Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2890448483', 'doi': 'https://doi.org/10.1530/erc-18-0289', 'title': 'Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond', 'display_name': 'Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond', 'publication_year': 2018, 'publication_date': '2018-09-18', 'ids': {'openalex': 'https://openalex.org/W2890448483', 'doi': 'https://doi.org/10.1530/erc-18-0289', 'mag': '2890448483', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30382692', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6215909'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1530/erc-18-0289', 'pdf_url': 'https://erc.bioscientifica.com/downloadpdf/journals/erc/26/1/ERC-18-0289.pdf', 'source': {'id': 'https://openalex.org/S193349529', 'display_name': 'Endocrine Related Cancer', 'issn_l': '1351-0088', 'issn': ['1351-0088', '1479-6821'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319937', 'host_organization_name': 'Bioscientifica', 'host_organization_lineage': ['https://openalex.org/P4310319937'], 'host_organization_lineage_names': ['Bioscientifica'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://erc.bioscientifica.com/downloadpdf/journals/erc/26/1/ERC-18-0289.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061546693', 'display_name': 'Simon Linder', 'orcid': 'https://orcid.org/0000-0002-3315-305X'}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}, {'id': 'https://openalex.org/I4210111138', 'display_name': 'Oncode Institute', 'ror': 'https://ror.org/01n92vv28', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I4210111138']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Simon Linder', 'raw_affiliation_strings': ['1Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '1Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2898336195', 'https://openalex.org/I4210111138']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013864806', 'display_name': 'Henk G. van der Poel', 'orcid': 'https://orcid.org/0000-0002-8772-1120'}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Henk G van der Poel', 'raw_affiliation_strings': ['2Division of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '2Division of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2898336195']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031117246', 'display_name': 'Andries M. Bergman', 'orcid': 'https://orcid.org/0000-0001-5223-2549'}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}, {'id': 'https://openalex.org/I4210111138', 'display_name': 'Oncode Institute', 'ror': 'https://ror.org/01n92vv28', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I4210111138']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Andries M Bergman', 'raw_affiliation_strings': ['3Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands', '4Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '4Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2898336195']}, {'raw_affiliation_string': '3Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210111138', 'https://openalex.org/I2898336195']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006708192', 'display_name': 'Wilbert Zwart', 'orcid': 'https://orcid.org/0000-0002-9823-7289'}, 'institutions': [{'id': 'https://openalex.org/I4210111138', 'display_name': 'Oncode Institute', 'ror': 'https://ror.org/01n92vv28', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I4210111138']}, {'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}, {'id': 'https://openalex.org/I83019370', 'display_name': 'Eindhoven University of Technology', 'ror': 'https://ror.org/02c2kyt77', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I83019370']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Wilbert Zwart', 'raw_affiliation_strings': ['1Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands', '5Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '1Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210111138', 'https://openalex.org/I2898336195']}, {'raw_affiliation_string': '5Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands', 'institution_ids': ['https://openalex.org/I83019370']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5078298172', 'display_name': 'Stefan Prekovic', 'orcid': 'https://orcid.org/0000-0002-7051-9321'}, 'institutions': [{'id': 'https://openalex.org/I4210111138', 'display_name': 'Oncode Institute', 'ror': 'https://ror.org/01n92vv28', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I4210111138']}, {'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Stefan Prekovic', 'raw_affiliation_strings': ['1Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': '1Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210111138', 'https://openalex.org/I2898336195']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5078298172'], 'corresponding_institution_ids': ['https://openalex.org/I4210111138', 'https://openalex.org/I2898336195'], 'apc_list': None, 'apc_paid': None, 'fwci': 5.213, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 62, 'citation_normalized_percentile': {'value': 0.890108, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '26', 'issue': '1', 'first_page': 'R31', 'last_page': 'R52'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9874, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9873, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/enzalutamide', 'display_name': 'Enzalutamide', 'score': 0.99327326}], 'concepts': [{'id': 'https://openalex.org/C2776551883', 'wikidata': 'https://www.wikidata.org/wiki/Q1996756', 'display_name': 'Enzalutamide', 'level': 5, 'score': 0.99327326}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.9112197}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7718109}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.70097077}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.57214135}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.45872518}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.45119238}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.43353456}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.36413562}], 'mesh': [{'descriptor_ui': 'D010669', 'descriptor_name': 'Phenylthiohydantoin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010669', 'descriptor_name': 'Phenylthiohydantoin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010669', 'descriptor_name': 'Phenylthiohydantoin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010669', 'descriptor_name': 'Phenylthiohydantoin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1530/erc-18-0289', 'pdf_url': 'https://erc.bioscientifica.com/downloadpdf/journals/erc/26/1/ERC-18-0289.pdf', 'source': {'id': 'https://openalex.org/S193349529', 'display_name': 'Endocrine Related Cancer', 'issn_l': '1351-0088', 'issn': ['1351-0088', '1479-6821'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319937', 'host_organization_name': 'Bioscientifica', 'host_organization_lineage': ['https://openalex.org/P4310319937'], 'host_organization_lineage_names': ['Bioscientifica'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6215909', 'pdf_url': 'https://europepmc.org/articles/pmc6215909?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://research.tue.nl/nl/publications/e684cbca-aa8a-4687-a92c-cecbb6d86f63', 'pdf_url': 'https://research.tue.nl/files/111513632/_14796821_Endocrine_Related_Cancer_Enzalutamide_therapy_for_advanced_prostate_cancer_efficacy_resistance_and_beyond.pdf', 'source': {'id': 'https://openalex.org/S4306401843', 'display_name': 'Data Archiving and Networked Services (DANS)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1322597698', 'host_organization_name': 'Royal Netherlands Academy of Arts and Sciences', 'host_organization_lineage': ['https://openalex.org/I1322597698'], 'host_organization_lineage_names': ['Royal Netherlands Academy of Arts and Sciences'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://pure.tue.nl/ws/files/111513632/_14796821_Endocrine_Related_Cancer_Enzalutamide_therapy_for_advanced_prostate_cancer_efficacy_resistance_and_beyond.pdf', 'pdf_url': 'https://pure.tue.nl/ws/files/111513632/_14796821_Endocrine_Related_Cancer_Enzalutamide_therapy_for_advanced_prostate_cancer_efficacy_resistance_and_beyond.pdf', 'source': None, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215909', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30382692', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1530/erc-18-0289', 'pdf_url': 'https://erc.bioscientifica.com/downloadpdf/journals/erc/26/1/ERC-18-0289.pdf', 'source': {'id': 'https://openalex.org/S193349529', 'display_name': 'Endocrine Related Cancer', 'issn_l': '1351-0088', 'issn': ['1351-0088', '1479-6821'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319937', 'host_organization_name': 'Bioscientifica', 'host_organization_lineage': ['https://openalex.org/P4310319937'], 'host_organization_lineage_names': ['Bioscientifica'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 207, 'referenced_works': ['https://openalex.org/W1551341102', 'https://openalex.org/W1578291413', 'https://openalex.org/W1584828549', 'https://openalex.org/W1776913920', 'https://openalex.org/W1838436554', 'https://openalex.org/W1868837506', 'https://openalex.org/W1893347245', 'https://openalex.org/W1914046922', 'https://openalex.org/W1922704711', 'https://openalex.org/W1932317695', 'https://openalex.org/W1962994287', 'https://openalex.org/W1963614111', 'https://openalex.org/W1965383997', 'https://openalex.org/W1966978530', 'https://openalex.org/W1969202480', 'https://openalex.org/W1971208896', 'https://openalex.org/W1973462980', 'https://openalex.org/W1977645286', 'https://openalex.org/W1980244461', 'https://openalex.org/W1992127633', 'https://openalex.org/W1996389184', 'https://openalex.org/W2003955264', 'https://openalex.org/W2004131109', 'https://openalex.org/W2005958584', 'https://openalex.org/W2007334137', 'https://openalex.org/W2008690941', 'https://openalex.org/W2009607678', 'https://openalex.org/W2010072924', 'https://openalex.org/W2011143895', 'https://openalex.org/W2015582646', 'https://openalex.org/W2017919614', 'https://openalex.org/W2025723175', 'https://openalex.org/W2027735722', 'https://openalex.org/W2036054914', 'https://openalex.org/W2037564713', 'https://openalex.org/W2038994244', 'https://openalex.org/W2039511031', 'https://openalex.org/W2040389858', 'https://openalex.org/W2041051519', 'https://openalex.org/W2041535798', 'https://openalex.org/W2043179716', 'https://openalex.org/W2043672855', 'https://openalex.org/W2045641554', 'https://openalex.org/W2049553585', 'https://openalex.org/W2050595427', 'https://openalex.org/W2051410494', 'https://openalex.org/W2053700053', 'https://openalex.org/W2054281770', 'https://openalex.org/W2054621094', 'https://openalex.org/W2055346449', 'https://openalex.org/W2068577449', 'https://openalex.org/W2075004958', 'https://openalex.org/W2077244514', 'https://openalex.org/W2078699963', 'https://openalex.org/W2078764407', 'https://openalex.org/W2080748037', 'https://openalex.org/W2081365151', 'https://openalex.org/W2082462837', 'https://openalex.org/W2086116124', 'https://openalex.org/W2088318211', 'https://openalex.org/W2088516053', 'https://openalex.org/W2096795721', 'https://openalex.org/W2097226696', 'https://openalex.org/W2097995306', 'https://openalex.org/W2101496134', 'https://openalex.org/W2101606728', 'https://openalex.org/W2101619520', 'https://openalex.org/W2103177037', 'https://openalex.org/W2103959341', 'https://openalex.org/W2106315111', 'https://openalex.org/W2107633226', 'https://openalex.org/W2107759665', 'https://openalex.org/W2110534364', 'https://openalex.org/W2110841612', 'https://openalex.org/W2116708359', 'https://openalex.org/W2117792530', 'https://openalex.org/W2118428599', 'https://openalex.org/W2118564089', 'https://openalex.org/W2118836961', 'https://openalex.org/W2119504728', 'https://openalex.org/W2120292596', 'https://openalex.org/W2121023961', 'https://openalex.org/W2121076737', 'https://openalex.org/W2121158863', 'https://openalex.org/W2123526148', 'https://openalex.org/W2123629153', 'https://openalex.org/W2126253217', 'https://openalex.org/W2126785034', 'https://openalex.org/W2129128353', 'https://openalex.org/W2133918562', 'https://openalex.org/W2137077335', 'https://openalex.org/W2137467802', 'https://openalex.org/W2139773658', 'https://openalex.org/W2140665438', 'https://openalex.org/W2141454098', 'https://openalex.org/W2141569270', 'https://openalex.org/W2146777557', 'https://openalex.org/W2147376175', 'https://openalex.org/W2148643283', 'https://openalex.org/W2149131962', 'https://openalex.org/W2149936559', 'https://openalex.org/W2150418305', 'https://openalex.org/W2150865892', 'https://openalex.org/W2150981195', 'https://openalex.org/W2151701050', 'https://openalex.org/W2151964152', 'https://openalex.org/W2156923287', 'https://openalex.org/W2157985656', 'https://openalex.org/W2159810380', 'https://openalex.org/W2160463964', 'https://openalex.org/W2161112598', 'https://openalex.org/W2162738516', 'https://openalex.org/W2162935887', 'https://openalex.org/W2164092182', 'https://openalex.org/W2165542862', 'https://openalex.org/W2165782799', 'https://openalex.org/W2166912270', 'https://openalex.org/W2166918329', 'https://openalex.org/W2167331614', 'https://openalex.org/W2167609397', 'https://openalex.org/W2167749314', 'https://openalex.org/W2168108459', 'https://openalex.org/W2170668585', 'https://openalex.org/W2170818614', 'https://openalex.org/W2172018719', 'https://openalex.org/W2189189437', 'https://openalex.org/W2214621962', 'https://openalex.org/W2221976755', 'https://openalex.org/W2227395130', 'https://openalex.org/W2235405584', 'https://openalex.org/W2235954515', 'https://openalex.org/W2256020981', 'https://openalex.org/W2257564321', 'https://openalex.org/W2262087934', 'https://openalex.org/W2268281268', 'https://openalex.org/W2271989793', 'https://openalex.org/W2292362441', 'https://openalex.org/W2296575890', 'https://openalex.org/W2308639964', 'https://openalex.org/W2311796770', 'https://openalex.org/W2339784500', 'https://openalex.org/W2345014259', 'https://openalex.org/W2346545616', 'https://openalex.org/W2376226802', 'https://openalex.org/W2394605535', 'https://openalex.org/W2401991052', 'https://openalex.org/W2402183197', 'https://openalex.org/W2403998898', 'https://openalex.org/W2408795123', 'https://openalex.org/W2415481598', 'https://openalex.org/W2419426348', 'https://openalex.org/W2431521472', 'https://openalex.org/W2462985846', 'https://openalex.org/W2476122439', 'https://openalex.org/W2479766819', 'https://openalex.org/W2489425084', 'https://openalex.org/W2513255463', 'https://openalex.org/W2522730613', 'https://openalex.org/W2525688488', 'https://openalex.org/W2530715453', 'https://openalex.org/W2539520833', 'https://openalex.org/W2540537925', 'https://openalex.org/W2547028490', 'https://openalex.org/W2559686304', 'https://openalex.org/W2586777675', 'https://openalex.org/W2586987557', 'https://openalex.org/W2603336551', 'https://openalex.org/W2604800509', 'https://openalex.org/W2611178729', 'https://openalex.org/W2611922828', 'https://openalex.org/W2613332942', 'https://openalex.org/W2613362156', 'https://openalex.org/W2617455688', 'https://openalex.org/W2620746860', 'https://openalex.org/W2620798309', 'https://openalex.org/W2621884886', 'https://openalex.org/W2626230492', 'https://openalex.org/W2664930764', 'https://openalex.org/W2726186366', 'https://openalex.org/W2734474559', 'https://openalex.org/W2743661585', 'https://openalex.org/W2745907548', 'https://openalex.org/W2746053356', 'https://openalex.org/W2751208409', 'https://openalex.org/W2751993670', 'https://openalex.org/W2752461037', 'https://openalex.org/W2752859040', 'https://openalex.org/W2752867062', 'https://openalex.org/W2756240008', 'https://openalex.org/W2758743773', 'https://openalex.org/W2760356806', 'https://openalex.org/W2764113329', 'https://openalex.org/W2770044416', 'https://openalex.org/W2772636479', 'https://openalex.org/W2778786812', 'https://openalex.org/W2787804990', 'https://openalex.org/W2787956080', 'https://openalex.org/W2792086148', 'https://openalex.org/W2792512835', 'https://openalex.org/W2794303722', 'https://openalex.org/W2805553258', 'https://openalex.org/W2806590927', 'https://openalex.org/W2806710293', 'https://openalex.org/W2807013439', 'https://openalex.org/W2810806599', 'https://openalex.org/W2863183338', 'https://openalex.org/W4230037721'], 'related_works': ['https://openalex.org/W3122236002', 'https://openalex.org/W3024577600', 'https://openalex.org/W3023935924', 'https://openalex.org/W2890448483', 'https://openalex.org/W2773216890', 'https://openalex.org/W2681186693', 'https://openalex.org/W2593283143', 'https://openalex.org/W2479406918', 'https://openalex.org/W1993338898', 'https://openalex.org/W1848444843'], 'abstract_inverted_index': {'The': [0], 'androgen': [1, 32], 'receptor': [2, 33], 'drives': [3], 'the': [4, 15, 36, 42, 64, 117, 126, 150], 'growth': [5], 'of': [6, 17, 38, 46, 67, 116, 123, 128], 'metastatic': [7, 74, 105], 'castration-resistant': [8, 75, 106], 'prostate': [9, 76, 107, 130], 'cancer.': [10, 108], 'This': [11, 109], 'has': [12], 'led': [13], 'to': [14, 52, 62, 101], 'development': [16], 'multiple': [18], 'novel': [19, 70, 145], 'drugs': [20, 71], 'targeting': [21], 'this': [22], 'hormone-regulated': [23], 'transcription': [24], 'factor,': [25], 'such': [26], 'as': [27], 'enzalutamide': [28, 124, 138], '–': [29], 'a': [30, 53, 113], 'potent': [31], 'antagonist.': [34], 'Despite': [35], 'plethora': [37], 'possible': [39], 'treatment': [40, 48, 96, 103, 127, 147], 'options,': [41], 'absolute': [43], 'survival': [44], 'benefit': [45, 84], 'each': [47], 'separately': [49], 'is': [50], 'limited': [51], 'few': [54], 'months.': [55], 'Therefore,': [56], 'current': [57], 'research': [58, 136], 'efforts': [59], 'are': [60], 'directed': [61], 'determine': [63], 'optimal': [65], 'sequence': [66], 'therapies,': [68], 'discover': [69], 'effective': [72], 'in': [73, 125, 149], 'cancer': [77], 'and': [78, 98, 121, 142], 'define': [79], 'patient': [80], 'subpopulations': [81], 'that': [82], 'ultimately': [83], 'from': [85], 'these': [86], 'treatments.': [87], 'Molecular': [88], 'studies': [89], 'provide': [90], 'evidence': [91], 'on': [92], 'which': [93], 'pathways': [94], 'mediate': [95], 'resistance': [97, 141], 'may': [99], 'lead': [100], 'improved': [102], 'for': [104], 'review': [110], 'provides,': [111], 'firstly': [112], 'concise': [114], 'overview': [115], 'clinical': [118], 'development,': [119], 'use': [120], 'effectiveness': [122], 'advanced': [129], 'cancer,': [131], 'secondly': [132], 'it': [133], 'describes': [134], 'translational': [135], 'addressing': [137], 'response': [139], 'vs': [140], 'lastly': [143], 'highlights': [144], 'potential': [146], 'strategies': [148], 'enzalutamide-resistant': [151], 'setting.': [152]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2890448483', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-12-08T05:59:47.987541', 'created_date': '2018-09-27'}