Title: Amoxapine versus amitriptyline combined with perphenazine in the treatment of psychotic depression
Abstract: Back to table of contents Previous article Next article No AccessAmoxapine versus amitriptyline combined with perphenazine in the treatment of psychotic depressionPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.147.9.1203AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractIn a double-blind study lasting for 4 weeks, the authors compared the effectiveness of amoxapine, an antidepressant with potential antipsychotic properties, with a combination of amitriptyline plus perphenazine in the treatment of 38 patients who had the diagnosis of major depression with psychotic features (psychotic or delusional depression). Patients in each group showed similar improvement in depression and psychosis. There was a tendency for the patients treated with amitriptyline plus perphenazine to have higher global response rates. However, the patients given amoxapine had significantly fewer extrapyramidal side effects. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byPharmacological treatment for psychotic depression7 December 2021 | Cochrane Database of Systematic Reviews, Vol. 2021, No. 12Psychotic Depression: Diagnosis, Differential Diagnosis, and Treatment9 November 2020 | Psychotherapy and Psychosomatics, Vol. 90, No. 3Advances in the Treatment of Psychotic Depression30 January 2019 | Current Treatment Options in Psychiatry, Vol. 6, No. 1Clinical PsychopharmacologyCochrane Database of Systematic ReviewsAddition of amoxapine improves positive and negative symptoms in a patient with schizophrenia25 July 2013 | Therapeutic Advances in Psychopharmacology, Vol. 3, No. 6Schizophrenia Bulletin, Vol. 39, No. 4Revista Colombiana de Psiquiatría, Vol. 41, No. 4Psychiatry Research, Vol. 197, No. 3European Archives of Psychiatry and Clinical Neuroscience, Vol. 261, No. S3Case Reports in Medicine, Vol. 2011Cellular Physiology and Biochemistry, Vol. 28, No. 1Journal of Pharmacology and Experimental Therapeutics, Vol. 332, No. 2Effects of different antidepressant treatments on the core of depression1 April 2022 | Dialogues in Clinical Neuroscience, Vol. 10, No. 3The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An Update on Psychotic DepressionHarvard Review of Psychiatry, Vol. 16, No. 4International Journal of Psychiatry in Clinical Practice, Vol. 12, No. 1Amoxapine as an AntipsychoticJournal of Clinical Psychopharmacology, Vol. 27, No. 6Psychosis in Major DepressionCochrane Database of Systematic ReviewsPharmacotherapy for Psychotic DepressionJournal of Psychosocial Nursing and Mental Health Services, Vol. 44, No. 12Biological Psychiatry, Vol. 60, No. 12British Journal of Psychiatry, Vol. 188, No. 5Expert Review of Neurotherapeutics, Vol. 6, No. 7Drug Safety, Vol. 29, No. 6Neuropsychopharmacology, Vol. 30, No. 12A Double-Blind, Randomized Study of Olanzapine and Olanzapine/Fluoxetine Combination for Major Depression With Psychotic FeaturesJournal of Clinical Psychopharmacology, Vol. 24, No. 4Australian & New Zealand Journal of Psychiatry, Vol. 38, No. 6The Showa University Journal of Medical Sciences, Vol. 16, No. 4Biological Psychiatry, Vol. 53, No. 8Schizophrenia Research, Vol. 59, No. 1A Dynamic Algorithm for the Treatment of Psychotic Major DepressionPsychiatric Annals, Vol. 32, No. 11Novel Strategies in the Treatment of Psychotic Major DepressionPsychiatric Annals, Vol. 32, No. 11Biological Psychiatry, Vol. 52, No. 5Journal of Clinical Psychopharmacology, Vol. 21, No. 5The American Journal of Geriatric Psychiatry, Vol. 9, No. 4British Journal of Psychiatry, Vol. 178, No. 2Current Psychiatry Reports, Vol. 2, No. 4Biological Psychiatry, Vol. 47, No. 8Biological Psychiatry, Vol. 47, No. 7Clinical Neuropharmacology, Vol. 23, No. 6Journal of Clinical Psychopharmacology, Vol. 20, No. 5Biological Psychiatry, Vol. 45, No. 9Rapid Mood Swings After Unmonitored Light ExposureYbe Meesters, Ph.D., and Comelis A.J. Van Houwelingen, M.D., 1 February 1998 | American Journal of Psychiatry, Vol. 155, No. 2Dr. Mulsant and Colleagues ReplyBenoit H. Mulsant, M.D., , ROGER F. HASKETT, M.D., JOAN PRUDIC, M.D., MICHAEL E. THASE, M.D., and HAROLD A. SACKEIM, PH.D.1 February 1998 | American Journal of Psychiatry, Vol. 155, No. 2Low use of neuroleptic drugs in the treatment of psychotic major depression1 April 2006 | American Journal of Psychiatry, Vol. 154, No. 4Schizophrenia Research, Vol. 27, No. 2-3Journal of Clinical Psychopharmacology, Vol. 17Journal of Clinical Psychopharmacology, Vol. 17, No. 4The Journal of Nervous & Mental Disease, Vol. 185, No. 12, Vol. 120Psychiatric Clinics of North America, Vol. 19, No. 2The American Journal of Geriatric Psychiatry, Vol. 4, No. 4Journal of Affective Disorders, Vol. 31, No. 4International Journal of Geriatric Psychiatry, Vol. 8, No. 12Brain Research, Vol. 627, No. 1Journal of Affective Disorders, Vol. 28, No. 2International Journal of Mental Health, Vol. 22, No. 2Psychotic (delusional) major depression: should it be included as a distinct syndrome in DSM-IV?1 April 2006 | American Journal of Psychiatry, Vol. 149, No. 6 Volume 147Issue 9 September 1990Pages 1203-1208 Metrics PDF download History Published online 1 April 2006 Published in print 1 September 1990
Publication Year: 1990
Publication Date: 1990-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 98
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot