Title: Antispasmodic activity of diclofenac and its combination with pitofenone and fenpiverinium on rat colon
Abstract: Objective: To study the antispasmodic activity of diclofenac per se and its combination with pitofenone and fenpiverinium.
Method: The antispasmodic activity study was carried out against acetylcholine (10 - 640 ng ml-1)-induced concentrations on rat colon.
Results: Acetylcholine (10 - 640ngml-1) induced a concentration - dependent contraction of the smooth muscle. In concentration of 9.4x1O-5 and 14.1 x10-5 mol L-1 diclofenac, a non-steroidal antiinflammatory agent shifted the concentration-response curve of acetylcholine to the right without suppressing the maximum, whereas diclofenac in higher concentration, 18.9x10-5 mol L-l induced unsurmountable blockade. Diclofenac (9.4x1O-5 mol L-1) potentiated antispasmodic activity of pitofenone (2.5x10-6 mol L-l) and fenpiverinium (2.3x10-8 mol L-l).
Conclusion: The present study suggests that combination of diclofenac, pitofenone and fenpiverinium may prove to be an effective antispasmodic formulation.
Publication Year: 1998
Publication Date: 1998-09-01
Language: en
Type: article
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Cited By Count: 5
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