Publication Information

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'https://openalex.org/W227934003', 'https://openalex.org/W2094003629', 'https://openalex.org/W2042949990', 'https://openalex.org/W2029377139', 'https://openalex.org/W2020987091', 'https://openalex.org/W1983163659', 'https://openalex.org/W1979154669'], 'abstract_inverted_index': {'Heat': [0, 223, 1401], 'shock': [1, 135, 224, 358, 450, 1885, 1900, 2873, 3006, 3393, 3674, 3683, 3764, 3884, 3907, 4091, 4102, 4135, 4149, 4395, 4460], 'protein': [2, 225, 451, 453, 2241, 3963, 4257], '70': [3, 226], '(HSP70)': [4, 227], 'has': [5, 228, 1096, 1256], 'been': [6, 229, 552, 1098, 1257], 'shown': [7, 230, 3837, 4227, 4514], 'to': [8, 49, 102, 181, 194, 231, 272, 325, 404, 417, 806, 912, 927, 1120, 1126, 1218, 1364, 1640, 1694, 1749, 1887, 2115, 2119, 2197, 2244, 2457, 2661, 2777, 2870, 2879, 2942, 3011, 3245, 3255, 3409, 3431, 3447, 3456, 3466, 3516, 3671, 3705, 3740, 3761, 3776, 3781, 3793, 3819, 3903, 3942, 4067, 4170, 4358, 4392, 4489, 4556], 'act': [9, 232], 'as': [10, 206, 233, 429, 643, 736, 868, 1106, 1123, 1208, 1215, 1259, 1332, 1658, 1660, 2013, 2026, 2137, 2300, 2627, 2808, 2988, 3116, 3175, 3372, 3836, 3944, 4051], 'an': [11, 19, 66, 234, 242, 289, 1654, 2662, 3160, 3350, 3503, 3520, 3891, 3945, 4052, 4253], 'inhibitor': [12, 235, 446, 3925, 3946], 'of': [13, 22, 60, 85, 98, 118, 138, 158, 169, 210, 214, 220, 236, 245, 283, 308, 321, 341, 361, 381, 392, 433, 437, 443, 447, 493, 549, 617, 622, 750, 839, 844, 862, 900, 908, 915, 998, 1010, 1078, 1092, 1339, 1373, 1400, 1424, 1587, 1636, 1674, 1680, 1918, 2054, 2152, 2211, 2240, 2247, 2256, 2267, 2343, 2460, 2537, 2547, 2619, 2665, 2699, 2713, 2726, 2729, 2749, 2754, 2853, 3050, 3071, 3165, 3181, 3200, 3217, 3225, 3229, 3380, 3421, 3433, 3464, 3512, 3568, 3578, 3584, 3590, 3602, 3637, 3669, 3679, 3709, 3722, 3742, 3751, 3774, 3807, 3833, 3858, 3893, 3926, 3930, 3937, 3940, 3947, 3951, 4007, 4038, 4059, 4070, 4087, 4100, 4163, 4184, 4210, 4239, 4290, 4302, 4343, 4372, 4432, 4467, 4472, 4494, 4506, 4529, 4551, 4554], 'apoptosis.': [14, 237, 3854, 4082], 'We': [15, 238, 1652, 3375], 'have': [16, 239, 551, 3866], 'also': [17, 240, 3769, 3828, 3889, 4011, 4141, 4424, 4502], 'observed': [18, 241, 3443, 3755, 3867, 4012, 4321, 4425], 'inhibitory': [20, 243], 'effect': [21, 59, 244, 282, 3379, 4099, 4235], 'HSP70': [23, 44, 61, 101, 114, 155, 170, 204, 246, 267, 284, 324, 337, 378, 393, 427, 1255, 1418, 1529, 1588, 1669, 1889, 2609, 2620, 2681, 3411, 3422, 3481, 3711, 3723, 3845, 3859, 3880, 3921, 3941, 3953, 3962, 3975, 3993, 4017, 4033, 4177, 4191, 4232, 4405, 4555], 'on': [24, 62, 247, 285, 2216, 2384, 2794, 2927, 3059, 3135, 3384, 3509, 3954, 4103, 4236], 'apoptotic': [25, 63, 248, 286, 909, 985, 1425, 3495, 4164, 4495], 'cell': [26, 142, 249, 365, 475, 928, 1012, 1914, 1964, 2058, 2153, 2213, 2248, 2407, 2700, 2904, 3037, 3352, 3355, 3873, 4165, 4421, 4433, 4496], 'death': [27, 143, 250, 366, 929, 1013, 4166, 4497], 'both': [28, 145, 251, 368, 4350, 4384], 'in': [29, 65, 67, 77, 144, 164, 252, 288, 290, 300, 367, 387, 554, 920, 1003, 1082, 1535, 1644, 1655, 1844, 1859, 1875, 2000, 2084, 2170, 2289, 2340, 2397, 2431, 2503, 2556, 2570, 2603, 2719, 2721, 2746, 2888, 2898, 2952, 3167, 3169, 3197, 3349, 3387, 3423, 3444, 3454, 3474, 3493, 3504, 3519, 3616, 3625, 3646, 3657, 3715, 3717, 3725, 3732, 3756, 3779, 3830, 3838, 3851, 3870, 3901, 3998, 4013, 4020, 4044, 4081, 4130, 4159, 4168, 4200, 4215, 4228, 4242, 4278, 4293, 4308, 4317, 4326, 4349, 4356, 4377, 4383, 4426, 4446, 4450, 4457, 4487, 4498, 4515, 4532, 4537], 'preheated': [30, 90, 146, 253, 313, 369, 1661, 3184, 3425, 3452, 3475, 3556, 3629, 3650, 3743, 3797, 3839, 4216, 4309, 4351, 4385, 4451, 4468, 4542], 'U937': [31, 36, 91, 147, 254, 259, 314, 370, 1840, 3388, 3981, 4110, 4217, 4310, 4352, 4360, 4386, 4452, 4543], 'and': [32, 72, 109, 141, 148, 187, 218, 255, 295, 332, 364, 371, 410, 441, 481, 491, 561, 739, 801, 853, 859, 922, 925, 1087, 1089, 1102, 1108, 1204, 1211, 1230, 1273, 1342, 1371, 1404, 1441, 1532, 1662, 1683, 1715, 1794, 1805, 1813, 1822, 1828, 1855, 1873, 1897, 1920, 1995, 2016, 2060, 2088, 2140, 2162, 2251, 2264, 2338, 2419, 2446, 2501, 2529, 2590, 2598, 2623, 2641, 2667, 2682, 2733, 2770, 2781, 2799, 2858, 2877, 2894, 2920, 2947, 2962, 2966, 3014, 3035, 3045, 3131, 3149, 3206, 3223, 3250, 3285, 3318, 3366, 3555, 3564, 3580, 3595, 3736, 3802, 3823, 3898, 3957, 3976, 3986, 4218, 4305, 4311, 4323, 4345, 4353, 4361, 4387, 4438, 4449], 'stably': [33, 256], 'transfected': [34, 257, 1958, 2122], 'HSP70-overexpressing': [35, 258, 1267, 1663, 3186, 3702], '(U937/HSP70)': [37, 260], 'cells.': [38, 94, 261, 317, 1664, 2123, 3389, 3798, 3816, 3840, 4246, 4527], 'However,': [39, 262, 1075], 'the': [40, 58, 96, 130, 173, 184, 188, 263, 281, 319, 353, 396, 407, 411, 494, 623, 751, 802, 842, 906, 913, 992, 996, 1004, 1011, 1076, 1090, 1584, 1634, 1645, 1685, 1689, 1788, 1880, 1960, 1996, 2001, 2045, 2051, 2116, 2121, 2133, 2141, 2147, 2198, 2229, 2389, 2420, 2458, 2696, 2711, 2720, 2747, 2778, 2938, 2948, 3036, 3064, 3081, 3094, 3150, 3168, 3198, 3215, 3218, 3251, 3338, 3378, 3416, 3419, 3424, 3434, 3451, 3457, 3494, 3510, 3575, 3581, 3585, 3593, 3607, 3617, 3626, 3638, 3647, 3658, 3667, 3677, 3707, 3716, 3749, 3766, 3782, 3805, 3918, 3938, 3949, 4036, 4056, 4068, 4085, 4098, 4160, 4201, 4208, 4237, 4279, 4294, 4300, 4303, 4315, 4318, 4341, 4366, 4378, 4407, 4427, 4465, 4470, 4490, 4530, 4552], 'molecular': [41, 264, 746, 1757], 'mechanism': [42, 265, 1091, 1586], 'whereby': [43, 266], 'prevents': [45, 115, 268, 338, 1223, 1530, 4035], 'apoptosis': [46, 116, 211, 269, 339, 434, 448, 550, 1083, 1122, 1265, 1540, 1646, 1672, 2450, 2723, 3403, 3506, 3518, 3569, 3714, 3810, 3927, 4043, 4060, 4093, 4179, 4202, 4524], 'still': [47, 125, 270, 348, 1085, 1590], 'remains': [48, 271], 'be': [50, 273, 612, 1118, 1326], 'solved.': [51, 274], 'To': [52, 275, 1910, 2709, 3345, 3489, 4083, 4204, 4297, 4402], 'address': [53, 276, 3706, 4084, 4205], 'this': [54, 277, 1637, 3612, 3916, 4153, 4206], 'issue,': [55, 278], 'we': [56, 201, 279, 424, 3501, 3700, 3865, 4174, 4187, 4320], 'investigated': [57, 280], 'processes': [64, 287], 'vitro': [68, 291, 2449, 2722, 3170, 3505, 3718, 3809, 3985, 4046], 'system.': [69, 292, 3719, 3970, 4047], 'Caspase-3': [70, 293, 2192, 4381], 'cleavage': [71, 108, 294, 331, 907, 3850, 3997], 'DNA': [73, 110, 296, 333, 482, 634, 2715, 2787, 2804, 2984, 2991, 3440, 3467, 3471, 3641, 3654, 3752, 3777, 3825, 3899, 3958, 4008], 'fragmentation': [74, 297, 2805, 2985, 2992, 3441, 3468, 3472, 3583, 3636, 3655, 3753, 3778, 3826, 3900, 3959, 4009], 'were': [75, 298, 1706, 1720, 1752, 1764, 1785, 1798, 1815, 1831, 1842, 1868, 1902, 1957, 1993, 1998, 2011, 2098, 2135, 2144, 2156, 2182, 2206, 2284, 2332, 2391, 2454, 2496, 2542, 2568, 2621, 2649, 2656, 2669, 2687, 2704, 2738, 2845, 2868, 2886, 2896, 2906, 2930, 2940, 2950, 3009, 3023, 3039, 3066, 3096, 3111, 3122, 3137, 3153, 3188, 3221, 3231, 3243, 3253, 3260, 3297, 3558, 3827, 3960, 3983, 4112, 4347, 4396, 4441, 4455, 4535], 'detected': [76, 299, 4277], 'cytosolic': [78, 104, 301, 327, 2730, 3117, 3151, 3831, 3977, 4211, 4280, 4295], 'fractions': [79, 105, 302, 328, 2698, 3148, 3152], 'from': [80, 89, 127, 303, 312, 350, 1113, 1421, 1708, 1722, 1732, 1754, 1766, 1778, 1787, 1800, 1817, 1833, 2050, 2490, 2973, 3183, 3359, 3553, 3619, 3628, 3649, 3661, 3814, 3979, 4064, 4409], 'normal': [81, 103, 304, 326, 4359], 'cells': [82, 305, 1420, 1841, 1867, 1992, 1997, 2010, 2083, 2097, 2134, 2143, 2155, 2181, 2202, 2331, 2390, 2840, 2852, 2867, 3008, 3065, 3187, 3360, 3426, 3436, 3445, 3476, 3557, 3630, 3663, 3670, 3703, 3727, 3734, 3744, 3758, 3768, 3784, 3835, 3878, 3912, 3982, 4111, 4140, 4220, 4313, 4329, 4355, 4389, 4408, 4448, 4453, 4477, 4500, 4508, 4520], 'upon': [83, 306, 4390], 'addition': [84, 97, 307, 320, 1363], 'dATP,': [86, 309], 'but': [87, 310, 1678, 4018], 'not': [88, 311, 1097, 3401, 3405, 3914, 4019, 4151, 4276], 'or': [92, 315, 625, 640, 648, 1007, 1538, 1745, 1907, 3185, 3202, 3885, 4474, 4480, 4544], 'U937/hsp70': [93, 149, 316, 372, 3726, 3757, 3767, 3815, 3834, 4219, 4312, 4499, 4519, 4545], 'Moreover,': [95, 318], 'purified': [99, 166, 322, 389, 2688, 3965], 'recombinant': [100, 323, 2647, 3952, 3974, 3992, 4016], 'prevented': [106, 329, 3829], 'caspase-3': [107, 119, 139, 196, 221, 330, 342, 362, 419, 444, 1233, 1531, 1681, 1696, 2234, 3166, 3603, 3821, 3849, 3894, 3931, 3955, 3989, 3996, 4185, 4304, 4322, 4370, 4412], 'fragmentation,': [111, 334, 483], 'suggesting': [112, 335], 'that': [113, 154, 172, 203, 336, 377, 395, 426, 1668, 1684, 3399, 3432, 3741, 3844, 3920, 4032, 4155, 4176, 4285, 4454, 4505], 'upstream': [117, 219, 340, 442, 1679, 3929, 4183, 4198], 'processing.': [120, 197, 343, 420], 'Because': [121, 344, 1100, 3666, 4138, 4247], 'cytochrome': [122, 159, 215, 345, 382, 438, 840, 999, 1079, 1093, 1224, 1675, 1718, 1795, 3015, 3524, 4095, 4104, 4118, 4143, 4156, 4240, 4248, 4334, 4418], 'c': [123, 160, 216, 346, 383, 439, 1080, 1094, 1225, 1676, 1719, 1792, 3162, 3525, 4049, 4096, 4105, 4119, 4127, 4144, 4157, 4241, 4249, 4335, 4419], 'was': [124, 152, 192, 347, 375, 415, 1730, 1776, 1891, 2024, 2048, 2079, 2113, 2126, 2194, 2231, 2242, 2297, 2409, 2422, 2441, 2611, 2775, 2788, 2806, 2976, 2986, 3017, 3083, 3172, 3335, 3357, 3407, 3427, 3442, 3477, 3482, 3571, 3604, 3622, 3642, 3728, 3737, 3754, 3964, 4010, 4107, 4121, 4128, 4213, 4275, 4283, 4287, 4375, 4414, 4423, 4484, 4501], 'released': [126, 349], 'mitochondria': [128, 351, 807, 993, 4065, 4292], 'into': [129, 352, 1959, 2613, 2625, 2651, 2716, 3592, 4076], 'cytosol': [131, 354, 4131], 'by': [132, 355, 474, 614, 905, 1328, 1650, 1969, 2393, 2411, 2534, 2694, 2790, 2978, 3484, 3499, 3573, 3881, 4123, 4146, 4337, 4443, 4509], 'lethal': [133, 356, 1898, 2871, 3004, 3363, 3448, 3762, 3905, 4089, 4115, 4133, 4147, 4223, 4243, 4327, 4338, 4393, 4458], 'heat': [134, 357, 449, 644, 1428, 1536, 1884, 1899, 2872, 3005, 3364, 3385, 3392, 3417, 3449, 3487, 3673, 3682, 3763, 3852, 3883, 3906, 4090, 4101, 4116, 4134, 4148, 4171, 4224, 4244, 4339, 4394, 4459], 'despite': [136, 359], 'prevention': [137, 360], 'activation': [140, 363, 621, 989, 1234, 1534, 3570, 3822, 3956, 4037, 4069], 'cells,': [150, 373, 3453, 3459, 3621, 3651, 4363, 4469, 4546], 'it': [151, 374, 809, 1116, 4282], 'evident': [153, 376], 'acts': [156, 205, 379, 428, 4050], 'downstream': [157, 213, 380, 436, 864, 1673], 'release.': [161, 384], 'Results': [162, 385], 'obtained': [163, 386, 1721, 1731, 1753, 1765, 1816, 2789, 3795], 'vitrowith': [165, 388], 'deletion': [167, 390, 2617, 2684], 'mutants': [168, 391, 2618], 'showed': [171, 394, 1270, 3460, 3770, 3890, 4142, 4521], 'carboxyl': [174, 397], 'one-third': [175, 398], 'region': [176, 399, 1687], '(from': [177, 400], 'amino': [178, 401, 1334], 'acids': [179, 402], '438': [180, 403], '641)': [182, 405], 'including': [183, 406, 557, 620, 1427], 'peptide-binding': [185, 408, 1690], 'domain': [186, 409, 804, 1691], 'carboxyl-terminal': [189, 412, 803, 1686], 'EEVD': [190, 413], 'sequence': [191, 414], 'essential': [193, 416], 'prevent': [195, 418], 'From': [198, 421], 'these': [199, 422, 901, 1128, 3877], 'results,': [200, 423], 'conclude': [202, 425], 'a': [207, 430, 615, 845, 849, 1124, 1260, 1422, 1860, 1876, 1912, 2014, 2063, 2085, 2106, 2138, 2186, 2290, 2398, 2432, 2538, 2557, 2690, 2795, 2889, 2899, 2943, 3003, 3072, 3461, 3485, 3771, 3861, 3871, 3904, 3923, 3934, 3967, 4538], 'strong': [208, 431], 'suppressor': [209, 432], 'acting': [212, 435, 3928], 'release': [217, 440, 812, 838, 997, 1081, 1095, 4063, 4106, 4120, 4145, 4238, 4336], 'activation.': [222, 445, 1697, 3932, 3990], 'stress-activated': [452], 'kinase/c-Jun': [454], 'N-terminal': [455], 'kinase': [456], 'cytokine': [457], 'response': [458, 3902, 4169], 'modifier': [459], 'A': [460, 2345, 2751, 3052, 3390], 'dithiothreitol': [461], 'poly(ADP-ribose)polymerase': [462], 'propidium': [463], 'iodide': [464], 'phosphate-buffered': [465], 'saline': [466], 'p-nitroanilide': [467], '1,4-piperazinediethanesulfonic': [468], 'acid': [469, 1335], 'Apoptosis,': [470], 'which': [471, 855, 1001, 1642, 2132, 3491, 3614, 4072, 4195], 'is': [472, 484, 856, 903, 1084, 1589, 1639, 1648, 1692, 3497, 3860, 3922, 4196], 'characterized': [473], 'shrinkage,': [476], 'membrane': [477, 4256], 'blebbing,': [478], 'nuclear': [479, 923], 'breakdown,': [480], 'indispensable': [485], 'for': [486, 987, 1263, 1368, 1760, 1772, 1783, 1894, 1905, 2018, 2090, 2128, 2146, 2174, 2218, 2233, 2280, 2386, 2413, 2553, 2677, 2743, 2855, 2874, 2882, 2935, 2968, 3029, 3061, 3103, 3142, 3155, 3208, 3239, 3279, 3289, 3321, 3611, 3988], 'embryo': [487], 'development,': [488], 'tissue': [489], 'homeostasis,': [490], 'regulation': [492], 'immune': [495], 'system': [496, 1657, 3171, 3507], '(1Steller': [497], 'H.': [498, 708, 818, 1151], 'Science.': [499, 586, 601, 724, 975, 1039, 1066, 1980, 4266], '1995;': [500, 587, 669, 1506], '267:': [501, 588, 1355], '1445-1449Crossref': [502], 'PubMed': [503, 515, 527, 579, 590, 605, 672, 696, 728, 771, 789, 832, 893, 946, 968, 979, 1026, 1043, 1070, 1177, 1198, 1248, 1296, 1319, 1383, 1453, 1468, 1486, 1509, 1524, 1576, 1608, 1628, 1952, 1984, 2039, 2322, 2484, 2829, 3546, 3695, 4270], 'Scopus': [504, 516, 528, 544, 580, 591, 606, 673, 697, 729, 772, 790, 833, 894, 947, 980, 1027, 1044, 1071, 1178, 1199, 1249, 1297, 1320, 1384, 1454, 1469, 1487, 1510, 1525, 1577, 1609, 1629, 1953, 1985, 2040, 2323, 2485, 2830, 3547, 3696, 4271], '(2431)': [505], 'Google': [506, 518, 530, 546, 582, 593, 608, 675, 699, 718, 731, 774, 792, 835, 896, 949, 969, 982, 1029, 1046, 1073, 1180, 1201, 1251, 1299, 1322, 1360, 1386, 1456, 1471, 1489, 1512, 1527, 1558, 1579, 1611, 1631, 1955, 1987, 2042, 2325, 2487, 2832, 3549, 3698, 4273], 'Scholar,': [507, 519, 531, 583, 594, 676, 700, 719, 775, 950, 970, 1030, 1047, 1300, 1387, 1457, 1472, 1490, 1513, 1559, 1612], '2White': [508], 'E.': [509, 1016, 1034, 4261], 'Genes': [510], 'Dev.': [511], '1996;': [512, 725, 1380, 1521, 2314, 2476, 2826, 3538, 3692], '10:': [513], '1-15Crossref': [514], '(1325)': [517], '3Kerr': [520], 'J.F.R.': [521, 535], 'J.': [522, 668, 685, 940, 959, 1022, 1049, 1290, 1351, 1389, 1447, 1482, 1503, 1624, 2308, 2470, 3532], 'Pathol.': [523], '1971;': [524], '105:': [525], '13-20Crossref': [526], '(681)': [529], '4Wyllie': [532], 'A.H.': [533], 'Kerr': [534], 'Currie': [536, 1305], 'A.R.': [537], 'Int.': [538], 'Rev.': [539], 'Cytol.': [540], '1980;': [541], '65:': [542], '251-305Crossref': [543], '(6725)': [545], 'Scholar).': [547, 609, 732, 793, 836, 897, 983, 1074, 1202, 1252, 1323, 1361, 1528, 1580, 1632, 1988, 2043, 2488, 3550], 'Malfunctions': [548], 'implicated': [553], 'human': [555, 2608], 'diseases': [556, 1104, 1110, 1129], 'cancer,': [558], 'neurodegenerative': [559, 1103], 'disorders,': [560], 'ischemic': [562], 'stroke': [563], '(5Jacobson': [564], 'M.D.': [565], 'Weil': [566], 'M.': [567, 682, 723, 879, 1145, 1283, 1474, 1500, 1614, 1622], 'Raff': [568], 'M.C.': [569], 'Cell.': [570, 780, 823, 884, 1168, 1189, 1239, 1448, 1519, 1571, 1603, 1947, 2313, 2475, 3537, 3690], '1997;': [571, 781, 885, 976, 1040, 1067, 1240, 1316, 1573, 1605, 4267], '88:': [572], '347-354Abstract': [573], 'Full': [574, 576, 691, 693, 784, 786, 827, 829, 888, 890, 965, 1172, 1174, 1193, 1195, 1243, 1245, 1357, 2317, 2319, 2479, 2481, 3541, 3543], 'Text': [575, 577, 692, 694, 785, 787, 828, 830, 889, 891, 966, 1173, 1175, 1194, 1196, 1244, 1246, 1358, 2318, 2320, 2480, 2482, 3542, 3544], 'PDF': [578, 695, 788, 831, 892, 967, 1176, 1197, 1247, 1359, 2321, 2483, 3545], '(2409)': [581], '6Thompson': [584], 'C.B.': [585], '1456-1462Crossref': [589], '(6191)': [592], '7Price': [595], 'D.L.': [596], 'Sisodia': [597], 'S.S.': [598], 'Borchelt': [599], 'D.R.': [600, 666, 1020, 1036, 4263], '1998;': [602, 688, 824, 1023, 1190, 1293, 1625, 1949], '282:': [603], '1079-1083Crossref': [604], '(227)': [607], 'Apoptosis': [610, 733], 'can': [611, 1325, 1670, 3675], 'induced': [613, 1327, 2670, 3483], 'variety': [616], 'different': [618, 2875, 3681, 3872], 'signals,': [619], 'Fas': [624, 737], 'tumor': [626, 740, 1430], 'necrosis': [627, 741, 1431], 'factor': [628, 631, 742, 1434], 'receptors,': [629], 'growth': [630, 1433], 'deprivation,': [632], 'excessive': [633, 1114], 'damage,': [635], 'treatment': [636, 3394], 'with': [637, 1849, 1871, 2074, 2081, 2103, 2159, 2164, 2185, 2208, 2253, 2327, 2335, 2369, 2498, 2674, 2834, 2847, 2862, 2908, 3042, 3047, 3068, 3125, 3128, 3159, 3190, 3233, 3262, 3287, 3299, 3327, 3362, 3369, 3560, 3606, 3796, 3909, 4000, 4042, 4114, 4222, 4504, 4541], 'chemotherapeutic': [638, 1438], 'drugs,': [639], 'stresses': [641, 1330], 'such': [642, 735, 867, 1105, 1207, 1331], 'shock,': [645, 647, 1429, 3365, 3450, 4117, 4340], 'hyperosmotic': [646], 'UV': [649, 2802], 'irradiation': [650], '(8Martin': [651], 'S.J.': [652], 'Newmeyer': [653, 1017, 1037, 4264], 'D.D.': [654, 1018, 1038, 1444, 1561, 1593, 4265], 'Mathias': [655], 'S.': [656, 766, 933, 1161, 1165, 1184, 2824, 2902], 'Farschon': [657], 'D.M.': [658], 'Wang': [659, 821, 882, 1064, 2311, 2473, 3535], 'H.G.': [660], 'Reed': [661], 'J.C.': [662, 1302, 1930], 'Kolesnick': [663], 'R.N.': [664], 'Green': [665, 1019, 1035, 4262], 'EMBO': [667, 1021, 1481, 1623], '14:': [670], '5191-5200Crossref': [671], '(241)': [674], '9Buzzard': [677], 'K.A': [678], 'Giaccia': [679], 'A.J.': [680], 'Killender': [681], 'Anderson': [683], 'R.L.': [684], 'Biol.': [686, 942, 960, 1352, 1572, 1604], 'Chem.': [687, 961, 1353], '273:': [689], '17147-17153Abstract': [690], '(268)': [698], '10Wei': [701], 'Y.Q.': [702], 'Zhao': [703], 'X.': [704, 814], 'Kariya': [705], 'Y.': [706, 756], 'Fukata': [707], 'Teshigawara': [709], 'K.': [710, 764, 1053, 1350, 1618], 'Uchida': [711], 'A.': [712, 760, 958, 1395, 1496, 1515, 2708, 3686], 'Cancer': [713], 'Res.': [714, 1520, 3691], '1994;': [715, 962], '54:': [716], '4952-4957PubMed': [717], '11Rosette': [720], 'C.': [721, 820, 1397, 1459, 1494, 1567, 1599, 1975, 2304, 2466, 3528], 'Karin': [722], '274:': [726], '1194-1197Crossref': [727], '(943)': [730], 'signals': [734, 986], 'ligand': [738], 'activate': [743], 'procaspase-8': [744], 'through': [745, 2062, 2544, 2689], 'interactions': [747], 'between': [748], 'components': [749], 'death-inducing': [752], 'signaling': [753], 'complex': [754, 846], '(12Imai': [755], 'Kimura': [757], 'T.': [758, 972, 1502, 1620, 2032], 'Murakami': [759], 'Yajima': [761], 'N.': [762, 2306, 2468, 3530], 'Sakamaki': [763], 'Yonehara': [765], 'Nature.': [767, 1379, 2035, 2825], '1999;': [768, 1169, 1555], '398:': [769], '777-785Crossref': [770], '(204)': [773], '13Salvesen1': [776], 'G.S.': [777, 1135, 1236], 'Dixit': [778, 1237], 'V.M.': [779, 1238], '91:': [782, 886, 1241], '443-446Abstract': [783, 1242], '(1936)': [791, 1250], 'Activated': [794], 'caspase-8': [795], 'cleaves': [796], 'Bid': [797], '(Bcl-2': [798], 'interacting': [799], 'protein),': [800], 'translocates': [805], 'where': [808], 'initiates': [810, 4092], 'cytochromec': [811, 4193, 4212, 4316], '(14Luo': [813], 'Budihardjo': [815, 874], 'I.': [816, 875], 'Zou': [817], 'Slaughter': [819], 'X.D.': [822, 883, 1065, 2312, 2474, 3536], '94:': [825], '481-490Abstract': [826], '(3080)': [834], 'The': [837, 898, 1398, 1665, 1698, 1724, 1740, 1756, 2008, 2021, 2070, 2096, 2124, 2180, 2201, 2294, 2406, 2540, 2565, 2606, 2903, 2971, 2982, 3109, 3119, 3145, 3258, 3295, 3566, 3720, 4492], 'ctriggers': [841], 'formation': [843], 'containing': [847, 1688, 1866, 2004, 3053, 3523, 3973, 4015, 4022], 'Apaf1,': [848], 'mammalian': [850], 'CED-4': [851], 'homologue,': [852], 'procaspase-9,': [854], 'then': [857, 2099, 2183, 3286, 3319, 3367, 4073], 'autoprocessed': [858], 'thereby': [860], 'capable': [861, 4371], 'processing': [863, 899, 3577], 'effector': [865], 'procaspases': [866], 'procaspase-3': [869, 4075, 4344], '(15Li': [870], 'P.': [871], 'Nijhawan': [872], 'D.': [873, 1186, 1308, 1476, 1616], 'Srinivasula': [876], 'M.S.': [877, 1147], 'Ahmad': [878], 'Alnemri': [880], 'E.S.': [881], '479-489Abstract': [887], '(6239)': [895], 'caspases': [902], 'followed': [904], 'substrates,': [910], 'leading': [911], 'disruption': [914], 'important': [916, 4053], 'cellular': [917, 921], 'processes,': [918], 'changes': [919], 'morphology,': [924], 'ultimately': [926], '(16Lazebnik': [930], 'Y.A.': [931], 'Cole': [932], 'Cooke': [934], 'C.A.': [935], 'Nelson': [936], 'W.G.': [937], 'Earnshaw': [938], 'W.C.': [939], 'Cell': [941, 1313], '1993;': [943, 1354, 1465], '123:': [944], '7-22Crossref': [945], '(426)': [948], '17Casciola-Rosen': [951], 'L.A.': [952], 'Miller': [953], 'D.K.': [954], 'Anhalt': [955], 'G.J.': [956], 'Rosen': [957], '269:': [963], '30757-30760Abstract': [964], '18Rubel': [971], 'Bokoch': [973], 'G.M.': [974], '276:': [977], '1571-1574Crossref': [978], '(604)': [981], 'Diverse': [984], 'caspase': [988], 'converge': [990], 'at': [991, 1879, 2093, 2177, 2277, 2286, 2416, 2425, 2443, 2550, 2562, 2594, 2600, 2658, 2671, 2740, 2783, 2932, 3019, 3025, 3032, 3090, 3099, 3106, 3113, 3139, 3211, 3282, 3292, 3324, 4055, 4180], 'level,': [994], 'provoking': [995], 'c,': [1000], 'participates': [1002, 4158], 'central': [1005], 'control': [1006, 3435, 3458, 3554, 3620, 3662, 3733, 3910, 3980, 4447], 'executioner': [1008, 4161], 'phase': [1009, 4162], 'cascade': [1014, 4167], '(19Bossy-Wetzel': [1015], '17:': [1024, 1574, 1606, 1626], '37-49Crossref': [1025], '(1107)': [1028], '20Kluck': [1031], 'R.M.': [1032, 4259], 'Bossy-Wetzel': [1033, 4260], '275:': [1041, 1068, 4268], '1132-1136Crossref': [1042, 4269], '(4277)': [1045, 4272], '21Yang': [1048], 'Liu': [1050, 2461], 'X.S.': [1051], 'Bhalla': [1052], 'Kim': [1054, 2305, 2467, 3529], 'N.K.': [1055], 'Ibrado': [1056], 'A.M.': [1057, 1304], 'Cai': [1058], 'J.Y.': [1059], 'Peng': [1060], 'T.I.': [1061], 'Jones': [1062], 'D.P.': [1063], '1129-1132Crossref': [1069], '(4410)': [1072], 'role': [1077], 'confusing': [1086], 'contradictable,': [1088], 'elucidated.': [1099], 'ischemia': [1101, 1275], "Alzheimer's": [1107], "Huntington's": [1109], 'may': [1111, 1117], 'result': [1112, 3842], 'apoptosis,': [1115, 1220, 3948], 'beneficial': [1119], 'limit': [1121], 'way': [1125], 'manage': [1127], '(22Gervais': [1130], 'F.G.': [1131], 'Xu': [1132], 'D.G.': [1133], 'Robertson': [1134], 'Vaillancourt': [1136], 'J.P.': [1137], 'Zhu': [1138], 'Y.X.': [1139], 'Huang': [1140], 'J.Q.': [1141], 'Smith': [1142], 'A.L.D.': [1143], 'Rigby': [1144], 'Shearman': [1146], 'Clarke': [1148], 'E.E.': [1149], 'Zheng': [1150], 'Van': [1152], 'Der': [1153], 'Ploeg': [1154], 'L.H.T.': [1155], 'Ruffolo': [1156], 'S.C.': [1157], 'Thornberry': [1158], 'N.A.': [1159], 'Xanthoudakis': [1160], 'Zamboni': [1162], 'R.J.': [1163], 'Roy': [1164], 'Nicholson': [1166], 'D.W.': [1167], '97:': [1170], '395-406Abstract': [1171], '(716)': [1179], 'Scholar,23Saudou': [1181], 'F.': [1182], 'Finkbeiner': [1183], 'Devys': [1185], 'Greenberg': [1187], 'M.E.': [1188], '95:': [1191, 1507], '55-66Abstract': [1192], '(1371)': [1200], 'Cellular': [1203], 'viral': [1205, 2022, 2046, 2071], 'proteins': [1206, 1403, 2668, 2686, 2703, 3252, 3684], 'Bcl-2,': [1209], 'CrmA,': [1210], 'IAP1': [1212], 'might': [1213], 'serve': [1214], 'therapeutic': [1216], 'agents': [1217], 'inhibit': [1219, 1671, 1695], 'because': [1221, 1266, 3864], 'Bcl-2': [1222], 'release,': [1226, 1677, 4097, 4194, 4420], 'CrmA': [1227], 'inhibits': [1228, 3713], 'caspase-8,': [1229], 'IAP': [1231], 'blocks': [1232, 3848, 4178], '(13Salvesen1': [1235], 'In': [1253, 1362, 3817, 4464], 'addition,': [1254], 'suggested': [1258], 'promising': [1261], 'molecule': [1262, 4054], 'controlling': [1264], 'transgenic': [1268], 'mice': [1269, 2495], 'reduced': [1271], 'brain': [1272], 'heart': [1274, 1717], '(24Trost': [1276], 'S.U.': [1277], 'Omens': [1278], 'J.H.': [1279, 1542], 'Karlon': [1280], 'W.J.': [1281], 'Meyer': [1282], 'Mestril': [1284], 'R.': [1285, 1977, 2310, 2472, 3534], 'Covell': [1286], 'J.W.': [1287], 'Dillmann': [1288], 'W.H.': [1289], 'Clin.': [1291, 1504], 'Invest.': [1292, 1505], '101:': [1294], '855-862Crossref': [1295], '(131)': [1298], '25Plumier': [1301], 'Krueger': [1303], 'R.W.': [1306], 'Kontoyiannis': [1307], 'Kollias': [1309], 'G.': [1310, 2814, 3332], 'Pagoulatos': [1311], 'G.N.': [1312], 'Stress': [1314], 'Chaperones.': [1315, 1406], '2:': [1317], '162-167Crossref': [1318], '(193)': [1321], 'HSPs': [1324], 'various': [1329], 'ethanol,': [1333], 'analogues,': [1336], 'infection,': [1337], 'inhibitors': [1338, 2371], 'energy': [1340], 'metabolism,': [1341], 'heavy': [1343], 'metals': [1344], '(26Morimoto': [1345], 'R.I.': [1346, 1393], 'Sarge': [1347], 'K.D.': [1348], 'Abravaya': [1349], '21987-21990Abstract': [1356], 'its': [1365, 2683, 4077], 'chaperoning': [1366], 'function': [1367, 3857, 3943], 'folding,': [1369], 'transport,': [1370], 'assembly': [1372], 'newly': [1374], 'synthesized': [1375], 'polypeptides': [1376], '(27Hartl': [1377], 'F.U.': [1378], '381:': [1381, 2827], '571-580Crossref': [1382], '(3121)': [1385], '28Frydman': [1388], 'Hartl': [1390], 'F.-U.': [1391], 'Morimoto': [1392], 'Tissieres': [1394], 'Georgopoulos': [1396], 'Biology': [1399], 'Shock': [1402], 'Molecular': [1405, 1710, 1806, 1824, 2168], 'Cold': [1407, 1412], 'Spring': [1408, 1413], 'Harbor': [1409], 'Laboratory': [1410], 'Press,': [1411], 'Harbor,': [1414], 'NY1994:': [1415], '251-283Google': [1416], 'Scholar),': [1417, 3699, 4274], 'protects': [1419], 'number': [1423], 'stimuli,': [1426], 'factor,': [1432], 'withdrawal,': [1435], 'oxidative': [1436], 'stress,': [1437], 'agents,': [1439], 'ceramide,': [1440], 'radiation': [1442], '(29Mosser': [1443], 'Martin': [1445], 'L.H.': [1446], 'Physiol.': [1449], '1992;': [1450, 1483], '151:': [1451], '561-570Crossref': [1452], '(142)': [1455], '30Mailhos': [1458], 'Howard': [1460, 1978], 'M.K.': [1461], 'Latchman': [1462], 'D.S.': [1463], 'Neuroscience.': [1464], '55:': [1466], '621-627Crossref': [1467], '(154)': [1470], '31Jäättelä': [1473], 'Wissing': [1475, 1615], 'Bauer': [1477], 'P.A.': [1478], 'Li': [1479], 'G.C.': [1480], '11:': [1484], '3507-3512Crossref': [1485], '(354)': [1488], '32Simon': [1491], 'M.M.': [1492], 'Krone': [1493], 'Schwarz': [1495, 1501], 'Luger': [1497], 'T.A.': [1498], 'Jaattela': [1499], '926-933Crossref': [1508], '(217)': [1511], '33Samali': [1514], 'Cotter': [1516, 3687], 'T.G.': [1517, 3688], 'Exp.': [1518, 3689], '223:': [1522, 3693], '163-170Crossref': [1523, 3694], '(481)': [1526, 3697], 'SAPK/JNK': [1533], 'shock-': [1537], 'ceramide-induced': [1539], '(34Ahn': [1541], 'Ko': [1543], 'Y.G.': [1544, 1936], 'Park': [1545, 1931, 1937, 1943], 'W.Y.': [1546, 1944], 'Kang': [1547], 'Y.S.': [1548], 'Chung': [1549, 1939, 1941], 'H.Y.': [1550, 1942], 'Seo': [1551, 1945], 'J.S.': [1552, 1946, 2822], 'Mol.': [1553, 1570, 1602], 'Cells.': [1554], '9:': [1556], '200-206PubMed': [1557], '35Mosser': [1560], 'Caron': [1562, 1594], 'A.W.': [1563, 1595], 'Bourget': [1564, 1596], 'L.': [1565, 1597], 'Denis-Larose': [1566, 1598], 'Massie': [1568, 1600], 'B.': [1569, 1601, 2816], '5317-5327Crossref': [1575, 1607], '(869)': [1578, 1610], 'Despite': [1581, 4333], 'recent': [1582], 'advances,': [1583], 'anti-apoptotic': [1585], 'controversial': [1591], '(35Mosser': [1592], '36Jäättelä': [1613], 'Kokholm': [1617], 'Kallunki': [1619], 'Egeblad': [1621], '6124-6134Crossref': [1627], '(617)': [1630], 'Therefore,': [1633], 'aim': [1635], 'study': [1638], 'elucidate': [1641, 3490], 'step': [1643, 3492, 4199], 'pathway': [1647, 3496], 'affected': [1649], 'HSP70.': [1651], 'used': [1653, 2017, 2145, 2232, 2447, 3154, 3408, 3610], 'vitroapoptosis': [1656], 'well': [1659], 'results': [1666, 3789, 3806, 3869, 4030], 'demonstrate': [1667, 4031], 'cleavage,': [1682, 3897], 'sufficient': [1693], 'deoxynucleotide': [1699], "triphosphates'": [1700], 'pepstatin': [1701, 2374], 'A,': [1702, 2375, 4231], 'leupeptin,': [1703, 2378], 'andN-acetyl-leucyl-leucyl-norleucina': [1704], '(ALLN)': [1705], 'purchased': [1707, 1777, 1786, 1799, 1832], 'Roche': [1709, 1823], 'Biochemicals.': [1711], 'Phenylmethylsulfonyl': [1712], 'fluoride,': [1713], 'aprotinin,': [1714], 'bovine': [1716, 1853, 4001, 4024], 'Sigma.': [1723], 'Cpp32/caspase-3': [1725], 'colorimetric': [1726, 2235], 'protease': [1727, 2236, 2370], 'assay': [1728, 3811], 'kit': [1729, 3341], 'Medical': [1733], '&': [1734], 'Biological': [1735], 'Laboratories': [1736, 1819], 'Co.': [1737], '(Nagoya,': [1738], 'Japan).': [1739], 'secondary': [1741], 'antibodies,': [1742], 'goat': [1743], 'anti-rabbit': [1744], 'anti-mouse': [1746, 3330], 'lgG': [1747], 'conjugated': [1748], 'horseradish': [1750, 3328], 'peroxidase,': [1751], 'Pierce.': [1755], 'weight': [1758], 'standards': [1759], 'SDS-polyacrylamide': [1761, 3247], 'gel': [1762, 3248], 'electrophoresis': [1763], 'Bio-Rad.': [1767], 'Enhanced': [1768], 'chemiluminescence': [1769], '(ECL)': [1770], 'reagent': [1771], 'Western': [1773, 3156], 'blotting': [1774], 'detection': [1775, 3334, 3340], 'Amersham': [1779], 'Pharmacia': [1780, 3343], 'Biotech.': [1781], 'Antibodies': [1782], 'immunoblotting': [1784], 'following': [1789], 'sources.': [1790], 'Anti-cytochrome': [1791], '(7H8.2C12)': [1793], 'oxidase': [1796, 4250], 'II': [1797], 'PharMingen': [1801], '(San': [1802], 'Diego,': [1803], 'CA)': [1804], 'Probes': [1807], '(Eugene,': [1808], 'OR),': [1809], 'respectively.': [1810, 1826, 4364, 4547], 'Anti-caspase-3': [1811], '(CPP32)': [1812], 'anti-PARP': [1814, 3370], 'Transduction': [1818], '(Lexington,': [1820], 'KY)': [1821], 'Biochemicals,': [1825], 'Anti-HSP70': [1827], 'anti-actin': [1829], 'antibodies': [1830], 'Santa': [1834], 'Cruz': [1835], 'Biotechnology': [1836], '(Santa': [1837], 'Cruz,': [1838], 'CA).': [1839], 'grown': [1843, 2657], 'RPMI': [1845], '1640': [1846], 'medium': [1847, 2118], 'supplemented': [1848, 2073, 2368], '10%': [1850], 'heat-inactivated': [1851], 'fetal': [1852], 'serum': [1854, 4002, 4025], '50': [1856, 2245, 2254, 2727], 'μg/ml': [1857, 2006, 2076, 2373, 2377, 2380], 'penicillin-streptomycin': [1858], '5%': [1861], 'CO2': [1862], 'incubator.': [1863], 'Culture': [1864], 'plates': [1865], 'wrapped': [1869], 'tightly': [1870], 'parafilm': [1872], 'immersed': [1874], 'water': [1877], 'bath': [1878], 'desired': [1881], 'temperature.': [1882, 2179, 3294], 'Mild': [1883], 'conditions': [1886, 1901], 'induce': [1888, 3402, 3410, 3517, 3676], 'synthesis': [1890, 3678], '42': [1892], '°C': [1893, 1904, 2279, 2445, 2602, 2660, 2673, 2742, 2785, 2881, 3115], '30': [1895, 2925, 3133, 3397], 'min,': [1896, 2226, 2388, 2937, 3063, 3241], '43': [1903], '60': [1906], '80': [1908, 2578], 'min.': [1909, 2220, 3144], 'establish': [1911], 'retrovirus-producing': [1913], 'line,': [1915, 3874], '10': [1916, 2129, 2219, 2261, 2351, 2376, 2414, 2535, 2545, 2848, 2912, 2936, 2958, 3030, 3088, 3143, 3193], 'μg': [1917, 2239, 3180, 3228], 'MFG.HPS70.puro': [1919], 'MFG.puro': [1921], 'plasmids': [1922, 2648], '(37Kwak': [1923], 'H.J.': [1924], 'Jun': [1925], 'C.D.': [1926], 'Pae': [1927], 'H.O.': [1928], 'Yoo': [1929], 'Y.C.': [1932], 'Choi': [1933], 'B.M.': [1934], 'Na': [1935], 'R.K.': [1938], 'H.T.': [1940], 'Immunol.': [1948], '187:': [1950], '1-12Crossref': [1951], '(47)': [1954], 'Scholar)': [1956, 2326, 2833], 'PA317': [1961], 'retrovirus': [1962, 2019], 'packaging': [1963], 'line': [1965], '(ATCC;': [1966], 'CRL': [1967], '9078)': [1968], 'thecalcium': [1970], 'phosphate': [1971], 'precipitation': [1972], 'method': [1973, 2459], '(38Gorman': [1974], 'Padmanabhan': [1976], 'B.H.': [1979], '1983;': [1981], '221:': [1982], '551-553Crossref': [1983], '(450)': [1986], 'After': [1989, 2105, 2221, 2275, 2382, 2924, 3002, 3057, 3080, 3237, 4109], '48': [1990, 2107], 'h,': [1991, 2282], 'harvested,': [1994], 'incubated': [1999, 2089, 2163, 2739, 2782, 3207, 3261, 3320, 3559], 'selective': [2002], 'media': [2003], '2': [2005, 2091, 2281, 2379, 2516, 2678, 2734, 3191, 3786], 'puromycin.': [2007], 'selected': [2009, 2142], 'maintained': [2012, 2136], 'population': [2015, 2139], 'production.': [2020], 'infection': [2023], 'performed': [2025, 3336], 'described': [2027, 2301, 2809], 'previously': [2028, 2810], '(39Dzierzak': [2029], 'E.A.': [2030], 'Papayannopoulou': [2031], 'Mulligan': [2033], 'R.C.': [2034], '1988;': [2036], '331:': [2037], '35-41Crossref': [2038], '(229)': [2041], 'Briefly,': [2044, 2330, 2837], 'supernatant': [2047, 2230, 2421, 2438, 3226], 'harvested': [2049, 2887], 'overnight': [2052], 'culture': [2053, 2117], '70%': [2055], 'confluent': [2056], 'producer': [2057], 'layers': [2059], 'filtered': [2061], '0.45-μm': [2064], 'syringe': [2065], 'filter': [2066], '(Corning,': [2067], 'Corning,': [2068], 'NY).': [2069], 'supernatant,': [2072], '8': [2075, 3069], 'polybrene': [2077], '(Sigma),': [2078], 'mixed': [2080, 2252, 3189, 3232], 'target': [2082], 'conical': [2086], 'tube': [2087, 2891, 2900, 2944, 2975], 'h': [2092, 2108, 2430, 2555, 2745, 2857, 3210, 3281, 3291, 3323, 3414], '37': [2094, 2278, 2659, 2672, 2741, 2784, 2880, 3012, 3212], '°C.': [2095, 2564, 3108, 3213], 'washed': [2100, 2157, 2333, 2859, 3040, 3123, 3298], 'two': [2101], 'times': [2102, 2396, 2861, 2876, 3317], 'PBS.': [2104], 'incubation,': [2109, 3219], 'puromycin': [2110], '(2': [2111], 'μg/ml)': [2112], 'added': [2114, 2776, 3514, 4023], 'select': [2120], 'selection': [2125], 'continued': [2127], 'days': [2130], 'after': [2131, 3132, 3415, 3759, 4132, 4417], 'experiments.': [2148], 'For': [2149, 4430], 'quantitative': [2150], 'analysis': [2151, 3158], 'viability,': [2154, 4434], 'once': [2158, 3041, 3124], 'ice-cold': [2160, 2336, 2499, 3043], 'PBS': [2161, 2337, 2500, 3044], 'annexin': [2165, 4435, 4481], 'V-fluorescein/PI': [2166], '(Roche': [2167], 'Biochemicals)': [2169], 'calcium-containing': [2171], 'HEPES': [2172], 'buffer': [2173, 2215, 2250, 2259, 2344, 2504, 2548, 2571, 2707, 2755, 2910, 2954, 3051, 3264, 3301], '15': [2175, 2387, 2395, 2513, 3062, 3104], 'min': [2176, 2415, 2926, 3031, 3089, 3105, 3134], 'room': [2178, 3283, 3293, 3325], 'analyzed': [2184, 3018, 4122, 4376, 4442], 'FACScan': [2187], 'machine': [2188], '(FACSCalibur,': [2189], 'Becton': [2190], 'Dickinson).': [2191], 'activity': [2193, 4413], 'measured': [2195, 3473, 4214, 4536], 'according': [2196, 2456], "manufacturer's": [2199], 'protocol.': [2200], '(5': [2203, 2372], '×': [2204, 2427, 2596, 2735, 2842, 2850, 2995, 3027, 3086, 3101, 3192], '106)': [2205], 'lysed': [2207, 3127], '250': [2209, 2588, 3054], 'μl': [2210, 2246, 2255, 2266, 2728], 'chilled': [2212], 'lysis': [2214, 2249], 'ice': [2217, 2385, 3060, 3136], 'microcentrifugation': [2222], '(10,000': [2223], '×g,': [2224], '1': [2225, 2357, 2361, 2365, 2429, 2554, 2591, 2675, 2744, 2921, 2963, 3209, 3280, 3290, 3322, 3632, 3746], '4': [2227, 2268, 2417, 2563, 3033, 3091, 3107, 3114, 4230, 4331, 4400, 4462, 4517, 4534], '°C),': [2228], 'assay.': [2237], '170': [2238], 'diluted': [2243], '2×': [2257, 3234], 'reaction': [2258, 2779], '(containing': [2260, 2911, 2955], 'mm': [2262, 2347, 2352, 2355, 2358, 2362, 2366, 2507, 2514, 2517, 2521, 2524, 2527, 2531, 2574, 2579, 2582, 2585, 2592, 2758, 2763, 2913, 2922, 2964, 3055, 3272, 3277, 3303, 3308], 'DTT)': [2263, 2593], '5': [2265, 2584, 2762, 2856, 3048, 3240], 'mmAsp-Glu-Val-Asp-p-nitroanilide': [2269], '(DEVD-pNA)': [2270], '(200': [2271], 'μm': [2272, 3204], 'final': [2273], 'concentration).': [2274], 'incubation': [2276, 3058], 'sample': [2283], 'read': [2285], '405': [2287], 'nm': [2288], 'microtiter': [2291], 'plate': [2292], 'reader.': [2293], 'S-100': [2295, 3521], 'fraction': [2296, 3522], 'prepared': [2298, 2455, 3358, 3552, 3660, 3701], 'essentially': [2299], '(40Liu': [2302, 2464, 3526], 'X.,': [2303, 2465, 3527], 'Yang': [2307, 2469, 3531], 'Jemmerson': [2309, 2471, 3533], '86:': [2315, 2477, 3539], '147-157Abstract': [2316, 2478, 3540], '(4463)': [2324, 2486, 3548], 'several': [2328, 3680], 'modifications.': [2329, 2836], 'twice': [2334], 'suspended': [2339, 2907], '3': [2341], 'volumes': [2342, 3049], '(20': [2346, 3302], 'Hepes-KOH,': [2348, 2508], 'pH': [2349, 2509, 2576, 2760, 2915, 2960, 3274, 3305], '7.5,': [2350], 'KCl,': [2353, 2515, 2580], '1.5': [2354], 'MgCl2,': [2356], 'sodium': [2359, 2363, 2518, 2586], 'EDTA,': [2360, 2519, 2764], 'EGTA,': [2364, 2587], 'DTT),': [2367], 'aprotinin).': [2381], 'sitting': [2383], 'disrupted': [2392], 'douncing': [2394], '2-ml': [2399, 3073], 'Wheaton': [2400, 3074], 'Dounce': [2401, 3075], 'homogenizer': [2402, 3076], '(Kontes': [2403, 3077], 'Glass': [2404, 3078], 'Co.).': [2405, 3079], 'extract': [2408, 3618, 3627, 3648, 3659], 'clarified': [2410], 'centrifugation': [2412], '°C,': [2418, 3013, 3034, 3396], 'further': [2423, 3935, 4197], 'centrifuged': [2424, 2543, 2931, 3024, 3084, 3097, 3138], '105': [2426, 2736, 2843], 'gfor': [2428], 'table-top': [2433], 'Beckman': [2434], 'Ultracentrifuge.': [2435], 'This': [2436, 3841, 3855], 'resulting': [2437, 3146, 4080], '(S-100': [2439], 'fraction)': [2440], 'stored': [2442, 2599, 2897, 3112], '−70': [2444], 'forin': [2448], 'assays.': [2451], 'Liver': [2452], 'nuclei': [2453, 2566, 2737, 3196, 3563], 'et': [2462], 'al.': [2463], 'Livers': [2489], 'four': [2491], 'FVB': [2492], 'strain': [2493], 'male': [2494], 'rinsed': [2497], 'homogenized': [2502, 3067], 'B': [2505, 2549, 3801], '(10': [2506, 2573], '7.6,': [2510], '2.4': [2511], 'msucrose,': [2512], '0.15': [2520, 2523], 'spermine,': [2522], 'spermidine,': [2525], '0.5': [2526, 2530], 'DTT,': [2528], 'phenylmethylsulfonyl': [2532], 'fluoride)': [2533], 'strokes': [2536, 3070], 'tissue-tearer.': [2539], 'homogenates': [2541], 'ml': [2546], '25,000': [2551], 'rpm': [2552, 2934, 3141], 'SW': [2558], '28': [2559], 'rotor': [2560], '(Backman)': [2561], 'pellets': [2567, 2905, 2949, 3038, 3121], 'resuspended': [2569, 2951, 3046], 'C': [2572], 'PIPES,': [2575], '7.4,': [2577, 2916, 2961, 3275, 3306], '20': [2581, 2969, 3271], 'NaCl,': [2583, 2766, 3309], 'mmsucrose,': [2589], '8.5': [2595], '107nuclei/ml': [2597], '−80': [2601], 'multiple': [2604], 'aliquots.': [2605], 'full-length': [2607], 'gene': [2610], 'cloned': [2612], 'pET30a': [2614, 2626], '(Novagen).': [2615], 'Several': [2616], 'created': [2622], 'ligated': [2624], 'follows:': [2628, 2989], 'hsp70ΔB': [2629], 'lacking': [2630, 2634, 2638], 'theBglII-BglII': [2631], 'fragment,': [2632, 2636, 2640], 'hsp70ΔS': [2633], 'theSmaI-SmaI': [2635], 'hsp70ΔN': [2637], 'theNcoI-NcoI': [2639], 'hsp70ΔC': [2642], 'deleted': [2643], 'nucleotides': [2644], '1756–1923.': [2645], 'All': [2646, 4528], 'transformed': [2650], 'Escherichia': [2652], 'coli': [2653], 'BL21.': [2654], 'Bacteria': [2655], 'optical': [2663], 'density': [2664], '0.6,': [2666], 'mmisopropyl-β-d-thiogalactopyranoside': [2676], 'h.': [2679, 2884, 3021], 'His-tagged': [2680], 'mutant': [2685], 'nickel': [2691], 'affinity': [2692], 'column': [2693], 'passing': [2695], 'soluble': [2697], 'lysates.': [2701], 'Eluted': [2702], 'dialyzed': [2705], 'against': [2706], 'determine': [2710], 'degradation': [2712], 'chromosomal': [2714], 'nucleosome-sized': [2717], 'fragments': [2718], 'system,': [2724, 3353], 'aliquots': [2725, 3224], 'faction': [2731], '(S-100)': [2732], 'presence': [2748, 3199, 4209], 'dATP.': [2750, 3565], '500-μl': [2752], 'aliquot': [2753], 'D': [2756], '(100': [2757], 'Tris-HCl,': [2759, 2914, 3273, 3304], '8.5,': [2761], '0.2m': [2765], '0.2%': [2767, 2917], '(w/v)': [2768], 'SDS,': [2769, 2957], '0.2': [2771], 'mg/ml': [2772], 'proteinase': [2773], 'K)': [2774], 'mixture': [2780], 'overnight.': [2786], 'ethanol': [2791], 'precipitation,': [2792], 'separated': [2793], '1.8%': [2796], 'agarose': [2797], 'gel,': [2798], 'visualized': [2800], 'under': [2801], 'light.': [2803], 'quantitated': [2807], '(41Cuvillier': [2811], 'O.': [2812], 'Pirianov': [2813], 'Kleuser': [2815], 'Vanek': [2817], 'P.G.': [2818], 'Coso': [2819], 'O.A.': [2820], 'Gutkind': [2821], 'Spiegel': [2823], '800-803Crossref': [2828], '(1352)': [2831], 'some': [2835, 4181], 'exponentially': [2838], 'growing': [2839], '(2.5': [2841], 'cells/ml)': [2844], 'labeled': [2846, 2892, 2901, 2945], 'μCi/2.5': [2849], '106': [2851], '[methyl-3H]thymidine': [2854], 'three': [2860, 3316], 'nonradioactive': [2863], 'fresh': [2864], 'medium.': [2865], 'Labeled': [2866], 'exposed': [2869, 3446, 4456], 'returned': [2878, 3010], '12': [2883, 3020, 3413], 'Cells': [2885, 3022], 'microcentrifuge': [2890], 'B,': [2893], 'supernatants': [2895, 2939, 3095, 3110], 'TTE': [2909], 'Triton': [2918], 'X-100,': [2919], 'EDTA).': [2923], 'ice,': [2928], 'samples': [2929, 3220, 3242], '14,000': [2933, 3140], 'transferred': [2941, 3254], 'T,': [2946], 'STE': [2953], '1%': [2956, 3313], 'mmTris-HCl,': [2959], 'EDTA)': [2965], 'sonicated': [2967], 's.': [2970], 'radioactivity': [2972], 'each': [2974], 'determined': [2977, 3572, 4284], 'liquid': [2979], 'scintillation': [2980], 'counting.': [2981], 'percent': [2983, 3750, 4471], 'calculated': [2987], '%': [2990], '=': [2993], '100': [2994], '(S': [2996], '+T)/(S': [2997], '+': [2998, 3000], 'T': [2999], 'B).': [3001, 3470, 4028, 4401], 'treatment,': [3007, 3418], 'crelease': [3016], '600': [3026], 'g': [3028, 3102], 'sucrose.': [3056], 'homogenate': [3082], '(750': [3085], 'g,': [3087], '°C)': [3092], 'twice,': [3093], 'again': [3098], '12,000': [3100], 'fractions.': [3118, 4296], 'mitochondrial': [3120, 3147, 4255], 'PBS,': [3126], 'radioimmunoprecipitation': [3129], 'buffer,': [3130], 'blot': [3157], 'anti-cytochrome': [3161], 'antibody.': [3163], 'Detection': [3164], 'carried': [3173], 'out': [3174], 'follows.': [3176], 'Cytosolic': [3177], 'extracts': [3178, 3813, 3832, 3978, 4014, 4021], '(250': [3179], 'protein)': [3182, 3230], '5mouse': [3194], 'liver': [3195, 3562, 3587, 3640], '300': [3201], '500': [3203], 'dATP': [3205, 3515], 'At': [3214, 4365], 'end': [3216], 'centrifuged,': [3222], '(50': [3227], 'SDS-sample': [3235], 'buffer.': [3236], 'boiling': [3238], 'subjected': [3244], '12%': [3246], 'electrophoresis,': [3249], 'nitrocellulose': [3256], 'membranes.': [3257], 'membranes': [3259, 3296], 'blocking': [3263], '(10%': [3265], 'non-fat': [3266, 3314], 'milk,': [3267], '0.1%': [3268, 3310], 'Tween': [3269, 3311], '20,': [3270, 3312], '150': [3276, 3307], 'NaCl)': [3278], 'temperature': [3284, 3326], 'anti-caspase-3': [3288, 3608], 'washing': [3300], 'milk)': [3315], 'peroxidase-conjugated': [3329], 'immunoglobulin': [3331], 'Antibody': [3333], 'using': [3337, 3812, 3966], 'ECL': [3339], '(Amersham': [3342], 'Biotech).': [3344], 'detect': [3346], 'PARP': [3347, 3896, 4306, 4324, 4346], 'cleavages': [3348, 4307, 4325, 4342], 'intact': [3351, 4291], 'whole': [3354], 'lysate': [3356], 'treated': [3361, 4113, 4221], 'immunoblotted': [3368], 'antibody': [3371, 3609], 'mentioned': [3373], 'above.': [3374], 'first': [3376], 'examined': [3377, 3987, 4189], 'elevated': [3381, 3429], 'HSP': [3382], 'expression': [3383, 3969], 'resistance': [3386, 3465, 3775], 'mild': [3391, 3486, 3672, 3882], '(42': [3395], 'min)': [3398], 'did': [3400], '(data': [3404, 3913, 4150], 'shown)': [3406], 'synthesis.': [3412], 'level': [3420, 3463, 3721, 3773], 'substantially': [3428, 4522], 'relative': [3430], '(Fig.1': [3437, 3469, 3664], 'A).': [3438, 3747, 3787, 4005, 4137, 4332], 'When': [3439, 3748, 3876], 'contrast': [3455, 3780, 3818, 4357], 'dramatic': [3462, 3772], 'decreased': [3478, 4486], '3.6–4.0-fold': [3479], 'when': [3480, 4411], 'treatment.': [3488], 'regulated': [3498], 'HSP70,': [3500], 'employed': [3502], 'based': [3508], 'ability': [3511, 3939], 'exogenously': [3513], 'Extracts': [3551], 'exogenous': [3561], 'extent': [3567, 4301, 4493], 'monitoring': [3574], 'proteolytic': [3576], 'pro-caspase-3': [3579, 3591], 'intranucleosomal': [3582, 3635, 3824], 'mouse': [3586, 3639], 'DNA.': [3588], 'Processing': [3589], 'p19': [3594], 'p17': [3596], 'subunits': [3597], '(the': [3598], 'small': [3599], 'p12': [3600], 'subunit': [3601, 4251], 'undetectable': [3605], 'study),': [3613], 'occurred': [3615, 3656], 'completely': [3623, 3644], 'inhibited': [3624, 3995], '(Fig.': [3631, 3745, 3785, 4330, 4399, 4461], 'C).': [3633, 4463], 'Additionally,': [3634], 'almost': [3643], 'blocked': [3645, 4415], 'whereas': [3652], 'extensive': [3653], 'D).': [3665], 'exposure': [3668, 4391], '(33Samali': [3685], '(U937/hsp70)': [3704], 'question': [3708, 4086], 'whether': [3710, 4088, 4190, 4404], 'itself': [3712, 4034], 'accumulation': [3724], 'much': [3729], 'higher': [3730], 'than': [3731, 4525], '(U937/puro)': [3735], 'very': [3738, 3791, 4397], 'similar': [3739, 3792, 3868], 'exposing': [3760], 'treatments,': [3765], 'U937/puro': [3783, 4362, 4507, 4526], 'These': [3788, 4029], 'are': [3790], 'those': [3794], 'Fig.': [3799, 4229, 4516, 4533], '2,': [3800], 'C,': [3803, 4518], 'shows': [3804], 'thein': [3808], 'U937/puro,': [3820], 'suggests': [3843], 'per': [3846], 'se': [3847], 'shock-induced': [3853], 'antiapoptotic': [3856], 'general': [3862, 3924], 'phenomenon,': [3863], 'HL60.': [3875], 'accumulated': [3879], 'byHSP70': [3886], 'transfection,': [3887], 'they': [3888], 'inhibition': [3892], 'activation,': [3895, 4186], 'compared': [3908, 4503], 'HL60': [3911, 4139], 'shown);': [3915], 'supports': [3917], 'suggestion': [3919], 'As': [3933, 4226, 4513], 'test': [3936], 'effects': [3950], 'determined.': [3961, 4108], 'bacterial': [3968], 'Reaction': [3971], 'mixtures': [3972], 'incubatedin': [3984], 'Purified': [3991], 'clearly': [3994, 4485], 'comparison': [3999, 4488], 'albumin': [4003, 4026], '(Fig.3': [4004, 4027], 'Inhibition': [4006], 'key': [4039], 'molecules': [4040], 'associated': [4041], 'anin': [4045], 'Cytochrome': [4048, 4126], 'early': [4057, 4473], 'stage': [4058], 'pathway.': [4061, 4203], 'Its': [4062], 'leads': [4066], 'caspase-9,': [4071], 'converts': [4074], 'active': [4078, 4369], 'form,': [4079], 'via': [4094], 'immunoblot': [4124], 'analysis.': [4125, 4512], 'increased': [4129], '(Fig.4': [4136], 'shown),': [4152], 'indicates': [4154], 'shock.': [4172, 4225], 'Since': [4173], 'found': [4175], 'point': [4182], 'next': [4188], 'affects': [4192], 'question,': [4207], 'had': [4233], 'no': [4234, 4288], 'shocked': [4245], 'II,': [4252], 'inner': [4254], '(20Kluck': [4258], 'extracts,': [4281], 'there': [4286], 'contamination': [4289], 'know': [4298], 'exactly': [4299], 'detecting': [4314], 'cytosol,': [4319], 'heat-shocked': [4328], 'protected': [4348, 4406], 'U937/HSP70': [4354, 4388], 'same': [4367, 4379, 4428], 'time,': [4368], 'cleaving': [4373], 'DEVD-pNA': [4374], 'experiment.': [4380, 4429], 'activities': [4382], 'low': [4398], 'clarify': [4403], 'dying': [4410], 'even': [4416], 'viability': [4422], 'measurement': [4431], 'V': [4436], 'binding': [4437], 'PI': [4439], 'uptake': [4440], 'flow': [4444, 4510], 'cytometry': [4445, 4511], 'case': [4466], 'late': [4475], 'apoptotic/necrotic': [4476], '(annexin': [4478], 'V+/PI−': [4479], 'V+/PI+': [4482], 'cells)': [4483], 'control.': [4491], 'less': [4523], 'parameters': [4531], 'single': [4539], 'experiment': [4540], 'Taken': [4548], 'together,': [4549], 'regardless': [4550], 'inability': [4553], 'blo': [4557]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2084736894', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 15}, {'year': 2018, 'cited_by_count': 17}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 19}, {'year': 2013, 'cited_by_count': 22}, {'year': 2012, 'cited_by_count': 20}], 'updated_date': '2024-12-31T14:50:11.507980', 'created_date': '2016-06-24'}