Publication Information

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2724, 2769, 2942, 2969, 3020, 3066, 3091, 3210, 3267, 3384, 3575], 'with': [8, 86, 117, 239, 317, 348, 593, 1077, 1214, 1396, 2298, 2399, 2620, 2675, 2882, 3149, 3235, 3506, 3660, 3753, 3835, 3921, 3940, 4070, 4093, 4214], 'multiple': [9, 183, 240, 414], 'intracellular': [10, 241], 'extracellular': [12, 243, 594], 'functions': [13, 225, 244, 456, 518, 1183], 'in': [14, 38, 46, 101, 105, 132, 139, 143, 168, 245, 269, 277, 332, 336, 363, 370, 374, 399, 487, 516, 647, 746, 772, 895, 999, 1139, 1167, 1316, 1362, 1450, 1521, 1550, 1584, 1697, 1703, 1754, 1788, 1863, 1969, 2000, 2186, 2235, 2296, 2331, 2356, 2404, 2418, 2473, 2565, 2704, 2713, 2716, 2723, 2809, 2934, 2946, 3001, 3089, 3109, 3247, 3329, 3422, 3462, 3468, 3471, 3611, 3694, 3726, 3855, 3858, 3888, 3891, 3913, 3924, 3949, 4040, 4066, 4126, 4156, 4175, 4188, 4220, 4223, 4248], 'signaling,': [15, 246, 522, 836], 'regulation,': [16, 247, 523], 'defense.': [18, 249], 'The': [19, 198, 250, 429, 1178, 1245, 1279, 1435, 1625, 1860, 2090, 2130, 2148, 2369, 3308, 3416, 3480, 3733, 3832, 4190], 'two': [20, 251, 1209, 1266, 1445, 1694, 2123, 2157, 3582, 3781], 'not': [23, 100, 254, 331, 1287, 1378, 1460, 2432, 3324, 3595, 3829], 'detected': [24, 255], 'as': [25, 65, 256, 296, 1380, 1389, 1412, 2095, 2329, 2623, 2680, 2983, 3353, 3771, 3830, 3919], 'monomers': [26, 257], 'but': [27, 99, 258, 330, 1294, 1457, 4252], 'form': [28, 259, 686, 1461, 1628, 1998, 2039, 2408, 3325], 'various': [29, 60, 260, 291, 517, 1094, 3317], 'noncovalent': [30, 261, 1390], 'homo-': [31, 135, 262, 366], 'or': [32, 72, 81, 148, 263, 303, 312, 379, 1072, 1163, 1305, 2456, 2912, 3030, 3032, 3230, 3288, 4073], 'hetero-oligomers': [33, 264, 1391], 'related': [34, 265, 1683], 'to': [35, 121, 159, 191, 220, 266, 352, 390, 422, 451, 475, 502, 520, 539, 588, 670, 751, 1118, 1219, 1307, 1326, 1684, 1846, 1870, 1976, 2010, 2013, 2240, 2325, 2470, 2572, 2616, 2628, 2689, 2805, 2831, 2888, 2904, 2910, 2951, 2971, 2980, 3238, 3280, 3347, 3399, 3526, 3632, 3766, 3809, 3850, 3860, 4026, 4113, 4147, 4199], 'specific': [36, 267, 1263, 1633], 'activities': [37, 268, 1933, 2490, 2529], 'human': [39, 270, 687, 1001, 1082, 1095, 1250, 1615, 2272, 2294, 2938, 3177, 3263, 3637], 'physiology.': [40, 271], 'Because': [41, 272], 'of': [42, 59, 68, 125, 146, 177, 195, 205, 209, 273, 290, 299, 356, 377, 408, 426, 436, 440, 484, 564, 616, 667, 694, 775, 806, 869, 915, 926, 988, 996, 1069, 1080, 1137, 1181, 1184, 1193, 1248, 1258, 1265, 1281, 1331, 1343, 1392, 1410, 1421, 1465, 1517, 1546, 1555, 1580, 1593, 1613, 1653, 1678, 1687, 1750, 1759, 1819, 1843, 1934, 1966, 1996, 2036, 2041, 2050, 2053, 2072, 2107, 2114, 2138, 2142, 2159, 2169, 2189, 2293, 2315, 2416, 2480, 2487, 2530, 2562, 2599, 2633, 2643, 2695, 2720, 2744, 2764, 2790, 2824, 2894, 2926, 2997, 3006, 3038, 3064, 3070, 3083, 3105, 3114, 3139, 3145, 3176, 3215, 3218, 3228, 3250, 3284, 3300, 3311, 3335, 3362, 3429, 3453, 3533, 3548, 3573, 3588, 3618, 3666, 3692, 3717, 3740, 3756, 3795, 3867, 3932, 4051, 4153, 4164, 4178, 4208], 'their': [43, 156, 224, 274, 387, 455, 700, 1282, 1290, 2449, 2488, 2919, 2972, 4028, 4167], 'significant': [44, 275, 2762, 4124], 'roles': [45, 276, 745, 2234], 'numerous': [47, 278], 'medical': [48, 279], 'conditions,': [49, 162, 280, 393, 1454], 'there': [50, 281, 2412], 'has': [51, 282, 1188, 2624, 2709], 'been': [52, 283, 1190, 2625, 2711], 'intense': [53, 284], 'research': [54, 219, 285, 450], 'on': [55, 286, 921, 1235, 1289, 1296, 1637, 3142, 3377, 3945, 3987, 4063], 'the': [56, 94, 123, 144, 175, 178, 182, 187, 192, 196, 206, 287, 325, 354, 375, 406, 409, 413, 418, 423, 427, 437, 476, 481, 710, 747, 773, 1000, 1078, 1191, 1236, 1249, 1317, 1341, 1440, 1444, 1463, 1471, 1476, 1551, 1591, 1614, 1685, 1704, 1755, 1775, 1799, 1820, 1881, 1993, 2001, 2023, 2028, 2031, 2034, 2051, 2054, 2127, 2139, 2156, 2166, 2170, 2178, 2187, 2199, 2236, 2269, 2352, 2357, 2393, 2419, 2476, 2630, 2691, 2696, 2765, 2785, 2791, 2891, 2924, 3002, 3051, 3068, 3081, 3084, 3110, 3143, 3216, 3226, 3242, 3248, 3255, 3277, 3282, 3297, 3316, 3400, 3423, 3430, 3434, 3442, 3460, 3530, 3534, 3563, 3574, 3585, 3612, 3633, 3655, 3684, 3689, 3754, 3767, 3772, 3780, 3785, 3796, 3799, 3810, 3825, 3851, 3869, 3901, 3907, 3922, 3930, 3935, 3941, 3946, 3971, 3988, 3991, 3999, 4008, 4048, 4077, 4085, 4091, 4094, 4102, 4114, 4137, 4142, 4148, 4150, 4154, 4176, 4200, 4227, 4249], 'conformational': [57, 207, 288, 438, 1256, 2631, 2693, 2718, 2892, 2927, 3531], 'properties': [58, 96, 208, 289, 327, 439, 925, 1635, 2920], 'proteoforms': [64, 167, 295, 398, 3072, 3365], 'essential': [66, 297, 698, 2108], 'targets': [67, 298], 'drug': [69, 300], 'discovery.': [70, 301], 'NMR': [71, 302], 'crystal': [73, 304, 1246], 'structures': [74, 305, 1229, 2385, 2424, 2974, 3087], 'currently': [76, 307], 'available': [77, 308, 1220], 'only': [78, 309, 1208, 1288, 2392, 3212, 3661, 3833, 3938], 'for': [79, 155, 181, 217, 226, 310, 386, 412, 448, 457, 596, 699, 739, 1032, 1054, 1336, 1340, 1346, 1455, 1475, 2047, 2228, 2684, 2750, 2857, 3034, 3245, 3419, 3433, 3614, 3672, 3678, 3688, 3720, 3736, 3793, 3872, 3970, 4130, 4246, 4257], 'mutated': [80, 311, 2455], 'truncated': [82, 313], 'protein': [83, 170, 314, 401, 712, 958, 1320, 1419, 1569, 1692, 1801, 1883, 2201, 2271, 2807, 2932, 3636, 3797, 4068, 4104], 'complexes,': [84, 315], 'mainly': [85, 316, 2403, 3961], 'bound': [87, 318], 'metal': [88, 319, 696, 707, 1689, 1780, 1796, 1878, 2110, 2196, 2377, 2406, 2747, 4179], 'ions,': [89, 320, 1781, 2317], 'that': [90, 172, 321, 403, 691, 1201, 1314, 1577, 1631, 2725, 2768, 2918, 3050, 3205, 3546, 3750], 'may': [91, 173, 322, 404, 1586], 'well': [92, 323, 3752], 'reflect': [93, 324, 2784], "proteins'": [95, 326], 'outside': [97, 328], 'cells': [98, 329, 587, 2335], 'other': [102, 333, 1594, 3289, 3989], 'biological': [103, 334, 503, 540, 1119, 1237, 1386, 1634, 2489], 'contexts': [104, 335], 'which': [106, 337, 479, 1469, 2458], 'they': [107, 338, 579, 845, 3475], 'perform.': [108, 339], 'Here,': [109, 340], 'we': [110, 341, 2667, 2886, 2916, 3272, 3295, 3544], 'used': [111, 342, 3349], 'structural': [112, 343, 924, 1211, 1301, 2685, 2786, 2829, 4230], 'mass': [113, 344, 1023, 2671, 2865, 3542, 3642], 'spectrometry': [114, 345, 1024, 2672, 2866], 'methods': [115, 200, 346, 431, 2619], 'combined': [116, 347, 2674], 'molecular': [118, 349, 929, 932, 2676, 2832, 2883], 'dynamics': [119, 350, 933, 2632, 2677, 2789, 2830, 3532, 4065], 'simulations': [120, 351, 2679], 'compare': [122, 353], 'conformations': [124, 355], 'wildtype': [126, 357], 'full-length': [127, 358], 'subunits': [131, 362, 2898, 4155], 'biologically': [133, 364, 1595], 'relevant': [134, 365], 'heterodimers': [137, 368, 3033, 4157], 'higher': [140, 371, 1334, 3233, 3495, 3747, 4194], 'oligomers': [141, 372, 1630, 1861, 3234], 'formed': [142, 373, 2125, 3211, 3355], 'presence': [145, 376, 1554, 1758, 3005, 3113, 3217, 3249], 'calcium': [147, 378, 1417, 3933], 'zinc': [149, 380, 2299], 'ions.': [150, 381, 1690, 2111, 3220], 'We': [151, 382, 2687, 3522, 3682], 'provide,': [152, 383], 'first,': [153, 384], 'rationales': [154, 385, 2371], 'functional': [157, 388, 1473, 2436], 'response': [158, 389, 750, 2239], 'changing': [160, 391], 'environmental': [161, 392, 1638], 'by': [163, 394, 584, 591, 709, 742, 797, 960, 1658, 1798, 1880, 2104, 2122, 2198, 2231, 2268, 2351, 2966, 2975, 3303, 3369, 3552, 3640, 3744, 4184], 'elucidating': [164, 395], 'differences': [165, 396, 2437, 3600, 3725], 'between': [166, 397, 2030, 2438, 3601, 3729, 3779, 3998], 'flexible': [169, 400, 2400], 'regions': [171, 402, 2401, 2933, 3742, 3826], 'provide': [174, 214, 405, 445, 2690], 'plasticity': [176, 407], 'binding': [179, 410, 1418, 1686, 2043, 2113, 2749, 3631, 3931], 'sites': [180, 411, 1790, 2124], 'targets,': [184, 415], 'second,': [186, 417], 'key': [188, 419], 'factors': [189, 420, 1299], 'contributing': [190, 421], 'variable': [193, 424], 'stability': [194, 425, 922, 3310, 3371, 3496], 'oligomers.': [197, 428, 2914, 3539], 'described': [199, 430, 2984], 'a': [202, 215, 433, 446, 1051, 1215, 1413, 2100, 2133, 2151, 2405, 2426, 2460, 2681, 3024, 3285, 3341, 3615, 3662], 'systematic': [203, 434], 'view': [204, 435], 'complexes': [213, 444, 690, 1597, 2963], 'basis': [216, 447, 738, 2227], 'further': [218, 449, 4088, 4218], 'characterize': [221, 452], 'modulate': [223, 454, 846], 'basic': [227, 458], 'science': [228, 459], 'therapies.': [230, 461], 'small': [466], '(10.8': [467], '13.1': [469], 'kDa,': [470], 'respectively)': [471], 'α-helical': [472, 3086], 'belonging': [474], 'S100': [477, 565, 668, 870, 1165, 1319, 1363, 1825, 1847, 2644], 'family,': [478], 'is': [480, 1197, 1439, 1682, 2044, 2120, 2132, 2150, 2413, 2459, 2615, 2767, 3396, 3411, 3425, 3967], 'largest': [482], 'group': [483, 3141], 'calcium-binding': [485], 'humans': [488], '(1Jukic': [489, 526, 1105], 'A.': [490, 527, 604, 760, 913, 947, 1047, 1106, 1132, 1244, 1609, 1645, 2060, 2249, 2345, 2741, 3134], 'Bakiri': [491, 528, 1107], 'L.': [492, 529, 1045, 1108, 1601, 2290, 2640, 2735], 'Wagner': [493, 530, 1109], 'E.F.': [494, 531, 953, 1110], 'Tilg': [495, 532, 1111], 'H.': [496, 533, 911, 1112, 1900, 2286, 2496, 3132], 'Adolph': [497, 534, 1113], 'T.E.': [498, 535, 727, 1114, 2216], 'Calprotectin:': [499, 536, 1115, 1133], 'from': [500, 537, 1116, 1385, 1452, 1588, 1992, 2163, 2177, 2828, 2902, 2907, 2977, 3562, 3568, 3584, 3801, 3844], 'biomarker': [501, 538, 1117, 1136], 'function.Gut.': [504, 541, 1120], '2021;': [505, 542, 816, 1121, 1144], '70:': [506, 543, 1122], '1978-1988Crossref': [507, 544, 1123], 'PubMed': [508, 545, 572, 629, 653, 679, 719, 764, 819, 877, 901, 939, 972, 1016, 1062, 1124, 1173, 1274, 1369, 1432, 1503, 1529, 1563, 1620, 1672, 1733, 1767, 1808, 1855, 1890, 1917, 1946, 1982, 2085, 2208, 2253, 2280, 2307, 2364, 2513, 2542, 2578, 2607, 2659, 2814, 2838, 2873, 3014, 3122, 3183, 3650], 'Scopus': [509, 546, 573, 630, 654, 680, 720, 765, 820, 878, 902, 940, 973, 1017, 1063, 1125, 1174, 1275, 1370, 1504, 1530, 1564, 1621, 1673, 1734, 1768, 1809, 1856, 1891, 1918, 1947, 1983, 2086, 2209, 2254, 2281, 2308, 2365, 2514, 2543, 2579, 2608, 2660, 2757, 2839, 2874, 3015, 3123, 3156, 3184, 3651], '(105)': [510, 547, 1126], 'Google': [511, 548, 575, 632, 656, 682, 722, 767, 822, 880, 904, 942, 975, 1019, 1065, 1127, 1147, 1176, 1277, 1372, 1433, 1506, 1532, 1566, 1623, 1675, 1736, 1770, 1811, 1834, 1858, 1893, 1920, 1949, 1985, 2088, 2211, 2256, 2283, 2310, 2367, 2516, 2545, 2581, 2610, 2662, 2759, 2815, 2841, 2876, 3017, 3125, 3158, 3186, 3653], 'Scholar).': [512, 576, 683, 823, 1020, 1066, 1177, 1278, 1373, 1434, 1567, 1624, 1676, 1771, 1859, 1986, 2089, 2311, 2368, 2611, 2663, 2760, 2877, 3018], 'They': [513, 684, 1382], 'involved': [515], 'connected': [519, 1213], 'cell': [521], 'defense': [525], 'Scholar,': [549, 633, 657, 723, 881, 905, 943, 976, 1128, 1148, 1507, 1533, 1737, 1812, 1835, 1894, 1921, 1950, 2212, 2257, 2284, 2517, 2546, 2582, 2816, 2842, 3126, 3159], '2Donato': [550], 'R.': [551, 637, 783, 856, 885, 1404], 'Cannon': [552, 857], 'B.R.': [553, 858], 'Sorci': [554, 859], 'G.': [555, 661, 860, 1130, 1814], 'Riuzzi': [556, 861], 'F.': [557, 862, 949, 1242, 1513, 2586, 3128], 'Hsu': [558, 863, 1901, 2497], 'K.': [559, 864, 1539, 1541, 1743, 1745, 1902, 2337, 2498, 2737, 2990, 2992, 3098, 3100], 'Weber': [560, 865], 'D.J.': [561, 866], 'et': [562, 613, 736, 790, 867, 956, 1610, 1907, 1963, 2069, 2225, 2348, 2503, 2559, 2855], 'al.Functions': [563, 868], 'proteins.Curr.': [566, 871], 'Mol.': [567, 872, 1269, 1498, 1728], 'Med.': [568, 873], '2013;': [569, 761, 874, 2250], '13:': [570, 817, 875, 1501, 1731], '24-57Crossref': [571, 876], '(944)': [574, 879], 'For': [577, 1987, 3812], 'instance,': [578, 1988], 'overexpressed': [581, 2945], 'secreted': [583], 'white': [585], 'blood': [586], 'mediate': [589], 'inflammation': [590, 2015, 2055], 'interacting': [592, 1259], 'receptors,': [595], 'example,': [597, 1456], 'TLR4': [598, 2011, 2042], 'RAGE': [600], '(3Vogl': [601, 2057], 'T.': [602, 608, 1043, 1480, 1515, 1535, 1710, 1739, 2058, 2064, 2986, 3094], 'Stratis': [603, 2059], 'Wixler': [605, 2061], 'V.': [606, 2062, 2341, 2343], 'Völler': [607, 2063], 'Thurainayagam': [609, 2065], 'S.': [610, 635, 643, 733, 759, 787, 883, 891, 978, 982, 1155, 1511, 2066, 2222, 2248, 2854], 'Jorch': [611, 2067], 'S.K.': [612, 2068, 3167], 'al.Autoinhibitory': [614, 2070], 'regulation': [615, 1280, 2071], 'S100A8/S100A9': [617, 1436, 1989, 2073, 3246], 'alarmin': [618, 2074], 'activity': [619, 854, 998, 2075], 'locally': [620, 2076], 'restricts': [621, 2077], 'sterile': [622, 2078], 'inflammation.J.': [623, 2079], 'Clin.': [624, 2080], 'Invest.': [625, 2081], '2018;': [626, 650, 716, 898, 1526, 1805, 1887, 2082, 2205, 2604], '128:': [627, 2083], '1852-1866Crossref': [628, 2084], '(125)': [631, 2087], '4Wang': [634, 882], 'Song': [636, 884], 'Wang': [638, 642, 786, 886, 890], 'Z.': [639, 641, 779, 887, 889], 'Jing': [640, 888], 'Ma': [644, 788, 892], 'J.': [645, 893, 945, 1161, 1400, 1497, 1543, 1727, 1747, 1927, 1956, 2523, 2552, 2739, 2994, 3102, 3179, 3621], 'S100A8/A9': [646, 894, 2354, 3147], 'inflammation.Front.': [648, 896], 'Immunol.': [649, 897, 1667, 1913, 2509], '9:': [651, 899], '1298Crossref': [652, 900], '(665)': [655, 903], '5Leclerc': [658], 'E.': [659, 1509, 2947], 'Fritz': [660], 'Vetter': [662], 'S.W.': [663], 'Heizmann': [664, 1815], 'C.W.': [665], 'Binding': [666, 1824, 1842], 'RAGE:': [671], 'an': [672, 1134, 2096, 2313, 2649, 2802, 3035, 3426, 3450, 4058, 4122], 'update.Biochim.': [673], 'Biophys.': [674, 1523, 1558, 1762, 3009, 3117, 3151], 'Acta.': [675, 1559, 1763, 3010, 3118, 3152], '2009;': [676, 2361], '1793:': [677], '993-1007Crossref': [678], '(393)': [681], 'also': [685, 1295, 1777, 3367, 3954], '"nutritional': [688, 2101], 'immunity"': [689, 2102], 'deprive': [692], 'bacteria': [693, 2106], 'transition': [695, 1779, 1844, 2109], 'ions': [697, 1696, 3253, 4180, 4216], 'growth': [701, 805], '(6Zygiel': [702, 1791, 1873, 2191], 'E.M.': [703, 705, 1792, 1794, 1874, 1876, 2192, 2194, 2261, 2265, 2592, 3627], 'Nolan': [704, 1793, 1875, 2193, 2264, 2591, 3626], 'Transition': [706, 1795, 1877, 2181, 2195], 'sequestration': [708, 741, 1797, 1879, 2197, 2230, 2267], 'host-defense': [711, 1800, 1882, 2200, 2270], 'calprotectin.Annu.': [713, 1802, 1884, 2202], 'Rev.': [714, 1803, 1885, 2203], 'Biochem.': [715, 1804, 1886, 2204], '87:': [717, 1806, 1888, 2206], '621-643Crossref': [718, 1807, 1889, 2207], '(117)': [721, 1810, 1892, 2210], '7Damo': [724, 2213], 'S.M.': [725, 2214], 'Kehl-Fie': [726, 2215], 'Sugitani': [728, 2217], 'N.': [729, 907, 1408, 1537, 1647, 1741, 2218, 2988, 3096, 3136], 'Holt': [730, 2219], 'M.E.': [731, 2220], 'Rathi': [732, 2221], 'Murphy': [734, 2223], 'W.J.': [735, 1841, 2224], 'al.Molecular': [737, 2226], 'manganese': [740, 2229], 'calprotectin': [743, 927, 1967, 2007, 2018, 2232, 2318, 2417, 2563, 3474, 3619, 3638, 4213], 'innate': [748, 2237, 3634], 'immune': [749, 2238, 3635], 'invading': [752, 2241], 'bacterial': [753, 2242], 'pathogens.Proc.': [754, 2243], 'Natl.': [755, 2244], 'Acad.': [756, 2245], 'Sci.': [757, 1499, 1729, 1851, 2246], 'U.': [758, 2247], '110:': [762, 2251], '3841-3846Crossref': [763, 2252], '(285)': [766, 2255], 'Scholar)': [768, 3187], 'anti-inflammatory': [771, 1911, 2507], 'process': [774, 3279], 'wound': [776], 'healing': [777], '(8Xu': [778], 'Cheng': [780], 'C.': [781, 1039, 1150, 1605, 1649, 1816, 2797, 2852], 'Kong': [782], 'Liu': [784], 'Y.': [785, 789, 2636, 3163], 'al.S100A8': [791], 'S100A9,': [793, 1071, 1655, 3569, 3679], 'both': [794, 1073, 1202, 3928, 4022, 4185, 4224], 'transcriptionally': [795], 'regulated': [796], 'PU.1,': [798], 'promote': [799], 'epithelial-mesenchymal': [800], 'transformation': [801], '(EMT)': [802], 'invasive': [804], 'dermal': [807], 'keratinocytes': [808], 'during': [809], 'scar': [810], 'formation': [811, 1520, 2350, 3082, 3283], 'post': [812], 'burn.Aging': [813], '(Albany': [814], 'NY).': [815], '15523-15537Crossref': [818], '(11)': [821, 941], 'Inside': [824], 'cells,': [825, 1997], 'regulate': [829, 2485], 'nitric': [830], 'oxide': [831], 'reactive': [833, 1661, 2450], 'oxygen': [834, 1662], 'species': [835, 1663], 'NADPH': [837], 'oxidase': [838], 'activation,': [839], 'arachidonic': [841], 'acid': [842], 'transport,': [843], 'tubulin': [847], 'intermediate': [849], 'filament': [850], 'assembly': [851, 1442], 'telomerase': [853, 997], '(2Donato': [855], '9Gheibi': [906], 'Ghorbani': [908], 'M.': [909, 1049, 1157, 1402, 1599, 1898, 2494, 2731, 2733, 2818, 3161], 'Shariatifar': [910], 'Farasat': [912], 'Effects': [914], 'unsaturated': [916], 'fatty': [917], 'acids': [918], '(arachidonic/oleic': [919], 'acids)': [920], 'using': [928, 2956, 3027, 3373], 'docking': [930], 'simulation': [934], 'approach.PLoS': [935], 'One.': [936, 2360, 2754], '2020;': [937, 1170, 2811, 2835, 3647], '15e0230780Crossref': [938], '10Jia': [944], 'Arif': [946], 'Terenzi': [948], 'Willard': [950], 'B.': [951, 1353], 'Plow': [952], 'Hazen': [954], 'S.L.': [955], 'al.Target-selective': [957], 'S-nitrosylation': [959, 2745], 'sequence': [961, 1323, 1342], 'motif': [962], 'recognition.Cell.': [963], '2014;': [964, 3180], '159:': [965], '623-634Abstract': [966], 'Full': [967, 969, 1011, 1013, 1429, 1941, 1943, 2537, 2539], 'Text': [968, 970, 1012, 1014, 1430, 1942, 1944, 2538, 2540], 'PDF': [971, 1015, 1431, 1945, 2541], '(126)': [974], '11Rosenberger': [977], 'Thorey': [979], 'I.S.': [980], 'Werner': [981], 'Boukamp': [983], 'P.': [984, 1406, 1607], 'A': [985, 1333, 2612, 2761, 3980, 4238], 'novel': [986, 1910, 2506], 'regulator': [987], 'telomerase:': [989], 's100A8': [990], 'mediates': [991], 'differentiation-dependent': [992], 'calcium-induced': [994], 'inhibition': [995], 'epidermal': [1002], 'keratinocyte': [1003], 'line': [1004], 'HaCaT∗.J.': [1005], 'Biol.': [1006, 1270, 1424, 1936, 1978, 2303, 2532, 2574], 'Chem.': [1007, 1425, 1937, 2275, 2533, 2602, 2654, 3645], '2007;': [1008, 1271], '282:': [1009], '6126-6135Abstract': [1010], '(42)': [1018], 'Recent': [1021], 'affinity-capture': [1022], 'identifications': [1025], 'suggest': [1026], 'over': [1027], '150': [1028], '229': [1030], 'interactors': [1031], 'proteins,': [1036, 1206], 'respectively': [1037], '(12Stark': [1038], 'Breitkreutz': [1040, 1046], 'B.-J.': [1041], 'Reguly': [1042], 'Boucher': [1044], 'Tyers': [1048], 'BioGRID:': [1050], 'general': [1052], 'repository': [1053], 'interaction': [1055, 3144], 'datasets.Nucleic': [1056], 'Acids': [1057], 'Res.': [1058, 1524, 1668], '2006;': [1059, 1560, 1764, 3011, 3119], '34:': [1060], 'D535-D539Crossref': [1061], '(2873)': [1064], 'Expression': [1067], 'levels': [1068, 1330, 1579, 3687, 3728, 3787, 3815], 'S100A8,': [1070, 1654, 3673], 'change': [1075], 'significantly': [1076, 2185], 'development': [1079], 'many': [1081], 'diseases,': [1083], 'including': [1084, 1097], 'rheumatoid': [1085], 'arthritis,': [1086], 'psoriasis,': [1087, 2006], 'ulcerative': [1088], 'colitis,': [1089], 'Crohn': [1091], 'disease,': [1092], 'cancers,': [1096], 'breast,': [1098], 'prostate,': [1099], 'pancreatic,': [1100], 'liver,': [1101], 'skin': [1103], 'cancer': [1104, 2334], '13Chatziparasidis': [1129], 'Kantar': [1131], 'ignored': [1135], 'neutrophilia': [1138], 'pediatric': [1140], 'respiratory': [1141], 'diseases.Children': [1142], '(Basel).': [1143, 1169], '8:': [1145, 2812], '428PubMed': [1146], '14Allgöwer': [1149], 'Kretz': [1151], 'A.-L.': [1152], 'von': [1153], 'Karstedt': [1154], 'Wittau': [1156], 'Henne-Bruns': [1158], 'D.': [1159, 2795, 2800, 2820], 'Lemke': [1160], 'Friend': [1162], 'foe:': [1164], 'cancer.Cancers': [1168], '12:': [1171], '2037Crossref': [1172], '(71)': [1175], 'extraordinary': [1179], 'diversity': [1180], 'physiological': [1182], 'long': [1189], 'subject': [1192], 'research.': [1194], 'However,': [1195], 'it': [1196, 1458, 3354, 4254], 'still': [1198, 2381], 'puzzling,': [1199], 'considering': [1200], 'single-domain': [1205], 'containing': [1207], 'EF-hand': [1210, 1267, 3782], 'motifs': [1212], 'short': [1216], 'linker.': [1217], 'According': [1218, 3237], 'data,': [1221], 'have': [1225, 1312, 1327, 2425, 2448, 3385], 'almost': [1226], 'identical': [1227], '3D': [1228, 1817], 'yet': [1230], 'perform': [1231], 'diverse': [1232], 'roles,': [1233], 'depending': [1234, 1636], 'context': [1238], '(15Korndörfer': [1239], 'I.P.': [1240], 'Brueckner': [1241], 'Skerra': [1243], 'structure': [1247, 1973, 2292, 2415, 2569, 2728, 3174], '(S100A8/S100A9)2': [1251], 'heterotetramer,': [1252], 'calprotectin,': [1253], 'illustrates': [1254], 'how': [1255, 2890], 'changes': [1257], 'α-helices': [1260, 3757, 3828], 'can': [1261, 1627, 2770], 'determine': [1262], 'association': [1264], 'proteins.J.': [1268], '370:': [1272], '887-898Crossref': [1273], '(219)': [1276], 'function': [1283], 'must': [1284], 'thus': [1285], 'rely': [1286], 'overall': [1291, 4103, 4123], 'static': [1292, 2388], 'fold': [1293], 'more': [1297, 3358, 3397, 3886, 3911, 4000, 4037, 4060, 4171], 'transient': [1298], 'modulating': [1300], 'dynamics,': [1302], 'thermal': [1303, 3370], 'stability,': [1304, 1865], 'susceptibility': [1306, 1869, 1975, 2571], 'additional': [1308, 1789, 3451], 'factors.': [1309], 'Theoretical': [1310], 'studies': [1311, 1575], 'suggested': [1313], 'intertwined': [1315], 'conserved': [1318], 'folds': [1321], 'fragments': [1324, 3583, 3764], 'predicted': [1325], 'high': [1328], 'intrinsic': [1329], 'disorder.': [1332], 'propensity': [1335], 'disorder': [1337, 1361], 'was': [1338, 3366, 4193, 4243], 'proposed': [1339], 'than': [1345, 3410, 3890, 4195], '(16Permyakov': [1348], 'S.E.': [1349], 'Ismailov': [1350], 'R.G.': [1351], 'Xue': [1352], 'Denesyuk': [1354], 'A.I.': [1355], 'Uversky': [1356], 'V.N.': [1357], 'Permyakov': [1358], 'E.A.': [1359], 'Intrinsic': [1360], 'proteins.Mol.': [1364], 'Biosyst.': [1365], '2011;': [1366], '7:': [1367], '2164-2180Crossref': [1368], '(28)': [1371], 'do': [1377, 2431], 'exist': [1379], 'monomers.': [1381], 'isolated': [1384], 'samples': [1387], 'mostly': [1388], '1:1': [1397], 'stoichiometry': [1398], '(17Edgeworth': [1399], 'Gorman': [1401], 'Bennett': [1403], 'Freemont': [1405], 'Hogg': [1407], 'Identification': [1409], 'p8,14': [1411], 'highly': [1414], 'abundant': [1415], 'heterodimeric': [1416], 'complex': [1420, 2297, 3148], 'myeloid': [1422], 'cells.J.': [1423], '1991;': [1426], '266:': [1427], '7706-7713Abstract': [1428], 'heterodimer': [1437, 2128, 3424], '(calprotectin)': [1438], 'preferred': [1441], 'if': [1443], 'recombinant': [1446, 3146], 'cofolded': [1449], 'vitro,': [1451], 'denaturing': [1453, 2954], 'does': [1459], 'upon': [1462, 3225], 'mixing': [1464], 'already': [1466, 2626, 2710, 4244], 'folded': [1467], 'homodimers,': [1468, 3929, 4149], 'minimal': [1472], 'units': [1474], 'individual': [1477], '(18Vogl': [1479, 1709], 'Gharibyan': [1481, 1711], 'A.L.': [1482, 1712], 'Morozova-Roche': [1483, 1713], 'L.A.': [1484, 1714], 'Pro-inflammatory': [1485, 1715], 'proteins:': [1489, 1719, 2645], 'self-assembly': [1490, 1720], 'into': [1491, 1721, 2320, 3022, 3223, 3231, 3529], 'multifunctional': [1492, 1722], 'native': [1493, 1723, 2973, 3239], 'amyloid': [1495, 1725, 2327], 'complexes.Int.': [1496, 1726], '2012;': [1500, 1730], '2893-2917Crossref': [1502, 1732], '(137)': [1505, 1735], '19Källberg': [1508], 'Tahvili': [1510], 'Ivars': [1512], 'Leanderson': [1514], 'Induction': [1516], 'homodimer': [1519, 3025, 4115], 'vivo.Biochem.': [1522], 'Commun.': [1525], '500:': [1527], '564-568Crossref': [1528], '(7)': [1531], '20Vogl': [1534, 1738], 'Leukert': [1536, 1740, 2987, 3095], 'Barczyk': [1538, 1742, 2989, 3097], 'Strupat': [1540, 1744, 2991, 3099], 'Roth': [1542, 1746, 2993, 3101], 'Biophysical': [1544, 1748, 2995, 3103], 'characterization': [1545, 1749, 2996, 3104], 'absence': [1552, 1756, 2188, 3003, 3111, 4177], 'bivalent': [1556, 1760, 3007, 3115], 'cations.Biochim.': [1557, 1761, 3008, 3116], '1763:': [1561, 1765, 3012, 3120], '1298-1306Crossref': [1562, 1766, 3013, 3121], '(144)': [1565, 1769, 3016, 3124], 'Tissue-specific': [1568], 'expression': [1570], 'profiles': [1571, 2881, 4023, 4152, 4169], 'detailed': [1573], 'proteomic': [1574], 'indicate': [1576], 'relative': [1578, 4112], 'vivo': [1585], 'depart': [1587], 'equimolar,': [1589], 'suggesting': [1590], 'significance': [1592], 'active': [1596, 2826], '(21Uhlén': [1598], 'Fagerberg': [1600], 'Hallström': [1602], 'B.M.': [1603], 'Lindskog': [1604], 'Oksvold': [1606], 'Mardinoglu': [1608], 'al.Tissue-based': [1611], 'map': [1612], 'proteome.Science.': [1616], '2015;': [1617, 1669], '347:': [1618], '1260419Crossref': [1619], '(8252)': [1622], 'higher-order': [1629], 'exhibit': [1632], 'conditions': [1639, 2955], '(22Tardif': [1640], 'M.R.': [1641], 'Chapeton-Montes': [1642], 'J.A.': [1643], 'Posvandzic': [1644], 'Pagé': [1646], 'Gilbert': [1648], 'Tessier': [1650], 'P.A.': [1651, 1962, 2558], 'Secretion': [1652], 'S100A12': [1657], 'neutrophils': [1659], 'involves': [1660], 'potassium': [1665], 'efflux.J.': [1666], '2015:': [1670], '296149Crossref': [1671], '(60)': [1674], 'Oligomerization': [1677], 'divalent': [1688], 'Each': [1691], 'binds': [1693], 'Ca2+': [1695, 2190, 3229, 4197, 4215], 'noncanonical': [1698, 2322], 'canonical': [1700, 3947], 'loops': [1701, 3909, 3923, 3937, 4097, 4187], 'located': [1702], 'N-': [1705], 'C-terminal': [1707], 'EF-hands': [1708], 'Some': [1772], 'proteoforms,': [1773], 'particularly': [1774, 2468], 'heterodimer,': [1776, 4251], 'bind': [1778, 2009], 'including,': [1782], 'Zn2+,': [1783, 2115], 'Ni2+,': [1784, 2117], 'Fe2+,': [1785], 'Mn2+,': [1787, 2116], '23Fritz': [1813], 'Structures': [1818], 'Calcium': [1821, 3630], 'Zinc': [1823], 'Proteins.': [1826], 'John': [1827], 'Wiley': [1828], '&': [1829], 'Sons,': [1830], 'Ltd,': [1831], 'Hoboken,': [1832], 'NJ2006Crossref': [1833], '24Gilston': [1836], 'B.A.': [1837], 'Skaar': [1838], 'E.P.': [1839], 'Chazin': [1840], 'metals': [1845], 'proteins.Sci.': [1848], 'China': [1849], 'Life': [1850], '2016;': [1852, 2304, 2755], '59:': [1853], '792-801Crossref': [1854], '(55)': [1857], 'differ': [1862], 'proteolytic': [1864, 2597], 'ligand/ion': [1866], 'specificity,': [1867], 'posttranslational': [1871, 2477, 2721], 'modifications': [1872, 2472, 2479, 2595, 2722], '25Lim': [1895], 'S.Y.': [1896, 1923, 2492, 2519], 'Raftery': [1897, 1924, 2493, 2520], 'Cai': [1899, 2495], 'Yan': [1903, 2499], 'W.X.': [1904, 2500], 'Hseih': [1905, 2501], 'H.-L.': [1906, 2502], 'al.S-nitrosylated': [1908, 2504], 'S100A8:': [1909, 2505], 'properties.J.': [1912, 2508], '2008;': [1914, 2510], '181:': [1915, 2511], '5627-5636Crossref': [1916, 2512], '(91)': [1919, 2515], '26Lim': [1922, 2518], 'M.J.': [1925, 1958, 2521, 2554], 'Goyette': [1926, 2522], 'Geczy': [1928, 2524], 'C.L.': [1929, 2263, 2525], 'S-glutathionylation': [1930, 2526], 'regulates': [1931, 2527], 'inflammatory': [1932, 2528], 'S100A9.J.': [1935, 2531], '2010;': [1938, 2534], '285:': [1939, 2535], '14377-14388Abstract': [1940, 2536], '(58)': [1948, 2544], '27Hoskin': [1951, 2547], 'T.S.': [1952, 2548], 'Crowther': [1953, 2549], 'J.M.': [1954, 2550], 'Cheung': [1955, 2551], 'Epton': [1957, 2553], 'Sly': [1959, 2555], 'P.D.': [1960, 2556], 'Elder': [1961, 2557], 'al.Oxidative': [1964, 2560], 'cross-linking': [1965, 2561], 'occurs': [1968, 2564], 'vivo,': [1970, 2474, 2566], 'altering': [1971, 2567], 'its': [1972, 2037, 2568], 'proteolysis.Redox': [1977, 2573], '2019;': [1979, 2575, 2870], '24:': [1980, 2576], '101202Crossref': [1981, 2577], '(26)': [1984, 2580], 'heterodimers,': [1990, 2905], 'released': [1991], 'low-Ca2+': [1994], 'interior': [1995], 'tetramers': [1999, 3224], 'Ca2+-rich': [2002], 'intercellular': [2003], 'space.': [2004], 'In': [2005, 2312, 2664, 3168, 3390, 3927, 3985, 4076, 4145], 'dimers': [2008, 3052, 3357], 'receptors': [2012], 'induce': [2014], 'signals.': [2016], 'Tetrameric': [2017], 'loses': [2019], 'this': [2020, 2665, 3873, 3966], 'capability': [2021], 'because': [2022, 2462], 'TLR4-binding': [2024], 'epitope': [2025], 'hides': [2026], 'at': [2027, 2126, 2923, 2930, 3337, 3392, 3403, 3488, 3554, 3697, 3707, 3900, 3974], 'interface': [2029], 'dimers.': [2032], 'Thus,': [2033], 'localization': [2035, 3755], 'dimeric': [2038], 'capable': [2040], 'focused,': [2045], 'allowing': [2046], 'precise': [2048], 'control': [2049, 2642], 'spread': [2052], 'signal': [2056], 'Ca2+-bound': [2091], 'tetramer': [2092, 3256], 'acts': [2093], 'instead': [2094], 'antibacterial': [2097], 'agent': [2098], 'through': [2099], 'mechanism': [2103], 'depriving': [2105], 'Strong': [2112], 'Fe2+': [2119], 'provided': [2121], 'interface.': [2129], 'first': [2131], 'classical': [2134, 2727], 'H3D': [2135], 'site': [2136, 2154], 'built': [2137], 'side': [2140, 3455], 'chains': [2141], 'H83A8,': [2143], 'H87A8,': [2144], 'H20A9,': [2145], 'D30A9.': [2147], 'second': [2149], 'unique': [2152], 'H6': [2153], 'involving': [2155], 'imidazoles': [2158, 2168], 'H17A8': [2160], 'H27A8': [2162], 'four': [2167], 'H91A9,': [2171], 'H95A9,': [2172], 'H103A9,': [2173], 'H105A9': [2175], 'residues': [2176, 2484], 'tail.': [2180], 'ion': [2182, 2748], 'affinity': [2183], 'drops': [2184, 3445], '28Nakashige': [2258], 'T.G.': [2259], 'Zygiel': [2260], 'Drennan': [2262], 'Nickel': [2266], 'calprotectin.J.': [2273, 2600], 'Am.': [2274, 2601, 2653, 3644], 'Soc.': [2276, 2603, 2655, 3646], '2017;': [2277, 2656, 3153], '139:': [2278, 2657], '8828-8836Crossref': [2279], '(85)': [2282], '29Lin': [2285], 'Andersen': [2287], 'G.R.': [2288, 2844], 'Yatime': [2289], 'Crystal': [2291], 'calcium.BMC': [2301], 'Struct.': [2302], '16:': [2305, 2871], '8Crossref': [2306], '(21)': [2309], 'excess': [2314, 3251], 'Zn2+': [2316], 'assembles': [2319], 'higher,': [2321], 'oligomers,': [2323], 'leading': [2324], 'harmful': [2326], 'deposits,': [2328], 'observed': [2330, 2435, 3088, 3481, 3545], 'Zn2+-rich': [2332], 'prostate': [2333], '(30Yanamandra': [2336], 'Alexeyev': [2338], 'O.': [2339], 'Zamotin': [2340], 'Srivastava': [2342], 'Shchukarev': [2344], 'Brorsson': [2346], 'A.-C.': [2347], 'al.Amyloid': [2349], 'pro-inflammatory': [2353], 'ageing': [2358], 'prostate.PLoS': [2359], '4:': [2362], 'e5562Crossref': [2363], '(86)': [2366], 'mechanistic': [2370], 'underlying': [2372], 'effects': [2373, 3138], 'like': [2374], 'heterodimerization': [2375, 4174], 'ion–dependent': [2378], 'tetramerization': [2379], 'under': [2382, 2441, 2776, 2953], 'debate.': [2383], 'Available': [2384], 'represent': [2386], 'primarily': [2387], 'data': [2389], 'describe': [2391], 'limited,': [2394], 'successfully': [2395], 'crystallized': [2396, 2446], 'conformers': [2397], 'determined': [2398], 'excluded,': [2402], 'ion–loaded': [2407], '(Table': [2409], 'S1).': [2410], 'Remarkably,': [2411], 'no': [2414], 'apo': [2420, 2908, 3721, 3737, 4029, 4072, 4250], 'form.': [2421], 'All': [2422], 'published': [2423], 'similar': [2427], 'main-chain': [2428], 'conformation': [2429], 'clearly': [2433, 3968], 'explain': [2434], 'oligomeric': [2439, 2706], 'assemblies': [2440], 'varying': [2442, 2778], 'conditions.': [2443, 2779], 'Also,': [2444, 3880], 'most': [2445, 3794, 3852, 3942], 'cysteines': [2451, 3312], '(C42A8': [2452], 'C3A9)': [2454], 'removed,': [2457], 'disadvantage': [2461], 'susceptible': [2469], 'oxidative': [2471], 'redox': [2478, 3309], 'methionine': [2481], 'cysteine': [2483, 3270, 3301], 'some': [2486], '(25Lim': [2491], '31Stephan': [2583], 'J.R.': [2584, 3623], 'Yu': [2585], 'Costello': [2587], 'R.M.': [2588], 'Bleier': [2589], 'B.S.': [2590], 'Oxidative': [2593], 'post-translational': [2594], 'accelerate': [2596], 'degradation': [2598], '140:': [2605], '17444-17455Crossref': [2606], '(18)': [2609, 2840], 'promising': [2613], 'direction': [2614], 'combine': [2617], 'biophysical': [2618], 'computer': [2621], 'simulations,': [2622, 2885], 'done': [2627], 'study': [2629], 'S100A11': [2634], '(32Xiao': [2635], 'Shaw': [2637], 'G.S.': [2638, 2850], 'Konermann': [2639], 'Calcium-mediated': [2641], 'allosteric': [2646], 'communication': [2647], 'via': [2648], 'agitator/signal': [2650], 'blocking': [2651], 'mechanism.J.': [2652], '11460-11470Crossref': [2658], '(15)': [2661], 'work,': [2666], 'applied': [2668], 'hydrogen–deuterium': [2669], 'exchange': [2670, 2822, 2864, 3044, 3699, 3786, 3870, 4110, 4209], '(HDx-MS)': [2673], '(MD)': [2678], 'complementary': [2682], 'technique': [2683], 'studies.': [2686], 'aimed': [2688], 'missing': [2692], 'comparison': [2694], 'full-length,': [2697], 'nonmutated': [2698], 'arranged': [2703], 'different': [2705, 2935, 3490], 'structures.': [2707], 'HDx-MS': [2708, 2782, 3524, 3719], 'helpful,': [2712], 'our': [2714, 3602], 'hands,': [2715], 'studying': [2717], 'consequences': [2719], 'escape': [2726], 'elucidation': [2729], '(33Bajor': [2730], 'Zaręba-Kozioł': [2732], 'Zhukova': [2734], 'Goryca': [2736], 'Poznański': [2738], 'Wysłouch-Cieszyńska': [2740], 'An': [2742], 'interplay': [2743], 'astrocytic': [2751], 'S100B': [2752], 'protein.PLoS': [2753], '11e0154822Crossref': [2756], '(13)': [2758], 'advantage': [2763], 'method': [2766], 'be': [2771, 3348, 3596], 'analyzed': [2772, 3364], 'without': [2773, 3340], 'labeling': [2774], 'widely': [2777], 'Most': [2780], 'importantly,': [2781], 'results': [2783, 3657], 'flexibility': [2787], 'investigated': [2792], 'systems': [2793], '(34Narang': [2794], 'Lento': [2796], 'J': [2798], 'Wilson': [2799], 'HDX-MS:': [2801], 'analytical': [2803, 3200], 'tool': [2804], 'capture': [2806], 'motion': [2808], 'action.Biomedicines.': [2810], '224Crossref': [2813], '35Giladi': [2817], 'Khananshvili': [2819], 'Hydrogen-deuterium': [2821], 'mass-spectrometry': [2823], 'secondary': [2825, 3171], 'transporters:': [2827], 'mechanisms.Front.': [2833], 'Pharmacol.': [2834], '11:': [2836], '70Crossref': [2837], '36Masson': [2843], 'Burke': [2845], 'J.E.': [2846], 'Ahn': [2847], 'N.G.': [2848], 'Anand': [2849], 'Borchers': [2851], 'Brier': [2853], 'al.Recommendations': [2856], 'performing,': [2858], 'interpreting': [2859], 'reporting': [2861], 'hydrogen': [2862], 'deuterium': [2863, 3685, 3748, 3838, 4182], '(HDX-MS)': [2867], 'experiments.Nat.': [2868], 'Methods.': [2869], '595-602Crossref': [2872], '(322)': [2875], 'By': [2878], 'superimposing': [2879], 'HDx': [2880, 3734, 3814, 3992, 4064, 4127, 4151, 4168, 4221], 'dynamic': [2884, 3912, 3960], 'tried': [2887], 'infer': [2889], 'characteristics': [2893], 'evolve': [2899], 'when': [2900, 3026], 'switching': [2901], 'homodimers': [2903, 3213, 3391, 3435, 3507, 3722, 4201], 'forms': [2909], 'Ca2+-': [2911], 'Zn2+-loaded': [2913], 'Eventually,': [2915], 'demonstrate': [2917], 'modulated': [2922], 'level': [2925], 'plasticity,': [2928], 'tuned': [2929], 'particular': [2931], 'proteoforms.': [2936, 3319], 'Wildtype': [2937], 'were': [2943, 2964, 3053, 3484, 3816, 3885], 'individually': [2944], 'coli': [2948], 'purified': [2950, 3039, 3318], 'homogeneity': [2952], 'HPLC': [2957, 3304], '(Fig.': [2958, 3073, 3188, 3196, 3202, 3257, 3520, 3576, 4202, 4210, 4236], 'S1A).': [2959], 'obtained': [2965, 3432, 3667], 'refolding': [2967], 'denatured': [2968], 'back': [2970, 4025], 'dialysis': [2976], 'pH': [2978, 2981, 3555], '2.5': [2979, 3556], '7.5,': [2982], '(20Vogl': [2985, 3093], 'Refolded': [3019], 'assembled': [3021, 3222], 'either': [3023, 4071], 'pure': [3028, 3206], 'equimolar': [3036], 'mixture': [3037], 'S100A9.': [3042, 4189], 'Anion': [3043], 'chromatography': [3045, 3060, 3194], 'gel': [3047], 'filtration': [3048], 'showed': [3049, 3493], 'noncovalent,': [3054], 'HPLC,': [3056], 'SDS-PAGE,': [3057], 'liquid': [3059], '(LC)–electrospray': [3061], 'ionization': [3062], '(ESI)–MS': [3063], 'whole': [3065], 'confirmed': [3067, 3296], 'composition': [3069], 'appropriate': [3071], 'S1,': [3074, 3189], 'A–C).': [3075], 'Circular': [3076], 'dichroism': [3077], '(CD)': [3078], 'spectroscopy': [3079], 'demonstrated': [3080, 3723], 'expected': [3085], 'these': [3090], 'previously': [3092, 3609], '37NematiNiko': [3127], 'Chegini': [3129], 'K.G.': [3130], 'Asghari': [3131], 'Amini': [3133], 'Gheibi': [3135], 'Modifying': [3137], 'carboxyl': [3140], 'tyrosinase.Biochim.': [3150], '1865:': [3154], '370-379Crossref': [3155], '(4)': [3157], '38Imani': [3160], 'Bahrami': [3162], 'Jaliani': [3164], 'H.Z.': [3165], 'Ardestani': [3166], 'solution': [3169, 3330], 'cation-induced': [3170], 'tertiary': [3173], 'alterations': [3175], 'calprotectin.Protein': [3178], '33:': [3181], '465-473Crossref': [3182], '(5)': [3185], 'D': [3190], 'E).': [3192], 'Size-exclusion': [3193], '(SEC)': [3195], '1,': [3197, 3258], 'A–C)': [3198], 'ultracentrifugation': [3201], '1D)': [3203], 'indicated': [3204], 'regardless': [3214], 'Ca2+/Zn2+': [3219, 3252], 'Heterodimers': [3221], 'addition': [3227, 3705, 4198], 'even': [3232, 3331, 4059, 4160], 'Zn2+.': [3236], 'MS': [3240, 3306], 'results,': [3241], 'predominant': [3243], 'proteoform': [3244, 3551, 3696], 'remained': [3254, 3658, 3806, 4036, 4053], 'E': [3259], 'F).': [3261], 'Since': [3262], 'possess': [3268], 'reduced': [3269, 3298], 'residues,': [3271], 'paid': [3273], 'special': [3274], 'attention': [3275], 'throughout': [3276], 'purification': [3278], 'prevent': [3281], 'covalent': [3286, 3326, 3356], 'disulfide': [3287, 3327], 'oxidation': [3290], 'product.': [3291], 'Before': [3292], 'each': [3293, 3549, 3695, 4067], 'experiment,': [3294], 'state': [3299], 'thiols': [3302], 'analysis.': [3307, 3380], 'differed': [3313], 'markedly': [3314], 'among': [3315, 3558], 'Calprotectin': [3320, 3492], '(S100A8)2': [3322, 3463, 3730, 3738, 3889, 3914, 3957, 4041], 'did': [3323], 'bonds': [3328], 'after': [3332, 3351, 3703, 3790, 3840, 3862, 3916, 4161, 4196, 4205], 'several': [3333], 'days': [3334], 'storage': [3336], '4': [3338], '°C': [3339], 'thiol-reducing': [3342], 'agent,': [3343], 'while': [3344, 3470], '(S100A9)2': [3345, 3472, 3892, 3925, 4052], 'had': [3346, 4057], 'immediately': [3350, 3702], 'purification,': [3352], 'efficiently.': [3359], 'Proper': [3360], 'folding': [3361], 'all': [3363, 3975], 'assessed': [3368], 'measurements': [3372], 'nanodifferential': [3374], 'fluorescence': [3375, 3379, 3421, 3444], 'based': [3376], 'tryptophan': [3378, 3387], 'one': [3386], 'residue': [3388], 'each.': [3389], 'room': [3393], 'temperature,': [3394, 3459], 'W88A9': [3395], 'exposed': [3398, 3477], 'solvent': [3401], '(fluorescence': [3402], '350': [3404], 'nm/330': [3405], 'nm': [3406], '[F]': [3407], '=': [3408, 3414, 3437, 3447, 3498, 3509, 3515], '0.94)': [3409], 'W54A8': [3412], '(F': [3413, 3436, 3446], '0.74).': [3415], 'F': [3417], 'value': [3418], 'Trp': [3420, 3443, 3454], 'arithmetic': [3427], 'mean': [3428], 'values': [3431], '0.84).': [3438], 'Upon': [3439], 'Ca2+-induced': [3440], 'tetramerization,': [3441], '0.71),': [3448], 'indicating': [3449], 'burial': [3452], 'chains.': [3456], 'With': [3457], 'increasing': [3458, 4090], 'tryptophans': [3461], 'become': [3464, 3476], 'buried': [3465], '(red': [3466], 'shifted': [3467], 'fluorescence),': [3469], '(blue': [3478], 'shifted).': [3479], 'unfolding': [3482], 'transitions': [3483], 'sudden': [3485], 'occurred': [3487], 'quite': [3489], 'temperatures.': [3491], 'much': [3494, 3817], '(Tm[A8A9apo]': [3497], '70.2': [3499], '°C,': [3500, 3513], 'Tm[A8A9Ca2+]': [3501], '≈': [3502, 3511, 3517], '75': [3503], '°C)': [3504, 3519], 'compared': [3505, 3920, 4069], '(Tm[A8apo]': [3508], 'Tm[A8Ca2+]': [3510], '60.5': [3512], 'Tm[A9apo]': [3514], 'Tm[A9Ca2+]': [3516], '61.7': [3518], 'S1F).': [3521], 'performed': [3523], 'experiments': [3525], 'gain': [3527], 'insight': [3528], 'homogenous': [3535], 'Using': [3540], 'tandem': [3541], 'spectrometry,': [3543], 'digestion': [3547, 3656], 'studied': [3550], 'pepsin': [3553], 'yielded,': [3557], 'others,': [3559], '39': [3560], 'peptides': [3561, 3668, 3693, 3800], 'subunit': [3565], '49': [3567, 3675], 'altogether': [3570], 'covering': [3571], '93%': [3572], '2': [3577], 'Table': [3579, 3680], 'S2).': [3580, 3681, 3761, 3984], 'Only': [3581, 4031], 'N': [3586], 'termini': [3587], 'helices': [3589, 3881, 4002, 4032, 4080, 4131], 'IV': [3590, 3884, 4014, 4107], '(A869–74': [3591], 'A979–83)': [3593], 'could': [3594], 'detected.': [3597], 'Despite': [3598, 4101], 'minor': [3599], 'protocols': [3603], '(see': [3604], 'Experimental': [3605], 'procedures)': [3606], 'those': [3608], 'reported': [3610], 'literature': [3613], 'Cys/Ser': [3616], 'mutant': [3617], '(39Adhikari': [3620], 'Stephan': [3622], 'Rempel': [3624], 'D.L.': [3625], 'Gross': [3628], 'M.L.': [3629], 'revealed': [3639], 'integrated': [3641], 'spectrometry.J.': [3643], '142:': [3648], '13372-13383Crossref': [3649], '(10)': [3652], 'Scholar),': [3654], 'consistent,': [3659], 'slightly': [3663], 'decreased': [3664, 4181], 'number': [3665], '(39': [3669], 'versus': [3670, 3676, 3894, 3898], '40': [3671], '55': [3677], 'measured': [3683, 3976], 'uptake': [3686, 3749, 3839, 4183], 'same': [3690], 'sets': [3691], 'five': [3698], 'time': [3700, 3903], 'points:': [3701], 'D2O': [3704], '10': [3708, 3841, 3917], 's,': [3709], '1': [3710, 3863], 'min,': [3711, 3713, 4021], '5': [3712, 3791, 3865, 4020, 4162, 4206], '24': [3715], 'h': [3716], 'HDx.': [3718], 'substantial': [3724, 3955], 'deuteration': [3727], '(S100A9)2.': [3732, 3950], 'profile': [3735, 3993], 'consists': [3739], 'alternating': [3741], 'characterized': [3743], 'lower': [3745], 'correlate': [3751], '(Figs.': [3758, 3820, 3978, 4015, 4116], '3A': [3759], 'Less': [3762], 'protected': [3763, 3853, 3887, 4001, 4010, 4235], 'correspond': [3765], 'loose': [3768], 'parts,': [3769], 'such': [3770], "protein's": [3773], 'termini,': [3774], 'loops,': [3776], 'linker': [3778, 4011, 4086], 'motifs.': [3783], 'While': [3784], 'eventually': [3788], 'saturated': [3789], 'min': [3792, 3866, 4163, 4207], 'sequence,': [3798], 'helix': [3802, 3845, 3963, 4013, 4099, 4106, 4139, 4232], 'I': [3803, 3846, 4033, 4081], '(i.e.,': [3804], 'A85–15)': [3805], 'barely': [3807], 'accessible': [3808, 4095], 'solvent.': [3811], '(S100A9)2,': [3813, 3986], 'less': [3818, 3959, 4009, 4054], 'differentiated': [3819, 3997], '3B': [3821], 'S3),': [3823], 'within': [3827, 3962, 4136], 'pronounced.': [3831], 'peptide': [3834, 3874, 3972], 'low': [3836], '(<25%)': [3837], 's': [3842], 'derives': [3843], '(A914–19)': [3847], 'corresponds': [3849], 'fragment': [3854], '(S100A8)2.': [3856], 'Yet,': [3857], 'contrast': [3859, 4092, 4146], '(S100A8)2,': [3861], 'exchange,': [3868, 4165], 'rates': [3871, 4111], 'reached': [3875], '60%': [3876], '90%,': [3878], 'respectively.': [3879], 'II': [3882, 4035, 4083], '(∼30%': [3893], '∼55%,': [3895], '45%': [3897], '80%': [3899], '10-s': [3902], 'point,': [3904], 'respectively).': [3905], 'Conversely,': [3906], '(80%–100%': [3915], 's)': [3918], '(∼70%).': [3926], 'stabilizes': [3934], 'slightly,': [3939], 'pronounced': [3943, 3969, 4245], 'effect': [3944, 4062, 4242], 'loop': [3948, 4191], 'There': [3951], 'are,': [3952], 'however,': [3953], 'differences.': [3956], 'becomes': [3958], 'II,': [3964, 4004, 4133], 'A831–39': [3973], 'times': [3977], '4,': [3979, 4043], 'C': [3982, 4044, 4049], 'hand,': [3990], 'deviated': [3994], 'substantially,': [3995], 'becoming': [3996], 'I,': [4003, 4132], 'III': [4006, 4135], '4B': [4016], 'S3).': [4018, 4119], 'After': [4019], 'converged': [4024], 'resemble': [4027], 'counterparts.': [4030], 'protected,': [4038, 4089], 'especially': [4039, 4129, 4204], '(Fig': [4042], 'D),': [4046], 'terminus': [4050], 'protected.': [4055], 'Heterodimerization': [4056], 'profound': [4061], 'Ca2+-loaded': [4074], 'homodimers.': [4075], 'subunit,': [4079], 'became': [4087, 4170, 4234, 4255], 'III.': [4100], 'stabilization,': [4105], 'experienced': [4108], 'increased': [4109], 'S2': [4117], 'displayed': [4121], 'decrease': [4125], 'levels,': [4128], 'linker;': [4138], 'IV;': [4140], 'loops.': [4144], 'retained': [4158], 'definition': [4159], 'alike.': [4172], 'Notably,': [4173], 'protection': [4192], '4B),': [4203], '4D).': [4211], 'Loading': [4212], 'promoted': [4217], 'decline': [4219], 'ratios': [4222], 'subunits.': [4225], 'Now': [4226], 'last': [4228], 'core': [4229], 'element,': [4231], 'III,': [4233], '5,': [4237], 'B).': [4240], 'This': [4241], 'here': [4253], 'apparent': [4256], 'b': [4258]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4318563500', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 3}], 'updated_date': '2025-01-04T17:46:13.425129', 'created_date': '2023-01-31'}