Title: ~(99m)Tc-MIBI SPECT/CT diagnosis of primary hyperparathyroidism
Abstract: Objective To assess the value of SPECT/CT in diagnosing primary hyperparathyroidism (PHPT) with 99mTc-MIBI. Methods Dual-phase static planar acquisitions of the neck and chest after intravenous injection of 370-740 MBq of 99mTc-MIBI were performed immediately and 40 min later. SPECT/CT images were acquired 20 min after injection. Two experienced doctors independently interpreted the images and assessed whether the conventional SPECT would provide more information than planar images, and whether SPECT/CT was superior to planar images and conventional SPECT images. Biochemical markers of serum were also analyzed statistically. Results Compared with pathological results, the coincidence rate of planar imaging plus SPECT and planar imaging plus SPECT/CT to identify the diseased parathyroid gland was 86.96% in normal thyroid glands and 100% in multinodular glands, with a total coincidence of 91.30%. With the help of SPECT/CT, 1 case was changed from positive to negative and 3 cases were better located. SPECT/CT was obviously helpful in locating two ectopic parathyroid adenomas. No significant correlation was found between biochemical markers and image findings. Conclusion SPECT/CT has significant clinical value in locating lesions of PHPT.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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