Title: Biochemical Pathology of Vitamin B6 Deficiency
Abstract: Various pyridoxal phosphate enzymes are affected differently by vitamin B6 depletion. Enzymes involved in the degradation of tryptophan and of the sulfur amino acids are impaired at an early stage of the deficiency. Therefore, alterations of the metabolism of these amino acids are the first signs of the vitamin B6 deficiency state. The apoenzyme synthesis of pyridoxal phosphate-containing enzymes seems to be induced and regulated by pyridoxal phosphate. Consequently, organs with a high protein turnover lose their pyridoxal phosphate enzymes more rapidly by vitamin B6 depletion than those with a low protein turnover. Correlations exist between cerebral symptoms produced by vitamin B6 depletion, the reduction of the pyridoxal phosphate content in the brain and the activity of its enzymes dependent on pyridoxal phosphate.
Publication Year: 1964
Publication Date: 1964-01-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 49
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