Publication Information

{'id': 'https://openalex.org/W4376113189', 'doi': 'https://doi.org/10.1158/1535-7163.mct-22-0564', 'title': 'Identification of 2′,4′,6′-Trihydroxyacetophenone as Promising Cysteine Conjugate Beta-Lyase Inhibitor for Preventing Cisplatin-Induced Nephrotoxicity', 'display_name': 'Identification of 2′,4′,6′-Trihydroxyacetophenone as Promising Cysteine Conjugate Beta-Lyase Inhibitor for Preventing Cisplatin-Induced Nephrotoxicity', 'publication_year': 2023, 'publication_date': '2023-05-10', 'ids': {'openalex': 'https://openalex.org/W4376113189', 'doi': 'https://doi.org/10.1158/1535-7163.mct-22-0564', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37163384'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-22-0564', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://aacr.figshare.com/articles/journal_contribution/Figure_S1_from_Identification_of_2_4_6_-Trihydroxyacetophenone_as_Promising_Cysteine_Conjugate_Beta-Lyase_Inhibitor_for_Preventing_Cisplatin-Induced_Nephrotoxicity/23473212/1/files/41181558.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5092122180', 'display_name': 'Nao Sukeda', 'orcid': 'https://orcid.org/0009-0005-8899-4015'}, 'institutions': [{'id': 'https://openalex.org/I145673806', 'display_name': 'Fujita Health University', 'ror': 'https://ror.org/046f6cx68', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I145673806']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Nao Sukeda', 'raw_affiliation_strings': ['1Department of Advanced Diagnostic System Development, Fujita Health University Graduate School of Health Sciences, Aichi, Japan.'], 'affiliations': [{'raw_affiliation_string': '1Department of Advanced Diagnostic System Development, Fujita Health University Graduate School of Health Sciences, Aichi, Japan.', 'institution_ids': ['https://openalex.org/I145673806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074210193', 'display_name': 'Hidetsugu Fujigaki', 'orcid': 'https://orcid.org/0000-0001-9655-1074'}, 'institutions': [{'id': 'https://openalex.org/I145673806', 'display_name': 'Fujita Health University', 'ror': 'https://ror.org/046f6cx68', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I145673806']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hidetsugu Fujigaki', 'raw_affiliation_strings': ['1Department of Advanced Diagnostic System Development, Fujita Health University Graduate School of Health Sciences, Aichi, Japan.'], 'affiliations': [{'raw_affiliation_string': '1Department of Advanced Diagnostic System Development, Fujita Health University Graduate School of Health Sciences, Aichi, Japan.', 'institution_ids': ['https://openalex.org/I145673806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045962218', 'display_name': 'Tatsuya Ando', 'orcid': 'https://orcid.org/0000-0003-2274-5807'}, 'institutions': [{'id': 'https://openalex.org/I145673806', 'display_name': 'Fujita Health University', 'ror': 'https://ror.org/046f6cx68', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I145673806']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tatsuya Ando', 'raw_affiliation_strings': ['2Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University School of Medicine, Aichi, Japan.'], 'affiliations': [{'raw_affiliation_string': '2Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University School of Medicine, Aichi, Japan.', 'institution_ids': ['https://openalex.org/I145673806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044373635', 'display_name': 'Honomi Ando', 'orcid': 'https://orcid.org/0009-0002-9253-209X'}, 'institutions': [{'id': 'https://openalex.org/I145673806', 'display_name': 'Fujita Health University', 'ror': 'https://ror.org/046f6cx68', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I145673806']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Honomi Ando', 'raw_affiliation_strings': ['1Department of Advanced Diagnostic System Development, Fujita Health University Graduate School of Health Sciences, Aichi, Japan.'], 'affiliations': [{'raw_affiliation_string': '1Department of Advanced Diagnostic System Development, Fujita Health University Graduate School of Health Sciences, Aichi, Japan.', 'institution_ids': ['https://openalex.org/I145673806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101504209', 'display_name': 'Yasuko Yamamoto', 'orcid': 'https://orcid.org/0000-0001-8825-9188'}, 'institutions': [{'id': 'https://openalex.org/I145673806', 'display_name': 'Fujita Health University', 'ror': 'https://ror.org/046f6cx68', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I145673806']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasuko Yamamoto', 'raw_affiliation_strings': ['1Department of Advanced Diagnostic System Development, Fujita Health University Graduate School of Health Sciences, Aichi, Japan.'], 'affiliations': [{'raw_affiliation_string': '1Department of Advanced Diagnostic System Development, Fujita Health University Graduate School of Health Sciences, Aichi, Japan.', 'institution_ids': ['https://openalex.org/I145673806']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101463445', 'display_name': 'Kuniaki Saito', 'orcid': 'https://orcid.org/0000-0001-5800-9305'}, 'institutions': [{'id': 'https://openalex.org/I145673806', 'display_name': 'Fujita Health University', 'ror': 'https://ror.org/046f6cx68', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I145673806']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kuniaki Saito', 'raw_affiliation_strings': ['1Department of Advanced Diagnostic System Development, Fujita Health University Graduate School of Health Sciences, Aichi, Japan.'], 'affiliations': [{'raw_affiliation_string': '1Department of Advanced Diagnostic System Development, Fujita Health University Graduate School of Health Sciences, Aichi, Japan.', 'institution_ids': ['https://openalex.org/I145673806']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.149, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.66009, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 84}, 'biblio': {'volume': '22', 'issue': '7', 'first_page': '873', 'last_page': '881'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12429', 'display_name': 'Chemotherapy-induced organ toxicity mitigation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12429', 'display_name': 'Chemotherapy-induced organ toxicity mitigation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10950', 'display_name': 'Acute Lymphoblastic Leukemia research', 'score': 0.9741, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T14415', 'display_name': 'Biomedical Research and Pathophysiology', 'score': 0.97, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nephrotoxicity', 'display_name': 'Nephrotoxicity', 'score': 0.95518017}, {'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.48792478}], 'concepts': [{'id': 'https://openalex.org/C126189478', 'wikidata': 'https://www.wikidata.org/wiki/Q1468324', 'display_name': 'Nephrotoxicity', 'level': 3, 'score': 0.95518017}, {'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.94315594}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.6939323}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.614279}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.48792478}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.47250497}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.46520525}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.45470434}, {'id': 'https://openalex.org/C2780306776', 'wikidata': 'https://www.wikidata.org/wiki/Q426660', 'display_name': 'Creatinine', 'level': 2, 'score': 0.42734236}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.38810834}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.32933462}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.31372523}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.30439937}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.2845261}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.25862068}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.1495879}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 8, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.mct-22-0564', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.23473212', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Figure_S1_from_Identification_of_2_4_6_-Trihydroxyacetophenone_as_Promising_Cysteine_Conjugate_Beta-Lyase_Inhibitor_for_Preventing_Cisplatin-Induced_Nephrotoxicity/23473212/1/files/41181558.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.23627275', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Figure_S1_from_Identification_of_2_4_6_-Trihydroxyacetophenone_as_Promising_Cysteine_Conjugate_Beta-Lyase_Inhibitor_for_Preventing_Cisplatin-Induced_Nephrotoxicity/23627275/1/files/41457997.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.23473209', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Figure_S2_from_Identification_of_2_4_6_-Trihydroxyacetophenone_as_Promising_Cysteine_Conjugate_Beta-Lyase_Inhibitor_for_Preventing_Cisplatin-Induced_Nephrotoxicity/23473209/1/files/41181552.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.23627272', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Figure_S2_from_Identification_of_2_4_6_-Trihydroxyacetophenone_as_Promising_Cysteine_Conjugate_Beta-Lyase_Inhibitor_for_Preventing_Cisplatin-Induced_Nephrotoxicity/23627272/1/files/41457994.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.23473206', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Figure_S3_from_Identification_of_2_4_6_-Trihydroxyacetophenone_as_Promising_Cysteine_Conjugate_Beta-Lyase_Inhibitor_for_Preventing_Cisplatin-Induced_Nephrotoxicity/23473206/1/files/41181549.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.23627269', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Figure_S3_from_Identification_of_2_4_6_-Trihydroxyacetophenone_as_Promising_Cysteine_Conjugate_Beta-Lyase_Inhibitor_for_Preventing_Cisplatin-Induced_Nephrotoxicity/23627269/1/files/41457991.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37163384', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.23473212', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Figure_S1_from_Identification_of_2_4_6_-Trihydroxyacetophenone_as_Promising_Cysteine_Conjugate_Beta-Lyase_Inhibitor_for_Preventing_Cisplatin-Induced_Nephrotoxicity/23473212/1/files/41181558.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.81, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320334764', 'funder_display_name': 'Japan Society for the Promotion of Science', 'award_id': '20K05757'}], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1651420115', 'https://openalex.org/W1982768697', 'https://openalex.org/W1987604182', 'https://openalex.org/W1989971260', 'https://openalex.org/W1997046377', 'https://openalex.org/W2014134598', 'https://openalex.org/W2017694968', 'https://openalex.org/W2028145669', 'https://openalex.org/W2030906673', 'https://openalex.org/W2035015964', 'https://openalex.org/W2061082542', 'https://openalex.org/W2065044374', 'https://openalex.org/W2066820242', 'https://openalex.org/W2067735894', 'https://openalex.org/W2098650139', 'https://openalex.org/W2106094071', 'https://openalex.org/W2119188198', 'https://openalex.org/W2120238759', 'https://openalex.org/W2151685988', 'https://openalex.org/W2162349483', 'https://openalex.org/W2337424574', 'https://openalex.org/W2604619953', 'https://openalex.org/W2610082023', 'https://openalex.org/W2791747855', 'https://openalex.org/W2943738258', 'https://openalex.org/W2956187355', 'https://openalex.org/W2969272535', 'https://openalex.org/W3005376403', 'https://openalex.org/W3023461923', 'https://openalex.org/W3028553592', 'https://openalex.org/W3112033270', 'https://openalex.org/W3150252631', 'https://openalex.org/W3202353251', 'https://openalex.org/W325847285', 'https://openalex.org/W4210330848'], 'related_works': ['https://openalex.org/W4376113189', 'https://openalex.org/W4360828057', 'https://openalex.org/W2596722927', 'https://openalex.org/W2399092465', 'https://openalex.org/W2160176015', 'https://openalex.org/W2099115268', 'https://openalex.org/W2077985528', 'https://openalex.org/W2056523973', 'https://openalex.org/W2050525330', 'https://openalex.org/W2046136537'], 'abstract_inverted_index': {'Abstract': [0], 'Cisplatin': [1, 31], 'is': [2, 24, 40], 'a': [3, 66, 86, 156, 186], 'chemotherapeutic': [4], 'agent': [5], 'used': [6], 'to': [7, 48], 'treat': [8], 'many': [9], 'types': [10], 'of': [11, 16, 28, 77, 95, 104, 109, 123, 149], 'malignant': [12], 'tumors.': [13, 176], 'However,': [14], 'irrespective': [15], 'its': [17, 167], 'potent': [18], 'anticancer': [19], 'properties': [20], 'and': [21, 39, 131, 147, 183], 'efficacy,': [22], 'nephrotoxicity': [23, 164, 182], 'the': [25, 37, 92, 102, 107, 126], 'dose-limiting': [26], 'factor': [27], 'cisplatin': [29, 105], 'treatment.': [30], 'infiltrates': [32], 'renal': [33, 111, 150], 'tubular': [34, 112, 151], 'cells': [35, 113, 152], 'in': [36, 85, 125, 139, 153, 155, 170], 'kidneys': [38], 'metabolized': [41], 'by': [42], 'cysteine': [43], 'conjugate-beta': [44], 'lyase': [45], '1': [46], '(CCBL1)': [47], 'form': [49], 'highly': [50], 'reactive': [51], 'thiol-cisplatin;': [52], 'this': [53], 'may': [54, 61, 184], 'mediate': [55], "cisplatin's": [56], 'nephrotoxicity.': [57, 64, 99], 'Therefore,': [58], 'CCBL1': [59, 82], 'inhibition': [60], 'prevent': [62, 180], 'cisplatin-induced': [63, 98, 121, 137, 163, 181], 'Using': [65], 'high-throughput': [67], 'screening': [68], 'assay,': [69], 'we': [70], 'identified': [71], '2′,4′,6′-trihydroxyacetophenone': [72], '(THA)': [73], 'as': [74], 'an': [75], 'inhibitor': [76], 'CCBL1.': [78], 'THA': [79, 96, 100, 133, 160, 177], 'inhibited': [80], 'human': [81], 'β-elimination': [83], 'activity': [84], 'concentration-dependent': [87], 'manner.': [88, 158], 'We': [89], 'further': [90], 'investigated': [91], 'preventive': [93], 'effect': [94, 103, 119], 'on': [97, 106, 120], 'attenuated': [101, 136, 162], 'viability': [108], 'confluent': [110], '(LLC-PK1': [114], 'cells)': [115], 'but': [116], 'had': [117], 'no': [118], 'reduction': [122], 'proliferation': [124], 'tumor': [127], 'cell': [128, 144], 'lines': [129], '(LLC': [130], 'MDA-MB-231).': [132], 'pretreatment': [134, 161], 'significantly': [135], 'increases': [138], 'blood': [140], 'urea': [141], 'nitrogen,': [142], 'creatinine,': [143], 'damage': [145], 'score,': [146], 'apoptosis': [148], 'mice': [154, 171], 'dose-dependent': [157], 'Furthermore,': [159], 'without': [165], 'compromising': [166], 'antitumor': [168], 'activities': [169], 'bearing': [172], 'subcutaneous': [173], 'syngeneic': [174], 'LLC': [175], 'could': [178], 'help': [179], 'provide': [185], 'new': [187], 'strategy': [188], 'for': [189], 'cisplatin-inclusive': [190], 'cancer': [191], 'treatments.': [192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4376113189', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}], 'updated_date': '2024-12-19T01:42:42.310856', 'created_date': '2023-05-12'}