Title: [75] Vitamin B6 antagonists of natural origin
Abstract: Vitamin B6 antagonists of natural origin are described in the chapter. Vitamin B6 antagonists are generally of two types: (1) structural analogs of a B6 vitamer or (2) carbonyl reagents—reactive hydrazines or hydroxylamines that are capable of forming hydrazones or oximes with pyridoxal or pyridoxal phosphate. A limited number of examples of substituted hydrazines and hydroxylamines have been reported to occur in plants or fungal secretions. There are no known examples of naturally occurring vitamin B6 antagonists, which are structural analogs of the B6 vitamers. The reaction product of a carbonyl reagent with pyridoxal or pyridoxal phosphate may be considered to be an analog of vitamin B6. These substituted oximes and hydrazones of pyridoxal phosphate probably function by binding on the apoenzyme at the binding site for pyridoxal phosphate. Methods for the preparation of some of the naturally occurring carbonyl reagents are listed in the chapter and their phosphopyridoxylidene derivatives are presented along with examples of the use of the carbonyl reagents in the study of enzymes.
Publication Year: 1979
Publication Date: 1979-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 9
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