Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2013816787', 'doi': 'https://doi.org/10.1053/jhep.2003.50295', 'title': 'Alcohol potentiates hepatitis C virus replicon expression', 'display_name': 'Alcohol potentiates hepatitis C virus replicon expression', 'publication_year': 2003, 'publication_date': '2003-06-26', 'ids': {'openalex': 'https://openalex.org/W2013816787', 'doi': 'https://doi.org/10.1053/jhep.2003.50295', 'mag': '2013816787', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12829987'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1053/jhep.2003.50295', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1053/jhep.2003.50295', 'source': {'id': 'https://openalex.org/S156174673', 'display_name': 'Hepatology', 'issn_l': '0270-9139', 'issn': ['0270-9139', '1527-3350'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1053/jhep.2003.50295', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100718339', 'display_name': 'Tiancheng Zhang', 'orcid': 'https://orcid.org/0009-0009-3449-2318'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}, {'id': 'https://openalex.org/I4210159329', 'display_name': "Children's Hospital of Fudan University", 'ror': 'https://ror.org/05n13be63', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210159329']}, {'id': 'https://openalex.org/I1335321130', 'display_name': "Children's Hospital of Philadelphia", 'ror': 'https://ror.org/01z7r7q48', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1335321130']}], 'countries': ['CN', 'US'], 'is_corresponding': True, 'raw_author_name': 'T Zhang', 'raw_affiliation_strings': ["Department of Infectious Diseases, The Children's Hospital of Fudan University, Shanghai, China", "Division of Allergy and Immunology, Joseph Stokes Jr. Research Institute at The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA"], 'affiliations': [{'raw_affiliation_string': "Division of Allergy and Immunology, Joseph Stokes Jr. Research Institute at The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA", 'institution_ids': ['https://openalex.org/I79576946', 'https://openalex.org/I1335321130']}, {'raw_affiliation_string': "Department of Infectious Diseases, The Children's Hospital of Fudan University, Shanghai, China", 'institution_ids': ['https://openalex.org/I4210159329']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5100718339'], 'corresponding_institution_ids': ['https://openalex.org/I79576946', 'https://openalex.org/I4210159329', 'https://openalex.org/I1335321130'], 'apc_list': None, 'apc_paid': None, 'fwci': 5.096, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 115, 'citation_normalized_percentile': {'value': 0.964041, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '38', 'issue': '1', 'first_page': '57', 'last_page': '65'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10151', 'display_name': 'Hepatitis C virus research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10151', 'display_name': 'Hepatitis C virus research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10351', 'display_name': 'Liver Disease Diagnosis and Treatment', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10308', 'display_name': 'Systemic Lupus Erythematosus Research', 'score': 0.9923, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/replicon', 'display_name': 'Replicon', 'score': 0.8985951}, {'id': 'https://openalex.org/keywords/hepatitis-c', 'display_name': 'Hepatitis C', 'score': 0.5065435}], 'concepts': [{'id': 'https://openalex.org/C18103114', 'wikidata': 'https://www.wikidata.org/wiki/Q1720369', 'display_name': 'Replicon', 'level': 4, 'score': 0.8985951}, {'id': 'https://openalex.org/C2776408679', 'wikidata': 'https://www.wikidata.org/wiki/Q708693', 'display_name': 'Hepatitis C virus', 'level': 3, 'score': 0.675524}, {'id': 'https://openalex.org/C2776455275', 'wikidata': 'https://www.wikidata.org/wiki/Q154869', 'display_name': 'Hepatitis C', 'level': 2, 'score': 0.5065435}, {'id': 'https://openalex.org/C2909179924', 'wikidata': 'https://www.wikidata.org/wiki/Q6046488', 'display_name': 'Alpha interferon', 'level': 3, 'score': 0.49456927}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4602062}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.45600876}, {'id': 'https://openalex.org/C2781066024', 'wikidata': 'https://www.wikidata.org/wiki/Q156', 'display_name': 'Alcohol', 'level': 2, 'score': 0.4456325}, {'id': 'https://openalex.org/C2776178377', 'wikidata': 'https://www.wikidata.org/wiki/Q188269', 'display_name': 'Interferon', 'level': 2, 'score': 0.42245018}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.39989153}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.35251322}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12537354}, {'id': 'https://openalex.org/C22744801', 'wikidata': 'https://www.wikidata.org/wiki/Q172778', 'display_name': 'Plasmid', 'level': 3, 'score': 0.07283676}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06324664}], 'mesh': [{'descriptor_ui': 'D002492', 'descriptor_name': 'Central Nervous System Depressants', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000431', 'descriptor_name': 'Ethanol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': True}, {'descriptor_ui': 'D019698', 'descriptor_name': 'Hepatitis C, Chronic', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': True}, {'descriptor_ui': 'D012093', 'descriptor_name': 'Replicon', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000931', 'descriptor_name': 'Antidotes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000931', 'descriptor_name': 'Antidotes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002492', 'descriptor_name': 'Central Nervous System Depressants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003484', 'descriptor_name': 'Cyanamide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003484', 'descriptor_name': 'Cyanamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004347', 'descriptor_name': 'Drug Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000431', 'descriptor_name': 'Ethanol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077604', 'descriptor_name': 'Fomepizole', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019698', 'descriptor_name': 'Hepatitis C, Chronic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009271', 'descriptor_name': 'Naltrexone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009271', 'descriptor_name': 'Naltrexone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009292', 'descriptor_name': 'Narcotic Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009292', 'descriptor_name': 'Narcotic Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012093', 'descriptor_name': 'Replicon', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D012093', 'descriptor_name': 'Replicon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1053/jhep.2003.50295', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1053/jhep.2003.50295', 'source': {'id': 'https://openalex.org/S156174673', 'display_name': 'Hepatology', 'issn_l': '0270-9139', 'issn': ['0270-9139', '1527-3350'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12829987', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1053/jhep.2003.50295', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1053/jhep.2003.50295', 'source': {'id': 'https://openalex.org/S156174673', 'display_name': 'Hepatology', 'issn_l': '0270-9139', 'issn': ['0270-9139', '1527-3350'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.87, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1618754640', 'https://openalex.org/W1963833324', 'https://openalex.org/W1973848277', 'https://openalex.org/W1976382352', 'https://openalex.org/W1976957825', 'https://openalex.org/W1982598173', 'https://openalex.org/W1984599257', 'https://openalex.org/W1987569391', 'https://openalex.org/W1996869017', 'https://openalex.org/W2006309458', 'https://openalex.org/W2013668795', 'https://openalex.org/W2015046028', 'https://openalex.org/W2018630692', 'https://openalex.org/W2019560693', 'https://openalex.org/W2020004919', 'https://openalex.org/W2020356688', 'https://openalex.org/W2022976224', 'https://openalex.org/W2024024390', 'https://openalex.org/W2031849354', 'https://openalex.org/W2035088045', 'https://openalex.org/W2037504375', 'https://openalex.org/W2045341302', 'https://openalex.org/W2052723208', 'https://openalex.org/W2054355347', 'https://openalex.org/W2066124462', 'https://openalex.org/W2068584461', 'https://openalex.org/W2070719888', 'https://openalex.org/W2078887917', 'https://openalex.org/W2079377965', 'https://openalex.org/W2082229496', 'https://openalex.org/W2082933842', 'https://openalex.org/W2085806058', 'https://openalex.org/W2088053309', 'https://openalex.org/W2090465247', 'https://openalex.org/W2093559862', 'https://openalex.org/W2094664659', 'https://openalex.org/W2104538950', 'https://openalex.org/W2124528668', 'https://openalex.org/W2126153046', 'https://openalex.org/W2133528239', 'https://openalex.org/W2151898297', 'https://openalex.org/W2162688555', 'https://openalex.org/W2163125473', 'https://openalex.org/W2165769699', 'https://openalex.org/W2314619766', 'https://openalex.org/W2317554121', 'https://openalex.org/W2328171401', 'https://openalex.org/W2341829866', 'https://openalex.org/W327837272', 'https://openalex.org/W4241374261', 'https://openalex.org/W4322388292', 'https://openalex.org/W70739328'], 'related_works': ['https://openalex.org/W2762048449', 'https://openalex.org/W2398766250', 'https://openalex.org/W2117027295', 'https://openalex.org/W2107508210', 'https://openalex.org/W2052290779', 'https://openalex.org/W2018670987', 'https://openalex.org/W2015916009', 'https://openalex.org/W1980791300', 'https://openalex.org/W1967069138', 'https://openalex.org/W1595407324'], 'abstract_inverted_index': {'HepatologyVolume': [0], '38,': [1], 'Issue': [2], '1': [3, 855, 1742, 1963], 'p.': [4], '57-65': [5, 2346], 'Original': [6], 'ArticleFree': [7], 'Access': [8], 'Alcohol': [9, 658, 742, 1233, 1243, 1401, 1444, 1445, 1547, 1786, 1807, 1819, 1850, 2047, 2048, 2250, 2251], 'potentiates': [10], 'hepatitis': [11, 880, 932, 962, 985, 1019, 1042, 1079, 1124, 1134, 1173, 1217, 1260, 1299, 1307, 1341, 1377, 1386, 1427, 1462, 1509, 1660, 1992, 2002, 2032, 2062, 2094, 2126], 'C': [12, 667, 933, 963, 986, 1020, 1043, 1080, 1135, 1261, 1300, 1308, 1378, 1398, 1428, 1463, 1510, 1661, 1955, 1993, 2033, 2063, 2127], 'virus': [13, 668, 912, 964, 1044, 1262, 1379, 1464, 1511, 1662, 1740, 1956, 1961, 1994, 2128], 'replicon': [14, 699, 716, 728, 740, 761, 804, 822], 'expression': [15, 725, 823, 1744], 'Ting': [16, 18, 299, 301], 'Zhang,': [17, 300], 'Zhang': [19, 302], 'Division': [20, 68, 104, 142, 240, 303, 351, 387, 425, 523], 'of': [21, 34, 37, 40, 43, 48, 54, 69, 82, 85, 88, 91, 105, 118, 121, 124, 127, 143, 156, 159, 162, 165, 181, 187, 190, 193, 209, 215, 218, 221, 241, 254, 257, 260, 263, 267, 274, 277, 280, 304, 317, 320, 323, 326, 331, 337, 352, 365, 368, 371, 374, 388, 401, 404, 407, 410, 426, 439, 442, 445, 448, 464, 470, 473, 476, 492, 498, 501, 504, 524, 537, 540, 543, 546, 550, 557, 560, 563, 608, 618, 631, 642, 671, 696, 748, 751, 779, 782, 800, 813, 829, 869, 913, 930, 961, 984, 1017, 1077, 1119, 1131, 1169, 1171, 1259, 1270, 1334, 1372, 1418, 1426, 1438, 1457, 1480, 1508, 1568, 1632, 1658, 1689, 1692, 1726, 1734, 1781, 1838, 2029, 2061, 2088, 2104, 2202, 2204, 2238, 2268, 2330], 'Allergy': [22, 70, 106, 144, 242, 268, 305, 353, 389, 427, 525, 551], 'and': [23, 71, 107, 145, 243, 269, 284, 306, 354, 390, 428, 526, 552, 567, 606, 610, 622, 629, 648, 663, 689, 714, 815, 824, 847, 1015, 1039, 1125, 1236, 1256, 1264, 1346, 1381, 1399, 1423, 1530, 1540, 1574, 1602, 1635, 1720, 1795, 1800, 1816, 1842, 1847, 1892, 1922, 1936, 1958, 2039, 2044, 2093, 2108, 2138, 2141, 2160, 2168, 2199, 2226, 2241, 2246, 2291, 2323], 'Immunology,': [24, 72, 108, 146, 244, 270, 307, 355, 391, 429, 527, 553], 'Joseph': [25, 73, 109, 147, 245, 308, 356, 392, 430, 528], 'Stokes': [26, 74, 110, 148, 246, 309, 357, 393, 431, 529], 'Jr.': [27, 75, 111, 149, 247, 310, 358, 394, 432, 530], 'Research': [28, 76, 112, 150, 248, 311, 359, 395, 433, 531], 'Institute': [29, 77, 113, 151, 249, 312, 360, 396, 434, 532], 'at': [30, 78, 114, 152, 250, 313, 361, 397, 435, 533], 'The': [31, 51, 79, 115, 153, 183, 211, 251, 271, 314, 334, 362, 398, 436, 466, 494, 534, 554, 694, 927, 959, 1074, 1085], "Children's": [32, 52, 80, 116, 154, 252, 272, 315, 335, 363, 399, 437, 535, 555], 'Hospital': [33, 53, 81, 117, 155, 253, 273, 316, 336, 364, 400, 438, 536, 556], 'Philadelphia,': [35, 45, 83, 93, 119, 129, 157, 167, 195, 223, 255, 265, 275, 288, 318, 328, 366, 376, 402, 412, 440, 450, 478, 506, 538, 548, 558, 571], 'Department': [36, 47, 84, 120, 158, 180, 208, 256, 319, 330, 367, 403, 441, 463, 491, 539], 'Pediatrics,': [38, 86, 122, 160, 258, 321, 369, 405, 443, 541], 'University': [39, 87, 123, 161, 189, 217, 259, 276, 322, 370, 406, 444, 472, 500, 542, 559], 'Pennsylvania': [41, 89, 125, 163, 191, 219, 261, 278, 324, 372, 408, 446, 474, 502, 544, 561], 'School': [42, 90, 126, 164, 192, 220, 262, 279, 325, 373, 409, 447, 475, 503, 545, 562], 'Medicine,': [44, 92, 128, 166, 194, 222, 264, 281, 327, 375, 411, 449, 477, 505, 547, 564], 'PA': [46, 289, 329, 572], 'Infectious': [49, 332], 'Diseases,': [50, 333], 'Fudan': [55, 338], 'University,': [56, 339], 'Shanghai,': [57, 340], 'ChinaSearch': [58, 341], 'for': [59, 95, 131, 169, 185, 197, 213, 225, 293, 342, 378, 414, 452, 468, 480, 496, 508, 576, 755, 905, 1166, 1215, 1297, 1506, 1628, 2295], 'more': [60, 96, 132, 170, 198, 226, 294, 343, 379, 415, 453, 481, 509, 577], 'papers': [61, 97, 133, 171, 199, 227, 295, 344, 380, 416, 454, 482, 510, 578], 'by': [62, 98, 134, 172, 200, 228, 296, 345, 381, 417, 455, 483, 511, 579, 1129, 1695, 1867, 1925, 2091], 'this': [63, 99, 135, 173, 201, 229, 297, 346, 382, 418, 456, 484, 512, 580, 643], 'authorYuan': [64, 347], 'Li,': [65, 348], 'Yuan': [66, 349], 'Li': [67, 350], 'PASearch': [94, 130, 168, 196, 224, 377, 413, 451, 479, 507], 'authorJian-Ping': [100, 383], 'Lai,': [101, 384], 'Jian-Ping': [102, 385], 'Lai': [103, 386, 1494], 'authorSteven': [136, 419], 'D.': [137, 140, 420, 423, 1590], 'Douglas,': [138, 421], 'Steven': [139, 422], 'Douglas': [141, 424, 1496], 'authorDavid': [174, 457], 'S.': [175, 178, 458, 461, 1254, 2054], 'Metzger,': [176, 459], 'David': [177, 460], 'Metzger': [179, 462, 1498], 'Psychiatry,': [182, 210, 465, 493], 'Center': [184, 212, 286, 467, 495, 569], 'Studies': [186, 214, 469, 497], 'Addiction,': [188, 216, 471, 499], 'authorCharles': [202, 485], 'P.': [203, 206, 486, 489, 1527], "O'Brien,": [204, 487], 'Charles': [205, 488], "O'Brien": [207, 490, 1771, 2262], 'authorDr.': [230, 513], 'Wen-Zhe': [231, 236, 514, 519], 'Ho,': [232, 515], 'Corresponding': [233, 516], 'Author': [234, 517], 'Dr.': [235, 518], 'Ho': [237, 520, 1502], '[email': [238, 521], 'protected]': [239, 522], 'PADivision': [266, 549], '34th': [282, 565], 'St.': [283, 566], 'Civic': [285, 568], 'Blvd.,': [287, 570], '19104.': [290, 573], 'fax:': [291, 574], '215-590-2025===Search': [292, 575], 'author': [298, 581], 'First': [582], 'published:': [583], '30': [584, 1755], 'December': [585], '2003': [586], 'https://doi.org/10.1053/jhep.2003.50295Citations:': [587], '76AboutPDF': [588], 'ToolsRequest': [589], 'permissionExport': [590], 'citationAdd': [591], 'to': [592, 614, 637, 708, 908, 1133, 1238, 1728, 1803], 'favoritesTrack': [593], 'citation': [594], 'ShareShare': [595], 'Give': [596], 'accessShare': [597, 600], 'full': [598], 'text': [599], 'full-text': [601, 616, 640], 'accessPlease': [602], 'review': [603], 'our': [604], 'Terms': [605, 628], 'Conditions': [607, 630], 'Use': [609], 'check': [611], 'box': [612], 'below': [613, 636], 'share': [615, 638], 'version': [617, 641], 'article.I': [619], 'have': [620], 'read': [621], 'accept': [623], 'the': [624, 634, 665, 697, 710, 727, 745, 752, 756, 780, 797, 811, 816, 826, 967, 988, 1018, 1082, 1167, 1239, 1268, 1421, 1461, 1629, 1730, 1763, 1779, 1801, 1836, 2058, 2266], 'Wiley': [625, 1409], 'Online': [626], 'Library': [627], 'UseShareable': [632], 'LinkUse': [633], 'link': [635], 'a': [639, 654, 705, 734, 776, 841, 870, 875, 909, 1046, 1600, 1665, 1783, 2197], 'article': [644], 'with': [645, 677, 1164, 1210, 1305, 1339, 1623, 1932, 2000, 2031, 2326], 'your': [646], 'friends': [647], 'colleagues.': [649], 'Learn': [650], 'more.Copy': [651], 'URL': [652], 'Share': [653], 'linkShare': [655], 'onEmailFacebookTwitterLinkedInRedditWechat': [656], 'Abstract': [657], 'consumption': [659, 1266, 1374, 1440, 1834], 'accelerates': [660], 'liver': [661, 1272, 1846, 1929, 2036], 'damage': [662, 1237], 'diminishes': [664], 'anti-hepatitis': [666], '(HCV)': [669, 1957], 'effect': [670, 747, 799, 828, 2040], 'interferon': [672, 1335, 1459, 1541], 'alfa': [673], '(IFN-α)': [674], 'in': [675, 726, 733, 838, 843, 966, 987, 1041, 1081, 1162, 1208, 1301, 1309, 1337, 1384, 1484, 1537, 1664, 1745, 1762, 1778, 1845, 1869, 1895, 1927, 1966, 2057, 2171, 2243, 2265], 'patients': [676, 1338, 1999], 'HCV': [678, 687, 691, 698, 715, 723, 739, 760, 786, 803, 821, 844, 852, 1481, 2100], 'infection.': [679, 853, 934, 1429], 'It': [680], 'is': [681, 2196], 'unknown,': [682], 'however,': [683], 'whether': [684, 720], 'alcohol': [685, 713, 721, 757, 764, 801, 832, 1265, 1373, 1419, 1439, 1531, 1796, 2227, 2269, 2296], 'enhances': [686, 722, 820], 'replication': [688, 1483, 1694], 'promotes': [690], 'disease': [692, 845], 'progression.': [693], 'availability': [695], 'containing': [700, 729], 'hepatic': [701, 730, 2089], 'cells': [702, 1698], 'has': [703], 'provided': [704], 'unique': [706, 1625], 'opportunity': [707], 'investigate': [709], 'interaction': [711], 'between': [712, 1344], 'expression.': [717, 741, 788, 805], 'We': [718], 'determined': [719], 'RNA': [724, 787, 1380, 1482, 1995], 'cells.': [731, 1747], 'Alcohol,': [732], 'concentration-dependent': [735], 'fashion,': [736], 'significantly': [737], 'increased': [738, 1923], 'also': [743], 'compromised': [744], 'anti-HCV': [746, 827], 'IFN-α.': [749, 830], 'Investigation': [750], 'mechanism(s)': [753], 'responsible': [754], 'action': [758, 1258], 'on': [759, 802, 1048, 1267, 1375, 1420, 1441, 1460, 2041], 'indicated': [762], 'that': [763, 1592], 'activated': [765], 'nuclear': [766, 1533, 1594, 2205], 'factor': [767, 1595, 1718, 1865, 2207], 'κB': [768], '(NF-κB)': [769], 'promoter.': [770], 'Caffeic': [771, 2192], 'acid': [772, 2193], 'phenethyl': [773, 2194], 'ester': [774, 2195], '(CAPE),': [775], 'specific': [777, 1724, 2200], 'inhibitor': [778, 2201], 'activation': [781, 812, 1536, 1691, 2087, 2203], 'NF-κB,': [783], 'abolished': [784], 'alcohol-induced': [785], 'In': [789, 806], 'addition,': [790], 'naltrexone,': [791], 'an': [792, 835, 2328], 'opiate': [793], 'receptor': [794, 2106], 'antagonist,': [795], 'abrogated': [796], 'enhancing': [798], 'conclusion,': [807], 'alcohol,': [808], 'probably': [809], 'through': [810, 971], 'NF-κB': [814], 'endogenous': [817, 2239], 'opioid': [818, 1798, 2224], 'system,': [819], 'compromises': [825], 'Thus,': [831], 'may': [833], 'play': [834], 'important': [836], 'role': [837], 'vivo': [839], 'as': [840, 1212, 1599], 'cofactor': [842], 'progression': [846, 1425], 'compromise': [848], 'IFN-α-based': [849], 'therapy': [850, 1296, 1336, 2294, 2325], 'against': [851], 'References': [854], 'Choo': [856, 889, 997], 'QL,': [857, 890, 998], 'Kuo': [858, 887], 'G,': [859, 888, 1252, 1521, 1525, 1829, 1884, 2118, 2120, 2283, 2313], 'Weiner': [860], 'AJ,': [861, 2281, 2309], 'Overby': [862], 'LR,': [863], 'Bradley': [864], 'DW,': [865], 'Houghton': [866], 'M.': [867, 1759], 'Isolation': [868], 'cDNA': [871], 'clone': [872], 'derived': [873, 1699], 'from': [874, 1700], 'blood-borne': [876], 'non-A,': [877, 915, 1089, 1122], 'non-B': [878, 916, 1090, 1123], 'viral': [879], 'genome.': [881], 'Science': [882, 918, 1487, 1669], '1989;': [883, 919, 1873, 1942], '244:': [884, 920], '359–362.': [885], '2': [886], 'Alter': [891, 943, 981, 1033, 1058], 'HJ,': [892, 1034], 'Gitnick': [893], 'GL,': [894, 1143], 'Redeker': [895], 'AG,': [896], 'Purcell': [897], 'RH,': [898], 'Miyamura': [899], 'T,': [900, 1105, 1320, 1328, 1681], 'et': [901, 957, 1011, 1072, 1116, 1156, 1202, 1293, 1369, 1988, 2025], 'al.': [902, 958, 1012, 1073, 1117, 1157, 1203, 1294, 1370, 1989, 2026], 'An': [903], 'assay': [904], 'circulating': [906], 'antibodies': [907], 'major': [910], 'etiologic': [911], 'human': [914, 1738, 1959, 2245], 'hepatitis.': [917, 1871], '362–364.': [921], '3': [922], 'Strader': [923], 'DB,': [924], 'Seeff': [925, 1035], 'LB.': [926, 1036], 'natural': [928, 1075], 'history': [929, 1076], 'chronic': [931, 1172, 1216, 1298, 1306, 1340, 1385, 1896, 2001, 2035, 2161], 'Eur': [935], 'J': [936, 975, 1096, 1182, 1225, 1313, 1349, 1466, 1513, 1579, 2065, 2112, 2334], 'Gastroenterol': [937, 1314, 1350], 'Hepatol': [938], '1996;': [939, 1315, 1787, 1808, 1820, 2217, 2252, 2338], '8:': [940], '324–328.': [941], '4': [942], 'MJ,': [944, 1059, 1560], 'Kruszon-Moran': [945], 'D,': [946, 1499, 1523, 1556, 2020, 2189], 'Nainan': [947], 'OV,': [948], 'McQuillan': [949], 'GM,': [950], 'Gao': [951, 2084], 'F,': [952, 1356, 1358, 1648, 1683, 2075], 'Moyer': [953], 'LA,': [954, 1774], 'Kaslow': [955], 'RA,': [956], 'prevalence': [960, 2038], 'infection': [965, 1263], 'United': [968, 1083], 'States,': [969], '1988': [970], '1994.': [972], 'N': [973, 1094, 1180, 1223], 'Engl': [974, 1095, 1181, 1224], 'Med': [976, 1097, 1183, 1226], '1999;': [977, 1405, 1446, 1670], '341:': [978], '556–562.': [979], '5': [980], 'MJ.': [982], 'Epidemiology': [983], 'West.': [989], 'Semin': [990, 1051], 'Liver': [991, 1052], 'Dis': [992, 1053], '1995;': [993], '15:': [994, 1642, 2114], '5–14.': [995], '6': [996], 'Richman': [999], 'KH,': [1000], 'Han': [1001], 'JH,': [1002, 1493], 'Berger': [1003], 'K,': [1004, 1063, 1103, 1111, 1280, 1284, 1288, 1290, 1324, 1330, 1987, 2182], 'Lee': [1005, 1196], 'C,': [1006, 1008, 1010, 1153, 1364, 1368, 1909, 2010, 2024], 'Dong': [1007], 'Gallegos': [1009], 'Genetic': [1013], 'organization': [1014], 'diversity': [1016], 'virus.': [1021, 1136, 2064], 'Proc': [1022, 1606, 2144, 2210], 'Natl': [1023, 1607, 2145, 2211], 'Acad': [1024, 1608, 2146, 2212], 'Sci': [1025, 1609, 2147, 2213], 'U': [1026, 1610, 2148, 2214], 'S': [1027, 1611, 2149, 2215], 'A': [1028, 1612, 2150, 2216, 2298], '1991;': [1029, 1900], '88:': [1030], '2451–2455.': [1031], '7': [1032], 'Recovery,': [1037], 'persistence,': [1038], 'sequelae': [1040], 'infection:': [1045], 'perspective': [1047], 'long-term': [1049], 'outcome.': [1050], '2000;': [1054, 1488, 2049], '20:': [1055, 2006], '17–35.': [1056], '8': [1057], 'Margolis': [1060], 'HS,': [1061], 'Krawczynski': [1062], 'Judson': [1064], 'FN,': [1065], 'Mares': [1066], 'A,': [1067, 1394, 1713, 1878, 1949, 1979, 2018], 'Alexander': [1068], 'WJ,': [1069], 'Hu': [1070, 2078], 'PY,': [1071], 'community-acquired': [1078], 'States.': [1084], 'Sentinel': [1086], 'Counties': [1087], 'Chronic': [1088, 1832], 'Hepatitis': [1091, 1176, 1219, 1397, 1954], 'Study': [1092], 'Team.': [1093], '1992;': [1098, 2274, 2304], '327:': [1099], '1899–1905.': [1100], '9': [1101], 'Kiyosawa': [1102], 'Sodeyama': [1104], 'Tanaka': [1106], 'E,': [1107, 1983, 2022], 'Gibo': [1108], 'Y,': [1109, 1113, 1326], 'Yoshizawa': [1110], 'Nakano': [1112], 'Furuta': [1114], 'S,': [1115, 1282, 1292, 1711, 1757, 2081, 2184], 'Interrelationship': [1118], 'blood': [1120], 'transfusion,': [1121], 'hepatocellular': [1126], 'carcinoma:': [1127], 'analysis': [1128, 1631, 2329], 'detection': [1130], 'antibody': [1132], 'Hepatology': [1137, 1274, 1388, 1430, 1872, 1899, 2004, 2176], '1990;': [1138], '12:': [1139], '671–675.': [1140], '10': [1141], 'Davis': [1142], 'Esteban-Mur': [1144], 'R,': [1145, 2122], 'Rustgi': [1146, 1198], 'V,': [1147, 1362, 1646], 'Hoefs': [1148], 'J,': [1149, 1650, 1905, 1907, 1915], 'Gordon': [1150, 1190], 'SC,': [1151, 1191], 'Trepo': [1152], 'Shiffman': [1154, 1194], 'ML,': [1155, 1195], 'Interferon': [1158, 1204, 1295, 1528], 'alfa-2b': [1159, 1205], 'alone': [1160, 1206], 'or': [1161, 1207, 2099], 'combination': [1163, 1209], 'ribavirin': [1165, 1211], 'treatment': [1168, 1214, 1780, 2267, 2332], 'relapse': [1170, 2321], 'C.': [1174, 1218, 1342, 1387, 1455, 2003, 2236], 'International': [1175], 'Interventional': [1177, 1220], 'Therapy': [1178, 1221], 'Group.': [1179, 1222], '1998;': [1184, 1227, 1247, 1275, 1389, 1431, 1854, 2177], '339:': [1185, 1228], '1493–1499.': [1186], '11': [1187], 'McHutchison': [1188], 'JG,': [1189], 'Schiff': [1192], 'ER,': [1193], 'WM,': [1197], 'VK,': [1199], 'Goodman': [1200], 'ZD,': [1201], 'initial': [1213], '1485–1492.': [1229], '12': [1230], 'Cook': [1231], 'RT.': [1232], 'abuse,': [1234], 'alcoholism,': [1235], 'immune': [1240], 'system—a': [1241], 'review.': [1242, 1785], 'Clin': [1244, 1402, 1548, 1703, 1851, 1939, 2336], 'Exp': [1245, 1403, 1549, 1704, 1852, 1940], 'Res': [1246, 1404, 1550, 1640, 1750, 1853], '22:': [1248, 1855], '1927–1942.': [1249], '13': [1250], 'Corrao': [1251], 'Arico': [1253], 'Independent': [1255], 'combined': [1257], 'risk': [1269], 'symptomatic': [1271], 'cirrhosis.': [1273, 1930], '27:': [1276, 1390], '914–919.': [1277], '14': [1278], 'Ohnishi': [1279], 'Matsuo': [1281], 'Matsutani': [1283], 'Itahashi': [1285], 'M,': [1286, 1366, 1412, 1588, 1975, 1985, 2013, 2261], 'Kakihara': [1287], 'Suzuki': [1289, 1323], 'Ito': [1291], 'habitual': [1302], 'drinkers:': [1303], 'comparison': [1304], 'infrequent': [1310], 'drinkers.': [1311, 1347], 'Am': [1312], '91:': [1316, 1707], '1374–1379.': [1317], '15': [1318], 'Okazaki': [1319], 'Yoshihara': [1321], 'H,': [1322, 1981], 'Yamada': [1325], 'Tsujimura': [1327], 'Kawano': [1329], 'Abe': [1331], 'H.': [1332], 'Efficacy': [1333], 'Comparison': [1343], 'non-drinkers': [1345], 'Scand': [1348], '1994;': [1351, 1581, 1752, 2005], '29:': [1352], '1039–1043.': [1353], '16': [1354], 'Pessione': [1355], 'Degos': [1357], 'Marcellin': [1359], 'P,': [1360, 1911], 'Duchatelle': [1361], 'Njapoum': [1363], 'Martinot-Peignoux': [1365], 'Degott': [1367], 'Effect': [1371, 1456], 'serum': [1376, 1920, 1934, 1991], 'histological': [1382, 1422], 'lesions': [1383], '1717–1722.': [1391], '17': [1392], 'Regev': [1393], 'Jeffers': [1395], 'LJ.': [1396], 'alcohol.': [1400], '23:': [1406], '1543–1551.': [1407], '18': [1408], 'TE,': [1410], 'McCarthy': [1411], 'Breidi': [1413], 'L,': [1414, 1654, 1880, 1913], 'Layden': [1415], 'TJ.': [1416], 'Impact': [1417], 'clinical': [1424, 1784], '28:': [1432, 2178], '805–809.': [1433], '19': [1434], 'Szabo': [1435, 1520], 'G.': [1436, 1620], 'Consequences': [1437], 'host': [1442], 'defence.': [1443], '34:': [1447], '830–841.': [1448], '20': [1449], 'Guo': [1450], 'JT,': [1451], 'Bichko': [1452], 'VV,': [1453], 'Seeger': [1454], 'alpha': [1458, 1529, 1542, 1719], 'replicon.': [1465], 'Virol': [1467, 1514], '2001;': [1468, 1551, 2068, 2113, 2151], '75:': [1469], '8516–8523.': [1470], '21': [1471], 'Blight': [1472], 'KJ,': [1473], 'Kolykhalov': [1474], 'AA,': [1475], 'Rice': [1476], 'CM.': [1477, 1564], 'Efficient': [1478], 'initiation': [1479], 'cell': [1485, 1667], 'culture.': [1486], '290:': [1489], '1972–1974.': [1490], '22': [1491], 'Yang': [1492, 1826], 'JP,': [1495], 'SD,': [1497], 'Zhu': [1500], 'XH,': [1501], 'WZ.': [1503], 'Real-time': [1504], 'RT-PCR': [1505], 'quantitation': [1507], 'RNA.': [1512], 'Methods': [1515], '2002;': [1516, 1767, 1970], '102:': [1517], '119–128.': [1518], '23': [1519], 'Catalano': [1522], 'Bellerose': [1524], 'Mandrekar': [1526], 'augment': [1532], 'regulatory': [1534, 1636], 'factor-kappaB': [1535], 'HepG2': [1538], 'cells,': [1539], 'increases': [1543, 2163], 'pro-inflammatory': [1544], 'cytokine': [1545], 'production.': [1546, 1938], '25:': [1552], '1188–1197.': [1553], '24': [1554], 'Petrak': [1555], 'Memon': [1557], 'SA,': [1558], 'Birrer': [1559], 'Ashwell': [1561], 'JD,': [1562, 1675], 'Zacharchuk': [1563], 'Dominant': [1565], 'negative': [1566], 'mutant': [1567], 'c-Jun': [1569], 'inhibits': [1570], 'NF-AT': [1571], 'transcriptional': [1572], 'activity': [1573], 'prevents': [1575], 'IL-2': [1576], 'gene': [1577, 1743], 'transcription.': [1578], 'Immunol': [1580, 1705, 1941], '153:': [1582], '2046–2051.': [1583], '25': [1584], 'Pierce': [1585], 'JW,': [1586], 'Lenardo': [1587], 'Baltimore': [1589], 'Oligonucleotide': [1591], 'binds': [1593], 'NF-kappa': [1596, 2142, 2208], 'B': [1597, 2095], 'acts': [1598], 'lymphoid-specific': [1601], 'inducible': [1603], 'enhancer': [1604], 'element.': [1605], '1988;': [1613], '85:': [1614], '1482–1486.': [1615], '26': [1616], 'Luckow': [1617], 'B,': [1618, 2077, 2311], 'Schutz': [1619], 'CAT': [1621], 'constructions': [1622], 'multiple': [1624], 'restriction': [1626], 'sites': [1627], 'functional': [1630], 'eukaryotic': [1633], 'promoters': [1634], 'elements.': [1637], 'Nucleic': [1638], 'Acids': [1639], '1987;': [1641], '5490.': [1643], '27': [1644], 'Lohmann': [1645], 'Korner': [1647], 'Koch': [1649], 'Herian': [1651], 'U,': [1652], 'Theilmann': [1653], 'Bartenschlager': [1655], 'R.': [1656], 'Replication': [1657], 'subgenomic': [1659], 'RNAs': [1663], 'hepatoma': [1666], 'line.': [1668], '285:': [1671], '110–113.': [1672], '28': [1673], 'Powell': [1674], 'Bednarik': [1676], 'DP,': [1677], 'Folks': [1678], 'TM,': [1679], 'Jehuda-Cohen': [1680], 'Villinger': [1682], 'Sell': [1684], 'KW,': [1685], 'Ansari': [1686], 'AA.': [1687], 'Inhibition': [1688], 'cellular': [1690], 'retroviral': [1693], 'CD8+': [1696], 'T': [1697], 'non-human': [1701], 'primates.': [1702], '1993;': [1706], '473–481.': [1708], '29': [1709], 'Swingler': [1710], 'Morris': [1712], 'Easton': [1714], 'A.': [1715, 2124, 2222], 'Tumour': [1716], 'necrosis': [1717, 1840, 1864, 1889], 'interleukin-1': [1721, 1891], 'beta': [1722], 'induce': [1723], 'subunits': [1725], 'NFKB': [1727], 'bind': [1729], 'HIV-1': [1731], 'enhancer:': [1732], 'characterisation': [1733], 'transcription': [1735, 2206], 'factors': [1736], 'controlling': [1737], 'immunodeficiency': [1739, 1960], 'type': [1741, 1962], 'neural': [1746], 'Biochem': [1748], 'Biophys': [1749], 'Commun': [1751], '203:': [1753], '623–630.': [1754], 'Ghosh': [1756], 'Karin': [1758], 'Missing': [1760], 'pieces': [1761], 'NF-kappaB': [1764, 2090], 'puzzle.': [1765], 'Cell': [1766], '109:': [1768], 'S81–96.': [1769], '31': [1770], 'CP,': [1772], 'Volpicelli': [1773, 1775, 2256], 'JR.': [1776], 'Naltrexone': [1777, 2264, 2290], 'alcoholism:': [1782, 2244], '13:': [1788, 1809, 1821, 1901], '35–39.': [1789], '32': [1790], 'Reid': [1791], 'LD.': [1792], 'Endogenous': [1793, 2223], 'opioids': [1794, 2240], 'dependence:': [1797], 'alkaloids': [1799], 'propensity': [1802], 'drink': [1804], 'alcoholic': [1805, 1870, 1897, 1928, 1998], 'beverages.': [1806], '5–11.': [1810], '33': [1811], 'Van': [1812], 'Ree': [1813], 'JM.': [1814], 'Endorphins': [1815], 'experimental': [1817], 'addiction.': [1818, 2228], '25–30.': [1822], '34': [1823], 'Lin': [1824], 'HZ,': [1825], 'SQ,': [1827], 'Zeldin': [1828], 'Diehl': [1830], 'AM.': [1831], 'ethanol': [1833, 2092, 2162], 'induces': [1835, 2135], 'production': [1837, 1866, 1924], 'tumor': [1839, 1863, 1888], 'factor-alpha': [1841], 'related': [1843], 'cytokines': [1844], 'adipose': [1848], 'tissue.': [1849], '231S–237S.': [1856], '35': [1857], 'McClain': [1858, 1881], 'CJ,': [1859, 1882], 'Cohen': [1860], 'DA.': [1861], 'Increased': [1862, 1990], 'monocytes': [1868], '9:': [1874], '349–351.': [1875], '36': [1876], 'Khoruts': [1877], 'Stahnke': [1879], 'Logan': [1883], 'Allen': [1885], 'JI.': [1886], 'Circulating': [1887], 'factor,': [1890], 'interleukin-6': [1893, 1919], 'concentrations': [1894], 'patients.': [1898], '267–276.': [1902], '37': [1903], 'Deviere': [1904], 'Content': [1906], 'Denys': [1908], 'Vandenbussche': [1910], 'Schandene': [1912], 'Wybran': [1914], 'Dupont': [1916], 'E.': [1917], 'High': [1918], 'levels': [1921, 1935, 1996], 'leucocytes': [1926], 'Correlation': [1931], 'IgA': [1933], 'lymphokines': [1937], '77:': [1943], '221–225.': [1944], '38': [1945], 'Prakash': [1946], 'O,': [1947], 'Mason': [1948], 'Luftig': [1950], 'RB,': [1951], 'Bautista': [1952], 'AP.': [1953], '(HIV-1)': [1964], 'infections': [1965], 'alcoholics.': [1967], 'Front': [1968], 'Biosci': [1969], '7:': [1971], 'e286–300.': [1972], '39': [1973], 'Oshita': [1974], 'Hayashi': [1976], 'N,': [1977], 'Kasahara': [1978], 'Hagiwara': [1980], 'Mita': [1982], 'Naito': [1984], 'Katayama': [1986], 'among': [1997], '1115–1120.': [2007], '40': [2008], 'Loguercio': [2009], 'Di': [2011, 2014], 'Pierro': [2012], 'Marino': [2015], 'MP,': [2016], 'Federico': [2017], 'Disalvo': [2019], 'Crafa': [2021], 'Tuccillo': [2023], 'Drinking': [2027], 'habits': [2028], 'subjects': [2030], 'virus-related': [2034], 'disease:': [2037], 'clinical,': [2042], 'virological': [2043], 'pathological': [2045], 'aspects.': [2046], '35:': [2050], '296–301.': [2051], '41': [2052], 'Rosenberg': [2053], 'Recent': [2055], 'advances': [2056], 'molecular': [2059], 'biology': [2060], 'Mol': [2066], 'Biol': [2067], '313:': [2069], '451–464.': [2070], '42': [2071], 'Kim': [2072], 'WH,': [2073], 'Hong': [2074], 'Jaruga': [2076], 'Z,': [2079], 'Fan': [2080], 'Liang': [2082], 'TJ,': [2083], 'B.': [2085, 2143, 2209, 2289], 'Additive': [2086], 'protein': [2096, 2130], 'X': [2097], '(HBX)': [2098], 'core': [2101], 'protein:': [2102], 'involvement': [2103], 'TNF-alpha': [2105], '1-independent': [2107], '-dependent': [2109], 'mechanisms.': [2110], 'FASEB': [2111], '2551–2553.': [2115], '43': [2116], 'Gong': [2117], 'Waris': [2119], 'Tanveer': [2121], 'Siddiqui': [2123], 'Human': [2125], 'NS5A': [2129], 'alters': [2131], 'intracellular': [2132], 'calcium': [2133], 'levels,': [2134], 'oxidative': [2136], 'stress,': [2137], 'activates': [2139], 'STAT-3': [2140], '98:': [2152], '9599–9604.': [2153], '44': [2154], 'Bailey': [2155], 'SM,': [2156], 'Cunningham': [2157], 'CC.': [2158], 'Acute': [2159], 'reactive': [2164], 'oxygen': [2165], 'species': [2166], 'generation': [2167], 'decreases': [2169], 'viability': [2170], 'fresh,': [2172], 'isolated': [2173], 'rat': [2174], 'hepatocytes.': [2175], '1318–1326.': [2179], '45': [2180], 'Natarajan': [2181], 'Singh': [2183], 'Burke': [2185], 'TR,': [2186], 'Jr.,': [2187], 'Grunberger': [2188], 'Aggarwal': [2190], 'BB.': [2191], 'potent': [2198], '93:': [2218], '9090–9095.': [2219], '46': [2220], 'Herz': [2221], 'systems': [2225], 'Psychopharmacology': [2229], '(Berl)': [2230], '1997;': [2231], '129:': [2232], '99–111.': [2233], '47': [2234], 'Gianoulakis': [2235], 'Implications': [2237], 'dopamine': [2242], 'basic': [2247], 'science': [2248], 'studies.': [2249], '31:': [2253], '33–42.': [2254], '48': [2255], 'JR,': [2257], 'Alterman': [2258], 'AI,': [2259], 'Hayashida': [2260], 'CP.': [2263], 'dependence.[comment].': [2270], 'Arch': [2271, 2301], 'Gen': [2272, 2302], 'Psychiatry': [2273, 2303], '49:': [2275, 2305], '876–880.': [2276], '49': [2277], "O'Malley": [2278, 2318], 'SS,': [2279], 'Jaffe': [2280, 2308], 'Chang': [2282, 2312], 'Schottenfeld': [2284, 2314], 'RS,': [2285, 2315], 'Meyer': [2286, 2316], 'RE,': [2287, 2317], 'Rounsaville': [2288, 2310], 'coping': [2292], 'skills': [2293], 'dependence.': [2297], 'controlled': [2299], 'study.': [2300], '881–887.': [2306], '50': [2307], 'SS.': [2319], 'Naltrexone,': [2320], 'prevention,': [2322], 'supportive': [2324], 'alcoholics:': [2327], 'patient': [2331], 'matching.': [2333], 'Consult': [2335], 'Psychol': [2337], '64:': [2339], '1044–1053.': [2340], 'Citing': [2341], 'Literature': [2342], 'Volume38,': [2343], 'Issue1July': [2344], '2003Pages': [2345], 'ReferencesRelatedInformation': [2347]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2013816787', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-16T12:48:00.624601', 'created_date': '2016-06-24'}