Enzalutamide induces PSMA upregulation in castration-resistant prostate cancer even in patients having previously progressed on enzalutamide

Name: Work Video:
Duration: 3 min 30 s
Description: Ziel/Aim There is preliminary evidence for prostate-specific membrane antigen (PSMA) upregulation effects of androgen receptor blockade in prostate cancer. In an attempt to find the best condition for PSMA radioligand therapy in metastatic castration-resistant prostate cancer (mCRPC) patients, we evaluated the effect of oral enzalutamide in each individual.
Florian Rosar; Sabrina Dewes; M. Ries; Fadi Khreish; H Bohnenberger; Andrea Schaefer-Schuler; Stephan Maus; Johannes Linxweiler; Mark Bartholomä; C. Ohlmann; Samer Ezziddin
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Ries', 'orcid': 'https://orcid.org/0000-0002-7351-6521'}, 'institutions': [{'id': 'https://openalex.org/I4210103170', 'display_name': 'Klinik und Poliklinik für Nuklearmedizin', 'ror': 'https://ror.org/00qqw1b44', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103170', 'https://openalex.org/I4210153755']}, {'id': 'https://openalex.org/I4210094678', 'display_name': 'Universitätsklinikum des Saarlandes', 'ror': 'https://ror.org/00nvxt968', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094678']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'M Ries', 'raw_affiliation_strings': ['Universitätsklinikum des Saarlandes, Klinik für Nuklearmedizin'], 'affiliations': [{'raw_affiliation_string': 'Universitätsklinikum des Saarlandes, Klinik für Nuklearmedizin', 'institution_ids': ['https://openalex.org/I4210103170', 'https://openalex.org/I4210094678']}]}, {'author_position': 'middle', 'author': {'id': 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