rRNA transcription is integral to phase separation and maintenance of nucleolar structure

Name: Work Video:
Duration: 3 min 30 s
Soma Dash; Maureen C. Lamb; Jeffrey J. Lange; Mary Cathleen McKinney; Dai Tsuchiya; Fengli Guo; Xia Zhao; Timothy J. Corbin; MaryEllen Kirkman; Kym Delventhal; Emma L. Moore; Sean McKinney; Rita Shiang; Paul A. Trainor
{'id': 'https://openalex.org/W4386212879', 'doi': 'https://doi.org/10.1371/journal.pgen.1010854', 'title': 'rRNA transcription is integral to phase separation and maintenance of nucleolar structure', 'display_name': 'rRNA transcription is integral to phase separation and maintenance of nucleolar structure', 'publication_year': 2023, 'publication_date': '2023-08-28', 'ids': {'openalex': 'https://openalex.org/W4386212879', 'doi': 'https://doi.org/10.1371/journal.pgen.1010854', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37639467'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pgen.1010854', 'pdf_url': 'https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010854&type=printable', 'source': {'id': 'https://openalex.org/S103870658', 'display_name': 'PLoS Genetics', 'issn_l': '1553-7390', 'issn': ['1553-7390', '1553-7404'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010854&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049527564', 'display_name': 'Soma Dash', 'orcid': 'https://orcid.org/0000-0002-9030-3341'}, 'institutions': [{'id': 'https://openalex.org/I114131015', 'display_name': 'Stowers Institute for Medical Research', 'ror': 'https://ror.org/04bgfm609', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I114131015']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Soma Dash', 'raw_affiliation_strings': ['Stowers Institute for Medical Research, Kansas City, Missouri, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America', 'institution_ids': ['https://openalex.org/I114131015']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025911801', 'display_name': 'Maureen C. Lamb', 'orcid': 'https://orcid.org/0000-0002-4522-1910'}, 'institutions': [{'id': 'https://openalex.org/I114131015', 'display_name': 'Stowers Institute for Medical Research', 'ror': 'https://ror.org/04bgfm609', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I114131015']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Maureen C. Lamb', 'raw_affiliation_strings': ['Stowers Institute for Medical Research, Kansas City, Missouri, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America', 'institution_ids': ['https://openalex.org/I114131015']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074105995', 'display_name': 'Jeffrey J. Lange', 'orcid': 'https://orcid.org/0000-0003-4970-6269'}, 'institutions': [{'id': 'https://openalex.org/I114131015', 'display_name': 'Stowers Institute for Medical Research', 'ror': 'https://ror.org/04bgfm609', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I114131015']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Jeffrey J. Lange', 'raw_affiliation_strings': ['Stowers Institute for Medical Research, Kansas City, Missouri, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America', 'institution_ids': ['https://openalex.org/I114131015']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077568567', 'display_name': 'Mary Cathleen McKinney', 'orcid': 'https://orcid.org/0000-0002-6819-1419'}, 'institutions': [{'id': 'https://openalex.org/I114131015', 'display_name': 'Stowers Institute for Medical Research', 'ror': 'https://ror.org/04bgfm609', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I114131015']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Mary C. McKinney', 'raw_affiliation_strings': ['Stowers Institute for Medical Research, Kansas City, Missouri, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America', 'institution_ids': ['https://openalex.org/I114131015']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047966510', 'display_name': 'Dai Tsuchiya', 'orcid': 'https://orcid.org/0000-0001-8385-2775'}, 'institutions': [{'id': 'https://openalex.org/I114131015', 'display_name': 'Stowers Institute for Medical Research', 'ror': 'https://ror.org/04bgfm609', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I114131015']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Dai Tsuchiya', 'raw_affiliation_strings': ['Stowers Institute for Medical Research, Kansas City, Missouri, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America', 'institution_ids': ['https://openalex.org/I114131015']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108761364', 'display_name': 'Fengli Guo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114131015', 'display_name': 'Stowers Institute for Medical Research', 'ror': 'https://ror.org/04bgfm609', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I114131015']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Fengli Guo', 'raw_affiliation_strings': ['Stowers Institute for Medical Research, Kansas City, Missouri, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America', 'institution_ids': ['https://openalex.org/I114131015']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060775825', 'display_name': 'Xia Zhao', 'orcid': 'https://orcid.org/0000-0002-2751-7160'}, 'institutions': [{'id': 'https://openalex.org/I114131015', 'display_name': 'Stowers Institute for Medical Research', 'ror': 'https://ror.org/04bgfm609', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I114131015']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Xia Zhao', 'raw_affiliation_strings': ['Stowers Institute for Medical Research, Kansas City, Missouri, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America', 'institution_ids': ['https://openalex.org/I114131015']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022889065', 'display_name': 'Timothy J. Corbin', 'orcid': 'https://orcid.org/0009-0008-6850-6805'}, 'institutions': [{'id': 'https://openalex.org/I114131015', 'display_name': 'Stowers Institute for Medical Research', 'ror': 'https://ror.org/04bgfm609', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I114131015']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Timothy J. Corbin', 'raw_affiliation_strings': ['Stowers Institute for Medical Research, Kansas City, Missouri, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America', 'institution_ids': ['https://openalex.org/I114131015']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065721608', 'display_name': 'MaryEllen Kirkman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114131015', 'display_name': 'Stowers Institute for Medical Research', 'ror': 'https://ror.org/04bgfm609', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I114131015']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'MaryEllen Kirkman', 'raw_affiliation_strings': ['Stowers Institute for Medical Research, Kansas City, Missouri, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America', 'institution_ids': ['https://openalex.org/I114131015']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022492688', 'display_name': 'Kym Delventhal', 'orcid': 'https://orcid.org/0000-0003-0505-9792'}, 'institutions': [{'id': 'https://openalex.org/I114131015', 'display_name': 'Stowers Institute for Medical Research', 'ror': 'https://ror.org/04bgfm609', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I114131015']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Kym Delventhal', 'raw_affiliation_strings': ['Stowers Institute for Medical Research, Kansas City, Missouri, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America', 'institution_ids': ['https://openalex.org/I114131015']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026439888', 'display_name': 'Emma L. Moore', 'orcid': 'https://orcid.org/0000-0003-4116-918X'}, 'institutions': [{'id': 'https://openalex.org/I114131015', 'display_name': 'Stowers Institute for Medical Research', 'ror': 'https://ror.org/04bgfm609', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I114131015']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Emma L. Moore', 'raw_affiliation_strings': ['Stowers Institute for Medical Research, Kansas City, Missouri, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America', 'institution_ids': ['https://openalex.org/I114131015']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061020885', 'display_name': 'Sean McKinney', 'orcid': 'https://orcid.org/0000-0002-9740-6247'}, 'institutions': [{'id': 'https://openalex.org/I114131015', 'display_name': 'Stowers Institute for Medical Research', 'ror': 'https://ror.org/04bgfm609', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I114131015']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Sean McKinney', 'raw_affiliation_strings': ['Stowers Institute for Medical Research, Kansas City, Missouri, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America', 'institution_ids': ['https://openalex.org/I114131015']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008345879', 'display_name': 'Rita Shiang', 'orcid': 'https://orcid.org/0000-0001-6575-0126'}, 'institutions': [{'id': 'https://openalex.org/I184840846', 'display_name': 'Virginia Commonwealth University', 'ror': 'https://ror.org/02nkdxk79', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I184840846']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Rita Shiang', 'raw_affiliation_strings': ['Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America', 'institution_ids': ['https://openalex.org/I184840846']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013638813', 'display_name': 'Paul A. Trainor', 'orcid': 'https://orcid.org/0000-0003-2774-3624'}, 'institutions': [{'id': 'https://openalex.org/I114131015', 'display_name': 'Stowers Institute for Medical Research', 'ror': 'https://ror.org/04bgfm609', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I114131015']}, {'id': 'https://openalex.org/I4210128618', 'display_name': 'University of Kansas Medical Center', 'ror': 'https://ror.org/036c9yv20', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128618']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Paul A. Trainor', 'raw_affiliation_strings': ['Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America', 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Stowers Institute for Medical Research, Kansas City, Missouri, United States of America', 'institution_ids': ['https://openalex.org/I114131015']}, {'raw_affiliation_string': 'Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, United States of America', 'institution_ids': ['https://openalex.org/I4210128618']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5049527564', 'https://openalex.org/A5025911801', 'https://openalex.org/A5074105995', 'https://openalex.org/A5077568567', 'https://openalex.org/A5047966510', 'https://openalex.org/A5108761364', 'https://openalex.org/A5060775825', 'https://openalex.org/A5022889065', 'https://openalex.org/A5065721608', 'https://openalex.org/A5022492688', 'https://openalex.org/A5026439888', 'https://openalex.org/A5061020885', 'https://openalex.org/A5008345879', 'https://openalex.org/A5013638813'], 'corresponding_institution_ids': ['https://openalex.org/I114131015', 'https://openalex.org/I114131015', 'https://openalex.org/I114131015', 'https://openalex.org/I114131015', 'https://openalex.org/I114131015', 'https://openalex.org/I114131015', 'https://openalex.org/I114131015', 'https://openalex.org/I114131015', 'https://openalex.org/I114131015', 'https://openalex.org/I114131015', 'https://openalex.org/I114131015', 'https://openalex.org/I114131015', 'https://openalex.org/I184840846', 'https://openalex.org/I114131015', 'https://openalex.org/I4210128618'], 'apc_list': {'value': 2655, 'currency': 'USD', 'value_usd': 2655, 'provenance': 'doaj'}, 'apc_paid': {'value': 2655, 'currency': 'USD', 'value_usd': 2655, 'provenance': 'doaj'}, 'fwci': 1.822, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.99998, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '19', 'issue': '8', 'first_page': 'e1010854', 'last_page': 'e1010854'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ribosome-biogenesis', 'display_name': 'ribosome biogenesis', 'score': 0.922865}, {'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription', 'score': 0.61897564}, {'id': 'https://openalex.org/keywords/rna-polymerase-i', 'display_name': 'RNA polymerase I', 'score': 0.61668384}, {'id': 'https://openalex.org/keywords/rna-polymerase-iii', 'display_name': 'RNA polymerase III', 'score': 0.42281973}], 'concepts': [{'id': 'https://openalex.org/C183873130', 'wikidata': 'https://www.wikidata.org/wiki/Q30869', 'display_name': 'Nucleolus', 'level': 3, 'score': 0.9653647}, {'id': 'https://openalex.org/C2779419633', 'wikidata': 'https://www.wikidata.org/wiki/Q7322423', 'display_name': 'Ribosome biogenesis', 'level': 5, 'score': 0.922865}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7705828}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.61897564}, {'id': 'https://openalex.org/C25281209', 'wikidata': 'https://www.wikidata.org/wiki/Q3502188', 'display_name': 'RNA polymerase I', 'level': 5, 'score': 0.61668384}, {'id': 'https://openalex.org/C67905577', 'wikidata': 'https://www.wikidata.org/wiki/Q215980', 'display_name': 'Ribosomal RNA', 'level': 3, 'score': 0.5477995}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.54474795}, {'id': 'https://openalex.org/C88478588', 'wikidata': 'https://www.wikidata.org/wiki/Q42244', 'display_name': 'Ribosome', 'level': 4, 'score': 0.51316243}, {'id': 'https://openalex.org/C184604658', 'wikidata': 'https://www.wikidata.org/wiki/Q968963', 'display_name': 'Nucleolus organizer region', 'level': 4, 'score': 0.47778973}, {'id': 'https://openalex.org/C70916841', 'wikidata': 'https://www.wikidata.org/wiki/Q3501658', 'display_name': 'RNA polymerase III', 'level': 5, 'score': 0.42281973}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.41923645}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3305611}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3092726}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.18615344}, {'id': 'https://openalex.org/C2776449523', 'wikidata': 'https://www.wikidata.org/wiki/Q272631', 'display_name': 'RNA polymerase', 'level': 4, 'score': 0.17314768}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.08526087}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002466', 'descriptor_name': 'Cell Nucleolus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D048750', 'descriptor_name': 'Cell Nucleus Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002466', 'descriptor_name': 'Cell Nucleolus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012318', 'descriptor_name': 'RNA Polymerase I', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012318', 'descriptor_name': 'RNA Polymerase I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012335', 'descriptor_name': 'RNA, Ribosomal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012335', 'descriptor_name': 'RNA, Ribosomal', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pgen.1010854', 'pdf_url': 'https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010854&type=printable', 'source': {'id': 'https://openalex.org/S103870658', 'display_name': 'PLoS Genetics', 'issn_l': '1553-7390', 'issn': ['1553-7390', '1553-7404'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10513380', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37639467', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pgen.1010854', 'pdf_url': 'https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010854&type=printable', 'source': {'id': 'https://openalex.org/S103870658', 'display_name': 'PLoS Genetics', 'issn_l': '1553-7390', 'issn': ['1553-7390', '1553-7404'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.58, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320310084', 'funder_display_name': 'Stowers Institute for Medical Research', 'award_id': '1008'}, {'funder': 'https://openalex.org/F4320316270', 'funder_display_name': 'American Association for Anatomy', 'award_id': '2021'}, {'funder': 'https://openalex.org/F4320337365', 'funder_display_name': 'National Institute of Dental and Craniofacial Research', 'award_id': 'R01 (DE13172)'}], 'datasets': [], 'versions': [], 'referenced_works_count': 102, 'referenced_works': ['https://openalex.org/W1531154876', 'https://openalex.org/W1547988901', 'https://openalex.org/W1895074262', 'https://openalex.org/W1963175326', 'https://openalex.org/W1965184827', 'https://openalex.org/W1966242253', 'https://openalex.org/W1970540591', 'https://openalex.org/W1978652855', 'https://openalex.org/W1978859977', 'https://openalex.org/W1980652053', 'https://openalex.org/W1980847733', 'https://openalex.org/W1983799614', 'https://openalex.org/W1984990382', 'https://openalex.org/W1990149668', 'https://openalex.org/W1994840640', 'https://openalex.org/W2003047104', 'https://openalex.org/W2006095009', 'https://openalex.org/W2008407125', 'https://openalex.org/W2014793949', 'https://openalex.org/W2022056903', 'https://openalex.org/W2024368545', 'https://openalex.org/W2026226960', 'https://openalex.org/W2031066426', 'https://openalex.org/W2031234106', 'https://openalex.org/W2033742799', 'https://openalex.org/W2034751313', 'https://openalex.org/W2037885180', 'https://openalex.org/W2040483206', 'https://openalex.org/W2054217952', 'https://openalex.org/W2058144279', 'https://openalex.org/W2062060771', 'https://openalex.org/W2065811810', 'https://openalex.org/W2069359878', 'https://openalex.org/W2077416416', 'https://openalex.org/W2084104969', 'https://openalex.org/W2084929037', 'https://openalex.org/W2085643090', 'https://openalex.org/W2089536182', 'https://openalex.org/W2095683355', 'https://openalex.org/W2103028847', 'https://openalex.org/W2103245284', 'https://openalex.org/W2119603106', 'https://openalex.org/W2138473958', 'https://openalex.org/W2143528844', 'https://openalex.org/W2146609854', 'https://openalex.org/W2151602082', 'https://openalex.org/W2153058771', 'https://openalex.org/W2167279371', 'https://openalex.org/W2167949249', 'https://openalex.org/W2217402320', 'https://openalex.org/W2247783571', 'https://openalex.org/W2255386862', 'https://openalex.org/W2402791934', 'https://openalex.org/W2476085369', 'https://openalex.org/W2498961155', 'https://openalex.org/W2508618197', 'https://openalex.org/W2560684820', 'https://openalex.org/W2612118981', 'https://openalex.org/W2713865210', 'https://openalex.org/W2734388176', 'https://openalex.org/W2753494561', 'https://openalex.org/W2766174495', 'https://openalex.org/W2778131996', 'https://openalex.org/W2786044533', 'https://openalex.org/W2788908723', 'https://openalex.org/W2790446628', 'https://openalex.org/W2802725533', 'https://openalex.org/W2803484355', 'https://openalex.org/W2806793653', 'https://openalex.org/W2887039385', 'https://openalex.org/W2898560457', 'https://openalex.org/W2903238489', 'https://openalex.org/W2904691429', 'https://openalex.org/W2908528290', 'https://openalex.org/W2921860932', 'https://openalex.org/W2922484113', 'https://openalex.org/W2926186183', 'https://openalex.org/W2941675075', 'https://openalex.org/W2949478542', 'https://openalex.org/W2964154812', 'https://openalex.org/W2964278177', 'https://openalex.org/W2965754337', 'https://openalex.org/W2966973269', 'https://openalex.org/W2970894940', 'https://openalex.org/W2973637866', 'https://openalex.org/W2981668195', 'https://openalex.org/W2982878894', 'https://openalex.org/W3009101585', 'https://openalex.org/W3023602638', 'https://openalex.org/W3046957326', 'https://openalex.org/W3082518512', 'https://openalex.org/W3092062500', 'https://openalex.org/W3093358877', 'https://openalex.org/W3094920154', 'https://openalex.org/W3139993593', 'https://openalex.org/W3173430012', 'https://openalex.org/W4205339332', 'https://openalex.org/W4226159395', 'https://openalex.org/W4231439871', 'https://openalex.org/W4288036132', 'https://openalex.org/W4366267823', 'https://openalex.org/W81758297'], 'related_works': ['https://openalex.org/W4386212879', 'https://openalex.org/W4309401091', 'https://openalex.org/W4236515226', 'https://openalex.org/W4200587745', 'https://openalex.org/W2946746091', 'https://openalex.org/W2802948734', 'https://openalex.org/W2606311860', 'https://openalex.org/W2462973229', 'https://openalex.org/W2413249070', 'https://openalex.org/W1485401273'], 'abstract_inverted_index': {'Transcription': [0], 'of': [1, 28, 62, 110, 120, 140, 177, 181, 206, 211, 245], 'ribosomal': [2], 'RNA': [3, 6], '(rRNA)': [4], 'by': [5, 115], 'Polymerase': [7], '(Pol)': [8], 'I': [9, 76, 142, 168, 226], 'in': [10, 32, 38, 42, 59, 74, 107, 118, 128, 133, 143, 151, 155, 242], 'the': [11, 60, 108, 175, 178, 182, 204, 212, 243], 'nucleolus': [12, 159, 183, 213], 'is': [13, 19, 173], 'necessary': [14], 'for': [15, 79, 233], 'ribosome': [16, 29, 50, 83], 'biogenesis,': [17], 'which': [18, 131, 185], 'intimately': [20], 'tied': [21], 'to': [22, 86, 192], 'cell': [23, 200], 'growth': [24], 'and': [25, 49, 58, 82, 101, 124, 145, 170, 214, 228, 237, 241], 'proliferation.': [26], 'Perturbation': [27], 'biogenesis': [30, 51, 84], 'results': [31, 132, 154], 'tissue': [33], 'specific': [34], 'disorders': [35], 'termed': [36], 'ribosomopathies': [37], 'association': [39], 'with': [40], 'alterations': [41], 'nucleolar': [43, 53, 121, 129, 235], 'structure.': [44], 'However,': [45, 197], 'how': [46], 'rRNA': [47, 80, 171, 207, 229], 'transcription': [48, 81, 172, 208, 230], 'regulate': [52], 'structure': [54, 109, 236], 'during': [55, 239], 'normal': [56], 'development': [57, 240], 'pathogenesis': [61, 244], 'disease': [63], 'remains': [64], 'poorly': [65], 'understood.': [66], 'Here': [67], 'we': [68, 90], 'show': [69], 'that': [70, 92, 165, 224], 'homozygous': [71], 'null': [72], 'mutations': [73], 'Pol': [75, 141, 167, 225], 'subunits': [77], 'required': [78, 232], 'lead': [85], 'preimplantation': [87, 144], 'lethality.': [88], 'Moreover,': [89], 'discovered': [91], 'Polr1a': [93], '-/-': [94, 97, 100, 103], ',': [95, 98], 'Polr1b': [96], 'Polr1c': [99], 'Polr1d': [102], 'mutants': [104], 'exhibit': [105], 'defects': [106], 'their': [111], 'nucleoli,': [112], 'as': [113, 148, 150, 216], 'evidenced': [114], 'a': [116, 125, 134, 156, 193, 199], 'decrease': [117], 'number': [119], 'precursor': [122], 'bodies': [123], 'concomitant': [126], 'increase': [127], 'volume,': [130], 'single': [135, 157, 194], 'condensed': [136, 158, 195], 'nucleolus.': [137, 196], 'Pharmacological': [138], 'inhibition': [139], 'midgestation': [146], 'embryos,': [147], 'well': [149], 'hiPSCs,': [152], 'similarly': [153], 'or': [160], 'fragmented': [161, 217], 'nucleoli.': [162, 218], 'We': [163], 'find': [164], 'when': [166], 'function': [169, 227], 'inhibited,': [174], 'viscosity': [176], 'granular': [179], 'compartment': [180], 'increases,': [184], 'disrupts': [186], 'its': [187], 'phase': [188], 'separation': [189], 'properties,': [190], 'leading': [191], 'if': [198], 'progresses': [201], 'through': [202], 'mitosis,': [203], 'absence': [205], 'prevents': [209], 'reassembly': [210], 'manifests': [215], 'Taken': [219], 'together,': [220], 'our': [221], 'data': [222], 'suggests': [223], 'are': [231], 'maintaining': [234], 'integrity': [238], 'disease.': [246]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4386212879', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 2}], 'updated_date': '2024-12-25T12:27:03.625731', 'created_date': '2023-08-29'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
