Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3088012430', 'doi': 'https://doi.org/10.1074/jbc.ra120.015577', 'title': 'Calnexin mediates the maturation of GPI-anchors through ER retention', 'display_name': 'Calnexin mediates the maturation of GPI-anchors through ER retention', 'publication_year': 2020, 'publication_date': '2020-09-23', 'ids': {'openalex': 'https://openalex.org/W3088012430', 'doi': 'https://doi.org/10.1074/jbc.ra120.015577', 'mag': '3088012430', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32967966', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7705322'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.ra120.015577', 'pdf_url': 'http://www.jbc.org/article/S0021925817504585/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925817504585/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101842642', 'display_name': 'Xinyu Guo', 'orcid': 'https://orcid.org/0000-0002-4329-6230'}, 'institutions': [{'id': 'https://openalex.org/I111599522', 'display_name': 'Jiangnan University', 'ror': 'https://ror.org/04mkzax54', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111599522']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xin-Yu Guo', 'raw_affiliation_strings': ['Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China', 'institution_ids': ['https://openalex.org/I111599522']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011279779', 'display_name': 'Yi‐Shi Liu', 'orcid': 'https://orcid.org/0000-0001-5640-1899'}, 'institutions': [{'id': 'https://openalex.org/I111599522', 'display_name': 'Jiangnan University', 'ror': 'https://ror.org/04mkzax54', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111599522']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yi-Shi Liu', 'raw_affiliation_strings': ['Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China', 'institution_ids': ['https://openalex.org/I111599522']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084191419', 'display_name': 'Xiao‐Dong Gao', 'orcid': 'https://orcid.org/0000-0002-8575-5095'}, 'institutions': [{'id': 'https://openalex.org/I111599522', 'display_name': 'Jiangnan University', 'ror': 'https://ror.org/04mkzax54', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111599522']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Dong Gao', 'raw_affiliation_strings': ['Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China', 'institution_ids': ['https://openalex.org/I111599522']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072623856', 'display_name': 'Taroh Kinoshita', 'orcid': 'https://orcid.org/0000-0001-7166-7257'}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Taroh Kinoshita', 'raw_affiliation_strings': ['Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan', 'WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan', 'institution_ids': ['https://openalex.org/I98285908']}, {'raw_affiliation_string': 'Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5082485542', 'display_name': 'Morihisa Fujita', 'orcid': 'https://orcid.org/0000-0002-0344-2408'}, 'institutions': [{'id': 'https://openalex.org/I111599522', 'display_name': 'Jiangnan University', 'ror': 'https://ror.org/04mkzax54', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111599522']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Morihisa Fujita', 'raw_affiliation_strings': ['Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China', 'institution_ids': ['https://openalex.org/I111599522']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5082485542'], 'corresponding_institution_ids': ['https://openalex.org/I111599522'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 1.781, 'has_fulltext': False, 'cited_by_count': 22, 'citation_normalized_percentile': {'value': 0.730737, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '295', 'issue': '48', 'first_page': '16393', 'last_page': '16410'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10890', 'display_name': 'Trypanosoma species research and implications', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9828, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/calnexin', 'display_name': 'Calnexin', 'score': 0.9974674}, {'id': 'https://openalex.org/keywords/er-retention', 'display_name': 'ER retention', 'score': 0.81670225}], 'concepts': [{'id': 'https://openalex.org/C130361206', 'wikidata': 'https://www.wikidata.org/wiki/Q908443', 'display_name': 'Calnexin', 'level': 4, 'score': 0.9974674}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.9418434}, {'id': 'https://openalex.org/C47450691', 'wikidata': 'https://www.wikidata.org/wiki/Q634510', 'display_name': 'Calreticulin', 'level': 3, 'score': 0.9072901}, {'id': 'https://openalex.org/C2778043179', 'wikidata': 'https://www.wikidata.org/wiki/Q5324093', 'display_name': 'ER retention', 'level': 4, 'score': 0.81670225}, {'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.7087981}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.665319}, {'id': 'https://openalex.org/C204328495', 'wikidata': 'https://www.wikidata.org/wiki/Q847556', 'display_name': 'Protein folding', 'level': 2, 'score': 0.48873234}, {'id': 'https://openalex.org/C2777427919', 'wikidata': 'https://www.wikidata.org/wiki/Q407997', 'display_name': 'Inositol', 'level': 3, 'score': 0.4211935}, {'id': 'https://openalex.org/C206212055', 'wikidata': 'https://www.wikidata.org/wiki/Q2553138', 'display_name': 'Glycan', 'level': 3, 'score': 0.41391227}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3978194}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39779586}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38768625}, {'id': 'https://openalex.org/C108625454', 'wikidata': 'https://www.wikidata.org/wiki/Q187126', 'display_name': 'Glycoprotein', 'level': 2, 'score': 0.25118157}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.1202628}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.ra120.015577', 'pdf_url': 'http://www.jbc.org/article/S0021925817504585/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705322', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2020.07.08.192955', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32967966', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.ra120.015577', 'pdf_url': 'http://www.jbc.org/article/S0021925817504585/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '31770853'}], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1504719146', 'https://openalex.org/W16780149', 'https://openalex.org/W1887562728', 'https://openalex.org/W1968124895', 'https://openalex.org/W1977265649', 'https://openalex.org/W1999466952', 'https://openalex.org/W2000444287', 'https://openalex.org/W2001056089', 'https://openalex.org/W2003322429', 'https://openalex.org/W2006373538', 'https://openalex.org/W2013096934', 'https://openalex.org/W2015227829', 'https://openalex.org/W2019577213', 'https://openalex.org/W2035765497', 'https://openalex.org/W2040856119', 'https://openalex.org/W2046847584', 'https://openalex.org/W2048384162', 'https://openalex.org/W2050444611', 'https://openalex.org/W2050680180', 'https://openalex.org/W2056404010', 'https://openalex.org/W2061070956', 'https://openalex.org/W2062613923', 'https://openalex.org/W2074554701', 'https://openalex.org/W2075761547', 'https://openalex.org/W2077237389', 'https://openalex.org/W2079230562', 'https://openalex.org/W2081104776', 'https://openalex.org/W2083197833', 'https://openalex.org/W2084394815', 'https://openalex.org/W2086069231', 'https://openalex.org/W2117672117', 'https://openalex.org/W2121217914', 'https://openalex.org/W2125149117', 'https://openalex.org/W2131642549', 'https://openalex.org/W2132102175', 'https://openalex.org/W2144528434', 'https://openalex.org/W2148517552', 'https://openalex.org/W2148658797', 'https://openalex.org/W2149369491', 'https://openalex.org/W2166185960', 'https://openalex.org/W2167251190', 'https://openalex.org/W2170702110', 'https://openalex.org/W2247024746', 'https://openalex.org/W2399755784', 'https://openalex.org/W2468066338', 'https://openalex.org/W2752295844', 'https://openalex.org/W2777604649', 'https://openalex.org/W2900789602', 'https://openalex.org/W2945949549', 'https://openalex.org/W2974819168', 'https://openalex.org/W3012101911', 'https://openalex.org/W655570148'], 'related_works': ['https://openalex.org/W2932835084', 'https://openalex.org/W2364142090', 'https://openalex.org/W2054795269', 'https://openalex.org/W2034384974', 'https://openalex.org/W2032217040', 'https://openalex.org/W1992604276', 'https://openalex.org/W1982844676', 'https://openalex.org/W1712519623', 'https://openalex.org/W1492115256', 'https://openalex.org/W1251615755'], 'abstract_inverted_index': {'The': [0], 'protein': [1, 89, 175], 'folding': [2, 176], 'and': [3, 42, 99, 109, 177], 'lipid': [4, 43], 'moiety': [5], 'status': [6], 'of': [7, 26, 36, 45, 140], 'glycosylphosphatidylinositol-anchored': [8], 'proteins': [9], '(GPI-APs)': [10], 'are': [11, 171], 'monitored': [12], 'in': [13, 23, 38, 47, 64, 106, 157], 'the': [14, 24, 29, 34, 39, 48, 53, 65, 93, 107, 113, 126, 150, 158], 'endoplasmic': [15], 'reticulum': [16], '(ER),': [17], 'with': [18], 'calnexin': [19, 37, 57], 'playing': [20], 'dual': [21], 'roles': [22], 'maturation': [25], 'GPI-APs.': [27], 'In': [28, 72, 116], 'present': [30], 'study,': [31], 'we': [32], 'investigated': [33], 'functions': [35], 'quality': [40, 166], 'control': [41, 167], 'remodeling': [44], 'GPI-APs': [46, 63, 101, 170], 'ER.': [49, 159], 'By': [50], 'directly': [51], 'binding': [52], 'N-glycan': [54], 'on': [55, 112, 125], 'proteins,': [56], 'was': [58, 78, 96, 123, 132], 'observed': [59], 'to': [60, 149], 'efficiently': [61], 'retain': [62], 'ER': [66, 75, 108, 135, 165], 'until': [67], 'they': [68, 154], 'were': [69, 110, 155], 'correctly': [70], 'folded.': [71], 'addition,': [73], 'sufficient': [74], 'retention': [76], 'time': [77, 152], 'crucial': [79], 'for': [80, 169, 173], 'GPI-inositol': [81, 145, 178], 'deacylation,': [82], 'which': [83], 'is': [84], 'mediated': [85], 'by': [86], 'post-GPI': [87], 'attachment': [88], '1': [90], '(PGAP1).': [91], 'Once': [92], 'calnexin/calreticulin': [94], 'cycle': [95], 'disrupted,': [97], 'misfolded': [98, 141], 'inositol-acylated': [100], 'could': [102], 'not': [103], 'be': [104], 'retained': [105, 156], 'exposed': [111], 'plasma': [114], 'membrane.': [115], 'calnexin/calreticulin-deficient': [117], 'cells,': [118], 'endogenous': [119], 'GPI-anchored': [120], 'alkaline': [121], 'phosphatase': [122], 'expressed': [124], 'cell': [127], 'surface,': [128], 'but': [129, 143], 'its': [130], 'activity': [131], 'significantly': [133], 'decreased.': [134], 'stress': [136], 'induced': [137], 'surface': [138], 'expression': [139], 'GPI-APs,': [142], 'proper': [144], 'deacylation': [146], 'occurred': [147], 'due': [148], 'extended': [151], 'that': [153, 163], 'Our': [160], 'results': [161], 'indicate': [162], 'calnexin-mediated': [164], 'systems': [168], 'necessary': [172], 'both': [174], 'deacylation.': [179]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3088012430', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 6}], 'updated_date': '2025-01-11T05:43:56.288690', 'created_date': '2020-10-01'}