Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3083103331', 'doi': 'https://doi.org/10.3760/cma.j.cn112144-20191210-00445', 'title': '[S100A8/A9 and periodontal inflammatory diseases].', 'display_name': '[S100A8/A9 and periodontal inflammatory diseases].', 'publication_year': 2020, 'publication_date': '2020-09-09', 'ids': {'openalex': 'https://openalex.org/W3083103331', 'doi': 'https://doi.org/10.3760/cma.j.cn112144-20191210-00445', 'mag': '3083103331', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32878406'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32878406', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5053600307', 'display_name': 'Hongyu Gao', 'orcid': 'https://orcid.org/0000-0001-8633-3604'}, 'institutions': [{'id': 'https://openalex.org/I4210136021', 'display_name': 'Tianjin Stomatological Hospital', 'ror': 'https://ror.org/047rxfg53', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136021']}, {'id': 'https://openalex.org/I5740404', 'display_name': 'Tianjin Medical University', 'ror': 'https://ror.org/02mh8wx89', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5740404']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'H Y Gao', 'raw_affiliation_strings': ['Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaGao Hongyu is working on the Department of Periodontology, Stomatological Hospital, Tianjin Medical University, Tianjin 300070, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaGao Hongyu is working on the Department of Periodontology, Stomatological Hospital, Tianjin Medical University, Tianjin 300070, China.', 'institution_ids': ['https://openalex.org/I4210136021', 'https://openalex.org/I5740404']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025370829', 'display_name': 'Haimei Meng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136021', 'display_name': 'Tianjin Stomatological Hospital', 'ror': 'https://ror.org/047rxfg53', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136021']}, {'id': 'https://openalex.org/I5740404', 'display_name': 'Tianjin Medical University', 'ror': 'https://ror.org/02mh8wx89', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5740404']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'H X Meng', 'raw_affiliation_strings': ['Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaGao Hongyu is working on the Department of Periodontology, Stomatological Hospital, Tianjin Medical University, Tianjin 300070, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaGao Hongyu is working on the Department of Periodontology, Stomatological Hospital, Tianjin Medical University, Tianjin 300070, China.', 'institution_ids': ['https://openalex.org/I4210136021', 'https://openalex.org/I5740404']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005618471', 'display_name': 'Jie Hou', 'orcid': 'https://orcid.org/0000-0003-3454-6274'}, 'institutions': [{'id': 'https://openalex.org/I4210136021', 'display_name': 'Tianjin Stomatological Hospital', 'ror': 'https://ror.org/047rxfg53', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136021']}, {'id': 'https://openalex.org/I5740404', 'display_name': 'Tianjin Medical University', 'ror': 'https://ror.org/02mh8wx89', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5740404']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'J X Hou', 'raw_affiliation_strings': ['Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaGao Hongyu is working on the Department of Periodontology, Stomatological Hospital, Tianjin Medical University, Tianjin 300070, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, ChinaGao Hongyu is working on the Department of Periodontology, Stomatological Hospital, Tianjin Medical University, Tianjin 300070, China.', 'institution_ids': ['https://openalex.org/I4210136021', 'https://openalex.org/I5740404']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.063923, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 60, 'max': 69}, 'biblio': {'volume': '55', 'issue': '9', 'first_page': '679', 'last_page': '684'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12030', 'display_name': 'S100 Proteins and Annexins', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12030', 'display_name': 'S100 Proteins and Annexins', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10257', 'display_name': 'Oral microbiology and periodontitis research', 'score': 0.9888, 'subfield': {'id': 'https://openalex.org/subfields/3506', 'display_name': 'Periodontics'}, 'field': {'id': 'https://openalex.org/fields/35', 'display_name': 'Dentistry'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 0.9655, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/s100a8', 'display_name': 'S100A8', 'score': 0.9648238}, {'id': 'https://openalex.org/keywords/s100a9', 'display_name': 'S100A9', 'score': 0.9586007}], 'concepts': [{'id': 'https://openalex.org/C2778557267', 'wikidata': 'https://www.wikidata.org/wiki/Q20969990', 'display_name': 'S100A8', 'level': 3, 'score': 0.9648238}, {'id': 'https://openalex.org/C2776307749', 'wikidata': 'https://www.wikidata.org/wiki/Q18031354', 'display_name': 'S100A9', 'level': 3, 'score': 0.9586007}, {'id': 'https://openalex.org/C2778292693', 'wikidata': 'https://www.wikidata.org/wiki/Q22328664', 'display_name': 'Calprotectin', 'level': 4, 'score': 0.916132}, {'id': 'https://openalex.org/C2780385504', 'wikidata': 'https://www.wikidata.org/wiki/Q520127', 'display_name': 'Periodontitis', 'level': 2, 'score': 0.7792387}, {'id': 'https://openalex.org/C2781197716', 'wikidata': 'https://www.wikidata.org/wiki/Q864574', 'display_name': 'Biomarker', 'level': 2, 'score': 0.5960444}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.5811016}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.53583544}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3283988}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.20687994}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2001032}, {'id': 'https://openalex.org/C199343813', 'wikidata': 'https://www.wikidata.org/wiki/Q12128', 'display_name': 'Dentistry', 'level': 1, 'score': 0.17779955}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.052314788}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2778260677', 'wikidata': 'https://www.wikidata.org/wiki/Q917447', 'display_name': 'Inflammatory bowel disease', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D040501', 'descriptor_name': 'Calgranulin A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D040502', 'descriptor_name': 'Calgranulin B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D039841', 'descriptor_name': 'Leukocyte L1 Antigen Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009504', 'descriptor_name': 'Neutrophils', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/32878406', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.74}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4309661693', 'https://openalex.org/W4223560537', 'https://openalex.org/W3175480027', 'https://openalex.org/W3083103331', 'https://openalex.org/W2885804435', 'https://openalex.org/W2528801841', 'https://openalex.org/W2159111033', 'https://openalex.org/W2141268830', 'https://openalex.org/W2038001185', 'https://openalex.org/W1972491378'], 'abstract_inverted_index': {'Calprotectin': [0], 'S100A8/A9,': [1], 'a': [2, 51], 'heterodimer': [3], 'composed': [4], 'of': [5, 13, 42, 69, 76], 'S100A8': [6], 'and': [7, 27, 40, 72, 96], 'S100A9,': [8], 'is': [9, 34, 47], 'the': [10, 23, 38, 67, 74, 87, 92], 'main': [11], 'component': [12], 'cytoplasmic': [14], 'proteins': [15], 'in': [16, 22, 62], 'neutrophils.': [17], 'It': [18], 'plays': [19], 'multiple': [20], 'roles': [21], 'immuno-inflammatory': [24], 'reactions': [25], 'intracellularly': [26], 'extracellularly.': [28], 'Recent': [29], 'studies': [30], 'find': [31], 'that': [32], 'S100A8/A9': [33, 46, 95], 'closely': [35], 'related': [36], 'with': [37, 64], 'initiation': [39], 'progression': [41], 'periodontal': [43, 56, 70, 97], 'inflammatory': [44, 57, 60, 98], 'diseases.': [45], 'expected': [48], 'to': [49, 79], 'be': [50], 'new': [52], 'biomarker': [53], 'for': [54], 'diagnosing': [55], 'diseases,': [58], 'monitoring': [59], 'activities': [61], 'patients': [63], 'periodontitis,': [65], 'evaluating': [66], 'outcome': [68], 'treatments': [71], 'predicting': [73], 'susceptibility': [75], 'individual': [77], 'patient': [78], 'periodontitis.': [80], 'In': [81], 'this': [82], 'literature': [83], 'review,': [84], 'we': [85], 'summarize': [86], 'clinical': [88], 'research': [89], 'progress': [90], 'on': [91], 'relation': [93], 'between': [94], 'diseases.S100A8/A9蛋白是由S100A8与S100A9蛋白组成的异二聚体,属于钙结合蛋白S100家族,是中性粒细胞的主要胞质蛋白,在免疫炎症反应中发挥多种胞内、胞外的生物学功能。近年研究发现,S100A8/A9与牙周炎症性疾病的发生发展关系密切。S100A8/A9在诊断牙周炎症性疾病、监测牙周炎症活动性、评价牙周治疗效果以及预测牙周炎易感性等方面有望成为新的生物标志物。本文就S100A8/A9蛋白与牙周炎症性疾病关系的临床研究进展作一文献综述。.': [99]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3083103331', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2025-01-05T11:12:20.120021', 'created_date': '2020-09-11'}