Title: Value of SPECT/CT for localizing lesions detected on indium-111 octreotide scintigraphy
Abstract: 1329 Objectives To determine the value of SPECT/CT for detecting and localizing lesions on 111In octreotide scintigraphy. Methods Forty-eight pts. (61±19 years; 44% males; 56% females) underwent SPECT/CT using an integrated SPECT/low energy CT system 24 hrs. after injection of 222 MBq of 111In-octreotide. SPECT data were acquired using medium energy collimators for 48 min, & reconstructed by iterative reconstruction, using a Butterworth filter with a cutoff = 0.7 and order = 10 and incorporating depth-dependent collimator resolution information. CT scans were acquired immediately after SPECT. SPECT and SPECT/CT were reviewed separately by 1 experienced individual. For both SPECT and SPECT/CT the reader scored the likelihood of a lesion and confidence of lesion location using 5-point scales. 78 sites were evaluated. Results There were 58 lesions. Lesions were located in the head/neck (1), chest (14), and abdomen/pelvis (43, including 26 hepatic). On SPECT, 55 of the lesions were positive. Thirteen sites were negative, and 7 were equivocal. The 58 lesions were positive on SPECT/CT, 20 sites were negative, and there were no equivocal SPECT/CT results. SPECT/CT was helpful in confirming normal physiological uptake and excluding disease in all 7 sites classified as equivocal on SPECT. SPECT/CT also was useful for more precisely localizing 45/55 (80%) lesions identified on SPECT. On a per patient basis, SPECT/CT was helpful in 50% of the cases. Conclusions For 111In-octreotide scintigraphy, SPECT/CT detects and/or localizes lesions more accurately than, and is superior to, SPECT alone.
Publication Year: 2009
Publication Date: 2009-05-01
Language: en
Type: article
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