Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1547361857', 'doi': 'https://doi.org/10.1111/j.1442-2042.2009.02284.x', 'title': 'Suppression of mutant androgen receptors by flutamide', 'display_name': 'Suppression of mutant androgen receptors by flutamide', 'publication_year': 2009, 'publication_date': '2009-04-06', 'ids': {'openalex': 'https://openalex.org/W1547361857', 'doi': 'https://doi.org/10.1111/j.1442-2042.2009.02284.x', 'mag': '1547361857', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19389135'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1442-2042.2009.02284.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S134892809', 'display_name': 'International Journal of Urology', 'issn_l': '0919-8172', 'issn': ['0919-8172', '1442-2042'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5001139671', 'display_name': 'Junichiro Ishioka', 'orcid': 'https://orcid.org/0000-0001-5320-8815'}, 'institutions': [{'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}, {'id': 'https://openalex.org/I4210123465', 'display_name': 'Saitama Cancer Center', 'ror': 'https://ror.org/03a4d7t12', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123465']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Junichiro Ishioka', 'raw_affiliation_strings': ['Department of Urology, Graduate School, Tokyo Medical and Dental University, Tokyo,', 'Department of Urology, Saitama Cancer Center, Kita-Adachi, Saitama,'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Graduate School, Tokyo Medical and Dental University, Tokyo,', 'institution_ids': ['https://openalex.org/I125602781']}, {'raw_affiliation_string': 'Department of Urology, Saitama Cancer Center, Kita-Adachi, Saitama,', 'institution_ids': ['https://openalex.org/I4210123465']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047414438', 'display_name': 'Shuntaro Hara', 'orcid': 'https://orcid.org/0000-0002-8348-9838'}, 'institutions': [{'id': 'https://openalex.org/I119182057', 'display_name': 'Showa University', 'ror': 'https://ror.org/04mzk4q39', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I119182057']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shuntaro Hara', 'raw_affiliation_strings': ['Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan,'], 'affiliations': [{'raw_affiliation_string': 'Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan,', 'institution_ids': ['https://openalex.org/I119182057']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043265453', 'display_name': 'John T. Isaacs', 'orcid': 'https://orcid.org/0000-0002-3854-4658'}, 'institutions': [{'id': 'https://openalex.org/I4210164401', 'display_name': 'Sidney Kimmel Comprehensive Cancer Center', 'ror': 'https://ror.org/05m5b8x20', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I2799853436', 'https://openalex.org/I4210164401']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John T Isaacs', 'raw_affiliation_strings': ['Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA,'], 'affiliations': [{'raw_affiliation_string': 'Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA,', 'institution_ids': ['https://openalex.org/I4210164401', 'https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067825922', 'display_name': 'Arihiro Tomura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210150228', 'display_name': 'Nippon Kayaku (Japan)', 'ror': 'https://ror.org/05cbf4214', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210150228']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Arihiro Tomura', 'raw_affiliation_strings': ['Pharmaceutical Research Laboratories, Research and Development Group, Nippon Kayaku Company Ltd., Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Pharmaceutical Research Laboratories, Research and Development Group, Nippon Kayaku Company Ltd., Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210150228']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023090524', 'display_name': 'Kiyohiro Nishikawa', 'orcid': 'https://orcid.org/0000-0003-2350-6189'}, 'institutions': [{'id': 'https://openalex.org/I4210150228', 'display_name': 'Nippon Kayaku (Japan)', 'ror': 'https://ror.org/05cbf4214', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210150228']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kiyohiro Nishikawa', 'raw_affiliation_strings': ['Pharmaceutical Research Laboratories, Research and Development Group, Nippon Kayaku Company Ltd., Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Pharmaceutical Research Laboratories, Research and Development Group, Nippon Kayaku Company Ltd., Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210150228']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051150655', 'display_name': 'Yukio Kageyama', 'orcid': 'https://orcid.org/0000-0001-9161-9105'}, 'institutions': [{'id': 'https://openalex.org/I125602781', 'display_name': 'Tokyo Medical and Dental University', 'ror': 'https://ror.org/051k3eh31', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I125602781']}, {'id': 'https://openalex.org/I4210123465', 'display_name': 'Saitama Cancer Center', 'ror': 'https://ror.org/03a4d7t12', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123465']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Yukio Kageyama', 'raw_affiliation_strings': ['Department of Urology, Graduate School, Tokyo Medical and Dental University, Tokyo,', 'Department of Urology, Saitama Cancer Center, Kita-Adachi, Saitama,'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Graduate School, Tokyo Medical and Dental University, Tokyo,', 'institution_ids': ['https://openalex.org/I125602781']}, {'raw_affiliation_string': 'Department of Urology, Saitama Cancer Center, Kita-Adachi, Saitama,', 'institution_ids': ['https://openalex.org/I4210123465']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5051150655'], 'corresponding_institution_ids': ['https://openalex.org/I125602781', 'https://openalex.org/I4210123465'], 'apc_list': {'value': 3400, 'currency': 'USD', 'value_usd': 3400, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.016, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.752871, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '16', 'issue': '5', 'first_page': '516', 'last_page': '521'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10683', 'display_name': 'Mass Spectrometry Techniques and Applications', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/flutamide', 'display_name': 'Flutamide', 'score': 0.91299653}, {'id': 'https://openalex.org/keywords/bicalutamide', 'display_name': 'Bicalutamide', 'score': 0.68525934}, {'id': 'https://openalex.org/keywords/dihydrotestosterone', 'display_name': 'Dihydrotestosterone', 'score': 0.5457472}, {'id': 'https://openalex.org/keywords/antiandrogens', 'display_name': 'Antiandrogens', 'score': 0.5117433}], 'concepts': [{'id': 'https://openalex.org/C2778313021', 'wikidata': 'https://www.wikidata.org/wiki/Q418669', 'display_name': 'Flutamide', 'level': 5, 'score': 0.91299653}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.8948537}, {'id': 'https://openalex.org/C2780962315', 'wikidata': 'https://www.wikidata.org/wiki/Q1988832', 'display_name': 'Bicalutamide', 'level': 5, 'score': 0.68525934}, {'id': 'https://openalex.org/C2779723316', 'wikidata': 'https://www.wikidata.org/wiki/Q6459234', 'display_name': 'LNCaP', 'level': 4, 'score': 0.6663594}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.5605315}, {'id': 'https://openalex.org/C2779881493', 'wikidata': 'https://www.wikidata.org/wiki/Q411054', 'display_name': 'Dihydrotestosterone', 'level': 4, 'score': 0.5457472}, {'id': 'https://openalex.org/C2910016293', 'wikidata': 'https://www.wikidata.org/wiki/Q574820', 'display_name': 'Antiandrogens', 'level': 5, 'score': 0.5117433}, {'id': 'https://openalex.org/C2779322244', 'wikidata': 'https://www.wikidata.org/wiki/Q574820', 'display_name': 'Antiandrogen', 'level': 4, 'score': 0.46820715}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.46333873}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4482069}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.3800246}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31810087}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3142957}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.14501399}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.079072595}], 'mesh': [{'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D005485', 'descriptor_name': 'Flutamide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000728', 'descriptor_name': 'Androgens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000728', 'descriptor_name': 'Androgens', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013196', 'descriptor_name': 'Dihydrotestosterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013196', 'descriptor_name': 'Dihydrotestosterone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005485', 'descriptor_name': 'Flutamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005485', 'descriptor_name': 'Flutamide', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008156', 'descriptor_name': 'Luciferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008156', 'descriptor_name': 'Luciferases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015533', 'descriptor_name': 'Transcriptional Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015533', 'descriptor_name': 'Transcriptional Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1442-2042.2009.02284.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S134892809', 'display_name': 'International Journal of Urology', 'issn_l': '0919-8172', 'issn': ['0919-8172', '1442-2042'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19389135', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.77}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 16, 'referenced_works': ['https://openalex.org/W1816722347', 'https://openalex.org/W1896816349', 'https://openalex.org/W2061686178', 'https://openalex.org/W2066570340', 'https://openalex.org/W2068152079', 'https://openalex.org/W2074985251', 'https://openalex.org/W2099594535', 'https://openalex.org/W2112202844', 'https://openalex.org/W2113031878', 'https://openalex.org/W2118906905', 'https://openalex.org/W2152325066', 'https://openalex.org/W2160064859', 'https://openalex.org/W2165611177', 'https://openalex.org/W2166912270', 'https://openalex.org/W2371997879', 'https://openalex.org/W2766162865'], 'related_works': ['https://openalex.org/W4255890258', 'https://openalex.org/W4229984084', 'https://openalex.org/W3148026613', 'https://openalex.org/W3003821987', 'https://openalex.org/W2165611177', 'https://openalex.org/W2065112594', 'https://openalex.org/W2010412515', 'https://openalex.org/W1978560708', 'https://openalex.org/W1975376586', 'https://openalex.org/W1592598587'], 'abstract_inverted_index': {'To': [0], 'examine': [1], 'the': [2, 9, 44, 51, 67, 75, 78, 83, 107, 124, 129, 157, 169], 'effects': [3, 37, 73, 141, 153, 176], 'of': [4, 11, 38, 50, 74, 82, 106, 126, 128, 159], 'flutamide': [5, 42, 163], 'and': [6, 46, 53, 80, 103, 137], 'hydroxyflutamide': [7, 40], 'on': [8, 43, 77, 142, 177], 'transactivation': [10], 'mutant': [12, 30, 33, 54, 91, 130, 178], 'androgen': [13, 34, 55, 93, 111, 131, 170, 179], 'receptors.Androgen-independent': [14], 'human': [15], 'prostate': [16, 191], 'cancer': [17], 'cell': [18], 'line': [19], 'PC3': [20], 'was': [21, 114], 'transfected': [22], 'with': [23, 149, 173], 'plasmids': [24], 'expressing': [25, 89], 'wild-type,': [26], 'W741C': [27], 'mutant,': [28], 'T877A': [29], 'or': [31, 41], 'W741C+T877A': [32], 'receptors.': [35], 'The': [36, 72], 'bicalutamide,': [39], 'basal': [45], 'dihydrotestosterone-induced': [47], 'transcriptional': [48], 'activities': [49], 'wild-type': [52], 'receptors': [56, 132], 'were': [57, 95, 154], 'evaluated': [58, 115], 'by': [59, 97, 116, 145, 162], 'luciferase': [60], 'assays': [61], 'using': [62], 'a': [63, 90], 'reporter': [64], 'plasmid': [65], 'containing': [66], 'prostate-specific': [68], 'antigen': [69], '(PSA)': [70], 'promoter.': [71], 'antiandrogens': [76, 108, 187], 'transcription': [79, 125], 'translation': [81], 'PSA': [84, 143], 'gene': [85], 'in': [86, 134], 'LNCaP': [87, 146], 'cells': [88, 147], '(T877A)': [92], 'receptor': [94, 112, 171], 'assessed': [96], 'real-time': [98], 'reverse': [99], 'transcription-polymerase': [100], 'chain': [101], 'reaction': [102], 'radioimmunoassays.': [104], 'Affinity': [105], 'to': [109, 168, 185], 'each': [110], 'construct': [113], 'ligand-binding': [117], 'assay.Flutamide,': [118], 'but': [119], 'not': [120, 156], 'hydroxyflutamide,': [121], 'successfully': [122], 'suppressed': [123], 'all': [127], 'examined': [133], 'this': [135], 'study': [136], 'also': [138], 'showed': [139], 'suppressive': [140, 175], 'secretion': [144], 'treated': [148], 'dihydrotestosterone.': [150], 'These': [151], 'inhibitory': [152], 'probably': [155], 'result': [158], 'competitive': [160], 'inhibition': [161], 'given': [164], 'its': [165, 174], 'low': [166], 'affinity': [167], 'constructs.Flutamide,': [172], 'receptors,': [180], 'may': [181], 'be': [182], 'an': [183], 'alternative': [184], 'conventional': [186], 'for': [188], 'hormone': [189], 'refractory': [190], 'cancer.': [192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1547361857', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-15T20:46:41.888655', 'created_date': '2016-06-24'}