Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2019174846', 'doi': 'https://doi.org/10.1073/pnas.94.5.1884', 'title': 'Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of “ER-resident” molecular chaperones', 'display_name': 'Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of “ER-resident” molecular chaperones', 'publication_year': 1997, 'publication_date': '1997-03-04', 'ids': {'openalex': 'https://openalex.org/W2019174846', 'doi': 'https://doi.org/10.1073/pnas.94.5.1884', 'mag': '2019174846', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9050874', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/20012'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.94.5.1884', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc20012?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002152110', 'display_name': 'David L. Wiest', 'orcid': 'https://orcid.org/0000-0002-0792-3188'}, 'institutions': [{'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David L. Wiest', 'raw_affiliation_strings': ['Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Room 4B-17, Building 10, Bethesda, MD 20892; Department of Cell Biology, New York University School of Medicine, New York, NY 10016; and Department of Immunology, Mayo Clinic, Rochester, MN 55905'], 'affiliations': [{'raw_affiliation_string': 'Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Room 4B-17, Building 10, Bethesda, MD 20892; Department of Cell Biology, New York University School of Medicine, New York, NY 10016; and Department of Immunology, Mayo Clinic, Rochester, MN 55905', 'institution_ids': ['https://openalex.org/I57206974', 'https://openalex.org/I1330342723', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042456497', 'display_name': 'Avinash Bhandoola', 'orcid': 'https://orcid.org/0000-0002-4657-8372'}, 'institutions': [{'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Avinash Bhandoola', 'raw_affiliation_strings': ['Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Room 4B-17, Building 10, Bethesda, MD 20892; Department of Cell Biology, New York University School of Medicine, New York, NY 10016; and Department of Immunology, Mayo Clinic, Rochester, MN 55905'], 'affiliations': [{'raw_affiliation_string': 'Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Room 4B-17, Building 10, Bethesda, MD 20892; Department of Cell Biology, New York University School of Medicine, New York, NY 10016; and Department of Immunology, Mayo Clinic, Rochester, MN 55905', 'institution_ids': ['https://openalex.org/I57206974', 'https://openalex.org/I1330342723', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082082458', 'display_name': 'Jennifer A. Punt', 'orcid': 'https://orcid.org/0000-0002-4439-5628'}, 'institutions': [{'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer Punt', 'raw_affiliation_strings': ['Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Room 4B-17, Building 10, Bethesda, MD 20892; Department of Cell Biology, New York University School of Medicine, New York, NY 10016; and Department of Immunology, Mayo Clinic, Rochester, MN 55905'], 'affiliations': [{'raw_affiliation_string': 'Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Room 4B-17, Building 10, Bethesda, MD 20892; Department of Cell Biology, New York University School of Medicine, New York, NY 10016; and Department of Immunology, Mayo Clinic, Rochester, MN 55905', 'institution_ids': ['https://openalex.org/I57206974', 'https://openalex.org/I1330342723', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080761072', 'display_name': 'Gert Kreibich', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gert Kreibich', 'raw_affiliation_strings': ['Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Room 4B-17, Building 10, Bethesda, MD 20892; Department of Cell Biology, New York University School of Medicine, New York, NY 10016; and Department of Immunology, Mayo Clinic, Rochester, MN 55905'], 'affiliations': [{'raw_affiliation_string': 'Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Room 4B-17, Building 10, Bethesda, MD 20892; Department of Cell Biology, New York University School of Medicine, New York, NY 10016; and Department of Immunology, Mayo Clinic, Rochester, MN 55905', 'institution_ids': ['https://openalex.org/I57206974', 'https://openalex.org/I1330342723', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108805419', 'display_name': 'D J McKean', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David McKean', 'raw_affiliation_strings': ['Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Room 4B-17, Building 10, Bethesda, MD 20892; Department of Cell Biology, New York University School of Medicine, New York, NY 10016; and Department of Immunology, Mayo Clinic, Rochester, MN 55905'], 'affiliations': [{'raw_affiliation_string': 'Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Room 4B-17, Building 10, Bethesda, MD 20892; Department of Cell Biology, New York University School of Medicine, New York, NY 10016; and Department of Immunology, Mayo Clinic, Rochester, MN 55905', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I57206974', 'https://openalex.org/I1330342723', 'https://openalex.org/I1299303238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006278200', 'display_name': 'Alfred Singer', 'orcid': 'https://orcid.org/0000-0002-6780-5108'}, 'institutions': [{'id': 'https://openalex.org/I57206974', 'display_name': 'New York University', 'ror': 'https://ror.org/0190ak572', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I57206974']}, {'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alfred Singer', 'raw_affiliation_strings': ['Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Room 4B-17, Building 10, Bethesda, MD 20892; Department of Cell Biology, New York University School of Medicine, New York, NY 10016; and Department of Immunology, Mayo Clinic, Rochester, MN 55905'], 'affiliations': [{'raw_affiliation_string': 'Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Room 4B-17, Building 10, Bethesda, MD 20892; Department of Cell Biology, New York University School of Medicine, New York, NY 10016; and Department of Immunology, Mayo Clinic, Rochester, MN 55905', 'institution_ids': ['https://openalex.org/I57206974', 'https://openalex.org/I1330342723', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.388, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 108, 'citation_normalized_percentile': {'value': 0.947467, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '94', 'issue': '5', 'first_page': '1884', 'last_page': '1889'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12856', 'display_name': 'Transgenic Plants and Applications', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/er-retention', 'display_name': 'ER retention', 'score': 0.8157476}, {'id': 'https://openalex.org/keywords/chemical-chaperone', 'display_name': 'Chemical chaperone', 'score': 0.5602003}, {'id': 'https://openalex.org/keywords/calnexin', 'display_name': 'Calnexin', 'score': 0.5115765}, {'id': 'https://openalex.org/keywords/chaperone', 'display_name': 'Chaperone (clinical)', 'score': 0.5101567}, {'id': 'https://openalex.org/keywords/thymocyte', 'display_name': 'Thymocyte', 'score': 0.43134347}], 'concepts': [{'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.9576162}, {'id': 'https://openalex.org/C2778043179', 'wikidata': 'https://www.wikidata.org/wiki/Q5324093', 'display_name': 'ER retention', 'level': 4, 'score': 0.8157476}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.75040805}, {'id': 'https://openalex.org/C61397870', 'wikidata': 'https://www.wikidata.org/wiki/Q1069458', 'display_name': 'Chemical chaperone', 'level': 4, 'score': 0.5602003}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.5187031}, {'id': 'https://openalex.org/C130361206', 'wikidata': 'https://www.wikidata.org/wiki/Q908443', 'display_name': 'Calnexin', 'level': 4, 'score': 0.5115765}, {'id': 'https://openalex.org/C2775962898', 'wikidata': 'https://www.wikidata.org/wiki/Q5073152', 'display_name': 'Chaperone (clinical)', 'level': 2, 'score': 0.5101567}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.49369416}, {'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.44077227}, {'id': 'https://openalex.org/C2778954852', 'wikidata': 'https://www.wikidata.org/wiki/Q7799635', 'display_name': 'Thymocyte', 'level': 4, 'score': 0.43134347}, {'id': 'https://openalex.org/C204328495', 'wikidata': 'https://www.wikidata.org/wiki/Q847556', 'display_name': 'Protein folding', 'level': 2, 'score': 0.42707655}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.35007155}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20672008}, {'id': 'https://openalex.org/C47450691', 'wikidata': 'https://www.wikidata.org/wiki/Q634510', 'display_name': 'Calreticulin', 'level': 3, 'score': 0.20576993}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.16497919}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.12025437}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.062033474}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.059033155}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.058281124}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.056615442}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.053990662}], 'mesh': [{'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017252', 'descriptor_name': 'CD3 Complex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017252', 'descriptor_name': 'CD3 Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002135', 'descriptor_name': 'Calcium-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002135', 'descriptor_name': 'Calcium-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D037281', 'descriptor_name': 'Calnexin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011233', 'descriptor_name': 'Precipitin Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017510', 'descriptor_name': 'Protein Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013950', 'descriptor_name': 'Thymus Gland', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D013950', 'descriptor_name': 'Thymus Gland', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.94.5.1884', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc20012', 'pdf_url': 'https://europepmc.org/articles/pmc20012?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9050874', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc20012', 'pdf_url': 'https://europepmc.org/articles/pmc20012?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land', 'score': 0.46}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W120298262', 'https://openalex.org/W121339944', 'https://openalex.org/W129375328', 'https://openalex.org/W1541968184', 'https://openalex.org/W1546074605', 'https://openalex.org/W1599120105', 'https://openalex.org/W1864683348', 'https://openalex.org/W18653780', 'https://openalex.org/W1939638263', 'https://openalex.org/W1967328876', 'https://openalex.org/W1970007744', 'https://openalex.org/W1977546470', 'https://openalex.org/W1991102055', 'https://openalex.org/W1994947913', 'https://openalex.org/W1999719904', 'https://openalex.org/W2002725367', 'https://openalex.org/W2011958996', 'https://openalex.org/W2022284744', 'https://openalex.org/W2030724377', 'https://openalex.org/W2037928475', 'https://openalex.org/W2038303530', 'https://openalex.org/W2042173550', 'https://openalex.org/W2042471874', 'https://openalex.org/W2047524608', 'https://openalex.org/W2051690692', 'https://openalex.org/W2051793369', 'https://openalex.org/W2054593368', 'https://openalex.org/W2062044807', 'https://openalex.org/W2070379407', 'https://openalex.org/W2080809922', 'https://openalex.org/W2087662274', 'https://openalex.org/W2095429868', 'https://openalex.org/W2095701936', 'https://openalex.org/W2099616208', 'https://openalex.org/W2102948276', 'https://openalex.org/W2106766643', 'https://openalex.org/W2107312415', 'https://openalex.org/W2121217914', 'https://openalex.org/W2133110610', 'https://openalex.org/W2135503300', 'https://openalex.org/W2145835877', 'https://openalex.org/W2146674279', 'https://openalex.org/W2162913734', 'https://openalex.org/W2169685188', 'https://openalex.org/W2170429205', 'https://openalex.org/W2171959398', 'https://openalex.org/W2336728022', 'https://openalex.org/W258316223', 'https://openalex.org/W270749527', 'https://openalex.org/W314850542', 'https://openalex.org/W86630917'], 'related_works': ['https://openalex.org/W4214517393', 'https://openalex.org/W3165347333', 'https://openalex.org/W2622529157', 'https://openalex.org/W2209762692', 'https://openalex.org/W2168919757', 'https://openalex.org/W2044541826', 'https://openalex.org/W2044287941', 'https://openalex.org/W2032217040', 'https://openalex.org/W1989203765', 'https://openalex.org/W1969829115'], 'abstract_inverted_index': {'The': [0], 'folding': [1], 'and': [2, 84], 'assembly': [3], 'of': [4, 30, 43, 76, 91], 'nascent': [5], 'proteins': [6, 66], 'in': [7, 81], 'the': [8, 22, 41, 57, 73], 'endoplasmic': [9], 'reticulum': [10], '(ER)': [11], 'is': [12, 50, 59, 79], 'assisted': [13], 'by': [14], 'molecular': [15, 35], 'chaperones': [16], 'that': [17, 27, 95], 'are': [18, 37], 'themselves': [19], 'retained': [20], 'within': [21], 'ER.': [23], 'We': [24], 'now': [25], 'report': [26], 'a': [28], 'number': [29], 'different': [31], 'ER': [32, 58, 65, 77], 'proteins,': [33], 'including': [34], 'chaperones,': [36], 'selectively': [38], 'expressed': [39], 'on': [40], 'surface': [42, 48, 89], 'immature': [44, 82], 'thymocytes,': [45], 'but': [46], 'their': [47], 'expression': [49, 90], 'extinguished': [51], 'upon': [52], 'further': [53], 'differentiation.': [54], 'Escape': [55], 'from': [56], 'only': [60], 'possible': [61], 'for': [62, 88], 'newly': [63], 'synthesized': [64], 'before': [67], 'they': [68], 'become': [69], 'permanently': [70], 'retained.': [71], 'Thus,': [72], 'cellular': [74], 'process': [75], 'retention': [78], 'incomplete': [80], 'thymocytes': [83], 'provides': [85], 'an': [86], 'explanation': [87], 'partial': [92], 'receptor': [93], 'complexes': [94], 'transduce': [96], 'differentiative': [97], 'signals': [98], 'during': [99], 'thymic': [100], 'development.': [101]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2019174846', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-12T02:06:50.323612', 'created_date': '2016-06-24'}