rRNA transcription is integral to liquid-liquid phase separation and maintenance of nucleolar structure

Name: Work Video:
Duration: 3 min 30 s
Soma Dash; Maureen C. Lamb; Jeffrey J. Lange; Mary Cathleen McKinney; Dai Tsuchiya; Fengli Guo; Xia Zhao; Timothy J. Corbin; MaryEllen Kirkman; Kym Delventhal; Emma L. Moore; Sean McKinney; Rita Shiang; Paul A. Trainor
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'transcription': [3, 63, 107, 144], 'of': [4, 27, 49, 112, 116], 'ribosomal': [5], 'RNA': [6, 9], '(rRNA)': [7], 'by': [8], 'Polymerase': [10], '(Pol)': [11], 'I': [12, 51, 68, 93, 140], 'in': [13, 129], 'the': [14, 39, 83, 110, 113, 117], 'nucleolus,': [15, 98], 'ribosome': [16, 28, 65], 'biogenesis': [17, 29], 'is': [18, 42, 108, 119], 'intimately': [19], 'tied': [20], 'to': [21, 34], 'cell': [22], 'growth': [23], 'and': [24, 56, 64, 74, 99, 142, 151], 'proliferation.': [25], 'Perturbation': [26], 'has': [30], 'been': [31], 'previously': [32], 'shown': [33], 'affect': [35], 'nucleolar': [36, 85, 149], 'structure,': [37], 'yet': [38], 'underlying': [40], 'mechanism': [41], 'unknown.': [43], 'We': [44, 102], 'generated': [45], 'loss-of-function': [46], 'mouse': [47], 'mutants': [48], 'Pol': [50, 67, 92, 139], 'subunits,': [52], 'Polr1a,': [53], 'Polr1b,': [54], 'Polr1c': [55], 'Polr1d': [57], ',': [58], 'thereby': [59], 'genetically': [60], 'inhibiting': [61], 'rRNA': [62, 106, 143], 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