Title: Gel chromatography of thyroidal iodo-compounds on Sephadex G-10
Abstract: The analysis of biological samples containing iodo-compounds was developed by combining partition chromatography and molecular sieving. Iodopeptides, iodide, 3-monoiodotyrosine, 3,5-diiodotyrosine and thyroid hormones are separated in a two-step single-column procedure using Sephadex G-10. The results demonstrate a good reproducibility for Kav and also for recoveries. The main advantages of this new technique are the achievement of total analysis on a single column, direct chromatography of the sample without pre-treatment (lipid removal, iodide removal, etc.), and the possibility of chromatography of large volumes. Applications to thyroid dialyzates and hydrolyzates are discussed.
Publication Year: 1974
Publication Date: 1974-05-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 12
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