Publication Information

{'id': 'https://openalex.org/W4388048170', 'doi': 'https://doi.org/10.1136/jitc-2023-sitc2023.0895', 'title': '895 Immunosuppressive signaling is activated in enzalutamide resistant prostate cancer', 'display_name': '895 Immunosuppressive signaling is activated in enzalutamide resistant prostate cancer', 'publication_year': 2023, 'publication_date': '2023-10-31', 'ids': {'openalex': 'https://openalex.org/W4388048170', 'doi': 'https://doi.org/10.1136/jitc-2023-sitc2023.0895'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/jitc-2023-sitc2023.0895', 'pdf_url': 'https://jitc.bmj.com/content/jitc/11/Suppl_1/996.full.pdf', 'source': {'id': 'https://openalex.org/S4363604233', 'display_name': 'Regular and Young Investigator Award Abstracts', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'proceedings-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://jitc.bmj.com/content/jitc/11/Suppl_1/996.full.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076559212', 'display_name': 'Pengfei Xu', 'orcid': 'https://orcid.org/0000-0002-9401-9487'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pengfei Xu', 'raw_affiliation_strings': ['University of California, Davis, Sacramento, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'University of California, Davis, Sacramento, CA, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086066594', 'display_name': 'Joy C. Yang', 'orcid': 'https://orcid.org/0000-0001-9162-481X'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joy C Yang', 'raw_affiliation_strings': ['University of California, Davis, Sacramento, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'University of California, Davis, Sacramento, CA, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100427402', 'display_name': 'Bo Chen', 'orcid': 'https://orcid.org/0000-0003-0812-5775'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bo Chen', 'raw_affiliation_strings': ['University of California, Davis, Sacramento, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'University of California, Davis, Sacramento, CA, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058947634', 'display_name': 'Christopher Nip', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher Nip', 'raw_affiliation_strings': ['University of California, Davis, Sacramento, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'University of California, Davis, Sacramento, CA, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101659600', 'display_name': 'Leyi Wang', 'orcid': 'https://orcid.org/0009-0008-7297-0643'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Leyi Wang', 'raw_affiliation_strings': ['University of California, Davis, Sacramento, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'University of California, Davis, Sacramento, CA, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075191225', 'display_name': 'Jonathan E. Van Dyke', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jonathan EVan Dyke', 'raw_affiliation_strings': ['University of California, Davis, Sacramento, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'University of California, Davis, Sacramento, CA, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088621070', 'display_name': 'Christopher P. Evans', 'orcid': 'https://orcid.org/0000-0001-5626-8901'}, 'institutions': [{'id': 'https://openalex.org/I4390039352', 'display_name': 'UC Davis Comprehensive Cancer Center', 'ror': 'https://ror.org/02kcc1z29', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160856', 'https://openalex.org/I4390039352']}, {'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher P Evans', 'raw_affiliation_strings': ['UC Davis Comprehensive Cancer Center, Sacramento, CA, USA', 'University of California, Davis, Sacramento, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'UC Davis Comprehensive Cancer Center, Sacramento, CA, USA', 'institution_ids': ['https://openalex.org/I4390039352', 'https://openalex.org/I84218800']}, {'raw_affiliation_string': 'University of California, Davis, Sacramento, CA, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042070203', 'display_name': 'William J. Murphy', 'orcid': 'https://orcid.org/0000-0002-2793-401X'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William Murphy', 'raw_affiliation_strings': ['University of California, Davis, Sacramento, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'University of California, Davis, Sacramento, CA, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101592945', 'display_name': 'Chengfei Liu', 'orcid': 'https://orcid.org/0000-0002-2452-8788'}, 'institutions': [{'id': 'https://openalex.org/I4390039352', 'display_name': 'UC Davis Comprehensive Cancer Center', 'ror': 'https://ror.org/02kcc1z29', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160856', 'https://openalex.org/I4390039352']}, {'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chengfei Liu', 'raw_affiliation_strings': ['UC Davis Comprehensive Cancer Center, Sacramento, CA, USA', 'University of California, Davis, Sacramento, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'UC Davis Comprehensive Cancer Center, Sacramento, CA, USA', 'institution_ids': ['https://openalex.org/I4390039352', 'https://openalex.org/I84218800']}, {'raw_affiliation_string': 'University of California, Davis, Sacramento, CA, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 67}, 'biblio': {'volume': None, 'issue': None, 'first_page': 'A996', 'last_page': 'A996'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy and Biomarkers', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/enzalutamide', 'display_name': 'Enzalutamide', 'score': 0.9795325}], 'concepts': [{'id': 'https://openalex.org/C2776551883', 'wikidata': 'https://www.wikidata.org/wiki/Q1996756', 'display_name': 'Enzalutamide', 'level': 5, 'score': 0.9795325}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8311589}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.7181487}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.55436635}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.5472819}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.43686628}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4209062}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41308102}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.41116905}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33935326}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3030123}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.28483355}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/jitc-2023-sitc2023.0895', 'pdf_url': 'https://jitc.bmj.com/content/jitc/11/Suppl_1/996.full.pdf', 'source': {'id': 'https://openalex.org/S4363604233', 'display_name': 'Regular and Young Investigator Award Abstracts', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1136/jitc-2023-sitc2023.0895', 'pdf_url': 'https://jitc.bmj.com/content/jitc/11/Suppl_1/996.full.pdf', 'source': {'id': 'https://openalex.org/S4363604233', 'display_name': 'Regular and Young Investigator Award Abstracts', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.87, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 4, 'referenced_works': ['https://openalex.org/W1582446028', 'https://openalex.org/W2463867199', 'https://openalex.org/W3127897162', 'https://openalex.org/W4205740972'], 'related_works': ['https://openalex.org/W3122236002', 'https://openalex.org/W3024577600', 'https://openalex.org/W3023935924', 'https://openalex.org/W2897595555', 'https://openalex.org/W2773216890', 'https://openalex.org/W2681186693', 'https://openalex.org/W2593283143', 'https://openalex.org/W2479406918', 'https://openalex.org/W1993338898', 'https://openalex.org/W1848444843'], 'abstract_inverted_index': {'<h3>Background</h3>': [0], 'Emerging': [1], 'data': [2, 177], 'suggested': [3], 'that': [4, 29], 'enzalutamide-treated': [5], 'prostate': [6, 47, 70, 80, 139, 304, 358, 403, 443, 578, 635], 'cancer': [7, 48, 71, 140, 305, 579], 'patients': [8, 44, 574], 'with': [9, 45, 269, 279, 502, 568, 575, 627, 673], 'increased': [10, 224, 251, 262], 'programmed': [11], 'death-ligand': [12], '1': [13], '(PD-L1)': [14], 'expression': [15, 84, 204, 233, 249], 'may': [16, 348], 'benefit': [17], 'from': [18, 290], 'anti-PD-L1': [19], 'treatment.<sup>1': [20], '2</sup>': [21], 'Unfortunately,': [22], 'the': [23, 30, 62, 74, 123, 176, 291, 310, 350, 662], 'Phase': [24, 508], 'III': [25, 564], 'IMbassador250': [26], 'trial': [27, 565], 'revealed': [28], 'combination': [31], 'of': [32, 64, 85, 115, 352, 438, 498, 669], 'atezolizumab': [33, 567], '(PD-L1': [34], 'inhibitor)': [35], 'and': [36, 72, 99, 122, 149, 159, 175, 192, 208, 231, 240, 247, 287, 331, 346, 376, 495, 666, 676], 'enzalutamide': [37, 68, 116, 127, 302, 569, 571, 628, 630], 'failed': [38], 'to': [39, 112, 126, 130, 293], 'extend': [40], 'overall': [41], 'survival': [42], 'in': [43, 67, 78, 137, 156, 198, 213, 234, 252, 263, 271, 301, 309, 342, 356, 365, 400, 441, 500, 573, 632], 'castration-resistant': [46, 577, 634], '(CRPC).<sup>3–5</sup>': [49], 'The': [50, 83, 134, 166, 337], 'mechanisms': [51, 136], 'underlying': [52], 'treatment': [53, 218], 'failure': [54], 'remain': [55], 'unknown.': [56], 'In': [57], 'this': [58], 'study,': [59], 'we': [60], 'investigated': [61], 'regulation': [63], 'immunosuppressive': [65, 328, 334], 'signaling': [66, 184, 243, 298], 'resistant': [69, 125, 303, 402], 'characterized': [73], 'immune': [75, 168, 241, 312, 353], 'infiltrating': [76], 'cells': [77, 108, 124, 141, 169, 278, 282], 'murine': [79, 235], 'tumors.': [81, 237, 274], '<h3>Methods</h3>': [82], 'interferon': [86], 'gamma-related': [87], 'genes': [88], 'was': [89, 205, 250, 363], 'determined': [90, 143, 171], 'using': [91, 104, 164, 180], 'qRT-PCR': [92], 'and/or': [93], 'western': [94], 'blotting.': [95], 'Androgen': [96], 'receptor': [97], '(AR)': [98], 'AR-V7': [100], 'levels': [101], 'were': [102, 109, 128, 142, 154, 162, 170, 178, 196, 245, 260, 659], 'downregulated': [103], 'specific': [105], 'siRNA.': [106], 'Myc-CaP': [107, 132, 148, 150, 236, 254, 264, 272, 280], 'chronically': [110], 'exposed': [111], 'increasing': [113], 'concentrations': [114], '(5–50': [117], 'μM)': [118], 'for': [119], '&gt;12': [120], 'months,': [121], 'referred': [129], 'as': [131], 'MDVR.': [133], 'gene-regulating': [135], 'drug-resistant': [138], 'by': [144, 172, 211, 318, 326, 367, 661], 'RNA': [145], 'sequencing': [146], 'analyses.': [147], 'MDVR': [151, 200, 215, 255, 265, 281], 'xenograft': [152], 'tumors': [153, 267], 'established': [155], 'FVB': [157], 'mice,': [158], 'tumor-infiltrating': [160], 'lymphocytes': [161], 'isolated': [163], 'Ficoll.': [165], 'stained': [167], 'flow': [173], 'cytometry,': [174], 'analyzed': [179], 'Flowjo.': [181], '<h3>Results</h3>': [182], 'Immune-related': [183], 'pathways': [185, 244], '(interferon': [186], 'alpha/gamma': [187], 'response,': [188], 'T': [189, 221, 343], 'cell': [190, 193, 222, 228, 329], 'activation,': [191], 'chemotaxis': [194, 239], 'pathways)': [195], 'suppressed': [197], 'C4–2B': [199, 214], 'cells.': [201, 216, 256, 306], 'However,': [202], 'PD-L1': [203, 232, 248, 396], 'highly': [206, 398], 'upregulated': [207], 'negatively': [209], 'regulated': [210], 'AR': [212], 'Enzalutamide': [217, 401], 'decreased': [219], 'CD8<sup>+</sup>': [220], 'but': [223], 'monocytic': [225], 'myeloid-derived': [226], 'suppressor': [227], '(M-MDSC)': [229], 'population': [230], 'Consistently,': [238], 'response-regulating': [242], 'suppressed,': [246], 'enzalutamide-resistant': [253, 319, 357, 442], 'Notably,': [257], 'MDSC': [258, 285], 'populations': [259], 'significantly': [261, 283], 'orthotopic': [266], 'compared': [268], 'those': [270], 'parental': [273], 'Co-culturing': [275], 'bone': [276], 'marrow': [277], 'promoted': [284, 316], 'differentiation': [286], 'polarized': [288], 'macrophages': [289, 347], 'M1': [292], 'M2': [294], 'phase.': [295], '<h3>Conclusions</h3>': [296], 'Immunosuppressive': [297, 307], 'is': [299, 397], 'dysregulated': [300], 'alterations': [308], 'tumor': [311, 335], 'microenvironment': [313], 'can': [314], 'be': [315], 'directly': [317], 'CRPC': [320], 'cells,': [321, 344], 'which': [322], 'promote': [323], 'self-immune': [324], 'evasion': [325], 'inducing': [327], 'infiltration': [330], 'forming': [332], 'an': [333], 'microenvironment.': [336], 'activated': [338], 'immune-related': [339], 'signatures': [340], 'involved': [341], 'MDSC,': [345], 'reduce': [349], 'efficacy': [351], 'checkpoint': [354], 'inhibitors': [355], 'cancer.': [359, 404, 444], '<h3>Acknowledgements</h3>': [360], 'This': [361], 'work': [362], 'supported': [364], 'part': [366], 'grants': [368], 'NIH/NCI': [369], 'R37CA249108': [370], '(C,': [371, 374, 379], 'Liu),': [372, 375], 'R01CA251253': [373], 'DoD': [377], 'HT94252310144': [378], 'Liu).': [380], '<h3>References</h3>': [381], 'Bishop': [382], 'JL,': [383], 'Sio': [384], 'A,': [385, 387, 619], 'Angeles': [386], 'Roberts': [388], 'ME,': [389], 'Azad': [390], 'AA,': [391], 'Chi': [392], 'KN,': [393], 'Zoubeidi': [394], 'A.': [395], 'expressed': [399], '<i>Oncotarget</i>.': [405, 445], '2015;<b>6</b>(1):234–42.': [406], 'doi:': [407, 449, 515, 647], '10.18632/oncotarget.2703.': [408], 'PubMed': [409, 451, 517, 649], 'PMID:': [410, 452, 518, 650], '25428917;': [411], 'PMCID:': [412, 454], '4381591.': [413], 'Graff': [414], 'JN,': [415], 'Alumkal': [416], 'JJ,': [417], 'Drake': [418, 597], 'CG,': [419, 598], 'Thomas': [420, 559], 'GV,': [421], 'Redmond': [422], 'WL,': [423], 'Farhad': [424], 'M,': [425, 473, 489], 'Cetnar': [426], 'JP,': [427, 471], 'Ey': [428], 'FS,': [429], 'Bergan': [430], 'RC,': [431], 'Slottke': [432], 'R,': [433], 'Beer': [434], 'TM.': [435], 'Early': [436], 'evidence': [437], 'anti-PD-1': [439], 'activity': [440], '2016;<b>7</b>(33):52810–7.': [446], 'Epub': [447, 645], '2016/07/19.': [448], '10.18632/oncotarget.10547.': [450], '27429197;': [453], 'PMC5288150.': [455], 'Petrylak': [456], 'DP,': [457], 'Loriot': [458], 'Y,': [459], 'Shaffer': [460], 'DR,': [461], 'Braiteh': [462], 'F,': [463], 'Powderly': [464], 'J,': [465], 'Harshman': [466], 'LC,': [467], 'Conkling': [468], 'P,': [469, 623], 'Delord': [470], 'Gordon': [472], 'Kim': [474], 'JW,': [475], 'Sarkar': [476], 'I,': [477], 'Yuen': [478, 587], 'K,': [479, 600], 'Kadel': [480, 591], 'EE,': [481, 592], 'Mariathasan': [482, 620], 'S,': [483, 487, 491, 524, 590, 621], "O'Hear": [484], 'C,': [485], 'Narayanan': [486], 'Fasso': [488], 'Carroll': [490], 'Powles': [492, 585], 'T.': [493], 'Safety': [494], 'Clinical': [496], 'Activity': [497], 'Atezolizumab': [499, 626], 'Patients': [501], 'Metastatic': [503], 'Castration-Resistant': [504], 'Prostate': [505], 'Cancer:': [506], 'A': [507, 562], 'I': [509], 'Study.': [510], '<i>Clin': [511], 'Cancer': [512], 'Res</i>.': [513], '2021;<b>27</b>(12):3360–9.': [514], '10.1158/1078-0432.CCR-20-1981.': [516], '33568344.': [519], 'Christopher': [520], 'J': [521, 537], 'Sweeney,': [522], 'Gillessen': [523, 589], 'Dana': [525], 'Rathkopf,': [526], 'Nobuaki': [527], 'Matsubara,': [528], 'Charles': [529], 'Drake,': [530], 'Karim': [531], 'Fizazi,': [532], 'Josep': [533], 'M': [534], 'Piulats,': [535], 'Piotr': [536], 'Wysocki,': [538], 'Gary': [539], 'L': [540], 'Buchschacher,': [541], 'Jennifer': [542], 'Doss,': [543], 'Sanjeev': [544], 'Mariathasan,': [545], 'Edward': [546], 'E': [547], 'Kadel,': [548], 'Kobe': [549], 'Yuen,': [550], 'Asim': [551], 'Datye,': [552], 'Grozdana': [553], 'Rasuo,': [554], 'Darren': [555], 'Tayama,': [556], 'Patrick': [557], 'Williams,': [558], 'Powles.': [560], 'IMbassador250:': [561], 'phase': [563, 639], 'comparing': [566], 'vs': [570], 'alone': [572, 631], 'metastatic': [576, 633], '(mCRPC).': [580], '<i>Cancer': [581], 'Research</i>.': [582], '2020;DOI:': [583], '10.1158/1538-7445.AM2020-CT014.': [584], 'T,': [586], 'KC,': [588], 'Rathkopf': [593], 'D,': [594], 'Matsubara': [595], 'N,': [596], 'Fizazi': [599], 'Piulats': [601], 'JM,': [602], 'Wysocki': [603], 'PJ,': [604], 'Buchschacher': [605], 'GL,': [606], 'Jr.,': [607], 'Alekseev': [608], 'B,': [609, 611, 613], 'Mellado': [610], 'Karaszewska': [612], 'Doss': [614], 'JF,': [615], 'Rasuo': [616], 'G,': [617], 'Datye': [618], 'Williams': [622], 'Sweeney': [624], 'CJ.': [625], 'versus': [629], 'cancer:': [636], 'a': [637], 'randomized': [638], '3': [640], 'trial.': [641], '<i>Nat': [642], 'Med</i>.': [643], '2022;<b>28</b>(1):144–53.': [644], '2022/01/12.': [646], '10.1038/s41591-021-01600-6.': [648], '35013615.': [651], '<h3>Ethics': [652], 'Approval</h3>': [653], 'All': [654], 'experimental': [655], 'procedures': [656], 'involving': [657], 'animals': [658], 'approved': [660], 'Institutional': [663], 'Animal': [664], 'Care': [665], 'Use': [667], 'Committee': [668], 'UC': [670], 'Davis': [671], 'complied': [672], 'ethical': [674], 'regulations': [675], 'humane': [677], 'endpoints.': [678]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4388048170', 'counts_by_year': [], 'updated_date': '2025-01-04T09:06:21.210452', 'created_date': '2023-11-01'}