PD-L1 is highly expressed in Enzalutamide resistant prostate cancer

Name: Work Video:
Duration: 3 min 30 s
Jennifer L. Bishop; Alexander Sio; Arkhjamil Angeles; Morgan E. Roberts; Arun Azad; Kim N.; Amina Zoubeidi
{'id': 'https://openalex.org/W1582446028', 'doi': 'https://doi.org/10.18632/oncotarget.2703', 'title': 'PD-L1 is highly expressed in Enzalutamide resistant prostate cancer', 'display_name': 'PD-L1 is highly expressed in Enzalutamide resistant prostate cancer', 'publication_year': 2014, 'publication_date': '2014-11-06', 'ids': {'openalex': 'https://openalex.org/W1582446028', 'doi': 'https://doi.org/10.18632/oncotarget.2703', 'mag': '1582446028', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25428917', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4381591'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2703', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=2703&path%5B%5D=5162', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=2703&path%5B%5D=5162', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102968181', 'display_name': 'Jennifer L. Bishop', 'orcid': 'https://orcid.org/0000-0003-3676-8743'}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Jennifer L. Bishop', 'raw_affiliation_strings': ['Vancouver Prostate Centre, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Vancouver Prostate Centre, Vancouver, BC, Canada', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037341472', 'display_name': 'Alexander Sio', 'orcid': None}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Alexander Sio', 'raw_affiliation_strings': ['Vancouver Prostate Centre, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Vancouver Prostate Centre, Vancouver, BC, Canada', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014115137', 'display_name': 'Arkhjamil Angeles', 'orcid': 'https://orcid.org/0000-0003-1467-0075'}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Arkhjamil Angeles', 'raw_affiliation_strings': ['Vancouver Prostate Centre, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Vancouver Prostate Centre, Vancouver, BC, Canada', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047068321', 'display_name': 'Morgan E. Roberts', 'orcid': 'https://orcid.org/0000-0002-5850-7985'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Morgan E. Roberts', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075093609', 'display_name': 'Arun Azad', 'orcid': 'https://orcid.org/0000-0001-7350-5622'}, 'institutions': [{'id': 'https://openalex.org/I1289530486', 'display_name': 'BC Cancer Agency', 'ror': 'https://ror.org/03sfybe47', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289530486']}, {'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Arun A. Azad', 'raw_affiliation_strings': ['Department of Medicine, Division of Medical Oncology, BC Cancer Agency, University of British Columbia, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Division of Medical Oncology, BC Cancer Agency, University of British Columbia, Vancouver, BC, Canada', 'institution_ids': ['https://openalex.org/I1289530486', 'https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005231494', 'display_name': 'Kim N.', 'orcid': 'https://orcid.org/0000-0002-3782-7226'}, 'institutions': [{'id': 'https://openalex.org/I1289530486', 'display_name': 'BC Cancer Agency', 'ror': 'https://ror.org/03sfybe47', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1289530486']}, {'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Kim N. Chi', 'raw_affiliation_strings': ['Department of Medicine, Division of Medical Oncology, BC Cancer Agency, University of British Columbia, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Division of Medical Oncology, BC Cancer Agency, University of British Columbia, Vancouver, BC, Canada', 'institution_ids': ['https://openalex.org/I1289530486', 'https://openalex.org/I141945490']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081653545', 'display_name': 'Amina Zoubeidi', 'orcid': 'https://orcid.org/0000-0002-0498-142X'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Amina Zoubeidi', 'raw_affiliation_strings': ['Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada', 'Vancouver Prostate Centre, Vancouver, BC, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Vancouver Prostate Centre, Vancouver, BC, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.', 'institution_ids': ['https://openalex.org/I141945490']}, {'raw_affiliation_string': 'Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada', 'institution_ids': ['https://openalex.org/I141945490']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 11.388, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 266, 'citation_normalized_percentile': {'value': 0.902179, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '6', 'issue': '1', 'first_page': '234', 'last_page': '242'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/enzalutamide', 'display_name': 'Enzalutamide', 'score': 0.96785414}, {'id': 'https://openalex.org/keywords/immune-checkpoint', 'display_name': 'Immune checkpoint', 'score': 0.48617738}], 'concepts': [{'id': 'https://openalex.org/C2776551883', 'wikidata': 'https://www.wikidata.org/wiki/Q1996756', 'display_name': 'Enzalutamide', 'level': 5, 'score': 0.96785414}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.7788552}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.72404975}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.6752211}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.51070243}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.50089765}, {'id': 'https://openalex.org/C2780851360', 'wikidata': 'https://www.wikidata.org/wiki/Q21686041', 'display_name': 'Immune checkpoint', 'level': 4, 'score': 0.48617738}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.45958534}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.40689027}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3506919}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.17923}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D060890', 'descriptor_name': 'B7-H1 Antigen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010669', 'descriptor_name': 'Phenylthiohydantoin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D060890', 'descriptor_name': 'B7-H1 Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003713', 'descriptor_name': 'Dendritic Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D003713', 'descriptor_name': 'Dendritic Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007167', 'descriptor_name': 'Immunotherapy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D007167', 'descriptor_name': 'Immunotherapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007963', 'descriptor_name': 'Leukocytes, Mononuclear', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D007963', 'descriptor_name': 'Leukocytes, Mononuclear', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009368', 'descriptor_name': 'Neoplasm Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010669', 'descriptor_name': 'Phenylthiohydantoin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010669', 'descriptor_name': 'Phenylthiohydantoin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2703', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=2703&path%5B%5D=5162', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4381591', 'pdf_url': 'https://europepmc.org/articles/pmc4381591?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381591', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25428917', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2703', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=2703&path%5B%5D=5162', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.78}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1966280949', 'https://openalex.org/W1971618361', 'https://openalex.org/W1979811833', 'https://openalex.org/W2004023311', 'https://openalex.org/W2010121426', 'https://openalex.org/W2014751188', 'https://openalex.org/W2025897548', 'https://openalex.org/W2045294456', 'https://openalex.org/W2048983733', 'https://openalex.org/W2055901890', 'https://openalex.org/W2057734107', 'https://openalex.org/W2057977955', 'https://openalex.org/W2073382063', 'https://openalex.org/W2074651601', 'https://openalex.org/W2075936080', 'https://openalex.org/W2097121410', 'https://openalex.org/W2097984421', 'https://openalex.org/W2102575291', 'https://openalex.org/W2107564997', 'https://openalex.org/W2109485845', 'https://openalex.org/W2130846254', 'https://openalex.org/W2144110960', 'https://openalex.org/W2149387197', 'https://openalex.org/W2149937232', 'https://openalex.org/W2158170171', 'https://openalex.org/W2159959302', 'https://openalex.org/W2160834915', 'https://openalex.org/W2162411576', 'https://openalex.org/W2165733309', 'https://openalex.org/W2165782799', 'https://openalex.org/W2167331614', 'https://openalex.org/W3147725646', 'https://openalex.org/W578040644'], 'related_works': ['https://openalex.org/W3122236002', 'https://openalex.org/W3024577600', 'https://openalex.org/W3023935924', 'https://openalex.org/W3005243004', 'https://openalex.org/W2897595555', 'https://openalex.org/W2890448483', 'https://openalex.org/W2773216890', 'https://openalex.org/W2681186693', 'https://openalex.org/W2593283143', 'https://openalex.org/W2479406918'], 'abstract_inverted_index': {'//': [0, 86], 'Jennifer': [1], 'L.': [2], 'Bishop': [3], '1': [4, 8, 12, 32], ',': [5, 9, 13, 18, 23, 164], 'Alexander': [6], 'Sio': [7], 'Arkhjamil': [10], 'Angeles': [11], 'Morgan': [14], 'E.': [15], 'Roberts': [16], '2': [17, 39], 'Arun': [19], 'A.': [20], 'Azad': [21], '3': [22, 27, 52], 'Kim': [24], 'N.': [25], 'Chi': [26], 'and': [28, 43, 134, 142, 166, 175, 212, 245, 278, 314, 342], 'Amina': [29, 83], 'Zoubeidi': [30], '1,4': [31], 'Vancouver': [33], 'Prostate': [34], 'Centre,': [35], 'Vancouver,': [36, 49, 67, 79], 'BC,': [37, 50, 68, 80], 'Canada': [38, 51, 69, 81], 'Department': [40, 53, 71], 'of': [41, 46, 54, 57, 64, 72, 76, 110, 149, 180, 216, 252, 258, 286, 303, 325, 328, 337, 345], 'Microbiology': [42], 'Immunology,': [44], 'University': [45, 63, 75], 'British': [47, 65, 77], 'Columbia,': [48, 66, 78], 'Medicine,': [55], 'Division': [56], 'Medical': [58], 'Oncology,': [59], 'BC': [60], 'Cancer': [61], 'Agency,': [62], '4': [70], 'Urologic': [73], 'Sciences,': [74], 'Correspondence:': [82], 'Zoubeidi,': [84], 'email:': [85], 'Keywords': [87], ':Enzalutamide': [88], 'resistant': [89, 115, 172], 'CRPC,': [90, 244], 'Immunotherapy,': [91], 'PD-L1': [92, 259, 333, 349], 'Received': [93], ':': [94, 99, 104], 'October': [95], '30,': [96], '2014': [97, 102, 107], 'Accepted': [98], 'November': [100, 105], '06,': [101, 106], 'Published': [103], 'Abstract': [108], 'Efficacy': [109], 'Enzalutamide': [111], '(ENZ)': [112], 'in': [113, 140, 170, 176, 202, 227, 237, 307, 312, 315, 335, 352], 'castration': [114], 'prostate': [116], 'cancer': [117], '(CRPC)': [118], 'patients': [119, 174, 190, 313, 354], 'is': [120, 146, 297, 320, 361], 'short-lived.': [121], 'Immunotherapy': [122], 'like': [123], 'T': [124, 219], 'cell': [125, 276, 332, 348], 'checkpoint': [126, 136, 359], 'blockade': [127], 'may': [128], 'improve': [129], 'patient': [130], 'survival.': [131], 'However,': [132], 'when': [133], 'where': [135], 'molecules': [137], 'are': [138, 168], 'expressed': [139, 248], 'CRPC': [141, 338, 353], 'whether': [143, 157], 'immune': [144, 309, 331], 'evasion': [145], 'a': [147, 177, 213, 316], 'mechanism': [148], 'ENZ': [150, 171, 181, 193, 295], 'resistance': [151, 296, 341], 'remains': [152], 'unclear.': [153], 'Thus,': [154], 'we': [155, 229], 'investigated': [156], 'clinically': [158], 'relevant': [159], 'immunotherapy': [160], 'targets,': [161], 'specifically': [162], 'PD-L1/2': [163, 197, 234, 268], 'PD-1': [165, 217], 'CTLA-4,': [167], 'upregulated': [169], '(ENZR)': [173], 'pre-clinical': [178, 225, 317], 'model': [179, 318], 'resistance.': [182], 'We': [183], 'show': [184, 283], 'for': [185], 'the': [186, 256, 264, 287, 300, 326, 343], 'first': [187], 'time': [188], 'that': [189, 280, 294, 319], 'progressing': [191], 'on': [192, 260], 'had': [194], 'significantly': [195, 231, 249], 'increased': [196, 232, 250], '+': [198, 218, 235, 269], 'dendritic': [199], 'cells': [200, 310], '(DC)': [201], 'blood': [203], 'compared': [204, 242], 'to': [205, 210, 243, 266, 274, 339, 355, 358], 'those': [206], 'na&iuml;ve': [207], 'or': [208, 263], 'responding': [209], 'treatment,': [211], 'high': [214], 'frequency': [215], 'cells.': [220], 'These': [221], 'data': [222], 'supported': [223], 'our': [224, 291], 'results,': [226], 'which': [228], 'found': [230], 'circulating': [233, 308, 347], 'DCs': [236], 'mice': [238], 'bearing': [239], 'ENZR': [240, 246, 261, 275], 'tumors': [241, 247], 'levels': [251], 'tumor-intrinsic': [253], 'PD-L1.': [254], 'Importantly,': [255], 'expression': [257, 302, 334], 'cells,': [262], 'ability': [265], 'modulate': [267], 'DC': [270], 'frequency,': [271], 'was': [272], 'unique': [273], 'lines': [277], 'xenografts': [279], 'did': [281], 'not': [282], 'classical': [284], 'activation': [285], 'androgen': [288], 'receptor.': [289], 'Overall,': [290], 'results': [292], 'suggest': [293], 'associated': [298], 'with': [299], 'strong': [301], 'anti-PD-1': [304], 'therapy': [305], 'targets': [306], 'both': [311], 'non-AR': [321], 'driven.': [322], 'Further': [323], 'evaluation': [324], 'contribution': [327], 'tumor': [329], 'vs.': [330], 'progression': [336], 'anti-androgen': [340], 'utility': [344], 'monitoring': [346], 'pathway': [350], 'activity': [351], 'predict': [356], 'responsiveness': [357], 'immunotherapy,': [360], 'warranted.': [362]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1582446028', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 22}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 41}, {'year': 2020, 'cited_by_count': 37}, {'year': 2019, 'cited_by_count': 31}, {'year': 2018, 'cited_by_count': 28}, {'year': 2017, 'cited_by_count': 32}, {'year': 2016, 'cited_by_count': 27}, {'year': 2015, 'cited_by_count': 14}], 'updated_date': '2024-12-10T21:46:12.942538', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
