Title: Absorption, Excretion, and Biotransformation of Dimethyl Sulfoxide in Man and Miniature Pigs After Topical Application as an 80% Gel
Abstract: The absorption, excretion, and biotransformation of dimet hyl sulfoxid e (DMSO) 80% gel, DEMASORB®, was studied in m an and in miniature pigs.DMSO 80% gel (15 cc, t .i.d.) was applied top ically t o the elbows of hwnan subj ec ts a nd allowed to remain there for 30 minut es after each applicat ion.Under t hese condiLions, daily tLbsorption of DMSO 80% gel ranged from 25 to 40% of the total close.DMSO 80% gel (15 g, t .i.d.) was completely a bsorbed wit hin 4 hours after application to the shaved backs of miniature p igs.Both m an and miniature p ig transformed D JVJ:SO t o dim ethylsulfone (DMSO, ) and dimethylsulfid e (DMS ).DMSO a nd DMSO.were excreted in th e urine, whereas DMS was eliminated in the e}.:pired air.In m an, the relat ive amounts of DMSO and DMS02 in the p lasma were similar to those found in t he urine.Th e biological half-life of DMSO, in both t he plasma an d urine of m an was 2.5 t o 3 days.Urinary excretion of DMSO plus D MS0 2 ranged from 9 to 35% of t he dose in bot h m an and miniature pigs ; on ly 1.6% of t he dose was present in t he fe ces of miniature pigs.Whereas DMS02 was t he m ain excretory p roduct in t he urine of m an, DMSO was the m a jor component in th e urine of miniature pigs.