Publication Information

{'id': 'https://openalex.org/W2046136537', 'doi': 'https://doi.org/10.1172/jci45586', 'title': 'Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer', 'display_name': 'Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer', 'publication_year': 2011, 'publication_date': '2011-06-01', 'ids': {'openalex': 'https://openalex.org/W2046136537', 'doi': 'https://doi.org/10.1172/jci45586', 'mag': '2046136537', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21633170', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3223835'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci45586', 'pdf_url': 'http://www.jci.org/articles/view/45586/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/45586/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5063733931', 'display_name': 'Navjotsingh Pabla', 'orcid': 'https://orcid.org/0000-0001-9408-0539'}, 'institutions': [{'id': 'https://openalex.org/I4210087454', 'display_name': 'Augusta University Health', 'ror': 'https://ror.org/007rawr89', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087454']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Navjotsingh Pabla', 'raw_affiliation_strings': ['Augusta University'], 'affiliations': [{'raw_affiliation_string': 'Augusta University', 'institution_ids': ['https://openalex.org/I4210087454']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037995264', 'display_name': 'Guie Dong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210087454', 'display_name': 'Augusta University Health', 'ror': 'https://ror.org/007rawr89', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087454']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Guie Dong', 'raw_affiliation_strings': ['Augusta University'], 'affiliations': [{'raw_affiliation_string': 'Augusta University', 'institution_ids': ['https://openalex.org/I4210087454']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111650171', 'display_name': 'Man Jiang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Man Jiang', 'raw_affiliation_strings': ['Cellular Biology and Anatomy'], 'affiliations': [{'raw_affiliation_string': 'Cellular Biology and Anatomy', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100765273', 'display_name': 'Shuang Huang', 'orcid': 'https://orcid.org/0000-0002-9674-2249'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Shuang Huang', 'raw_affiliation_strings': ['Biochemistry and Molecular Biology'], 'affiliations': [{'raw_affiliation_string': 'Biochemistry and Molecular Biology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108088086', 'display_name': 'M. Vijay Kumar', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M. Vijay Kumar', 'raw_affiliation_strings': ['VA Medical Center'], 'affiliations': [{'raw_affiliation_string': 'VA Medical Center', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010965435', 'display_name': 'Robert O. Messing', 'orcid': 'https://orcid.org/0000-0002-5345-4431'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Robert O. Messing', 'raw_affiliation_strings': ['Waggoner Center for Alcohol & Addiction Research'], 'affiliations': [{'raw_affiliation_string': 'Waggoner Center for Alcohol & Addiction Research', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5050155862', 'display_name': 'Zheng Dong', 'orcid': 'https://orcid.org/0000-0003-3538-8095'}, 'institutions': [{'id': 'https://openalex.org/I25041050', 'display_name': 'Augusta University', 'ror': 'https://ror.org/012mef835', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I25041050']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zheng Dong', 'raw_affiliation_strings': ['Medical College of Georgia', 'VA Medical Center'], 'affiliations': [{'raw_affiliation_string': 'Medical College of Georgia', 'institution_ids': ['https://openalex.org/I25041050']}, {'raw_affiliation_string': 'VA Medical Center', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 7.046, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 136, 'citation_normalized_percentile': {'value': 0.99992, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '121', 'issue': '7', 'first_page': '2709', 'last_page': '2722'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12429', 'display_name': 'Chemotherapy-induced organ toxicity mitigation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12429', 'display_name': 'Chemotherapy-induced organ toxicity mitigation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T14415', 'display_name': 'Biomedical Research and Pathophysiology', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9834, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nephrotoxicity', 'display_name': 'Nephrotoxicity', 'score': 0.94945323}], 'concepts': [{'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.9509449}, {'id': 'https://openalex.org/C126189478', 'wikidata': 'https://www.wikidata.org/wiki/Q1468324', 'display_name': 'Nephrotoxicity', 'level': 3, 'score': 0.94945323}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.6590851}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.6047562}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5391351}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.47732005}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4760701}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.46563545}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.44060513}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3023428}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.23912147}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.16377014}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.090679705}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D051745', 'descriptor_name': 'Protein Kinase C-delta', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000098', 'descriptor_name': 'Acetophenones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000098', 'descriptor_name': 'Acetophenones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001578', 'descriptor_name': 'Benzopyrans', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001578', 'descriptor_name': 'Benzopyrans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007687', 'descriptor_name': 'Kidney Tubules, Proximal', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D007687', 'descriptor_name': 'Kidney Tubules, Proximal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007687', 'descriptor_name': 'Kidney Tubules, Proximal', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007687', 'descriptor_name': 'Kidney Tubules, Proximal', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009368', 'descriptor_name': 'Neoplasm Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051745', 'descriptor_name': 'Protein Kinase C-delta', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051745', 'descriptor_name': 'Protein Kinase C-delta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051745', 'descriptor_name': 'Protein Kinase C-delta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019061', 'descriptor_name': 'src-Family Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019061', 'descriptor_name': 'src-Family Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci45586', 'pdf_url': 'http://www.jci.org/articles/view/45586/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3223835', 'pdf_url': 'https://europepmc.org/articles/pmc3223835?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223835', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21633170', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci45586', 'pdf_url': 'http://www.jci.org/articles/view/45586/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.86, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 73, 'referenced_works': ['https://openalex.org/W1530104357', 'https://openalex.org/W1577885098', 'https://openalex.org/W1607565010', 'https://openalex.org/W1842412546', 'https://openalex.org/W1865602869', 'https://openalex.org/W1967932438', 'https://openalex.org/W1969872582', 'https://openalex.org/W1970933571', 'https://openalex.org/W1971492805', 'https://openalex.org/W1974693247', 'https://openalex.org/W1974836020', 'https://openalex.org/W1975046195', 'https://openalex.org/W1975658493', 'https://openalex.org/W1983829192', 'https://openalex.org/W1983965827', 'https://openalex.org/W1993720756', 'https://openalex.org/W1998349282', 'https://openalex.org/W2002321863', 'https://openalex.org/W2003701831', 'https://openalex.org/W2007208661', 'https://openalex.org/W2016318035', 'https://openalex.org/W2019316722', 'https://openalex.org/W2021131539', 'https://openalex.org/W2024004416', 'https://openalex.org/W2030590419', 'https://openalex.org/W2033130441', 'https://openalex.org/W2038358991', 'https://openalex.org/W2039867775', 'https://openalex.org/W2043445391', 'https://openalex.org/W2044804580', 'https://openalex.org/W2046658387', 'https://openalex.org/W2058983867', 'https://openalex.org/W2060811507', 'https://openalex.org/W2061423814', 'https://openalex.org/W2061430098', 'https://openalex.org/W2069707552', 'https://openalex.org/W2075443188', 'https://openalex.org/W2075951376', 'https://openalex.org/W2077813812', 'https://openalex.org/W2082473607', 'https://openalex.org/W2085177403', 'https://openalex.org/W2085691401', 'https://openalex.org/W2086910295', 'https://openalex.org/W2087664337', 'https://openalex.org/W2089025179', 'https://openalex.org/W2098361993', 'https://openalex.org/W2100714950', 'https://openalex.org/W2102027021', 'https://openalex.org/W2103379588', 'https://openalex.org/W2106065518', 'https://openalex.org/W2106652794', 'https://openalex.org/W2108352961', 'https://openalex.org/W2111945616', 'https://openalex.org/W2114195790', 'https://openalex.org/W2114317477', 'https://openalex.org/W2117631891', 'https://openalex.org/W2118100544', 'https://openalex.org/W2121927491', 'https://openalex.org/W2123733969', 'https://openalex.org/W2126681184', 'https://openalex.org/W2135198134', 'https://openalex.org/W2136049487', 'https://openalex.org/W2140916429', 'https://openalex.org/W2150889068', 'https://openalex.org/W2155978870', 'https://openalex.org/W2157388811', 'https://openalex.org/W2164277862', 'https://openalex.org/W2164391817', 'https://openalex.org/W2187552024', 'https://openalex.org/W2306361384', 'https://openalex.org/W2316354035', 'https://openalex.org/W4234012993', 'https://openalex.org/W4240717991'], 'related_works': ['https://openalex.org/W4379981344', 'https://openalex.org/W4376113189', 'https://openalex.org/W4360828057', 'https://openalex.org/W2596722927', 'https://openalex.org/W2399092465', 'https://openalex.org/W2160176015', 'https://openalex.org/W2099115268', 'https://openalex.org/W2056523973', 'https://openalex.org/W2050525330', 'https://openalex.org/W2046136537'], 'abstract_inverted_index': {'Cisplatin': [0], 'is': [1], 'a': [2, 45, 149], 'widely': [3], 'used': [4], 'cancer': [5, 121, 168], 'therapy': [6], 'drug': [7], 'that': [8, 62], 'unfortunately': [9], 'has': [10], 'major': [11], 'side': [12], 'effects': [13, 129], 'in': [14, 19, 74, 119, 132, 153], 'normal': [15], 'tissues,': [16], 'notably': [17], 'nephrotoxicity': [18, 28, 155], 'kidneys.': [20], 'Despite': [21], 'intensive': [22], 'research,': [23], 'the': [24, 127], 'mechanism': [25], 'of': [26, 48, 93, 113, 130, 151], 'cisplatin-induced': [27, 116], 'remains': [29], 'unclear,': [30], 'and': [31, 71, 102, 135, 156], 'renoprotective': [32], 'approaches': [33], 'during': [34, 58, 64, 108, 166], 'cisplatin-based': [35, 167], 'chemotherapy': [36], 'are': [37], 'lacking.': [38], 'Here': [39], 'we': [40], 'have': [41], 'identified': [42], 'PKCδ': [43, 73, 80, 94, 114, 152, 159], 'as': [44, 160], 'critical': [46], 'regulator': [47], 'cisplatin': [49, 65, 109, 131, 154], 'nephrotoxicity,': [50, 66], 'which': [51], 'can': [52], 'be': [53], 'effectively': [54], 'targeted': [55], 'for': [56, 164], 'renoprotection': [57, 165], 'chemotherapy.': [59], 'We': [60], 'showed': [61], 'early': [63], 'Src': [67], 'interacted': [68], 'with,': [69], 'phosphorylated,': [70], 'activated': [72], 'mouse': [75, 137], 'kidney': [76, 99], 'lysates.': [77], 'After': [78], 'activation,': [79], 'regulated': [81], 'MAPKs,': [82], 'but': [83], 'not': [84], 'p53,': [85], 'to': [86], 'induce': [87], 'renal': [88, 106], 'cell': [89, 100, 117, 122], 'apoptosis.': [90], 'Thus,': [91], 'inhibition': [92, 112], 'pharmacologically': [95], 'or': [96], 'genetically': [97], 'attenuated': [98], 'apoptosis': [101], 'tissue': [103], 'damage,': [104], 'preserving': [105], 'function': [107], 'treatment.': [110], 'Conversely,': [111], 'enhanced': [115, 126], 'death': [118], 'multiple': [120], 'lines': [123], 'and,': [124], 'remarkably,': [125], 'chemotherapeutic': [128], 'several': [133], 'xenograft': [134], 'syngeneic': [136], 'tumor': [138], 'models': [139], 'while': [140], 'protecting': [141], 'kidneys': [142], 'from': [143], 'nephrotoxicity.': [144], 'Together': [145], 'these': [146], 'results': [147], 'demonstrate': [148], 'role': [150], 'support': [157], 'targeting': [158], 'an': [161], 'effective': [162], 'strategy': [163], 'therapy.': [169]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2046136537', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 15}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-11T19:49:55.371851', 'created_date': '2016-06-24'}