Clarification of mechanisms of acquired resistance for afatinib using plasma samples

Name: Work Video:
Duration: 3 min 30 s
Tomomi Nakamura; Chiho Nakashima; Kazutoshi Komiya; Shinya Kimura; Naoko Sueoka‐Aragane
{'id': 'https://openalex.org/W4231708084', 'doi': 'https://doi.org/10.1093/annonc/mdx697.008', 'title': 'Clarification of mechanisms of acquired resistance for afatinib using plasma samples', 'display_name': 'Clarification of mechanisms of acquired resistance for afatinib using plasma samples', 'publication_year': 2017, 'publication_date': '2017-10-01', 'ids': {'openalex': 'https://openalex.org/W4231708084', 'doi': 'https://doi.org/10.1093/annonc/mdx697.008'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/annonc/mdx697.008', 'pdf_url': 'https://academic.oup.com/annonc/article-pdf/28/suppl_9/mdx697.008/21525296/mdx697.008.pdf', 'source': {'id': 'https://openalex.org/S41454044', 'display_name': 'Annals of Oncology', 'issn_l': '0923-7534', 'issn': ['0923-7534', '1569-8041'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/annonc/article-pdf/28/suppl_9/mdx697.008/21525296/mdx697.008.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5014889359', 'display_name': 'Tomomi Nakamura', 'orcid': 'https://orcid.org/0000-0003-1943-7352'}, 'institutions': [{'id': 'https://openalex.org/I177136067', 'display_name': 'Saga University', 'ror': 'https://ror.org/04f4wg107', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I177136067']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tomomi Nakamura', 'raw_affiliation_strings': ['Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University', 'institution_ids': ['https://openalex.org/I177136067']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062825946', 'display_name': 'Chiho Nakashima', 'orcid': 'https://orcid.org/0000-0001-7918-7282'}, 'institutions': [{'id': 'https://openalex.org/I177136067', 'display_name': 'Saga University', 'ror': 'https://ror.org/04f4wg107', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I177136067']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Chiho Nakashima', 'raw_affiliation_strings': ['Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University', 'institution_ids': ['https://openalex.org/I177136067']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065907472', 'display_name': 'Kazutoshi Komiya', 'orcid': 'https://orcid.org/0000-0002-9026-1137'}, 'institutions': [{'id': 'https://openalex.org/I177136067', 'display_name': 'Saga University', 'ror': 'https://ror.org/04f4wg107', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I177136067']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazutoshi Komiya', 'raw_affiliation_strings': ['Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University', 'institution_ids': ['https://openalex.org/I177136067']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025614828', 'display_name': 'Shinya Kimura', 'orcid': 'https://orcid.org/0000-0003-1717-6208'}, 'institutions': [{'id': 'https://openalex.org/I177136067', 'display_name': 'Saga University', 'ror': 'https://ror.org/04f4wg107', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I177136067']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shinya Kimura', 'raw_affiliation_strings': ['Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University', 'institution_ids': ['https://openalex.org/I177136067']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039185381', 'display_name': 'Naoko Sueoka‐Aragane', 'orcid': 'https://orcid.org/0000-0002-7428-9068'}, 'institutions': [{'id': 'https://openalex.org/I177136067', 'display_name': 'Saga University', 'ror': 'https://ror.org/04f4wg107', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I177136067']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naoko Aragane', 'raw_affiliation_strings': ['Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University', 'institution_ids': ['https://openalex.org/I177136067']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4060, 'currency': 'USD', 'value_usd': 4060, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 63}, 'biblio': {'volume': '28', 'issue': None, 'first_page': 'ix76', 'last_page': 'ix76'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12318', 'display_name': 'Quinazolinone synthesis and applications', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11215', 'display_name': 'Chronic Myeloid Leukemia Treatments', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/afatinib', 'display_name': 'Afatinib', 'score': 0.9929929}, {'id': 'https://openalex.org/keywords/t790m', 'display_name': 'T790M', 'score': 0.9771357}, {'id': 'https://openalex.org/keywords/resistance-mutation', 'display_name': 'Resistance mutation', 'score': 0.51214004}], 'concepts': [{'id': 'https://openalex.org/C2780586478', 'wikidata': 'https://www.wikidata.org/wiki/Q4688818', 'display_name': 'Afatinib', 'level': 5, 'score': 0.9929929}, {'id': 'https://openalex.org/C2777930144', 'wikidata': 'https://www.wikidata.org/wiki/Q25100112', 'display_name': 'T790M', 'level': 5, 'score': 0.9771357}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.79411733}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5138612}, {'id': 'https://openalex.org/C182707283', 'wikidata': 'https://www.wikidata.org/wiki/Q7315622', 'display_name': 'Resistance mutation', 'level': 5, 'score': 0.51214004}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.48830533}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.43968275}, {'id': 'https://openalex.org/C2778820342', 'wikidata': 'https://www.wikidata.org/wiki/Q906415', 'display_name': 'Tyrosine-kinase inhibitor', 'level': 3, 'score': 0.41097468}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.39495528}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.34511197}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3217507}, {'id': 'https://openalex.org/C2780580887', 'wikidata': 'https://www.wikidata.org/wiki/Q417824', 'display_name': 'Gefitinib', 'level': 4, 'score': 0.13910559}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.10534093}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.062372923}, {'id': 'https://openalex.org/C49105822', 'wikidata': 'https://www.wikidata.org/wiki/Q176996', 'display_name': 'Polymerase chain reaction', 'level': 3, 'score': 0.04941365}, {'id': 'https://openalex.org/C156719811', 'wikidata': 'https://www.wikidata.org/wiki/Q28774', 'display_name': 'Reverse transcriptase', 'level': 4, 'score': 0.049059898}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/annonc/mdx697.008', 'pdf_url': 'https://academic.oup.com/annonc/article-pdf/28/suppl_9/mdx697.008/21525296/mdx697.008.pdf', 'source': {'id': 'https://openalex.org/S41454044', 'display_name': 'Annals of Oncology', 'issn_l': '0923-7534', 'issn': ['0923-7534', '1569-8041'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/annonc/mdx697.008', 'pdf_url': 'https://academic.oup.com/annonc/article-pdf/28/suppl_9/mdx697.008/21525296/mdx697.008.pdf', 'source': {'id': 'https://openalex.org/S41454044', 'display_name': 'Annals of Oncology', 'issn_l': '0923-7534', 'issn': ['0923-7534', '1569-8041'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.81}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4231708084', 'https://openalex.org/W3002825748', 'https://openalex.org/W2981810533', 'https://openalex.org/W2903782160', 'https://openalex.org/W2903701123', 'https://openalex.org/W2898126869', 'https://openalex.org/W2896277158', 'https://openalex.org/W2768041268', 'https://openalex.org/W2588596937', 'https://openalex.org/W2558415788'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4231708084', 'counts_by_year': [], 'updated_date': '2024-12-09T19:08:56.730450', 'created_date': '2022-05-12'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
