Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1595407324', 'doi': 'https://doi.org/10.1002/jmv.24302', 'title': 'Interferon‐inducible Protein 6‐16 (IFI‐6‐16, ISG16) promotes Hepatitis C virus replication in vitro', 'display_name': 'Interferon‐inducible Protein 6‐16 (IFI‐6‐16, ISG16) promotes Hepatitis C virus replication in vitro', 'publication_year': 2015, 'publication_date': '2015-06-24', 'ids': {'openalex': 'https://openalex.org/W1595407324', 'doi': 'https://doi.org/10.1002/jmv.24302', 'mag': '1595407324', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26105982'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/jmv.24302', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.24302', 'source': {'id': 'https://openalex.org/S49828768', 'display_name': 'Journal of Medical Virology', 'issn_l': '0146-6615', 'issn': ['0146-6615', '1096-9071'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.24302', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100369729', 'display_name': 'Shan Chen', 'orcid': 'https://orcid.org/0000-0001-6272-4686'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shan Chen', 'raw_affiliation_strings': ['Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical College Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical College Chengdu China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100740116', 'display_name': 'Shilin Li', 'orcid': 'https://orcid.org/0000-0001-7065-6150'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shilin Li', 'raw_affiliation_strings': ['Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical College Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Blood Transfusion Chinese Academy of Medical Sciences and Peking Union Medical College Chengdu China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100670786', 'display_name': 'Limin Chen', 'orcid': 'https://orcid.org/0000-0002-7370-6499'}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}, {'id': 'https://openalex.org/I2801845744', 'display_name': 'Toronto General Hospital', 'ror': 'https://ror.org/026pg9j08', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1325899441', 'https://openalex.org/I2801845744']}, {'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA', 'CN'], 'is_corresponding': False, 'raw_author_name': 'Limin Chen', 'raw_affiliation_strings': ['Institute of Blood Transfusion; Chinese Academy of Medical Sciences and Peking Union Medical College; Chengdu China', 'Toronto General Research Institute; University of Toronto; Toronto Ontario Canada'], 'affiliations': [{'raw_affiliation_string': 'Institute of Blood Transfusion; Chinese Academy of Medical Sciences and Peking Union Medical College; Chengdu China', 'institution_ids': ['https://openalex.org/I200296433']}, {'raw_affiliation_string': 'Toronto General Research Institute; University of Toronto; Toronto Ontario Canada', 'institution_ids': ['https://openalex.org/I2801845744', 'https://openalex.org/I185261750']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4020, 'currency': 'USD', 'value_usd': 4020, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.017, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.732163, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '88', 'issue': '1', 'first_page': '109', 'last_page': '114'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11668', 'display_name': 'interferon and immune responses', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11668', 'display_name': 'interferon and immune responses', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10151', 'display_name': 'Hepatitis C virus research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10308', 'display_name': 'Systemic Lupus Erythematosus Research', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/replicon', 'display_name': 'Replicon', 'score': 0.9204879}, {'id': 'https://openalex.org/keywords/hepatitis-c', 'display_name': 'Hepatitis C', 'score': 0.4369925}], 'concepts': [{'id': 'https://openalex.org/C18103114', 'wikidata': 'https://www.wikidata.org/wiki/Q1720369', 'display_name': 'Replicon', 'level': 4, 'score': 0.9204879}, {'id': 'https://openalex.org/C2776408679', 'wikidata': 'https://www.wikidata.org/wiki/Q708693', 'display_name': 'Hepatitis C virus', 'level': 3, 'score': 0.82347375}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.79500544}, {'id': 'https://openalex.org/C2776178377', 'wikidata': 'https://www.wikidata.org/wiki/Q188269', 'display_name': 'Interferon', 'level': 2, 'score': 0.77333826}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5745043}, {'id': 'https://openalex.org/C140704245', 'wikidata': 'https://www.wikidata.org/wiki/Q3933202', 'display_name': 'Viral replication', 'level': 3, 'score': 0.5391081}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.5205449}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.48096505}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.4793485}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.47877324}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.4736268}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.46247494}, {'id': 'https://openalex.org/C2776455275', 'wikidata': 'https://www.wikidata.org/wiki/Q154869', 'display_name': 'Hepatitis C', 'level': 2, 'score': 0.4369925}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.42385018}, {'id': 'https://openalex.org/C2781463415', 'wikidata': 'https://www.wikidata.org/wiki/Q2082778', 'display_name': 'Hepacivirus', 'level': 4, 'score': 0.41756415}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.36986393}, {'id': 'https://openalex.org/C22744801', 'wikidata': 'https://www.wikidata.org/wiki/Q172778', 'display_name': 'Plasmid', 'level': 3, 'score': 0.31754947}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.31539017}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.04779926}], 'mesh': [{'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D054884', 'descriptor_name': 'Host-Pathogen Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024101', 'descriptor_name': 'Mitochondrial Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D012367', 'descriptor_name': 'RNA, Viral', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/jmv.24302', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.24302', 'source': {'id': 'https://openalex.org/S49828768', 'display_name': 'Journal of Medical Virology', 'issn_l': '0146-6615', 'issn': ['0146-6615', '1096-9071'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26105982', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/jmv.24302', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.24302', 'source': {'id': 'https://openalex.org/S49828768', 'display_name': 'Journal of Medical Virology', 'issn_l': '0146-6615', 'issn': ['0146-6615', '1096-9071'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.84}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '91442128'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': 'NSFC 81471956'}], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1622488271', 'https://openalex.org/W1625377704', 'https://openalex.org/W1978652234', 'https://openalex.org/W2006309458', 'https://openalex.org/W2019654340', 'https://openalex.org/W2030925771', 'https://openalex.org/W2049037429', 'https://openalex.org/W2051956247', 'https://openalex.org/W2058005401', 'https://openalex.org/W2061154433', 'https://openalex.org/W2069379552', 'https://openalex.org/W2077819506', 'https://openalex.org/W2079607751', 'https://openalex.org/W2096313549', 'https://openalex.org/W2098484899', 'https://openalex.org/W2105764241', 'https://openalex.org/W2109105309', 'https://openalex.org/W2118542945', 'https://openalex.org/W2119847512', 'https://openalex.org/W2131242974', 'https://openalex.org/W2133402546', 'https://openalex.org/W2142775607', 'https://openalex.org/W2142879592', 'https://openalex.org/W2147718057', 'https://openalex.org/W2164889791', 'https://openalex.org/W2288149417', 'https://openalex.org/W319720829'], 'related_works': ['https://openalex.org/W4281843905', 'https://openalex.org/W2762048449', 'https://openalex.org/W2644744618', 'https://openalex.org/W2418235480', 'https://openalex.org/W2117027295', 'https://openalex.org/W2107508210', 'https://openalex.org/W2052290779', 'https://openalex.org/W2051894123', 'https://openalex.org/W2044193462', 'https://openalex.org/W1595407324'], 'abstract_inverted_index': {'Interferon‐inducible': [0], 'protein': [1, 128], '6‐16': [2], '(IFI‐6‐16,': [3], 'ISG16)': [4], 'is': [5, 64, 70], 'one': [6], 'of': [7, 33, 42, 75, 77, 100, 117, 121, 146, 149, 172, 177], 'the': [8, 38, 73, 118, 142, 157, 161, 169, 185], 'interferon': [9], 'stimulated': [10], 'genes': [11], '(ISGs)': [12], 'whose': [13], 'expression': [14, 31, 120], 'levels': [15, 32], 'can': [16], 'be': [17], 'induced': [18], 'by': [19, 137], 'type': [20], 'I': [21], 'interferons.': [22], 'Previous': [23], 'studies': [24], 'from': [25], 'our': [26], 'group': [27], 'indicated': [28], 'that': [29], 'higher': [30], 'ISG16': [34, 78, 101, 122, 150, 178], 'were': [35], 'detected': [36], 'in': [37, 61, 87, 141, 155], 'pre‐treatment': [39], 'liver': [40], 'tissues': [41], 'patients': [43], 'chronically': [44], 'infected': [45], 'with': [46], 'hepatitis': [47], 'C': [48], 'virus': [49], '(HCV)': [50], 'who': [51], 'do': [52], 'not': [53, 65], 'respond': [54], 'to': [55, 71], 'interferon‐based': [56], 'therapy.': [57], 'However,': [58], 'its': [59], 'role': [60], 'HCV': [62, 80, 89, 94, 107, 112, 132, 152, 162, 180], 'production': [63], 'well': [66], 'defined.': [67], 'This': [68], 'study': [69], 'test': [72], 'effect': [74], 'over‐expression': [76], 'on': [79], 'RNA': [81, 133, 153, 181], 'replication': [82, 154, 182], 'and': [83, 92, 104, 127, 160, 167, 183], 'IFN': [84], 'anti‐HCV': [85, 170, 187], 'activity': [86, 171], 'both': [88, 156], 'replicon': [90, 108, 159], 'cells': [91, 109], 'JFH‐1': [93, 111], 'culture': [95, 113, 165], 'system': [96, 166], '(HCVcc).': [97], 'Expression': [98], 'plasmid': [99], 'was': [102, 135], 'constructed': [103], 'transfected': [105], 'into': [106], 'or': [110, 144], 'system.': [114], 'After': [115], 'confirmation': [116], 'successful': [119], 'at': [123], 'mRNA': [124], '(real‐time': [125], 'PCR)': [126], '(Western': [129], 'Blot)': [130], 'levels,': [131], 'level': [134], 'analyzed': [136], 'real‐time': [138], 'quantitative': [139], 'PCR': [140], 'absence': [143], 'presence': [145], 'interferon‐α.': [147], 'Over‐expression': [148, 176], 'promoted': [151], 'Con1b': [158], 'JFH‐1‐based': [163], 'cell': [164], 'blunted': [168], 'IFN‐α.': [173], 'In': [174], 'conclusion,': [175], 'promotes': [179], 'rescues': [184], 'IFNα‐mediated': [186], 'activity.': [188], 'J.': [189], 'Med.': [190], 'Virol.': [191], '88:109–114,': [192], '2016': [193], '.': [194], '©': [195], '2015': [196], 'Wiley': [197], 'Periodicals,': [198], 'Inc.': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1595407324', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2024-12-08T20:08:33.456677', 'created_date': '2016-06-24'}