Publication Information

{'id': 'https://openalex.org/W1980314357', 'doi': 'https://doi.org/10.1074/jbc.m110.128835', 'title': 'Direct Synthesis of Lamin A, Bypassing Prelamin A Processing, Causes Misshapen Nuclei in Fibroblasts but No Detectable Pathology in Mice', 'display_name': 'Direct Synthesis of Lamin A, Bypassing Prelamin A Processing, Causes Misshapen Nuclei in Fibroblasts but No Detectable Pathology in Mice', 'publication_year': 2010, 'publication_date': '2010-05-04', 'ids': {'openalex': 'https://openalex.org/W1980314357', 'doi': 'https://doi.org/10.1074/jbc.m110.128835', 'mag': '1980314357', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20439468', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2898298'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m110.128835', 'pdf_url': 'http://www.jbc.org/article/S0021925820573687/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820573687/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5039907737', 'display_name': 'Catherine Coffinier', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Catherine Coffinier', 'raw_affiliation_strings': ['From the Department of Medicine, Los Angeles, California 90095'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037537612', 'display_name': 'Hea-Jin Jung', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hea-Jin Jung', 'raw_affiliation_strings': ['From the Department of Medicine, Los Angeles, California 90095'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100425000', 'display_name': 'Ziwei Li', 'orcid': 'https://orcid.org/0000-0002-9087-4881'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ziwei Li', 'raw_affiliation_strings': ['From the Department of Medicine, Los Angeles, California 90095'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008166631', 'display_name': 'Chika Nobumori', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chika Nobumori', 'raw_affiliation_strings': ['From the Department of Medicine, Los Angeles, California 90095'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076099268', 'display_name': 'Ui Jeong Yun', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ui Jeong Yun', 'raw_affiliation_strings': ['From the Department of Medicine, Los Angeles, California 90095'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082051802', 'display_name': 'Emily Farber', 'orcid': 'https://orcid.org/0000-0003-3474-2304'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Emily A. Farber', 'raw_affiliation_strings': ['From the Department of Medicine, Los Angeles, California 90095'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068135765', 'display_name': 'Brandon S.J. Davies', 'orcid': 'https://orcid.org/0000-0002-7168-8522'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brandon S. Davies', 'raw_affiliation_strings': ['From the Department of Medicine, Los Angeles, California 90095'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053017466', 'display_name': 'Michael M. Weinstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael M. Weinstein', 'raw_affiliation_strings': ['Department of Human Genetics, Los Angeles, California 90095', 'From the Department of Medicine, Los Angeles, California 90095'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I161318765']}, {'raw_affiliation_string': 'Department of Human Genetics, Los Angeles, California 90095', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110205957', 'display_name': 'Shao H. Yang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shao H. Yang', 'raw_affiliation_strings': ['From the Department of Medicine, Los Angeles, California 90095'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002335286', 'display_name': 'Jan Lammerding', 'orcid': 'https://orcid.org/0000-0003-4335-8611'}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jan Lammerding', 'raw_affiliation_strings': ["Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02139"], 'affiliations': [{'raw_affiliation_string': "Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02139", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016947384', 'display_name': 'Javad N. Farahani', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}, {'id': 'https://openalex.org/I142207940', 'display_name': 'California NanoSystems Institute', 'ror': 'https://ror.org/00q7fqf35', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I142207940', 'https://openalex.org/I154570441', 'https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Javad N. Farahani', 'raw_affiliation_strings': ['California NanoSystems Institute, University of California, Los Angeles, California 90095'], 'affiliations': [{'raw_affiliation_string': 'California NanoSystems Institute, University of California, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I161318765', 'https://openalex.org/I142207940']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053665679', 'display_name': 'Laurent A. Bentolila', 'orcid': 'https://orcid.org/0000-0002-8758-1594'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}, {'id': 'https://openalex.org/I142207940', 'display_name': 'California NanoSystems Institute', 'ror': 'https://ror.org/00q7fqf35', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I142207940', 'https://openalex.org/I154570441', 'https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laurent A. Bentolila', 'raw_affiliation_strings': ['California NanoSystems Institute, University of California, Los Angeles, California 90095', 'Department of Chemistry and Biochemistry, Los Angeles, California 90095'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Biochemistry, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I161318765']}, {'raw_affiliation_string': 'California NanoSystems Institute, University of California, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I142207940', 'https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068606823', 'display_name': 'Loren G. Fong', 'orcid': 'https://orcid.org/0000-0002-4465-5290'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Loren G. Fong', 'raw_affiliation_strings': ['From the Department of Medicine, Los Angeles, California 90095'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085755071', 'display_name': 'Stephen G. Young', 'orcid': 'https://orcid.org/0000-0001-7270-3176'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephen G. Young', 'raw_affiliation_strings': ['Department of Human Genetics, Los Angeles, California 90095', 'From the Department of Medicine, Los Angeles, California 90095'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, Los Angeles, California 90095', 'institution_ids': ['https://openalex.org/I161318765']}, {'raw_affiliation_string': 'Department of Human Genetics, Los Angeles, California 90095', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5039907737'], 'corresponding_institution_ids': ['https://openalex.org/I161318765'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 3.599, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 74, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '285', 'issue': '27', 'first_page': '20818', 'last_page': '20826'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13107', 'display_name': 'Congenital limb and hand anomalies', 'score': 0.9658, 'subfield': {'id': 'https://openalex.org/subfields/1309', 'display_name': 'Developmental Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lmna', 'display_name': 'LMNA', 'score': 0.9933622}, {'id': 'https://openalex.org/keywords/nuclear-lamina', 'display_name': 'Nuclear lamina', 'score': 0.8647883}, {'id': 'https://openalex.org/keywords/progeria', 'display_name': 'Progeria', 'score': 0.48040012}], 'concepts': [{'id': 'https://openalex.org/C2780654407', 'wikidata': 'https://www.wikidata.org/wiki/Q4253573', 'display_name': 'LMNA', 'level': 4, 'score': 0.9933622}, {'id': 'https://openalex.org/C179093185', 'wikidata': 'https://www.wikidata.org/wiki/Q424506', 'display_name': 'Lamin', 'level': 3, 'score': 0.9838551}, {'id': 'https://openalex.org/C94912109', 'wikidata': 'https://www.wikidata.org/wiki/Q687194', 'display_name': 'Nuclear lamina', 'level': 5, 'score': 0.8647883}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6094631}, {'id': 'https://openalex.org/C2778465436', 'wikidata': 'https://www.wikidata.org/wiki/Q213098', 'display_name': 'Progeria', 'level': 3, 'score': 0.48040012}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.46231824}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4393684}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.43854144}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3449419}, {'id': 'https://openalex.org/C29512474', 'wikidata': 'https://www.wikidata.org/wiki/Q16860021', 'display_name': 'Nuclear protein', 'level': 4, 'score': 0.3304419}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.32894278}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.22665206}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.103839785}], 'mesh': [{'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D034904', 'descriptor_name': 'Lamin Type A', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017124', 'descriptor_name': 'Conserved Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003433', 'descriptor_name': 'Crosses, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D007438', 'descriptor_name': 'Introns', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034904', 'descriptor_name': 'Lamin Type A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034904', 'descriptor_name': 'Lamin Type A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008745', 'descriptor_name': 'Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008856', 'descriptor_name': 'Microscopy, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046188', 'descriptor_name': 'Protein Modification, Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011498', 'descriptor_name': 'Protein Precursors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011498', 'descriptor_name': 'Protein Precursors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011498', 'descriptor_name': 'Protein Precursors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014714', 'descriptor_name': 'Vertebrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m110.128835', 'pdf_url': 'http://www.jbc.org/article/S0021925820573687/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2898298', 'pdf_url': 'https://europepmc.org/articles/pmc2898298?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898298', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20439468', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m110.128835', 'pdf_url': 'http://www.jbc.org/article/S0021925820573687/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1001811995', 'https://openalex.org/W1487741670', 'https://openalex.org/W1665551917', 'https://openalex.org/W1964551999', 'https://openalex.org/W1985981012', 'https://openalex.org/W2007472609', 'https://openalex.org/W2010819899', 'https://openalex.org/W2019042255', 'https://openalex.org/W2028408655', 'https://openalex.org/W2036973053', 'https://openalex.org/W2037999013', 'https://openalex.org/W2040205289', 'https://openalex.org/W2041297088', 'https://openalex.org/W2048445712', 'https://openalex.org/W2052373675', 'https://openalex.org/W2056074681', 'https://openalex.org/W2062459861', 'https://openalex.org/W2065240476', 'https://openalex.org/W2066889948', 'https://openalex.org/W2067540329', 'https://openalex.org/W2074997168', 'https://openalex.org/W2091602799', 'https://openalex.org/W2095202174', 'https://openalex.org/W2101410699', 'https://openalex.org/W2102775746', 'https://openalex.org/W2111175126', 'https://openalex.org/W2111819985', 'https://openalex.org/W2115739136', 'https://openalex.org/W2123704670', 'https://openalex.org/W2136490523', 'https://openalex.org/W2139797302', 'https://openalex.org/W2143185290', 'https://openalex.org/W2143963878', 'https://openalex.org/W2149035322', 'https://openalex.org/W2149619603', 'https://openalex.org/W2151331444', 'https://openalex.org/W2153825396', 'https://openalex.org/W2154950275', 'https://openalex.org/W2157478214', 'https://openalex.org/W2167960257', 'https://openalex.org/W2172254982', 'https://openalex.org/W254147912', 'https://openalex.org/W4247425028'], 'related_works': ['https://openalex.org/W4221022264', 'https://openalex.org/W4206098026', 'https://openalex.org/W3176419864', 'https://openalex.org/W2317718274', 'https://openalex.org/W2119526996', 'https://openalex.org/W2052034221', 'https://openalex.org/W2003768435', 'https://openalex.org/W1981901085', 'https://openalex.org/W1554973796', 'https://openalex.org/W1484768737'], 'abstract_inverted_index': {'Lamin': [0], 'A,': [1], 'a': [2, 105, 113], 'key': [3], 'component': [4], 'of': [5, 22, 28, 32, 40, 46, 121, 141, 159, 182, 199, 223, 235], 'the': [6, 23, 29, 33, 41, 47, 50, 86, 118, 160, 192, 197, 206, 233, 239], 'nuclear': [7, 87, 183, 207, 240], 'lamina,': [8], 'is': [9, 75, 163, 215], 'generated': [10], 'from': [11, 150, 165], 'prelamin': [12, 134, 166, 212], 'A': [13, 84, 131, 135, 144, 162, 179, 195, 213, 226, 237], 'by': [14, 59], 'four': [15], 'post-translational': [16], 'processing': [17, 66, 214], 'steps:': [18], 'farnesylation,': [19], 'endoproteolytic': [20, 38], 'release': [21, 39], 'last': [24, 42, 55, 119], 'three': [25], 'amino': [26, 44], 'acids': [27, 45], 'protein,': [30], 'methylation': [31], 'C-terminal': [34], 'farnesylcysteine,': [35], 'and': [36, 74, 137, 173, 219], 'finally,': [37], '15': [43], 'protein': [48], '(including': [49], 'farnesylcysteine': [51], 'methyl': [52], 'ester).': [53], 'The': [54, 139], 'cleavage': [56], 'step,': [57], 'mediated': [58], 'ZMPSTE24,': [60], 'releases': [61], 'mature': [62, 122, 129, 142, 193, 224], 'lamin': [63, 83, 107, 123, 130, 143, 161, 194, 225, 236], 'A.': [64, 124, 167], 'This': [65], 'scheme': [67], 'has': [68, 93, 227], 'been': [69, 95], 'conserved': [70], 'through': [71], 'vertebrate': [72], 'evolution': [73], 'widely': [76], 'assumed': [77], 'to': [78, 85, 238], 'be': [79], 'crucial': [80], 'for': [81], 'targeting': [82, 234], 'envelope.': [88], 'However,': [89], 'its': [90], 'physiologic': [91], 'importance': [92], 'never': [94], 'tested.': [96], 'To': [97], 'address': [98], 'this': [99], 'issue,': [100], 'we': [101], 'created': [102], 'mice': [103, 127, 147, 155, 201, 218], 'with': [104], '"mature': [106], 'A-only"': [108, 154], 'allele': [109], '(Lmna(LAO)),': [110], 'which': [111], 'contains': [112], 'stop': [114], 'codon': [115, 120], 'immediately': [116], 'after': [117], 'Thus,': [125], 'Lmna(LAO/LAO)': [126, 146, 168, 188, 200], 'synthesize': [128], 'directly,': [132], 'bypassing': [133], 'synthesis': [136, 222], 'processing.': [138], 'levels': [140], 'in': [145, 152, 187, 196, 217, 242], 'were': [148], 'indistinguishable': [149], 'those': [151], '"prelamin': [153], '(Lmna(PLAO/PLAO)),': [156], 'where': [157], 'all': [158], 'produced': [164], 'exhibited': [169], 'normal': [170], 'body': [171], 'weights': [172], 'had': [174], 'no': [175], 'detectable': [176], 'disease': [177], 'phenotypes.': [178], 'higher': [180], 'frequency': [181], 'blebs': [184], 'was': [185, 202], 'observed': [186], 'embryonic': [189], 'fibroblasts;': [190], 'however,': [191], 'tissues': [198], 'positioned': [203], 'normally': [204], 'at': [205], 'rim.': [208], 'We': [209], 'conclude': [210], 'that': [211, 220], 'dispensable': [216], 'direct': [221], 'little': [228], 'if': [229], 'any': [230], 'effect': [231], 'on': [232], 'rim': [241], 'mouse': [243], 'tissues.': [244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1980314357', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-26T21:07:50.938025', 'created_date': '2016-06-24'}