Title: bFGF Protects Neonatal Rats From Hypoxi-ischemic Brain Damage by Downregulation Caspase-3
Abstract:Aim:To explore the effect of bFGF on caspase-3 brotein and DNA fragmentation in later time after neonatal rat hypoxic-ischemic brain damage.Methods:caspase-3 protein and DNA fragmentation were measure...Aim:To explore the effect of bFGF on caspase-3 brotein and DNA fragmentation in later time after neonatal rat hypoxic-ischemic brain damage.Methods:caspase-3 protein and DNA fragmentation were measured by using immunohistochemistry and TUNEL.Results:①caspase-3 average OD values were significantly lower in bFGF group 1 (0.357±0.093) compared with those in control group 1 (0.371±0.042) P 0.05。 ②TUNEL positive cell counts were significantly lower in bFGF group 1 (4.20±1.30)compared with those in control group 1 (9.80±1.92), P 0.05.③There were no differences among the other: two groups P 0.05。Conclusion: It is suggested that bFGF might protect neuronal against apoptosis by down-regulation caspase-3 protein expression and followed DNA fragmentation,so a long and continue policy must be used.Read More
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot