Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2013450624', 'doi': 'https://doi.org/10.1021/ja309078t', 'title': 'Strategy for Dual-Analyte Luciferin Imaging: <i>In Vivo</i> Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation', 'display_name': 'Strategy for Dual-Analyte Luciferin Imaging: <i>In Vivo</i> Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation', 'publication_year': 2013, 'publication_date': '2013-01-25', 'ids': {'openalex': 'https://openalex.org/W2013450624', 'doi': 'https://doi.org/10.1021/ja309078t', 'mag': '2013450624', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23347279', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3583381'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ja309078t', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S111155417', 'display_name': 'Journal of the American Chemical Society', 'issn_l': '0002-7863', 'issn': ['0002-7863', '1520-5126', '1943-2984'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3583381?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062081650', 'display_name': 'Genevieve C. Van de Bittner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Genevieve C. Van de Bittner', 'raw_affiliation_strings': ['Departments\rof Chemistry and ‡Molecular and Cell Biology and §Howard Hughes Medical Institute, University of California, Berkeley,\rCalifornia 94720, United States'], 'affiliations': [{'raw_affiliation_string': 'Departments\rof Chemistry and ‡Molecular and Cell Biology and §Howard Hughes Medical Institute, University of California, Berkeley,\rCalifornia 94720, United States', 'institution_ids': ['https://openalex.org/I95457486', 'https://openalex.org/I1344073410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088409133', 'display_name': 'Carolyn R. Bertozzi', 'orcid': 'https://orcid.org/0000-0003-4482-2754'}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carolyn R. Bertozzi', 'raw_affiliation_strings': ['Departments\rof Chemistry and ‡Molecular and Cell Biology and §Howard Hughes Medical Institute, University of California, Berkeley,\rCalifornia 94720, United States'], 'affiliations': [{'raw_affiliation_string': 'Departments\rof Chemistry and ‡Molecular and Cell Biology and §Howard Hughes Medical Institute, University of California, Berkeley,\rCalifornia 94720, United States', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I95457486']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5072113162', 'display_name': 'Christopher J. Chang', 'orcid': 'https://orcid.org/0000-0001-5732-9497'}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher J. Chang', 'raw_affiliation_strings': ['Departments\rof Chemistry and ‡Molecular and Cell Biology and §Howard Hughes Medical Institute, University of California, Berkeley,\rCalifornia 94720, United States'], 'affiliations': [{'raw_affiliation_string': 'Departments\rof Chemistry and ‡Molecular and Cell Biology and §Howard Hughes Medical Institute, University of California, Berkeley,\rCalifornia 94720, United States', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I95457486']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 11.347, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 281, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '135', 'issue': '5', 'first_page': '1783', 'last_page': '1795'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12561', 'display_name': 'bioluminescence and chemiluminescence research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12561', 'display_name': 'bioluminescence and chemiluminescence research', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12236', 'display_name': 'Photoreceptor and optogenetics research', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 0.9912, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/luciferin', 'display_name': 'Luciferin', 'score': 0.7376793}, {'id': 'https://openalex.org/keywords/bioluminescence-imaging', 'display_name': 'Bioluminescence imaging', 'score': 0.5051697}, {'id': 'https://openalex.org/keywords/radiosynthesis', 'display_name': 'Radiosynthesis', 'score': 0.46055213}], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.8987938}, {'id': 'https://openalex.org/C2781309008', 'wikidata': 'https://www.wikidata.org/wiki/Q369745', 'display_name': 'Luciferin', 'level': 5, 'score': 0.7376793}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.7303337}, {'id': 'https://openalex.org/C5176359', 'wikidata': 'https://www.wikidata.org/wiki/Q179924', 'display_name': 'Bioluminescence', 'level': 2, 'score': 0.6419442}, {'id': 'https://openalex.org/C2779201268', 'wikidata': 'https://www.wikidata.org/wiki/Q186474', 'display_name': 'Cysteine', 'level': 3, 'score': 0.55284595}, {'id': 'https://openalex.org/C161997846', 'wikidata': 'https://www.wikidata.org/wiki/Q4915066', 'display_name': 'Bioluminescence imaging', 'level': 5, 'score': 0.5051697}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5006583}, {'id': 'https://openalex.org/C533411734', 'wikidata': 'https://www.wikidata.org/wiki/Q171877', 'display_name': 'Hydrogen peroxide', 'level': 2, 'score': 0.46980056}, {'id': 'https://openalex.org/C2776970183', 'wikidata': 'https://www.wikidata.org/wiki/Q20155580', 'display_name': 'Radiosynthesis', 'level': 3, 'score': 0.46055213}, {'id': 'https://openalex.org/C10390740', 'wikidata': 'https://www.wikidata.org/wiki/Q2282401', 'display_name': 'Analyte', 'level': 2, 'score': 0.44787887}, {'id': 'https://openalex.org/C29331040', 'wikidata': 'https://www.wikidata.org/wiki/Q7239554', 'display_name': 'Preclinical imaging', 'level': 3, 'score': 0.43477368}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.42500898}, {'id': 'https://openalex.org/C98424977', 'wikidata': 'https://www.wikidata.org/wiki/Q25805', 'display_name': 'Caspase', 'level': 4, 'score': 0.42100847}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.3991164}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.39670867}, {'id': 'https://openalex.org/C111335760', 'wikidata': 'https://www.wikidata.org/wiki/Q95385166', 'display_name': 'Luciferase', 'level': 4, 'score': 0.38838333}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.12908038}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.102856755}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.09819916}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C147789679', 'wikidata': 'https://www.wikidata.org/wiki/Q11372', 'display_name': 'Physical chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D052160', 'descriptor_name': 'Benzothiazoles', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D053181', 'descriptor_name': 'Caspase 8', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D006861', 'descriptor_name': 'Hydrogen Peroxide', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D057054', 'descriptor_name': 'Molecular Imaging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000208', 'descriptor_name': 'Acute Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052160', 'descriptor_name': 'Benzothiazoles', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D052160', 'descriptor_name': 'Benzothiazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053181', 'descriptor_name': 'Caspase 8', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053181', 'descriptor_name': 'Caspase 8', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006861', 'descriptor_name': 'Hydrogen Peroxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006861', 'descriptor_name': 'Hydrogen Peroxide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D049449', 'descriptor_name': 'Luminescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008163', 'descriptor_name': 'Luminescent Measurements', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ja309078t', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S111155417', 'display_name': 'Journal of the American Chemical Society', 'issn_l': '0002-7863', 'issn': ['0002-7863', '1520-5126', '1943-2984'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3583381', 'pdf_url': 'https://europepmc.org/articles/pmc3583381?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583381', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23347279', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3583381', 'pdf_url': 'https://europepmc.org/articles/pmc3583381?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 113, 'referenced_works': ['https://openalex.org/W1490993461', 'https://openalex.org/W1531336753', 'https://openalex.org/W1537971445', 'https://openalex.org/W1593388227', 'https://openalex.org/W1605122517', 'https://openalex.org/W1874751834', 'https://openalex.org/W1963548438', 'https://openalex.org/W1967964480', 'https://openalex.org/W1968780370', 'https://openalex.org/W1969848541', 'https://openalex.org/W1970254639', 'https://openalex.org/W1970841988', 'https://openalex.org/W1972088519', 'https://openalex.org/W1972634148', 'https://openalex.org/W1973447501', 'https://openalex.org/W1973804925', 'https://openalex.org/W1976838083', 'https://openalex.org/W1977789326', 'https://openalex.org/W1978961146', 'https://openalex.org/W1979914846', 'https://openalex.org/W1980029809', 'https://openalex.org/W1980322143', 'https://openalex.org/W1980550756', 'https://openalex.org/W1983722576', 'https://openalex.org/W1984372443', 'https://openalex.org/W1985802355', 'https://openalex.org/W1988087076', 'https://openalex.org/W1988230895', 'https://openalex.org/W1993772770', 'https://openalex.org/W1994043227', 'https://openalex.org/W1994112020', 'https://openalex.org/W1994419814', 'https://openalex.org/W1997992505', 'https://openalex.org/W1998089491', 'https://openalex.org/W2002134534', 'https://openalex.org/W2003473725', 'https://openalex.org/W2008893017', 'https://openalex.org/W2011871947', 'https://openalex.org/W2012627116', 'https://openalex.org/W2013812413', 'https://openalex.org/W2014791743', 'https://openalex.org/W2019265324', 'https://openalex.org/W2020352977', 'https://openalex.org/W2026722168', 'https://openalex.org/W2026738371', 'https://openalex.org/W2035152299', 'https://openalex.org/W2037124284', 'https://openalex.org/W2039707270', 'https://openalex.org/W2044385536', 'https://openalex.org/W2044627978', 'https://openalex.org/W2045936365', 'https://openalex.org/W2049321630', 'https://openalex.org/W2049662677', 'https://openalex.org/W2049990440', 'https://openalex.org/W2051494815', 'https://openalex.org/W2053552746', 'https://openalex.org/W2054705329', 'https://openalex.org/W2056840435', 'https://openalex.org/W2057630649', 'https://openalex.org/W2061497413', 'https://openalex.org/W2063459899', 'https://openalex.org/W2064203348', 'https://openalex.org/W2064611125', 'https://openalex.org/W2067338751', 'https://openalex.org/W2068258715', 'https://openalex.org/W2069401436', 'https://openalex.org/W2074452385', 'https://openalex.org/W2075498662', 'https://openalex.org/W2077628780', 'https://openalex.org/W2079302111', 'https://openalex.org/W2079557371', 'https://openalex.org/W2081287274', 'https://openalex.org/W2081589302', 'https://openalex.org/W2084504975', 'https://openalex.org/W2085744686', 'https://openalex.org/W2085934964', 'https://openalex.org/W2086523446', 'https://openalex.org/W2090851169', 'https://openalex.org/W2091717171', 'https://openalex.org/W2094265468', 'https://openalex.org/W2097427952', 'https://openalex.org/W2102619095', 'https://openalex.org/W2104877766', 'https://openalex.org/W2105811188', 'https://openalex.org/W2107366413', 'https://openalex.org/W2110215475', 'https://openalex.org/W2112592817', 'https://openalex.org/W2114911224', 'https://openalex.org/W2117419072', 'https://openalex.org/W2117852274', 'https://openalex.org/W2120319205', 'https://openalex.org/W2125762027', 'https://openalex.org/W2127915152', 'https://openalex.org/W2129482408', 'https://openalex.org/W2131106253', 'https://openalex.org/W2132343702', 'https://openalex.org/W2133188003', 'https://openalex.org/W2134390575', 'https://openalex.org/W2135925309', 'https://openalex.org/W2140082316', 'https://openalex.org/W2146948320', 'https://openalex.org/W2150860403', 'https://openalex.org/W2151818001', 'https://openalex.org/W2152165298', 'https://openalex.org/W2157285575', 'https://openalex.org/W2157791850', 'https://openalex.org/W2170640959', 'https://openalex.org/W2177120564', 'https://openalex.org/W2324541908', 'https://openalex.org/W2335370064', 'https://openalex.org/W271775295', 'https://openalex.org/W4234317413', 'https://openalex.org/W4252712324'], 'related_works': ['https://openalex.org/W4318686627', 'https://openalex.org/W4253858024', 'https://openalex.org/W3199135406', 'https://openalex.org/W3030290269', 'https://openalex.org/W2768191019', 'https://openalex.org/W2425539341', 'https://openalex.org/W2412506486', 'https://openalex.org/W2339964518', 'https://openalex.org/W1976838083', 'https://openalex.org/W1964907928'], 'abstract_inverted_index': {'In': [0, 59], 'vivo': [1, 211], 'molecular': [2, 169], 'imaging': [3, 35, 188, 271], 'holds': [4], 'promise': [5], 'for': [6, 67, 240, 262], 'understanding': [7], 'the': [8, 133, 175], 'underlying': [9], 'mechanisms': [10], 'of': [11, 50, 78, 135, 178, 189, 206, 265], 'health,': [12], 'injury,': [13, 252], 'aging,': [14, 253], 'and': [15, 56, 142, 156, 180, 200, 208, 219, 245, 254], 'disease,': [16, 255], 'as': [17, 25, 121, 123, 256, 258], 'it': [18], 'can': [19, 87], 'detect': [20, 38], 'distinct': [21], 'biochemical': [22, 42, 51, 92], 'processes': [23, 247], 'such': [24], 'enzymatic': [26], 'activity,': [27], 'reactive': [28, 118], 'small-molecule': [29], 'fluxes,': [30], 'or': [31, 192], 'post-translational': [32], 'modifications.': [33], 'Current': [34], 'techniques': [36], 'often': [37], 'only': [39, 157], 'a': [40, 64, 105, 124, 152, 213, 234, 259], 'single': [41], 'process,': [43], 'but,': [44], 'within': [45], 'whole': [46], 'organisms,': [47], 'multiple': [48, 266], 'types': [49], 'events': [52], 'contribute': [53], 'to': [54, 151], 'physiological': [55], 'pathological': [57], 'phenotypes.': [58], 'this': [60, 96, 117, 231], 'report,': [61], 'we': [62, 98], 'present': [63], 'general': [65], 'strategy': [66], 'dual-analyte': [68], 'detection': [69], 'in': [70, 75, 132, 147, 198, 201, 210, 216, 226, 248], 'living': [71, 227, 249], 'animals': [72, 250], 'that': [73, 86, 110, 172], 'employs': [74], 'situ': [76], 'formation': [77], 'firefly': [79, 145], 'luciferin': [80, 146], 'from': [81], 'two': [82], 'complementary': [83], 'caged': [84], 'precursors': [85], 'be': [88], 'unmasked': [89], 'by': [90], 'different': [91], 'processes.': [93], 'To': [94], 'establish': [95], 'approach,': [97], 'have': [99], 'developed': [100], 'Peroxy': [101], 'Caged': [102], 'Luciferin-2': [103], '(PCL-2),': [104], 'H(2)O(2)-responsive': [106], 'boronic': [107], 'acid': [108], 'probe': [109], 'releases': [111, 130], '6-hydroxy-2-cyanobenzothiazole': [112], '(HCBT)': [113], 'upon': [114], 'reacting': [115], 'with': [116], 'oxygen': [119], 'species,': [120], 'well': [122, 257], 'peptide-based': [125], 'probe,': [126], 'z-Ile-Glu-ThrAsp-D-Cys': [127], '(IETDC),': [128], 'which': [129], 'D-cysteine': [131, 143], 'presence': [134, 177], 'active': [136], 'caspase': [137, 181, 193, 220], '8.': [138], 'Once': [139], 'released,': [140], 'HCBT': [141], 'form': [144], 'situ,': [148], 'giving': [149], 'rise': [150], 'bioluminescent': [153], 'signal': [154], 'if': [155, 158], 'both': [159, 217], 'chemical': [160, 238], 'triggers': [161], 'proceed.': [162], 'This': [163], 'system': [164], 'thus': [165], 'constitutes': [166], 'an': [167], 'AND-type': [168], 'logic': [170], 'gate': [171], 'reports': [173], 'on': [174], 'simultaneous': [176, 242], 'H(2)O(2)': [179, 191, 218], '8': [182, 194, 221], 'activity.': [183], 'Using': [184], 'these': [185], 'probes,': [186], 'chemoselective': [187], 'either': [190], 'activity': [195, 222], 'was': [196], 'performed': [197], 'vitro': [199], 'vivo.': [202], 'Moreover,': [203], 'concomitant': [204], 'use': [205], 'PCL-2': [207], 'IETDC': [209], 'establishes': [212], 'concurrent': [214, 263], 'increase': [215], 'during': [223, 251], 'acute': [224], 'inflammation': [225, 246], 'mice.': [228], 'Taken': [229], 'together,': [230], 'method': [232], 'offers': [233], 'potentially': [235], 'powerful': [236], 'new': [237], 'tool': [239], 'studying': [241], 'oxidative': [243], 'stress': [244], 'versatile': [260], 'approach': [261], 'monitoring': [264], 'analytes': [267], 'using': [268], 'luciferin-based': [269], 'bioluminescence': [270], 'technologies.': [272]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2013450624', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 18}, {'year': 2022, 'cited_by_count': 21}, {'year': 2021, 'cited_by_count': 31}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 23}, {'year': 2018, 'cited_by_count': 32}, {'year': 2017, 'cited_by_count': 34}, {'year': 2016, 'cited_by_count': 26}, {'year': 2015, 'cited_by_count': 24}, {'year': 2014, 'cited_by_count': 27}, {'year': 2013, 'cited_by_count': 14}], 'updated_date': '2025-01-11T11:54:29.051592', 'created_date': '2016-06-24'}