Publication Information

{'id': 'https://openalex.org/W2022585982', 'doi': 'https://doi.org/10.1158/1538-7445.am2014-1333', 'title': 'Abstract 1333: Combining Afatinib and Cetuximab synergistically increases their cytotoxicity for EGFR T790M-harboring cells', 'display_name': 'Abstract 1333: Combining Afatinib and Cetuximab synergistically increases their cytotoxicity for EGFR T790M-harboring cells', 'publication_year': 2014, 'publication_date': '2014-10-01', 'ids': {'openalex': 'https://openalex.org/W2022585982', 'doi': 'https://doi.org/10.1158/1538-7445.am2014-1333', 'mag': '2022585982'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2014-1333', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101593797', 'display_name': 'Nobuyuki Tanaka', 'orcid': 'https://orcid.org/0000-0002-0229-8061'}, 'institutions': [{'id': 'https://openalex.org/I4210107389', 'display_name': 'Miyagi Prefectural Hospital Organization', 'ror': 'https://ror.org/01qt7mp11', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107389']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Nobuyuki Tanaka', 'raw_affiliation_strings': ['Miyagi Cancer Center Research Institute, Natori, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Miyagi Cancer Center Research Institute, Natori, Japan.', 'institution_ids': ['https://openalex.org/I4210107389']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085080040', 'display_name': 'Zenta Watanuki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210107389', 'display_name': 'Miyagi Prefectural Hospital Organization', 'ror': 'https://ror.org/01qt7mp11', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107389']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Zenta Watanuki', 'raw_affiliation_strings': ['Miyagi Cancer Center Research Institute, Natori, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Miyagi Cancer Center Research Institute, Natori, Japan.', 'institution_ids': ['https://openalex.org/I4210107389']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073197092', 'display_name': 'Tatsuro Fukuhara', 'orcid': 'https://orcid.org/0000-0003-0440-470X'}, 'institutions': [{'id': 'https://openalex.org/I4210107389', 'display_name': 'Miyagi Prefectural Hospital Organization', 'ror': 'https://ror.org/01qt7mp11', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107389']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tatsuro Fukuhara', 'raw_affiliation_strings': ['Miyagi Cancer Center Research Institute, Natori, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Miyagi Cancer Center Research Institute, Natori, Japan.', 'institution_ids': ['https://openalex.org/I4210107389']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007143858', 'display_name': 'Makoto Maemondo', 'orcid': 'https://orcid.org/0000-0002-1950-1943'}, 'institutions': [{'id': 'https://openalex.org/I4210107389', 'display_name': 'Miyagi Prefectural Hospital Organization', 'ror': 'https://ror.org/01qt7mp11', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107389']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Makoto Maemondo', 'raw_affiliation_strings': ['Miyagi Cancer Center Research Institute, Natori, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Miyagi Cancer Center Research Institute, Natori, Japan.', 'institution_ids': ['https://openalex.org/I4210107389']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '74', 'issue': '19_Supplement', 'first_page': '1333', 'last_page': '1333'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/afatinib', 'display_name': 'Afatinib', 'score': 0.9443407}, {'id': 'https://openalex.org/keywords/t790m', 'display_name': 'T790M', 'score': 0.854244}], 'concepts': [{'id': 'https://openalex.org/C2780586478', 'wikidata': 'https://www.wikidata.org/wiki/Q4688818', 'display_name': 'Afatinib', 'level': 5, 'score': 0.9443407}, {'id': 'https://openalex.org/C2777930144', 'wikidata': 'https://www.wikidata.org/wiki/Q25100112', 'display_name': 'T790M', 'level': 5, 'score': 0.854244}, {'id': 'https://openalex.org/C2779998722', 'wikidata': 'https://www.wikidata.org/wiki/Q420296', 'display_name': 'Cetuximab', 'level': 4, 'score': 0.7696544}, {'id': 'https://openalex.org/C2780580887', 'wikidata': 'https://www.wikidata.org/wiki/Q417824', 'display_name': 'Gefitinib', 'level': 4, 'score': 0.6650272}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6362591}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.53332555}, {'id': 'https://openalex.org/C2778087573', 'wikidata': 'https://www.wikidata.org/wiki/Q418369', 'display_name': 'Erlotinib', 'level': 4, 'score': 0.5048612}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.45328927}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.4336357}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.41549048}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.37329847}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.27461725}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.26042765}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.24620771}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.21783012}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.21716854}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.21227333}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.18202162}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.12506756}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.119829744}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09918502}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2014-1333', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.8}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4362621113', 'https://openalex.org/W4231708084', 'https://openalex.org/W3147989365', 'https://openalex.org/W2418692205', 'https://openalex.org/W2280113021', 'https://openalex.org/W2254126652', 'https://openalex.org/W2161112963', 'https://openalex.org/W2015548040', 'https://openalex.org/W2015104488', 'https://openalex.org/W2015000811'], 'abstract_inverted_index': {'Abstract': [0], 'Epidermal': [1], 'growth': [2], 'factor': [3], 'receptor': [4], '(EGFR)': [5], 'is': [6, 97], 'an': [7, 83], 'important': [8], 'therapeutic': [9, 70], 'target': [10], 'for': [11, 28, 49, 65, 74, 173, 268, 284], 'non-small': [12], 'cell': [13, 228], 'lung': [14], 'cancers': [15], '(NSCLCs).': [16], 'Tyrosine': [17], 'kinase': [18, 56], 'inhibitors': [19], '(TKIs),': [20], 'such': [21], 'as': [22], 'gefitinib': [23], 'and': [24, 126, 168, 193, 197, 208, 246, 262], 'erlotinib,': [25], 'are': [26, 112], 'effective': [27], 'patients': [29, 35], 'with': [30, 82, 117, 206], 'EGFR-activating': [31], 'mutations.': [32, 120], 'However,': [33], 'these': [34, 137, 181, 203], 'eventually': [36], 'develop': [37], 'resistance,': [38], 'usually': [39], 'through': [40, 225], 'a': [41, 77], 'secondary': [42], 'EGFR': [43, 119, 123, 145, 269], 'mutation,': [44, 146], 'T790M:': [45], 'substitution': [46], 'of': [47, 134, 187, 195, 214, 275, 280], 'methionine': [48], 'threonine': [50], 'at': [51], 'position': [52], '790': [53], 'in': [54, 180, 202, 211], 'the': [55, 66, 95, 143, 161, 188, 212, 222, 226, 240, 276, 281], 'domain.': [57], 'While': [58], 'second-generation': [59, 78], 'irreversible': [60], 'TKIs': [61, 138], 'have': [62], 'higher': [63], 'affinities': [64], 'double-mutant': [67, 177], 'EGFRs,': [68], 'their': [69, 266], 'effect': [71, 242], 'leaves': [72], 'room': [73], 'improvement.': [75], 'Combining': [76, 166, 260], 'TKI': [79], 'like': [80], 'afatinib': [81, 167, 245], 'anti-EGFR': [84, 163], 'monoclonal': [85, 162], 'antibody': [86, 164], 'has': [87], 'been': [88], 'shown': [89], 'to': [90, 114, 130, 136, 153, 239], 'improve': [91], 'clinical': [92], 'outcomes,': [93], 'although': [94], 'mechanism': [96], 'not': [98], 'fully': [99], 'understood.': [100], 'To': [101], 'investigate': [102], 'this': [103], 'mechanism,': [104], 'we': [105, 217], 'used': [106], 'human': [107], 'erythroleukemia': [108], 'K562': [109, 174], 'cells,': [110], 'which': [111], 'EGFR-negative,': [113], 'establish': [115], 'cells': [116, 175, 182, 204], 'known': [118], 'Two': [121], 'activating': [122], 'mutations,': [124], 'Ex19del': [125], 'L858R,': [127], 'were': [128, 150, 156], 'sensitive': [129, 152], 'first-generation': [131], 'TKIs.': [132], 'Acquisition': [133], 'resistance': [135], 'was': [139, 183], 'confirmed': [140], 'by': [141, 160, 185, 244], 'adding': [142], 'second': [144], 'T790M.': [147], 'Double-mutant': [148], 'EGFRs': [149], 'moderately': [151], 'afatinib,': [154], 'but': [155], 'only': [157], 'minimally': [158], 'affected': [159], 'cetuximab.': [165], 'cetuximab': [169, 220, 247], 'synergistically': [170, 264], 'increased': [171], 'cytotoxity': [172], 'carrying': [176], 'EGFRs.': [178], 'Apoptosis': [179], 'preceded': [184], 'induction': [186], 'pro-apoptotic': [189], 'protein': [190], 'BIM': [191], '(Bcl2L11)': [192], 'activation': [194], 'Caspase-3': [196], 'PARP.': [198], 'Afatinib': [199, 261], 'induced': [200], 'autophagy': [201], 'correlated': [205], 'AKT': [207], 'ERK1/2': [209], 'signaling': [210], 'course': [213], 'treatment.': [215], 'Accordingly,': [216], 'found': [218], 'that': [219, 234], 'enhanced': [221], 'afatinib-induced': [223], 'cytotoxicity': [224, 267], 'autophagic': [227], 'death': [229], 'pathway.': [230], 'Our': [231], 'results': [232], 'indicate': [233], 'two': [235], 'distinct': [236], 'mechanisms': [237], 'contribute': [238], 'synergistic': [241], 'exerted': [243], 'against': [248], 'NSCLCs.': [249], 'Citation': [250], 'Format:': [251], 'Nobuyuki': [252], 'Tanaka,': [253], 'Zenta': [254], 'Watanuki,': [255], 'Tatsuro': [256], 'Fukuhara,': [257], 'Makoto': [258], 'Maemondo.': [259], 'Cetuximab': [263], 'increases': [265], 'T790M-harboring': [270], 'cells.': [271], '[abstract].': [272], 'In:': [273], 'Proceedings': [274], '105th': [277], 'Annual': [278], 'Meeting': [279], 'American': [282], 'Association': [283], 'Cancer': [285, 296], 'Research;': [286], '2014': [287], 'Apr': [288], '5-9;': [289], 'San': [290], 'Diego,': [291], 'CA.': [292], 'Philadelphia': [293], '(PA):': [294], 'AACR;': [295], 'Res': [297], '2014;74(19': [298], 'Suppl):Abstract': [299], 'nr': [300], '1333.': [301], 'doi:10.1158/1538-7445.AM2014-1333': [302]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2022585982', 'counts_by_year': [], 'updated_date': '2024-12-08T13:07:28.019223', 'created_date': '2016-06-24'}