, 2724, 2775, 2809, 3011, 3366, 3386, 3490, 3496, 3567, 4048, 4212, 4256, 4302, 4312], 'cross-linking': [878], 'microsomal': [882, 2560, 3505, 3644, 3755, 3935], 'Rdh': [883], '(9Boerman': [884], 'Biochemistry.': [888, 1321, 1783, 4240], '34:': [890], '7027-7037Crossref': [891], '(74)': [893], 'Although': [896], 'Rdhs': [897], 'also': [901, 1715, 4139, 4250], 'occur': [902], 'cytoplasm,': [904], 'they': [905, 3922], 'are': [906, 1426, 1503, 1891, 3364, 3553, 3912, 3923, 4084, 4119, 4172], 'inhibited': [907], 'severely': [908], 'small': [911], 'apoCRBP': [914], '(10Boerman': [915, 964], '271:': [923, 972], '5610-5616Abstract': [924, 973], '(95)': [932, 981], 'Even': [935], 'uninhibited': [936], 'cytosolic': [937, 954], 'make': [939, 1993, 2012], 'quantitatively': [941], 'minor': [942], 'contribution': [943, 1050], 'total': [946], 'retinal-generating': [947], 'units.': [948], 'In': [949, 1792, 4092], 'contrast': [950], 'alcohol': [955, 1008, 1048], 'isozymes': [957], 'do': [958, 3918], 'vitro': [963], '11Kedishvili': [984], 'Gough': [986], 'Davis': [988], 'W.I.': [989], 'Parsons': [990], 'Li': [992, 1270, 3604], 'T.K.': [993], 'Bosron': [994], 'W.F.': [995], 'Biochem.': [996, 1159, 3525], 'Biophys.': [997], 'Res.': [998], 'Commun.': [999], '24:': [1001], '191-196Crossref': [1002], 'Moreover': [1007], 'access': [1010, 1865, 4190], 'amounts': [1013], 'cells': [1019, 1857, 2285, 2337, 2366, 2420, 2675, 2687, 2709, 2736, 2828, 2841, 2883, 2903, 2924, 2948, 2980, 3482, 3495, 3658, 3698, 3894, 3951, 4198, 4397, 4423], 'may': [1020, 4015], 'be': [1021, 1809], 'limited': [1022], 'very': [1026], 'low': [1027], 'solubility': [1028], 'aqueous': [1030], 'media': [1031], 'when': [1032, 1247, 4408], 'sequestered': [1034], 'tightly': [1035], 'CRBP.': [1037], 'Notably': [1038], 'knock-out': [1040], 'experiments': [1041, 1156], 'evidence': [1045], 'an': [1047, 1186, 2064, 2517, 2599, 3117, 3512, 3671, 4076, 4148], 'metabolism': [1053, 1077], 'under': [1054, 2753, 3083], 'normal': [1055, 1175], 'circumstances,': [1056], 'Adh1-/-,': [1058], 'Adh3-/-,': [1059], 'Adh4-/-,': [1060], 'dual': [1062, 3341], 'Adh1/Adh4-/-': [1063], 'null': [1064, 1170, 1228, 1289, 1501], 'mice': [1065, 1171, 1184, 1502], 'showed': [1066, 3952, 4108, 4140], 'no': [1067], 'retinoic': [1068], 'deficiency': [1070, 1241], 'phenotype': [1071], 'nor': [1072], 'any': [1073], 'disturbance': [1074], 'compensatory': [1079], 'response': [1080], '(12Molotkov': [1081], 'A.': [1082, 1108, 1129, 1202, 1446, 1688, 1690, 1725, 3208, 3281, 4235, 4344, 4348, 4378], 'Deltour': [1083, 1111], 'L.': [1084, 1112, 1261, 1515], 'Foglio': [1085, 1113], 'M.H.': [1086, 1114, 3579], 'Cuenca': [1087], 'A.E.': [1088], 'Duester': [1089, 1121], '2002;': [1094, 1130, 1275, 3464, 3589], '277:': [1095, 1276, 3465], '13804-13811Abstract': [1096], '(79)': [1104], '13Molotkov': [1107], 'Fan': [1109], 'Martras': [1115], 'Farres': [1117], 'Pares': [1119], 'Proc.': [1123, 3275], 'Natl.': [1124, 3276], 'Acad.': [1125, 3277], 'U.': [1127, 1448, 1696, 1727, 3279], '99:': [1131], '5337-5342Crossref': [1132], '(126)': [1135], 'importance': [1139], 'high': [1141], 'specific': [1143], 'chaperoning': [1146], 'vivo': [1149], 'illustrated': [1152], 'ablation': [1155], '(14Noy': [1157], '2000;': [1161, 3316], '348:': [1162], '481-495Crossref': [1163], '(363)': [1166], 'seem': [1173], 'morphologically': [1174], 'but': [1176, 1768, 3674, 3917, 3939, 4163], 'retinyl': [1178, 1295, 1508], 'esters': [1179, 1509], '6-fold': [1180], 'faster': [1181], 'wild-type': [1183], 'via': [1185], 'unknown': [1187], 'mechanism': [1188], '(15Ghyselinck': [1189], 'N.B.': [1190], 'Båvik': [1191], 'C.': [1192, 1200, 3235, 3605, 4370], 'Sapin': [1193], 'Mark': [1195], 'Bonnier': [1197], 'D.': [1198, 3178, 3233, 3262, 3458], 'Hindelang': [1199], 'Dierich': [1201], 'Nilsson': [1203], 'C.B.': [1204, 3615], 'Håkansson': [1205], 'H.': [1206, 1444], 'Sauvant': [1207], 'P.': [1208, 1216, 1265, 1318, 1525, 3266, 4233, 4346, 4374], 'Azaïs-Braesco': [1209], 'Frasson': [1211], 'Picaud': [1213], 'Chambon': [1215], 'EMBO': [1217, 1534], '18:': [1220, 1537], '4903-4914Crossref': [1221], '(261)': [1224], 'Mice': [1227, 1288], 'intestinal': [1231], 'II': [1236], 'die': [1237], 'within': [1242], '24': [1243], 'h': [1244, 2576, 2988, 3802, 3998], 'birth': [1246], 'delivered': [1248], 'dams': [1250], 'fed': [1251], 'diet': [1253], 'marginal': [1254], '(16E': [1258], 'Zhang': [1260, 3130], 'Lu': [1262], 'Tso': [1264], 'Blaner': [1266, 1516], 'W.S.': [1267, 1517], 'Levin': [1268], 'M.S.': [1269], 'E.': [1271, 1450], '36617-36623Abstract': [1277], '(83)': [1285], 'pigment': [1293, 1364, 1422], 'epithelium': [1294, 1423], 'ester-binding': [1296], 'RPE65': [1298, 1309], 'cannot': [1299, 1808], 'produce': [1300], '11-cis-retinol': [1301, 1381, 1424, 1574, 1664, 1711], 'production': [1303], 'rhodopsin,': [1305], 'mutations': [1307, 1951], 'cause': [1310, 1370, 4087], 'blindness': [1311, 1372, 1438], "(Leber's": [1312], 'congenital': [1313], 'amaurosis)': [1314], '(17Gollapalli': [1315], 'D.R.': [1316, 3585], 'Maiti': [1317], 'Rando': [1319], 'R.R.': [1320], '2003;': [1322, 3137, 3619], '42:': [1323], '11824-11830Crossref': [1324], '(65)': [1327], '18Mata': [1330], 'N.L.': [1331], 'Moghrabi': [1332], 'W.N.': [1333], 'Lee': [1334], 'J.S.': [1335], 'Bui': [1336], 'T.V.': [1337], 'Radu': [1338], 'R.A.': [1339], 'Horwitz': [1340], 'Travis': [1342], 'G.H.': [1343], '2004;': [1347, 4382], '279:': [1348, 4383], '635-643Abstract': [1349], '(113)': [1357], 'Mutations': [1360, 1412], 'another': [1362, 3029], 'epithelium-binding': [1365], 'protein,': [1366, 1369, 3544], 'retinal-binding': [1368], 'night': [1371, 1437], 'photoreceptor': [1374], 'degeneration': [1375], 'inefficient': [1377], 'metabolic': [1378], 'processing': [1379], '(19Saari': [1382], 'J.C.': [1383, 3237, 3274], 'Nawrot': [1384], 'Kennedy': [1386], 'B.N.': [1387], 'Garwin': [1388], 'G.G.': [1389], 'Hurley': [1390], 'J.B.': [1391, 3312], 'Huang': [1392], 'Possin': [1394], 'D.E.': [1395], 'Crabb': [1396], 'J.E.': [1397], 'Neuron.': [1398], '29:': [1400], '739-748Abstract': [1401], '(206)': [1409], 'hRdh5,': [1414], 'serves': [1416], 'dehydrogenases,': [1425], 'linked': [1427], 'rare,': [1430], 'autosomal': [1431], 'recessive': [1432], 'disease': [1433], 'fundus': [1434], 'albipunctatus,': [1435], 'i.e.': [1436], 'delayed': [1440], 'photopigment': [1441], 'regeneration': [1442], '(20Yamamoto': [1443], 'Eriksson': [1447, 1695, 1726], 'Harris': [1449], 'Berson': [1451], 'E.L.': [1452], 'Dryja': [1453], 'T.P.': [1454], 'Nat.': [1455, 3219], '22:': [1458], '188-191Crossref': [1459], '(254)': [1462], '21Jang': [1465], 'G.F.': [1466], 'Hooser': [1468], 'J.P.': [1469], 'Kuksa': [1470], 'McBee': [1472], 'J.K.': [1473, 1780], 'He': [1474], 'Y.G.': [1475], 'Janssen': [1476], 'J.J.': [1477, 3517], 'Driessen': [1478], 'C.A.': [1479], 'Palczewski': [1480], 'K.': [1481, 1723], '32456-32465Abstract': [1487], '(55)': [1495], 'Serum': [1498], 'unable': [1504], 'mobilize': [1506], 'hepatic': [1507], 'suffer': [1511], 'visual': [1512], 'impairment': [1513], '(22Quadro': [1514], 'Salchow': [1518], 'D.J.': [1519], 'Vogel': [1520], 'Piantedosi': [1522], 'R.': [1523, 3231, 3583], 'Gouras': [1524], 'Freeman': [1526], 'Cosma': [1528], 'M.P.': [1529], 'Colantuoni': [1530], 'Gottesman': [1532], 'M.E.': [1533], '4633-4644Crossref': [1538], '(415)': [1541], 'precise': [1545], 'models': [1546, 1610, 1807], 'retinoid-binding': [1552], 'understanding': [1558], 'enzymes.': [1563], 'retinoid-metabolizing,': [1565], 'SDRs,': [1567], 'including': [1568], 'rRodh1,': [1569], 'hRdh-E/Rodh4,': [1571], 'bovine': [1573, 2304, 2935], 'dehydrogenase/hRdh5/mRdh4,': [1575], 'consist': [1576], 'helices': [1580, 1600, 1631, 1672, 3825], '∼18': [1582], 'flanked': [1584, 3365], 'charges,': [1592], 'midprotein': [1593], 'helix-loop-helix': [1595], 'transmembrane': [1596], 'regions,': [1597], '∼23': [1602], 'close': [1604], 'termini.': [1608], 'Several': [1609], 'have': [1611, 1716], 'proposed': [1613, 1718], 'association': [1616], 'ER.': [1619, 1804, 3877, 4184], 'early': [1621], 'model': [1622, 1662, 1745, 3102, 3151], 'suggested': [1623], 'all': [1625], 'four': [1626], 'hRoDH4': [1629], 'transected': [1632], 'ER': [1634, 1676, 1766, 1845, 1876, 3062, 3330, 3387, 3513, 3558, 3652, 3672, 3851, 3915, 3953, 4017, 4077, 4088, 4123, 4321], 'membrane': [1635, 1677, 1767, 1879, 3362, 3514, 4211], '(7Gough': [1636], 'second': [1661, 2070, 2208, 2244], 'presented': [1663, 1746], 'projecting': [1673, 1773], 'bulk': [1680], 'lumen': [1686, 4324], '(23Simon': [1687], 'Romert': [1689, 1724], 'Gustafson': [1691], 'A.L.': [1692], 'McCaffery': [1693], 'J.M.': [1694], 'Cell': [1698, 3409, 3617], '112:': [1701], '549-558Crossref': [1702], 'orthologs': [1713], 'Rdh4/5': [1714], '(24Tryggvason': [1722], '19253-19258Abstract': [1733], '(22)': [1741], 'Another': [1744], 'rRodh1': [1747], '(also': [1752], 'known': [1753], 'reverse': [1755], 'buried': [1763], 'globular': [1771], 'cytoplasm': [1776], '(25Wang': [1777], 'Bongianni': [1779], '40:': [1785], '12533-12540Crossref': [1786], '(20)': [1789], 'this': [1793, 1833], 'model,': [1794], 'associated': [1798], 'surface': [1801], 'All': [1805], 'accurate': [1810], 'view': [1812], 'amino': [1815, 2099, 2118, 3119, 3348, 3866, 4135], 'similarity': [1817], 'among': [1818], 'closely': [1820], 'related': [1821], 'especially': [1823], 'putative': [1826], 'sequences.': [1829], 'goals': [1831], 'study': [1834], 'determine': [1837, 3844], 'whether': [1838, 3845, 3921], 'localizes': [1841], 'exclusively': [1842], 'membrane;': [1846], 'comparing': [1852], 'behavior': [1854], 'antibodies,': [1867], 'glycosylation;': [1869], 'establish': [1875], 'locus': [1881, 3486], 'cDNA': [1884], 'Constructs—Constructs': [1885], 'made': [1887, 1966, 2080, 2233, 3840, 4273], 'PCR': [1889, 2092, 2250], '(primers': [1890], 'detailed': [1892], 'Supplemental': [1895], 'material)': [1896], 'sequenced.': [1899], 'pcDNA3/Rdh1': [1900], 'was': [1901, 1965, 2000, 2009, 2037, 2105, 2123, 2140, 2198, 2217, 2232, 2251, 2266, 2278, 2380, 2405, 2435, 2447, 2471, 2490, 2529, 2554, 2562, 2578, 2608, 2649, 2773, 2812, 2899, 3040, 3068, 3103], 'template': [1905], 'Mutants': [1934, 2052, 2062, 3855], 'primers': [1937, 1990, 2060, 2108, 2126, 2201, 2220, 2235, 2258, 2269], '(forward/reverse,': [1938], 'respectively)': [1939], 'included': [1940, 2021], 'RD(1-18),': [1941], 'F1/R1;': [1942], 'RD(1-30),': [1943, 3764, 3858], 'F2/R1;': [1944], 'RD(289-317),': [1945], 'F3/R2;': [1946], 'RD2,': [1948, 3984], 'F1/R2.': [1949], 'Point': [1950], 'introduced': [1953], 'overlapping': [1957], 'PCR.': [1958], 'Mutant': [1959, 2035], 'glycosylation': [1960], 'site': [1961, 2169], 'residue': [1963, 2066, 2072], '213': [1964], 'primer': [1969, 2003, 2019, 2040, 2083, 2156], 'pairs': [1970, 2004, 2020, 2041, 2157], 'F3/R3': [1971], 'F4/R1': [1973], 'amplify': [1975], '5′-': [1977], '3′-sections': [1979], 'Rdh1.': [1981, 3654], 'gel-purified': [1983], 'products': [1984], 'templates': [1988], 'F3/R1': [1991, 2007, 2044], 'V213N.': [1996], 'Similarly': [1997], 'G251N': [1999], 'obtained': [2001, 2038, 2124, 2563], 'F5/R4': [2005], 'L253T.': [2015], 'Additional': [2016], 'R19Q,': [2022], 'F6/R5': [2023], 'F3/R1;': [2025, 2029], 'R21Q,': [2026], 'F7/R6': [2027], 'R(19,21)2Q,': [2031], 'F8/R7': [2032], 'F3/R1.': [2034], 'R(16,19,21)3Q': [2036], 'F9/R8': [2042], 'double': [2047], 'R(19,21)2Q': [2049], 'template.': [2051], 'L(3,5)2R,': [2053], 'L(3,5)2R/R(19,21)2Q,': [2054], 'L(3,5)2R/R(16,19,21)3Q': [2056], 'generated': [2058, 3104, 3985], 'F10/R1.': [2061], 'inserted': [2067], 'R3,': [2073], 'R3/19Q,': [2074], 'R3/21Q,': [2075], 'R3/(19,21)2Q,': [2076], 'R3/(16,19,21)3Q,': [2078], 'pair': [2084], 'F11/R1.': [2085], 'To': [2086, 2185, 4028, 4260], 'obtain': [2087, 2186, 2481], 'chimeric': [2089, 2275], '11β-HSD1(1-41)/Rdh1(23-317),': [2090], 'product': [2093], 'coding': [2094, 2134, 2213], 'first': [2097, 2193, 3346, 3862, 4064, 4101, 4115, 4278], '41': [2098, 4279], '11β-HSD1': [2104], 'amplified': [2106, 2199, 2218], 'F12/R9': [2109], 'digested': [2111, 2129, 2204, 2223, 2237], 'EcoRI/StuI.': [2113], 'DNA': [2115, 2189, 2209, 2245, 2276, 2324], 'fragment': [2116, 2190, 2210, 2246, 2277], 'encoding': [2117, 2191, 2211], 'acids': [2119], '23-317': [2120], 'F13/R1': [2127], 'PmlI/XhoI.': [2131], 'FLAG': [2137, 3043], 'epitope': [2138, 3044], '(DYKDDDDK)': [2139], 'attached': [2141], 'termini': [2147], 'FLAG-Rdh': [2152], 'Rdh-FLAG': [2154], 'F14/R1': [2158], 'F3/R10,': [2160], 'respectively.': [2161, 3066], 'subcloned': [2165], 'EcoRI/XhoI': [2168], 'pcDNA3': [2171], '(Invitrogen).': [2172], 'GFP': [2173, 2216, 4051, 4070, 4129, 4181], 'constructs': [2174, 2670], 'cloned': [2176, 2241], 'EcoRI/NotI': [2179], 'sites': [2180], 'pEGFP-N1': [2182], '(BD': [2183, 2804], 'Biosciences).': [2184, 2606, 2805], 'Rdh(1-22)/GFP,': [2187], 'F3/R14': [2202], 'EcoRI/PvuII.': [2206], 'region': [2214], 'F16/R11': [2221], 'PmlI/NotI.': [2225], 'fragments': [2228], 'cloned.': [2230, 2263, 2279], 'Rdh(1-18)/GFP': [2231], 'F3/R12,': [2236], 'EcoRI/DraI,': [2239], 'described': [2247, 2815, 3124], 'above.': [2248], 'Overlapping': [2249], 'GFP/Rdh(289-317)': [2256], 'F18/R13': [2259], 'F19/R14': [2261], 'Plasmid': [2264], 'Crad1(1-22)/GFP': [2265], 'constructed': [2267], 'F3/R15': [2270], 'F20/R11,': [2272], 'Subcellular': [2280], 'Fractionation': [2281], 'Western': [2283, 2584, 2601, 2666], 'Blotting—COS': [2284], '(ATCC)': [2286], 'grown': [2288, 2829], '37': [2290, 2652, 2706, 2722, 2767, 2916], '°C': [2291, 2374, 2653, 2768, 2917, 2960], '5%': [2293], 'CO2': [2294], "Dulbecco's": [2296], 'modified': [2297], 'essential': [2298], 'medium': [2299, 2846], 'supplemented': [2300], '10%': [2302, 2638], 'fetal': [2303], 'serum,': [2305], '100': [2306, 2310, 2625, 2786], 'units/ml': [2307, 2894], 'penicillin,': [2308], 'μg/ml': [2311], 'streptomycin.': [2312], 'Cells': [2313, 2757, 2806, 2850, 3073], '100-mm': [2315], 'plates': [2316, 2679], 'transfected': [2318, 2672, 2833, 3950, 4398], '8': [2320], 'μg': [2321, 2587], 'plasmid': [2323], '40': [2326], 'μl': [2327, 2643, 2698, 2728, 2741, 2746, 2787], 'SuperFect': [2329, 2681, 2835], '(Qiagen).': [2330, 2683, 2837], 'Twenty-four': [2331, 2684, 2838], 'hours': [2332, 2685, 2839], 'post-transfection,': [2333, 2686, 2840], '5': [2334, 2363, 2450, 2537], '×': [2335, 2427, 2439, 2475, 2514, 2546, 2572], '107': [2336], 'resuspended': [2339, 2448, 2491, 2711], '2': [2341, 2642, 2987], 'ml': [2342, 2451], 'ice-cold': [2344, 2399], 'HB': [2345, 2400], '(150': [2346], 'μm': [2347], 'MgCl2,10mm': [2348], 'KCl,': [2349, 2972], '10': [2350, 2430, 2442, 2461, 2478, 2586, 2627, 2703], 'mm': [2351, 2456, 2459, 2462, 2779, 2790, 2798, 2859, 2863, 2963, 2974, 2977], 'Tris-HCl,': [2352, 2463], 'pH': [2353, 2464, 2792, 2866, 2965], '6.7)': [2354], 'plus': [2355, 2466], 'protease': [2356, 2467, 2801], 'inhibitors': [2357], 'left': [2359, 3705, 3778], 'ice': [2361], 'min.': [2364, 2431, 2550, 2771, 2880], 'disrupted': [2368], 'nitrogen': [2370], 'cavitation': [2371], '4': [2373, 2524, 2959], '(80': [2375], 'p.s.i./30': [2376], 'min).': [2377], 'suspension': [2379, 2410], 'then': [2381, 2759], 'homogenized': [2382], 'five': [2384, 2493], 'gentle': [2385, 2494], 'strokes': [2386, 2495], 'Dounce': [2389, 2498], 'grinder': [2390], 'loose': [2393], 'pestle.': [2394], 'additional': [2396], '⅓': [2397], 'volume': [2398, 2631], 'm': [2403, 2795, 2968, 2971], 'sucrose': [2404, 2504, 3568], 'added': [2406], 'cell': [2409, 2416, 4059], 'mixed': [2412], 'well.': [2413], 'nuclei,': [2415], 'debris,': [2417], 'unbroken': [2419], 'removed': [2422], 'centrifugation': [2424, 2565, 3571], '700': [2426], 'g': [2428, 2440, 2476, 2515, 2547, 2573], 'postnuclear': [2433], 'supernatant': [2434, 2569], 'centrifuged': [2436, 2472, 2511, 2543], '5000': [2438, 2474], 'min,': [2443, 2721], 'pellet': [2446, 2489, 2553], 'buffer': [2453, 2540, 2557, 2581, 2636, 2857, 2911], 'B': [2454], '(250': [2455], 'sucrose,': [2457, 2796, 2969], 'EDTA,': [2460], '7.4)': [2465], 'inhibitors.': [2468], 'This': [2469, 3377], 'homogenate': [2470], 'min': [2479, 2522, 2704, 2888, 2914, 2942, 2957], 'crude': [2483, 2487], 'mitochondrial': [2484, 3646], 'pellet.': [2485], 'mitochondria': [2488, 2527, 3064, 3507, 3541, 3549, 3562, 3757, 3883, 3891, 3937, 3963, 3993], 'grinder,': [2499], 'layered': [2500], 'discontinuous': [2503], 'gradient': [2505, 3570], '(30,': [2506], '40,': [2507], '55%),': [2509], '150,000': [2513], 'SW41': [2518], 'rotor': [2519], '20': [2521, 2549, 2962], '°C.': [2525, 2707], 'fraction': [2528, 2561, 3884], 'collected': [2530], '40/55%': [2533], 'interface,': [2534], 'diluted': [2535], 'volumes': [2538], 'B,': [2541], '10,000': [2545], 'resulting': [2552], 'solubilized': [2555], 'B.': [2558, 2582], 'postmitochondrial': [2568], '100,000': [2571], 'rehomogenized': [2579], 'For': [2583], 'blotting,': [2585], 'analyzed': [2591, 2664], '12.5%': [2593, 2661], 'SDS-PAGE.': [2594], 'Results': [2595], 'imaged': [2597], 'ECL-Plus': [2600], 'blotting': [2602], 'detection': [2603, 3045], 'system': [2604], '(Amersham': [2605], 'Deglycosylation—Deglycosylation': [2607], 'done': [2609, 2813], 'F': [2612, 2646], '(New': [2613], 'England': [2614], 'Biolabs).': [2615], 'mixture': [2617, 2803], 'denatured': [2619], '(1×': [2621], 'Glycoprotein': [2622], 'Denature': [2623], 'Buffer,': [2624], '°C,': [2626], 'min)': [2628], '0.1': [2630, 2970], 'each': [2632], '10×': [2634], 'G7': [2635], 'Nonidet': [2639], 'P-40': [2640], '(500,000': [2647], 'units/ml)': [2648], 'incubated': [2650, 2843, 2885, 2908, 2926, 2982], 'h.': [2656, 2849, 3031], 'Mixtures': [2657], 'resolved': [2659], 'SDS-PAGE': [2662], 'blot.': [2667], 'Protease': [2668], 'Protection—cDNA': [2669], 'COS': [2674, 2827, 3481, 3697, 4197, 4396], 'cultured': [2676], '6-well': [2678], 'reagent': [2682, 2836], 'washed': [2689, 2714, 2852, 2905], 'three': [2690, 2853], 'times': [2691, 2854], 'PBS': [2693, 2732, 2743, 2752, 2928], 'trypsinized': [2695], '300': [2697], 'trypsin-EDTA': [2700], '(0.25%)': [2701], 'Trypsinized': [2708], 'twice': [2715], 'permeabilized': [2719, 2950, 3699], '(5': [2720, 2953, 3017, 3026], '°C)': [2723], 'addition': [2725, 2776], '200': [2727, 2740, 2745], 'SLO': [2730, 2856, 2896, 2898, 2910, 4206], '(1000': [2733], 'units/ml).': [2734], 'Alternatively': [2735, 2922], 'treated': [2738, 2760, 4199], '0.5%': [2748], 'Triton': [2749, 2931, 3702, 4204], 'X-100': [2750, 2932], 'same': [2755, 3640], 'conditions.': [2756], '(50': [2764], 'μg/ml)': [2765, 2954, 3018, 3027, 3039], '15': [2770, 2879, 2887, 2913, 2941, 2956], 'Digestion': [2772], 'stopped': [2774], 'phenylmethylsulfonyl': [2780], 'fluoride': [2781], '(Roche': [2782], 'Applied': [2783], 'Science)': [2784], '60': [2789], 'HEPES,': [2791, 2964], '7.2,': [2793], '1.5': [2794], '6': [2797], 'EDTA': [2799], 'containing': [2800], 'inhibitor': [2802], 'lysed': [2808], 'sonication.': [2810], 'Immunoblotting': [2811, 3498], 'above': [2816], 'anti-Rdh1': [2818, 2990, 3710], 'anti-GFP': [2820, 2999], 'monoclonal': [2821, 3001, 3036], 'antibody.': [2822], 'Antibodies': [2823], 'Fluorescence': [2825], 'Markers—Subconfluent': [2826], 'coverslips': [2831], 'serum-free': [2845], '(75': [2858], 'potassium': [2860], 'acetate,': [2861], '25': [2862], 'HEPES': [2864], 'buffer,': [2865], '7.2)': [2867], 'fixed': [2869, 2923, 2947, 3696], 'paraformaldehyde': [2871], '(4%': [2872], 'PBS)': [2874, 2939], 'room': [2876, 2890, 2944, 2984], 'temperature': [2877, 2891, 2985], 'After': [2881], 'washing,': [2882], '500': [2893], 'activated': [2895], '(Sigma).': [2897, 3046], 'removed,': [2900], 'once': [2906], 'allow': [2919], 'pore': [2920], 'formation.': [2921], '0.2%': [2930, 3701], '(containing': [2933], '1%': [2934], 'serum': [2936], 'albumin': [2937], 'temperature.': [2945], 'Some': [2946], 'digitonin': [2952], '6.9,': [2966], '0.3': [2967], '2.5': [2973], 'MgCl2,': [2975], 'EDTA.': [2978], 'Permeabilized': [2979], '(1:200,': [2991, 3000, 3008], 'raised': [2992], 'rabbits': [2994], 'against': [2995], 'peptide': [2997], 'DRLSSNTKMIWDKASSEVK),': [2998], 'JL-8,': [3003], 'BD': [3004], 'Biosciences),': [3005], 'anti-calnexin': [3007], 'Sigma)': [3009], 'followed': [3010], 'Alexa': [3012, 3020, 3047, 3716, 3732], 'Fluor': [3013, 3021, 3048, 3717, 3733], '488-conjugated': [3014, 3718], 'goat': [3015, 3023, 3719], 'anti-rabbit': [3016, 3720], '594-conjugated': [3022, 3049, 3734], 'anti-mouse': [3024], 'immunoglobulins': [3025], 'Fluorescein': [3032], 'isothiocyanate-conjugated': [3033], 'anti-FLAG': [3034], 'M2': [3035], '(10': [3038], 'ConA': [3050, 3735], 'MitoTracker': [3052, 3742], 'Red': [3053, 3744], 'CMXRos': [3054, 3745], '(both': [3055, 3752], 'Molecular': [3057, 3099], 'Probes)': [3058], 'markers,': [3065, 3758], 'DAPI': [3067, 3786], 'nuclear': [3071, 4145, 4153], 'counterstaining.': [3072], 'mounted': [3075], 'ProLong': [3077], 'Antifade': [3078], 'reagents': [3079], '(Molecular': [3080], 'Probes),': [3081], 'viewed': [3082], 'Zeiss': [3085, 3094], '510': [3086], 'laser': [3087], 'scanning': [3088], 'microscope,': [3090], 'processed': [3092], 'Bitplane': [3095], 'Imaris': [3096], '3.3': [3097], 'software.': [3098], 'Modeling—The': [3100], 'Swiss-Model': [3106], 'Version': [3107], '36.0002,': [3108], 'based': [3109], 'three-dimensional': [3111], 'structures': [3112, 3155], 'soluble': [3114, 4026, 4179], 'optimal': [3118], 'alignment': [3122], 'previously': [3125], '(26Song': [3126], 'M.-S.': [3127], '278:': [3138], '40079-40087Abstract': [3139], '(7)': [3147], 'relied': [3152], 'x-ray': [3154], '17β-hydroxysteroid': [3158], 'I': [3161], 'complexed': [3162], 'cofactor': [3164], 'and/or': [3165], 'substrate': [3166], '(39.8%': [3167], 'identity;': [3168, 3293], 'Protein': [3169, 3256, 3294], 'Data': [3170, 3257, 3295], 'Bank': [3171, 3258, 3296], 'codes': [3172, 3297], '1FDS,': [3173], '1A27,': [3174], '1EQU)': [3176], '(27Ghosh': [3177], 'Pletnev': [3179], 'V.Z.': [3180], 'Zhu': [3181, 3211], 'D.W.': [3182], 'Wawrzak': [3183], 'Z.': [3184], 'Duax': [3185, 3267], 'W.L.': [3186, 3268], 'Pangborn': [3187], 'Labrie': [3189, 3215], 'F.': [3190, 3216], 'Lin': [3191, 3217], 'S.X.': [3192], 'Structure.': [3193], '3:': [3195, 3223], '503-513Abstract': [3196], '(258)': [3204], '28Azzi': [3207], 'Rehse': [3209], 'P.H.': [3210], 'D.-W.': [3212], 'Campbell': [3213], 'R.I.': [3214], 'S.-X.': [3218], 'Struct.': [3220, 3313], '665-668Crossref': [3224], '(135)': [3227, 3416], '29Breton': [3230], 'Housset': [3232], 'Mazza': [3234], 'Fontecilla-Camps': [3236], 'Structure': [3238], '(Lond.).': [3239], '4:': [3241], '905-915Abstract': [3242], '(193)': [3250], 'Scholar),': [3252, 3288], '20β-hydroxysteroid': [3253], '(51.5%;': [3255], 'code': [3259], '1HU4)': [3260], '(30Ghosh': [3261], 'Weeks': [3263], 'C.M.': [3264], 'Grochulski': [3265], 'Erman': [3269], 'Rimsay': [3271], 'R.L.': [3272], 'Orr': [3273], '88:': [3283], '10064-10068Crossref': [3284], '(233)': [3286], 'β-ketoacyl-[acyl-carrier': [3290], 'protein]-reductase': [3291], '(41%': [3292], '1I0E': [3298], '1I0B)': [3300], '(31Fisher': [3301], 'Kroon': [3303], 'J.T.': [3304], 'Martindale': [3305], 'Stuitje': [3307], 'A.R.': [3308, 3310], 'Slabas': [3309], 'Rafferty': [3311], 'Fold.': [3314], 'Des.': [3315], '15:': [3317], '339-347Abstract': [3318], 'Only': [3328], 'Expresses': [3331], 'Rdh1—The': [3332], 'characteristics': [3338], 'mitochondria/microsomal': [3342], 'sequence.': [3344], '18': [3347, 3863, 3976, 4102, 4116], 'sufficiently': [3355], 'long': [3356], 'span': [3358], 'lipid': [3360], 'bilayer': [3361], 'positively': [3368], 'charged': [3369], 'Arg19,': [3371], 'Arg21,': [3372], 'Lys30': [3374], '(Fig.': [3375, 3499, 3662, 3853, 4090, 4414], '1).': [3376, 3854], 'resembles': [3378], 'expressed': [3384, 3478, 4195], 'dually': [3385], 'mitochondria,': [3389], 'CYP1A1,': [3392], 'CYP2E1,': [3393], 'P450MT2': [3395], '(32Addya': [3396], 'Anandatheerthavarada': [3398, 3423, 3449], 'H.K.': [3399, 3424, 3450], 'Biswas': [3400, 3421, 3451], 'Bhagwat': [3402], 'S.V.': [3403, 3420], 'Mullick': [3404], 'Avadhani': [3406, 3429, 3459], '1997;': [3411], '139:': [3412], '589-599Crossref': [3413], '33Bhagwat': [3419], 'Addya': [3425], 'Pandak': [3427], '274:': [3435, 4357], '24014-24022Abstract': [3436], '(49)': [3444], '34Robin': [3447], 'M.A.': [3448], 'Sepuri': [3453], 'N.B.V.': [3454], 'Gordon': [3455], 'D.M.': [3456], 'Pain': [3457], '40583-40593Abstract': [3466], '(137)': [3474], 'subcellular': [3488], 'fractions': [3489, 3938], 'immunoblotting': [3491], 'immunofluorescence.': [3497, 4049], '1)': [3500], 'revealed': [3501], 'fractions,': [3508, 3647], 'distributing': [3509, 4056], 'calnexin,': [3511], '(35Bergeron': [3516], 'Brenner': [3518], 'M.B.': [3519], 'Thomas': [3520], 'D.Y.': [3521], 'Williams': [3522], 'D.B.': [3523], 'Trends': [3524], '1994;': [3527], '19:': [3528], '124-128Abstract': [3529], '(472)': [3535], 'Cytochrome': [3538], 'c,': [3539, 3737, 3899], 'intermembrane': [3542], 'space': [3543], 'appeared': [3545], 'only': [3546, 3650, 3767, 3947, 4099], 'fraction.': [3550], 'results': [3552, 4264], 'consistent': [3554], 'reports': [3556], 'contamination': [3560], 'even': [3563], 'isolation': [3566], 'density': [3569, 3628], '(36Kuwana': [3572], 'Mackey': [3574], 'M.R.': [3575], 'Perkins': [3576], 'Ellisman': [3578], 'Lattérich': [3580], 'Schneider': [3582], 'Green': [3584], 'Niemeyer': [3586], 'D.D.': [3587], 'Cell.': [3588], '111:': [3590], '331-342Abstract': [3591], '(1250)': [3599], '37Zong': [3602], 'W.X.': [3603], 'Hatzivassiliou': [3606], 'Lindsten': [3608], 'Yu': [3610], 'Q.C.': [3611], 'Yuan': [3612], 'Thompson': [3614], '162:': [3620], '59-69Crossref': [3621], '(511)': [3624], 'relative': [3633], 'calnexin': [3636], 'remained': [3638], 'indicating': [3648, 4112], 'expresses': [3653], 'Immunofluorescence': [3655, 3944], 'observations': [3661], '2,': [3663, 3898, 3968, 3997], 'b).': [3666, 4418], 'colocalized': [3668], 'marker,': [3673], 'colocalize': [3677], 'MitoTracker.Fig.': [3679], '2Expression': [3680], 'deletion': [3684, 3691, 3841, 3926], 'immunostained': [3694], 'X-100.': [3703, 4205], 'column': [3706, 3729, 3771], 'shows': [3707, 3766, 3772], 'immunostaining': [3708], 'primary': [3713], 'IgG': [3721], 'secondary': [3724], '(green).': [3726], 'middle': [3728, 3780], 'alternates': [3730], 'showing': [3731], '(a,': [3736], 'f,': [3738], 'h)': [3740], '(Mito)': [3743], '(b,': [3746], 'd,': [3747, 3794, 3900], 'e,': [3748, 3796], 'g,': [3749, 3800], 'i)': [3751], 'red)': [3753], 'respectively,': [3759, 3871], 'exception': [3762], 'MitoTracker.': [3768], 'right': [3770], 'merged': [3774], 'image': [3775, 3811], 'columns.': [3781], 'Nuclei': [3782], 'stained': [3784], '(blue):': [3787], 'b,': [3790], 'Rdh1;': [3791], 'c': [3792, 3887], 'RD(1-18);': [3795], 'RD(1-30);': [3797], 'f': [3798, 3969], 'RD(289-317);': [3801], 'i,': [3804], 'RD2.View': [3805], 'Large': [3806], 'Image': [3807], 'Figure': [3808], 'ViewerDownload': [3809], 'Hi-res': [3810], 'Download': [3812], '(PPT)': [3813], 'Signaling': [3816], 'Sequence': [3817], 'Targets': [3818], 'ER—Rdh1': [3822], '1-18)': [3831], '289-311).': [3838], 'contribute': [3849], 'targeting': [3852, 4089], 'RD(1-18)': [3856], 'lack': [3860], '30': [3865], 'localize': [3874], 'Surprisingly': [3878], 'distributed': [3880], 'cytochrome': [3886], 'localized': [3889, 3989], '(Figs.': [3895, 3965, 3994], 'e).': [3902], 'show': [3905, 4157], '1-18': [3908], '1-30': [3911], 'localization': [3916], 'sufficient.': [3924], 'RD(289-317)': [3928], 'produced': [3929, 4072], 'immunoblot': [3930], 'signals': [3931, 4407], 'predominantly': [3940], 'mitochondria.': [3943], 'this:': [3946], '∼20%': [3948], 'localization,': [3954], 'whereas': [3955], 'rest': [3957], 'exhibited': [3958, 4404], 'punctate': [3960], 'g).': [3971], 'Deletion': [3972], '28': [3980], 'overwhelmingly': [3990], 'i).': [4000], 'Thus,': [4001], 'directs': [4006], 'C-region': [4012], 'promote': [4016], 'retention,': [4018], 'removing': [4020], 'does': [4022], 'protein.': [4027], 'further': [4029], 'define': [4030], 'helices,': [4039], 'we': [4040, 4272], 'loci': [4043], 'Rdh1/GFP': [4045], 'Native': [4050], 'had': [4052], 'diffuse': [4054, 4110, 4142], 'pattern,': [4055, 4079], '(not': [4060], 'shown).': [4061], 'Fusing': [4062], '(Rdh1(1-22)/GFP)': [4071], 'demonstrating': [4080], 'sufficient': [4085, 4121, 4173], '3).': [4091], 'contrast,': [4093], 'Rdh1(1-18)/GFP,': [4097], 'fused': [4105, 4284], 'signal,': [4111], 'alone': [4118], 'targeting.': [4124], 'last': [4132, 4166], '29': [4133, 4167], 'GFP/Rdh1(289-317),': [4138], 'intense': [4149], 'band': [4150], 'membrane.': [4154], 'direct': [4175, 4317], 'anchor': [4177], 'Faces': [4186], 'Cytoplasm—We': [4188], 'assessed': [4189], 'antibodies': [4192, 4413], 'digitonin,': [4202], 'selectively': [4207], 'permeabilizes': [4208], 'plasma': [4210, 4254], 'cholesterol': [4215], 'polymerizing': [4217], 'create': [4219], 'pores': [4220, 4252], '≥12': [4221], 'permitting': [4223], 'uptake': [4224], 'large': [4226], 'molecules': [4227], '(38Palmer': [4228], 'Vulicevic': [4230], 'I.': [4231], 'Saweljew': [4232], 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