Abstract: Several factors are important in determining the rate of progression of diabetic renal disease always starting from microalbuminuria (1), and elevated blood pressure (BP) seems to be a major factor, both in types 1 and 2 diabetes (1–3). This was confirmed in a new analysis in the follow-up studies of proteinuric patients conducted by Steno Diabetes Center (2,3). Although the prognosis for diabetic nephropathy has improved in the last two decades, it is clear that proteinuric patients still have a poor prognosis (1). For type 1 diabetes, this analysis (2) showed that elevated BP, glycemic control, and albuminuria were major factors in the progression. Serum cholesterol level also seemed to play some role. The rate of progression in patients with albuminuria and type 2 diabetes is quite similar (3), although it should be noted that patients with type 2 diabetes and proteinuria most often die from cardiovascular (CV) disease before progression to end-stage renal disease (ESRD), even more than patients with type 1 diabetes and albuminuria.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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