Publication Information

{'id': 'https://openalex.org/W2031454470', 'doi': 'https://doi.org/10.1016/s0022-5347(01)64039-4', 'title': 'HIGH DOSE BICALUTAMIDE FOR ANDROGEN INDEPENDENT PROSTATE CANCER: EFFECT OF PRIOR HORMONAL THERAPY', 'display_name': 'HIGH DOSE BICALUTAMIDE FOR ANDROGEN INDEPENDENT PROSTATE CANCER: EFFECT OF PRIOR HORMONAL THERAPY', 'publication_year': 1998, 'publication_date': '1998-01-01', 'ids': {'openalex': 'https://openalex.org/W2031454470', 'doi': 'https://doi.org/10.1016/s0022-5347(01)64039-4', 'mag': '2031454470', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9400459'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0022-5347(01)64039-4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5028590331', 'display_name': 'Robin Joyce', 'orcid': 'https://orcid.org/0000-0002-7251-8082'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robin Joyce', 'raw_affiliation_strings': ['Department of Medicine Harvard Medical School  Boston Massachusetts USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine Harvard Medical School  Boston Massachusetts USA', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073834752', 'display_name': 'Mary Anne Fenton', 'orcid': 'https://orcid.org/0000-0002-6467-5352'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mary Anne Fenton', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112421237', 'display_name': 'P Rode', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Paola Rode', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022511879', 'display_name': 'Michael Constantine', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Michael Constantine', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041181796', 'display_name': 'Lisa Gaynes', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Lisa Gaynes', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111511698', 'display_name': 'Geert J.C.M. Kolvenbag', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Geert Kolvenbag', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111660964', 'display_name': 'William C. DeWolf', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'William DeWolf', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113550740', 'display_name': 'Steve Balk', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Steve Balk', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112335202', 'display_name': 'Mary Ellen Taplin', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mary Ellen Taplin', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5043769628', 'display_name': 'Glenn J. Bubley', 'orcid': 'https://orcid.org/0000-0002-3062-643X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Glenn J. Bubley', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 13.468, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 210, 'citation_normalized_percentile': {'value': 0.933297, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '159', 'issue': '1', 'first_page': '149', 'last_page': '153'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bicalutamide', 'display_name': 'Bicalutamide', 'score': 0.98188174}, {'id': 'https://openalex.org/keywords/flutamide', 'display_name': 'Flutamide', 'score': 0.93909293}, {'id': 'https://openalex.org/keywords/hormonal-therapy', 'display_name': 'Hormonal Therapy', 'score': 0.4683045}], 'concepts': [{'id': 'https://openalex.org/C2780962315', 'wikidata': 'https://www.wikidata.org/wiki/Q1988832', 'display_name': 'Bicalutamide', 'level': 5, 'score': 0.98188174}, {'id': 'https://openalex.org/C2778313021', 'wikidata': 'https://www.wikidata.org/wiki/Q418669', 'display_name': 'Flutamide', 'level': 5, 'score': 0.93909293}, {'id': 'https://openalex.org/C2779322244', 'wikidata': 'https://www.wikidata.org/wiki/Q574820', 'display_name': 'Antiandrogen', 'level': 4, 'score': 0.8995927}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.86795557}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.7259481}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.57966465}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.53658444}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.47732908}, {'id': 'https://openalex.org/C2778311097', 'wikidata': 'https://www.wikidata.org/wiki/Q5903784', 'display_name': 'Hormonal therapy', 'level': 4, 'score': 0.4683045}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.4300695}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.42756173}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.36434036}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.31414998}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.25704432}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.2225442}], 'mesh': [{'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005485', 'descriptor_name': 'Flutamide', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D005485', 'descriptor_name': 'Flutamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010865', 'descriptor_name': 'Pilot Projects', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014105', 'descriptor_name': 'Tosyl Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0022-5347(01)64039-4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9400459', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1595712080', 'https://openalex.org/W1816722347', 'https://openalex.org/W1980850919', 'https://openalex.org/W2009269691', 'https://openalex.org/W2009402948', 'https://openalex.org/W2013614953', 'https://openalex.org/W2014145760', 'https://openalex.org/W2022635468', 'https://openalex.org/W2038052756', 'https://openalex.org/W2060181878', 'https://openalex.org/W2064968760', 'https://openalex.org/W2096496280', 'https://openalex.org/W2117399653', 'https://openalex.org/W2121146904', 'https://openalex.org/W2129630152', 'https://openalex.org/W2165631552', 'https://openalex.org/W2340799873', 'https://openalex.org/W2404117595', 'https://openalex.org/W2409999194', 'https://openalex.org/W2415683488', 'https://openalex.org/W4236637194'], 'related_works': ['https://openalex.org/W4229984084', 'https://openalex.org/W3148026613', 'https://openalex.org/W2589605293', 'https://openalex.org/W2165611177', 'https://openalex.org/W2065112594', 'https://openalex.org/W2031454470', 'https://openalex.org/W2013301667', 'https://openalex.org/W2010412515', 'https://openalex.org/W1978560708', 'https://openalex.org/W1592598587'], 'abstract_inverted_index': {'No': [0, 842], 'AccessJournal': [1], 'of': [2, 108, 170, 188, 202, 217, 284, 331, 352, 389, 396, 411, 459, 466, 502, 521, 542, 565, 615, 636, 680, 730, 738, 760, 768, 782, 785, 813, 816, 864, 891, 908, 932, 987, 1018, 1044, 1073, 1112, 1147, 1174], 'UrologyClinical': [3], 'Urology:': [4], 'Original': [5], 'Articles1': [6], 'Jan': [7], '1998HIGH': [8], 'DOSE': [9], 'BICALUTAMIDE': [10], 'FOR': [11], 'ANDROGEN': [12, 1101], 'INDEPENDENT': [13], 'PROSTATE': [14, 1105, 1167], 'CANCER:': [15, 1168], 'EFFECT': [16], 'OF': [17, 1164], 'PRIOR': [18], 'HORMONAL': [19], 'THERAPY': [20], 'Robin': [21, 45, 1205], 'Joyce,': [22], 'Mary': [23, 38, 49, 79, 1212, 1262], 'Anne': [24, 50, 52, 1213], 'Fenton,': [25], 'Paola': [26, 55, 1220], 'Rode,': [27], 'Michael': [28, 59, 1227], 'Constantine,': [29], 'Lisa': [30, 63, 1234], 'Gaynes,': [31], 'Geert': [32, 67, 847, 1241], 'Kolvenbag,': [33], 'William': [34, 71, 1248], 'DeWolf,': [35], 'Steve': [36, 75, 1255], 'Balk,': [37], 'Ellen': [39, 80, 82, 1263], 'Taplin,': [40], 'and': [41, 85, 143, 159, 254, 262, 334, 354, 360, 446, 464, 633, 678, 791, 800, 811, 889, 968, 1001, 1015, 1030, 1062, 1097, 1132, 1159], 'Glenn': [42, 86, 1270], 'J.': [43, 87, 89, 342, 365, 379, 490, 532, 572, 600, 623, 651, 742, 771, 1271], 'Bubley': [44, 90, 1272], 'JoyceRobin': [46], 'Joyce': [47, 1206], ',': [48, 54, 58, 62, 66, 70, 74, 78, 84], 'FentonMary': [51], 'Fenton': [53, 1214], 'RodePaola': [56], 'Rode': [57, 1221], 'ConstantineMichael': [60], 'Constantine': [61, 1228], 'GaynesLisa': [64], 'Gaynes': [65, 1235], 'KolvenbagGeert': [68], 'Kolvenbag': [69, 848, 1242], 'DeWolfWilliam': [72], 'DeWolf': [73, 1249], 'BalkSteve': [76], 'Balk': [77, 1256], 'TaplinMary': [81], 'Taplin': [83, 1264], 'BubleyGlenn': [88], 'View': [91], 'All': [92, 1279], 'Author': [93, 1203], 'Informationhttps://doi.org/10.1016/S0022-5347(01)64039-4AboutFull': [94], 'TextPDF': [95], 'ToolsAdd': [96], 'to': [97, 138, 228, 321, 570, 716, 1138], 'favoritesDownload': [98], 'CitationsTrack': [99], 'CitationsPermissionsReprints': [100], 'ShareFacebookLinked': [101], 'InTwitterEmail': [102], 'Abstract': [103], 'Purpose:': [104], 'A': [105, 328, 350, 902, 1064], 'pilot': [106], 'study': [107, 125, 146, 312, 351, 834], 'the': [109, 129, 167, 240, 276, 319, 394, 417, 460, 505, 522, 566, 598, 686, 707, 717, 758, 766, 780, 829, 861, 1041], 'antiandrogen': [110, 316, 718], 'bicalutamide': [111, 245], 'at': [112, 267, 289], '150': [113, 268], 'mg.': [114, 269], 'a': [115, 218, 248, 255, 270, 613, 641, 681], 'day': [116, 271], 'for': [117, 192, 197, 295, 304, 646, 685, 822, 831, 867, 895, 976, 1036, 1069], 'androgen': [118, 132, 149, 220, 232, 299, 433, 461, 544, 666, 687, 708], 'independent': [119, 133, 150, 300], 'prostate': [120, 155, 301, 362, 399, 468, 488, 508, 528, 548, 595, 621, 637, 691, 713, 740], 'cancer': [121], 'was': [122, 126, 176, 272], 'performed.': [123], 'This': [124, 311], 'based': [127], 'on': [128, 483, 504, 757], 'possibility': [130], 'that': [131, 314], 'cases': [134, 151], 'might': [135], 'display': [136], 'responses': [137], 'additional': [139], 'hormonal': [140, 323], 'agents.': [141, 324], 'Materials': [142], 'Methods:': [144], 'The': [145, 499, 792, 929, 1034], 'included': [147], '31': [148], 'with': [152, 179, 212, 231, 275, 298, 308, 333, 358, 398, 734, 853, 897], 'an': [153, 198, 437, 763], 'increasing': [154], 'specific': [156, 638, 682], 'antigen': [157, 413, 611, 639], '(PSA)': [158], 'progressive': [160], 'disease.': [161], 'PSA': [162, 174, 186, 242, 392, 761], 'measurements': [163], 'were': [164, 205], 'used': [165], 'as': [166, 215, 612, 640, 762], 'primary': [168], 'method': [169], 'assessing': [171], 'response.': [172], 'However,': [173], 'decline': [175], 'also': [177], 'correlated': [178], 'clinical': [180, 484, 642, 769], 'status.': [181], 'Results:': [182], 'Seven': [183], 'patients': [184, 210, 229, 244, 297, 357], 'demonstrated': [185], 'declines': [187], 'greater': [189], 'than': [190, 845], '50%': [191], '2': [193, 348, 906], 'months': [194], 'or': [195], 'more,': [196], 'overall': [199], 'response': [200, 224, 237, 320], 'rate': [201], '22.5%.': [203], 'Responses': [204], 'observed': [206], 'almost': [207], 'exclusively': [208], 'in': [209, 226, 247, 251, 257, 260, 337, 356, 375, 391, 393, 416, 436, 486, 525, 593, 618, 689, 706, 711, 736, 765, 855, 925, 1040], 'treated': [211, 230, 307], 'long-term': [213, 309], 'flutamide': [214, 235, 336], 'part': [216, 856], 'complete': [219], 'blockade': [221], 'regimen': [222], '(43%': [223], 'rate)': [225], 'contrast': [227], 'deprivation': [233], 'without': [234, 335], '(6%': [236], 'rate).': [238], 'Of': [239], '7': [241, 454], 'responding': [243], 'resulted': [246], 'significant': [249], 'improvement': [250], 'performance': [252], 'status': [253], 'decrease': [256], 'analgesic': [258], 'requirement': [259], '4': [261, 386], '3': [263, 372], 'remained': [264], 'asymptomatic.': [265], 'Bicalutamide': [266, 288, 894, 924], 'well': [273], 'tolerated,': [274], 'most': [277], 'frequent': [278], 'side': [279], 'effect': [280, 501], 'being': [281], 'mild': [282], 'exacerbation': [283], 'hot': [285], 'flashes.': [286], 'Conclusions:': [287], 'this': [290, 832, 1210, 1218, 1225, 1232, 1239, 1246, 1253, 1260, 1268, 1276], 'dose': [291], 'is': [292, 441], 'modestly': [293], 'effective': [294], 'some': [296], 'cancer,': [302], 'particularly': [303], 'those': [305], 'previously': [306], 'flutamide.': [310], 'indicates': [313], 'previous': [315], 'therapy': [317], 'alters': [318], 'subsequent': [322], 'References': [325], '1': [326, 1188], ':': [327, 349, 373, 387, 408, 431, 455, 477, 498, 519, 539, 558, 580, 590, 609, 631, 659, 676, 702, 727, 751], 'controlled': [329], 'trial': [330, 643], 'leuprolide': [332], 'prostatic': [338, 377, 419, 439, 649, 663], 'carcinoma..': [339, 363], 'New': [340, 530], 'Engl.': [341, 531], 'Med.1989;': [343], '321:': [344], '419.': [345], 'Google': [346, 370, 384, 405, 428, 452, 474, 495, 516, 536, 555, 577, 587, 606, 628, 656, 673, 699, 724, 748, 777], 'Scholar': [347, 371, 385, 406, 429, 453, 475, 496, 517, 537, 556, 578, 588, 607, 629, 657, 674, 700, 725, 749, 778], 'aminoglutethemide': [353], 'hydrocortisone': [355], 'advanced': [359, 712], 'refractory': [361, 648], 'Amer.': [364], 'Clin.': [366, 491, 550, 624], 'Oncol.1989;': [367], '12:': [368], '358.': [369], 'Flutamide': [374, 478], 'hormone-resistant': [376], 'cancer..': [378, 400, 469, 489, 529, 549, 622, 650, 741], 'Urol.1990;': [380], '144:': [381], '1411.': [382], 'Abstract,': [383, 655], 'Evaluation': [388], 'changes': [390], 'management': [395], 'men': [397], 'Sem.': [401], 'Oncol.1994;': [402], '21:': [403], '554.': [404], '5': [407], 'Hormonal': [409, 1038, 1067], 'regulation': [410], 'prostate-specific': [412], 'messenger': [414], 'RNA': [415], 'human': [418, 467, 507, 690], 'adenocarcinoma': [420], 'cell': [421, 510], 'line': [422, 511], 'LNCaP..': [423, 512], 'Cancer': [424, 551, 581, 602, 669, 744, 773, 900, 979, 1141], 'Res.1991;': [425], '51:': [426], '3748.': [427], '6': [430], 'Mutant': [432], 'receptor': [434, 462, 560, 667, 688, 709], 'detected': [435], 'advanced-stage': [438], 'carcinoma': [440, 664], 'activated': [442], 'by': [443, 857, 879, 1198, 1209, 1217, 1224, 1231, 1238, 1245, 1252, 1259, 1267, 1275], 'adrenal': [444], 'androgens': [445], 'progesterone..': [447], 'Mol.': [448], 'Endocr.1993;': [449], '7:': [450], '1541.': [451], 'In': [456], 'vivo': [457], 'amplification': [458], 'gene': [463, 524, 710], 'progression': [465], 'Nat.': [470], 'Genet.1995;': [471], '9:': [472], '401.': [473], '8': [476], 'withdrawal': [479, 719], 'syndrome:': [480], 'its': [481], 'impact': [482], 'trials': [485, 592], 'hormone-refractory': [487, 620], 'Oncol.1993;': [492, 625], '11:': [493, 626], '1566.': [494], '9': [497], 'proliferative': [500], '"anti-androgens"': [503], 'androgen-sensitive': [506], 'tumor': [509], 'Endocrinology1990;': [513], '126:': [514], '1457.': [515], '10': [518], 'Mutation': [520], 'androgen-receptor': [523], 'metastatic': [526, 619], 'androgen-independent': [527, 547], 'Med.1995;': [533], '332:': [534], '1393.': [535], '11': [538], 'Anti-androgen': [540], 'activation': [541], 'mutant': [543], 'receptors': [545], 'from': [546, 662, 860], 'Res.1997;': [552], '3:': [553], '1383.': [554], '12': [557], 'Androgen': [559, 985], 'antagonist': [561], 'versus': [562, 893, 923], 'agonist': [563], 'activities': [564], 'fungicide': [567], 'vinclozolin': [568], 'relative': [569], 'hydroxyflutamide..': [571], 'Biol.': [573], 'Chem.1995;': [574], '270:': [575], '19998.': [576], '13': [579], 'Pain': [582], 'Relief.': [583], 'Geneva,': [584], 'Switzerland:': [585], 'W.H.O.1986.': [586], '14': [589], 'Clinical': [591, 787, 1013], 'relapsed': [594], 'cancer:': [596, 714], 'defining': [597], 'target..': [599], 'Natl.': [601, 694, 743, 772], 'Inst.1996;': [603, 774], '88:': [604, 775], '1623.': [605], '15': [608], 'Prostate-specific': [610], 'measure': [614], 'disease': [616], 'outcome': [617], '607.': [627], '16': [630], 'Estramustine': [632], 'vinblastine:': [634], 'use': [635], 'end': [644], 'point': [645], 'hormone': [647], 'Urol.1992;': [652], '147:': [653], '931.': [654], '17': [658], 'Distant': [660], 'metastases': [661], 'express': [665], 'protein..': [668], 'Res.1995;': [670], '55:': [671], '3068.': [672], '18': [675], 'Cloning': [677], 'characterization': [679], 'activator,': [683], 'ARA70,': [684], 'cells..': [692], 'Proc.': [693], 'Acad.': [695], 'Sci.1996;': [696], '93:': [697], '5517.': [698], '19': [701], 'Codon': [703], '877': [704], 'mutation': [705], 'relationship': [715], 'syndrome..': [720], 'Prostate1996;': [721], '29:': [722], '152.': [723], '20': [726], 'Surprising': [728], 'activity': [729], 'flutamide-withdrawal,': [731], 'when': [732], 'combined': [733], 'aminoglutethimide,': [735], 'treatment': [737], '"hormone-refractory"': [739], 'Inst.1994;': [745], '86:': [746], '222.': [747], '21': [750], 'How': [752], 'much': [753], 'can': [754], 'we': [755], 'rely': [756], 'level': [759], 'endpoint': [764], 'evaluation': [767], 'trials..': [770], '779.': [776], 'From': [779], 'Department': [781], 'Medicine,': [783], 'Division': [784, 812], 'Hematology/Oncology,': [786, 814], 'Investigator': [788], 'Training': [789], 'Program,': [790], 'Beth': [793, 869], 'Israel-Deaconness': [794], 'Medical': [795, 798, 818], 'Center,': [796], 'Harvard': [797], 'School': [799], 'MIT': [801], 'Health': [802], 'Sciences': [803], 'Technology,': [804], 'Boston,': [805, 875], 'Massachusetts,': [806], 'Zeneca': [807], 'Pharmaceuticals,': [808], 'Wilmington,': [809], 'Delaware': [810], 'University': [815], 'Massachusetts': [817, 876], 'School,': [819], 'Worcester,': [820], 'MassachusettsAccepted': [821], 'publication': [823, 916, 940, 995, 1026, 1052, 1081, 1120, 1155, 1182], 'June': [824], '27,': [825], '1997Zeneca': [826], 'pharmaceuticals': [827], 'provided': [828], 'drug': [830], 'above': [833], 'but': [835], 'did': [836], 'not': [837], 'provide': [838], 'any': [839, 850], 'financial': [840, 851], 'support.': [841], 'author': [843, 1211, 1219, 1226, 1233, 1240, 1247, 1254, 1261, 1269, 1277], 'other': [844], 'Dr.': [846], 'has': [849], 'involvement': [852], 'ZenecaSupported': [854], 'Grant': [858], 'RR01032': [859], 'National': [862], 'Institutes': [863], 'Health(Bubley)': [865], 'Requests': [866], 'reprints:': [868], 'Israel': [870], 'Hospital,': [871], '330': [872], 'Brookline': [873], 'Ave.,': [874], '02215©': [877], '1998': [878, 1190, 1197], 'American': [880, 1199], 'Urological': [881, 1200], 'Association,': [882, 1201], 'Inc.FiguresReferencesRelatedDetailsCited': [883], 'byTaneja': [884], 'S': [885, 919, 1099], '(2016)': [886, 920], 'Re:': [887, 921], 'Efficacy': [888], 'Safety': [890], 'Enzalutamide': [892, 922], 'Patients': [896], 'Metastatic': [898, 1009], 'Prostate': [899, 927, 978, 1010, 1071, 1140], '(TERRAIN):': [901], 'Randomised,': [903], 'Double-Blind,': [904], 'Phase': [905], 'StudyJournal': [907], 'Urology,': [909, 933, 988, 1019, 1045, 1074, 1113, 1148, 1175], 'VOL.': [910, 934, 989, 1020, 1046, 1075, 1114, 1149, 1176], '197,': [911], 'NO.': [912, 936, 991, 1022, 1048, 1077, 1116, 1151, 1178], '1,': [913, 1078], '(152-152),': [914], 'Online': [915, 939, 994, 1025, 1051, 1080, 1119, 1154, 1181], 'date:': [917, 941, 996, 1027, 1053, 1082, 1121, 1156, 1183], '1-Jan-2017.Taneja': [918], 'Castration-Resistant': [926], 'Cancer:': [928, 1011], 'STRIVE': [930], 'TrialJournal': [931], '196,': [935], '3,': [937, 992, 1117], '(741-744),': [938], '1-Sep-2016.Suzuki': [942], 'H,': [943, 947, 965, 1125], 'Okihara': [944], 'K,': [945, 1127], 'Miyake': [946], 'Fujisawa': [948], 'M,': [949, 955, 1092, 1129], 'Miyoshi': [950], 'S,': [951, 963, 1059, 1123], 'Matsumoto': [952], 'T,': [953, 959, 961], 'Fujii': [954], 'Takihana': [956], 'Y,': [957, 1084], 'Usui': [958], 'Matsuda': [960], 'Ozono': [962], 'Kumon': [964], 'Ichikawa': [966], 'T': [967, 970, 1131], 'Miki': [969], '(2008)': [971], 'Alternative': [972, 1136], 'Nonsteroidal': [973], 'Antiandrogen': [974], 'Therapy': [975, 1068], 'Advanced': [977, 1070], 'That': [980], 'Relapsed': [981], 'After': [982, 1143], 'Initial': [983, 1144], 'Maximum': [984], 'BlockadeJournal': [986], '180,': [990], '(921-927),': [993], '1-Sep-2008.Gignac': [997], 'G,': [998, 1086], 'Morris': [999], 'M': [1000, 1003], 'Hussain': [1002], '(2007)': [1004], 'Castration': [1005], 'Resistant,': [1006], 'Taxane': [1007], 'Naïve': [1008], 'Current': [1012], 'Approaches': [1014], 'Future': [1016], 'DirectionsJournal': [1017], '178,': [1021], '3S,': [1023], '(S30-S35),': [1024], '1-Sep-2007.Small': [1028], 'E': [1029], 'Ryan': [1031], 'C': [1032], '(2018)': [1033, 1065, 1100, 1135, 1162], 'Case': [1035], 'Secondary': [1037, 1066], 'Therapies': [1039], 'Chemotherapy': [1042], 'AgeJournal': [1043], '176,': [1047], '6S,': [1049], '(S66-S71),': [1050], '1-Dec-2006.Lam': [1054], 'J,': [1055, 1057], 'Leppert': [1056], 'Vemulapalli': [1058], 'Shvarts': [1060], 'O': [1061], 'Belldegrun': [1063], 'CancerJournal': [1072], '175,': [1076], '(27-34),': [1079], '1-Jan-2006.KO': [1083], 'DEVI': [1085], 'LONDON': [1087], 'C,': [1088], 'KAYAS': [1089], 'A,': [1090], 'REDDY': [1091], 'IVERSEN': [1093], 'P,': [1094], 'BUBLEY': [1095], 'G': [1096], 'BALK': [1098], 'RECEPTOR': [1102], 'DOWN-REGULATION': [1103], 'IN': [1104], 'CANCER': [1106], 'WITH': [1107], 'PHOSPHORODIAMIDATE': [1108], 'MORPHOLINO': [1109], 'ANTISENSE': [1110], 'OLIGOMERSJournal': [1111], '172,': [1115], '(1140-1144),': [1118], '1-Sep-2004.KOJIMA': [1122], 'SUZUKI': [1124], 'AKAKURA': [1126], 'SHIMBO': [1128], 'ICHIKAWA': [1130], 'ITO': [1133], 'H': [1134], 'Antiandrogens': [1137], 'Treat': [1139], 'Relapse': [1142], 'Hormone': [1145], 'TherapyJournal': [1146], '171,': [1150], '2,': [1152], '(679-683),': [1153], '1-Feb-2004.OH': [1157], 'W': [1158], 'KANTOFF': [1160], 'P': [1161], 'MANAGEMENT': [1163], 'HORMONE': [1165], 'REFRACTORY': [1166], 'CURRENT': [1169], 'STANDARDS': [1170], 'AND': [1171], 'FUTURE': [1172], 'PROSPECTSJournal': [1173], '160,': [1177], '4,': [1179], '(1220-1229),': [1180], '1-Oct-1998.': [1184], 'Volume': [1185], '159': [1186], 'Issue': [1187], 'January': [1189], 'Page:': [1191], '149-153': [1192], 'Advertisement': [1193, 1280], 'Copyright': [1194], '&': [1195], 'Permissions©': [1196], 'Inc.Metrics': [1202], 'Information': [1204], 'More': [1207, 1215, 1222, 1229, 1236, 1243, 1250, 1257, 1265, 1273], 'articles': [1208, 1216, 1223, 1230, 1237, 1244, 1251, 1258, 1266, 1274], 'Expand': [1278], 'PDF': [1281], 'downloadLoading': [1282], '...': [1283]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2031454470', 'counts_by_year': [{'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-08T17:48:41.829835', 'created_date': '2016-06-24'}