Title: Protective effect of WEB 2086, a novel antagonist of platelet activating factor, in endotoxin shock
Abstract: WEB 2086, a novel specific platelet activating factor (PAF) antagonist derived from triazolodiazepines, inhibited in a dose-related manner the hypotensive and lethal effect of PAF as well as of E. coli endotoxin in the rat. The hypotension induced by endotoxin (15 mg/kg i.v.) or PAF (30 ng/(kg × min) i.v.) in anaesthetized rats was prevented by oral (1–10 mg/kg) and inhibited or reversed by i.v. (0.1–5.0 mg/kg or 0.1–1.0 mg/kg) doses of WEB 2086. Similar oral and i.v. doses of WEB 2086 protected conscious rats from PAF (15 μg/kg i.v.)- and endotoxin (7.5 mg/kg i.v.)-induced death. The results obtained with WEB 2086 confirm that PAF has an important role in the pathophysiology of endotoxin shock. This compound may have a therapeutic effect in human septic shock.
Publication Year: 1987
Publication Date: 1987-03-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 104
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