Title: The pharmacological treatment of delusional depression
Abstract: Back to table of contents Previous article Next article No AccessThe pharmacological treatment of delusional depressionPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.142.4.430AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractThe authors investigated the pharmacological treatment of delusional depression by assigning patients on a random double-blind basis to amitriptyline alone, perphenazine alone, or a combination of the two. Fourteen (78%) of the 18 patients assigned to amitriptyline plus perphenazine were responders, compared with seven (41%) of 17 patients treated with amitriptyline alone and three (19%) of the 16 patients treated with perphenazine alone. The combination of amitriptyline and perphenazine was clearly superior (p less than .01). Access content To read the fulltext, please use one of the options below to sign in or purchase access. 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FiguresReferencesCited byDetailsCited byGuidelines for the management of psychosis in the context of mood disordersSchizophrenia Research, Vol. 241Pharmacological treatment for psychotic depression7 December 2021 | Cochrane Database of Systematic Reviews, Vol. 2021, No. 12Antidepressant and antipsychotic treatment of Psychotic Major Depression in a British mental healthcare setting7 May 2021 | Journal of Mental Health, Vol. 29The assessment of resistance to antidepressant treatment: Rationale for the Antidepressant Treatment History Form: Short Form (ATHF-SF)Journal of Psychiatric Research, Vol. 113Advances in the Treatment of Psychotic Depression30 January 2019 | Current Treatment Options in Psychiatry, Vol. 6, No. 1Literaturverzeichnis zu Voderholzer/Hohagen (Hrsg.): Therapie psychischer Erkrankungen, 14. AuflageActa Psychiatrica Scandinavica, Vol. 139, No. 3British Journal of Pharmacology, Vol. 176, No. 18Targeting and transforming major depression16 December 2016 | Acta Psychiatrica Scandinavica, Vol. 135, No. 4Der Nervenarzt, Vol. 88, No. 5Literaturverzeichnis zu Voderholzer/Hohagen (Hrsg.): Therapie psychischer Erkrankungen, 13. AuflageFrontiers in Pharmacology, Vol. 8Clinical PsychopharmacologyRoyal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders7 December 2015 | Australian & New Zealand Journal of Psychiatry, Vol. 49, No. 12Depressive Disorders: Major Depressive Disorder and Persistent Depressive Disorder20 February 2015Perphenazine for schizophrenia6 March 2015 | Cochrane Database of Systematic Reviews, Vol. 19Cochrane Database of Systematic ReviewsActa Psychiatrica Scandinavica, Vol. 132, No. 5Measuring treatment response in psychotic depression: The Psychotic Depression Assessment Scale (PDAS) takes both depressive and psychotic symptoms into accountJournal of Affective Disorders, Vol. 160DNP - Der Neurologe und Psychiater, Vol. 15, No. 4Acta Psychiatrica Scandinavica, Vol. 129, No. 3Acta Psychiatrica Scandinavica, Vol. 129, No. 6Bipolar Disorders, Vol. 16, No. 2Medical managementThe treatment of psychotic depression: Is there consensus among guidelines and psychiatrists?Journal of Affective Disorders, Vol. 145, No. 2Schizophrenia Bulletin, Vol. 39, No. 4The World Journal of Biological Psychiatry, Vol. 14, No. 5Current Psychiatry Reports, Vol. 14, No. 6Revista Colombiana de Psiquiatría, Vol. 41, No. 4Psychiatric Clinics of North America, Vol. 35, No. 4Psychiatry Research, Vol. 197, No. 3Psychotherapy and Psychosomatics, Vol. 81, No. 3Classification of Depressive Disorders26 August 2012Journal of Psychiatric Research, Vol. 45, No. 7Case Reports in Medicine, Vol. 2011Cortical and Subcortical Abnormalities in Late-Onset Depression With History of Suicide Attempts Investigated With MRI and Voxel-Based Morphometry29 April 2010 | Journal of Geriatric Psychiatry and Neurology, Vol. 23, No. 3CNS Spectrums, Vol. 15, No. 8Acta Psychiatrica Scandinavica, Vol. 121, No. 3Electroconvulsive therapy or antipsychotic drugs (or benzodiazepines for catatonia)Suicide prevention in first-episode psychosisNordic Journal of Psychiatry, Vol. 63, No. 5Revista Brasileira de Psiquiatria, Vol. 31, No. suppl 1How Should Mood Disorders be Modelled?1 January 2008 | Australian & New Zealand Journal of Psychiatry, Vol. 42, No. 10The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An Update on Psychotic DepressionHarvard Review of Psychiatry, Vol. 16, No. 4Psychopharmacology, Vol. 201, No. 2Pharmacological Approaches to Treatment-Resistant DepressionJournal of Affective Disorders, Vol. 106, No. 3Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 32, No. 5International Journal of Psychiatry in Clinical Practice, Vol. 12, No. 1Journal of Clinical Psychopharmacology, Vol. 28, No. 2International Clinical Psychopharmacology, Vol. 23, No. 2Psychosis in Major DepressionComprehensive Psychiatry, Vol. 48, No. 6CNS Spectrums, Vol. 12, No. S22The World Journal of Biological Psychiatry, Vol. 8, No. 2Journal of the American Geriatrics Society, Vol. 55Acta Psychiatrica Scandinavica, Vol. 115, No. s433Through a Glass Darkly: The Disutility of the DSM Nosology of Depressive Disorders1 December 2006 | The Canadian Journal of Psychiatry, Vol. 51, No. 14Pharmacotherapy for Psychotic DepressionJournal of Psychosocial Nursing and Mental Health Services, Vol. 44, No. 12Treatments in depression1 April 2022 | Dialogues in Clinical Neuroscience, Vol. 8, No. 2Biological Psychiatry, Vol. 60, No. 12Neuropsychopharmacology, Vol. 31, No. 3Tardive dyskinesia and antipsychotics: a 5-year longitudinal study of frequency, correlates and courseInternational Clinical Psychopharmacology, Vol. 21, No. 1Expert Review of Neurotherapeutics, Vol. 6, No. 1Expert Review of Neurotherapeutics, Vol. 6, No. 7Drug Safety, Vol. 29, No. 6The pharmacological management of depression1 April 2022 | Dialogues in Clinical Neuroscience, Vol. 7, No. 3State of the Science on Psychosocial Interventions for Ethnic MinoritiesAnnual Review of Clinical Psychology, Vol. 1, No. 1Mixed depressive states: Nosologic and therapeutic issues11 July 2009 | International Review of Psychiatry, Vol. 17, No. 1Perphenazine for schizophrenia24 January 2005European Archives of Psychiatry and Clinical Neuroscience, Vol. 255, No. 2Journal of Affective Disorders, Vol. 87, No. 2-3Psychiatric Clinics of North America, Vol. 28, No. 4CNS Spectrums, Vol. 10, No. 4New England Journal of Medicine, Vol. 353, No. 17International Review of Psychiatry, Vol. 17, No. 1The World Journal of Biological Psychiatry, Vol. 6, No. sup2Acta Psychiatrica Scandinavica, Vol. 111, No. 2Advances in Psychiatric Treatment, Vol. 11, No. 1A Double-Blind, Randomized Study of Olanzapine and Olanzapine/Fluoxetine Combination for Major Depression With Psychotic FeaturesJournal of Clinical Psychopharmacology, Vol. 24, No. 4Australian and New Zealand Clinical Practice Guidelines for the Treatment of Bipolar Disorder26 June 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 38, No. 5Journal of Psychiatric Research, Vol. 38, No. 1EMC - Psychiatrie, Vol. 1, No. 4EMC - Psychiatrie, Vol. 1, No. 4Australian & New Zealand Journal of Psychiatry, Vol. 38, No. 6Australian and New Zealand Journal of Psychiatry, Vol. 38, No. 5Australian and New Zealand Journal of Psychiatry, Vol. 38, No. 6Indikationsabhängige Durchführung und Bewertung der ElektrokonvulsionstherapieInternational Journal of Geriatric Psychiatry, Vol. 18, No. 6Biological Psychiatry, Vol. 53, No. 8Biological Psychiatry, Vol. 53, No. 8Biological Psychiatry, Vol. 53, No. 8CNS Drugs, Vol. 17, No. 1A Dynamic Algorithm for the Treatment of Psychotic Major DepressionPsychiatric Annals, Vol. 32, No. 11Biological Psychiatry, Vol. 52, No. 5The World Journal of Biological Psychiatry, Vol. 3, No. 1A Novel Augmentation Strategy for Treating Resistant Major DepressionRichard C. Shelton, M.D., Gary D. Tollefson, M.D., Ph.D., Mauricio Tohen, M.D., Dr.P.H., Stephen Stahl, M.D., Kimberley S. Gannon, Ph.D., Thomas G. Jacobs, M.S., William R. Buras, B.Sc., Frank P. Bymaster, M.Sc., Wei Zhang, M.D., Ph.D., Kimberley A. Spencer, B.Sc., Peter D. Feldman, Ph.D., and Herbert Y. Meltzer, M.D.1 January 2001 | American Journal of Psychiatry, Vol. 158, No. 1Journal of Affective Disorders, Vol. 66, No. 2-3Current Opinion in Psychiatry, Vol. 14, No. 1Journal of Clinical Psychopharmacology, Vol. 21, No. 5The American Journal of Geriatric Psychiatry, Vol. 9, No. 4The Journal of ECT, Vol. 17, No. 4Journal of Psychiatric Practice, Vol. 7, No. 6The World Journal of Biological Psychiatry, Vol. 2, No. 1Classifying Depression: Should Paradigms Lost Be Regained?Gordon Parker, M.D., Ph.D., D.Sc., F.R.A.N.Z.C.P.1 August 2000 | American Journal of Psychiatry, Vol. 157, No. 8Current Psychiatry Reports, Vol. 2, No. 4CNS Spectrums, Vol. 5, No. 9Clinical Neuropharmacology, Vol. 23, No. 6Journal of Clinical Psychopharmacology, Vol. 20, No. 5Drugs & Therapy Perspectives, Vol. 15, No. 6Clinical Drug Investigation, Vol. 20, No. 6Treatment of Corticosteroid-Induced Mood Changes With OlanzapineE. SHERWOOD BROWN, PH.D., M.D., DAVID A. KHAN, M.D., and TRISHA SUPPES, M.D., PH.D., 1 June 1999 | American Journal of Psychiatry, Vol. 156, No. 6Selective Serotonin Reuptake Inhibitors and Delusional DepressionANTHONY J. ROTHSCHILD, M.D., , and KATHARINE A. PHILLIPS, M.D., 1 June 1999 | American Journal of Psychiatry, Vol. 156, No. 6Biological Psychiatry, Vol. 45, No. 2Biological Psychiatry, Vol. 45, No. 7Advances in Psychiatric Treatment, Vol. 5, No. 1Treatment-Resistant Depression: Progress and LimitationsPsychiatric Annals, Vol. 28, No. 11Venlafaxin for the treatment of psychotic depression16 April 2020 | European Psychiatry, Vol. 13, No. 5Combined Drug Treatment Strategies for Major DepressionPsychiatric Annals, Vol. 28, No. 4Rapid Mood Swings After Unmonitored Light ExposureYbe Meesters, Ph.D., and Comelis A.J. Van Houwelingen, M.D., 1 February 1998 | American Journal of Psychiatry, Vol. 155, No. 2Dr. Mulsant and Colleagues ReplyBenoit H. Mulsant, M.D., , ROGER F. HASKETT, M.D., JOAN PRUDIC, M.D., MICHAEL E. THASE, M.D., and HAROLD A. SACKEIM, PH.D.1 February 1998 | American Journal of Psychiatry, Vol. 155, No. 2Differential Response to Antidepressants in Melancholic and Severe DepressionPsychiatric Annals, Vol. 28, No. 2Pediatric Clinics of North America, Vol. 45, No. 5Advances in Psychiatric Treatment, Vol. 4, No. 6Refusal of ECT by a patient with recurrent depression, psychosis, and catatonia [clinical conference]1 April 2006 | American Journal of Psychiatry, Vol. 154, No. 9Treating older adults with psychotic symptoms1 April 2006 | Psychiatric Services, Vol. 48, No. 9Síntomas psicóticos en los trastornos del estado de ánimo: valoración de 159 pacientes internos12 May 2020 | European psychiatry (Ed. Española), Vol. 4, No. 5Low use of neuroleptic drugs in the treatment of psychotic major depression1 April 2006 | American Journal of Psychiatry, Vol. 154, No. 4Human Psychopharmacology: Clinical and Experimental, Vol. 12, No. 1Clinical Therapeutics, Vol. 19, No. 5Schizophrenia Research, Vol. 27, No. 2-3Thyrotropin and prolactin responses to TRH in delusional (psychotic) and nondelusional depressed patients16 April 2020 | European Psychiatry, Vol. 12, No. 5Journal of Clinical Psychopharmacology, Vol. 17Journal of Clinical Psychopharmacology, Vol. 17, No. 4Therapeutic Drug Monitoring, Vol. 19, No. 1Resistance to antidepressant medications and short-term clinical response to ECT1 April 2006 | American Journal of Psychiatry, Vol. 153, No. 8, Vol. 120Journal of Contemporary Psychotherapy, Vol. 26, No. 3Psychiatric Clinics of North America, Vol. 19, No. 2European Psychiatry, Vol. 11, No. 8The American Journal of Geriatric Psychiatry, Vol. 4, No. 4Depression, Vol. 3, No. 4Journal of Affective Disorders, Vol. 35, No. 3European Neuropsychopharmacology, Vol. 5The American Journal of Geriatric Psychiatry, Vol. 3, No. 1Comparative efficacy of selective serotonin reuptake inhibitors and tricyclics in the treatment of melancholia1 April 2006 | American Journal of Psychiatry, Vol. 151, No. 12An Algorithm for the Treatment of Major Depression and its SubtypesPsychiatric Annals, Vol. 24, No. 7General Hospital Psychiatry, Vol. 16, No. 5Journal of Affective Disorders, Vol. 31, No. 3Journal of Affective Disorders, Vol. 31, No. 4The American Journal of Geriatric Psychiatry, Vol. 2, No. 3A Consensus Conference on Psychotic Depression26 June 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 27, No. 4International Journal of Geriatric Psychiatry, Vol. 8, No. 1International Journal of Geriatric Psychiatry, Vol. 8, No. 12Journal of Neural Transmission, Vol. 91, No. 2-3Biological Psychiatry, Vol. 34, No. 6Journal of Affective Disorders, Vol. 28, No. 2Psychiatric Clinics of North America, Vol. 16, No. 3Psychological Medicine, Vol. 23, No. 4New England Journal of Medicine, Vol. 329, No. 9International Journal of Mental Health, Vol. 22, No. 2Antidepressiva in der Akutbehandlung depressiver SyndromePsychotic (delusional) major depression: should it be included as a distinct syndrome in DSM-IV?1 April 2006 | American Journal of Psychiatry, Vol. 149, No. 6The management of treatment-resistant affective disorder: clinical perspectives1 July 2016 | Journal of Psychopharmacology, Vol. 6, No. 2Commentary on 'The management of treatment-resistant affective disorder: clinical perspectives'1 July 2016 | Journal of Psychopharmacology, Vol. 6, No. 2Psychiatric Quarterly, Vol. 63, No. 4Clinics in Geriatric Medicine, Vol. 8, No. 2Journal of Child and Adolescent Psychopharmacology, Vol. 2, No. 1The Pharmacologic Treatment of DepressionNew England Journal of Medicine, Vol. 325, No. 9Platelet serotonin in subtypes of schizophrenia and unipolar depressionPsychiatry Research, Vol. 38, No. 2Psychotic Depression: A Review and Clinical Experience26 June 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 25, No. 2Psychopharmacology, Vol. 105, No. 2Biological Psychiatry, Vol. 30, No. 6Journal of Affective Disorders, Vol. 22, No. 3Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 15, No. 6Psychiatric Clinics of North America, Vol. 14, No. 4The American Journal of Drug and Alcohol Abuse, Vol. 17, No. 3Nordisk Psykiatrisk Tidsskrift, Vol. 45, No. sup24International Review of Psychiatry, Vol. 3, No. 1Amoxapine versus amitriptyline combined with perphenazine in the treatment of psychotic depression1 April 2006 | American Journal of Psychiatry, Vol. 147, No. 9Antidepressant Medication and Total Sleep Deprivation in DepressivesPsychiatry Research, Vol. 31, No. 3Mélancolie délirante: caractéristiques épidémiologiques, cliniques, biologiques et thérapeutiques28 April 2020 | Psychiatry and Psychobiology, Vol. 5, No. 5International Review of Psychiatry, Vol. 2, No. 2Antidepressants in “Depressed” SchizophrenicsEuropean Archives of Psychiatry and Neurological Sciences, Vol. 238, No. 5-6Journal of Affective Disorders, Vol. 17, No. 2Psychiatry Research, Vol. 27, No. 1Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 13, No. 1-2British Journal of Psychiatry, Vol. 154, No. 5Inadequate Provision for Electoconvulsive Therapy in the New South Wales Mental Health Act 198326 June 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 22, No. 4The heterogeneity of schizoaffective disorder: implications for treatment1 April 2006 | American Journal of Psychiatry, Vol. 145, No. 8Response of psychotic and nonpsychotic depression to phenelzine1 April 2006 | American Journal of Psychiatry, Vol. 145, No. 1Comprehensive Psychiatry, Vol. 29, No. 1Journal of Affective Disorders, Vol. 14, No. 1Medical Clinics of North America, Vol. 72, No. 4Acta Psychiatrica Scandinavica, Vol. 78, No. 6Annals of the New York Academy of Sciences, Vol. 537, No. 1 The MesocortiBMJ, Vol. 297, No. 6646BMJ, Vol. 297, No. 6646British Journal of Psychiatry, Vol. 152, No. 1British Journal of Psychiatry, Vol. 152, No. 4Late-Life Depression and DelusionsBarnett S. Meyers1 April 2006 | Psychiatric Services, Vol. 38, No. 6Pharmacologic Treatment of Resistant DepressionPsychiatric Annals, Vol. 17, No. 5DST and TRH stimulation test in mood disorder subtypes1 April 2006 | American Journal of Psychiatry, Vol. 144, No. 4Treatment-Resistant DepressionPsychiatric Annals, Vol. 17, No. 4, Vol. 5, Vol. 5Biological Psychiatry, Vol. 22, No. 1Comprehensive Psychiatry, Vol. 28, No. 2Acta Psychiatrica Scandinavica, Vol. 75, No. 1Acta Psychiatrica Scandinavica, Vol. 76, No. 6A Survey of Psychiatrists' Practices Related to the Use of Tricydic AntidepressantsSolomon C. Goldberg, David H. Tilley, Robert O. Friedel, Robert M. Hamer, and Thomas A. Ban1 April 2006 | Psychiatric Services, Vol. 37, No. 12Age-Related Patterns of Alcoholism Among Veterans in Ambulatory CareKathryn Magruder-Habib, Constance Corley Saltz, and Patricia M. Barron1 April 2006 | Psychiatric Services, Vol. 37, No. 12Delusional and Nondelusional Unipolar Depression: Further Evidence for Distinct SubtypesFrank Miller, and Linda Ann Chabrier1 April 2006 | Psychiatric Services, Vol. 37, No. 11Participation of Corporate Managers in Mental Health Quality Assurance TeamsAdrienne S. Plotkin1 April 2006 | Psychiatric Services, Vol. 37, No. 11Neuroleptic dose and desipramine concentrations during combined treatment of unipolar delusional depression1 April 2006 | American Journal of Psychiatry, Vol. 143, No. 9Lithium augmentation in psychotic depression refractory to combined drug treatment1 April 2006 | American Journal of Psychiatry, Vol. 143, No. 3Life Sciences, Vol. 39, No. 24Journal of Affective Disorders, Vol. 10, No. 3Acta Psychiatrica Scandinavica, Vol. 73, No. 3Journal of Affective Disorders, Vol. 9, No. 1 Volume 142Issue 4 April 1985Pages 430-436 Metrics PDF download History Published online 1 April 2006 Published in print 1 April 1985
Publication Year: 1985
Publication Date: 1985-04-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 347
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