Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4313500299', 'doi': 'https://doi.org/10.3390/molecules28020483', 'title': 'Tinosporaside from Tinospora cordifolia Encourages Skeletal Muscle Glucose Transport through Both PI-3-Kinase- and AMPK-Dependent Mechanisms', 'display_name': 'Tinosporaside from Tinospora cordifolia Encourages Skeletal Muscle Glucose Transport through Both PI-3-Kinase- and AMPK-Dependent Mechanisms', 'publication_year': 2023, 'publication_date': '2023-01-04', 'ids': {'openalex': 'https://openalex.org/W4313500299', 'doi': 'https://doi.org/10.3390/molecules28020483', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36677541'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/molecules28020483', 'pdf_url': 'https://www.mdpi.com/1420-3049/28/2/483/pdf?version=1672826599', 'source': {'id': 'https://openalex.org/S108911230', 'display_name': 'Molecules', 'issn_l': '1420-3049', 'issn': ['1420-3049', '1433-1373'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1420-3049/28/2/483/pdf?version=1672826599', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5026943274', 'display_name': 'Akansha Mishra', 'orcid': 'https://orcid.org/0000-0003-3574-5777'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}, {'id': 'https://openalex.org/I99364266', 'display_name': 'Academy of Scientific and Innovative Research', 'ror': 'https://ror.org/053rcsq61', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I99364266']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Akansha Mishra', 'raw_affiliation_strings': ['Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India', 'Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India', 'institution_ids': ['https://openalex.org/I185249246']}, {'raw_affiliation_string': 'Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India', 'institution_ids': ['https://openalex.org/I99364266']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031485630', 'display_name': 'Khushbu Sharma', 'orcid': 'https://orcid.org/0000-0002-1801-2881'}, 'institutions': [{'id': 'https://openalex.org/I51317819', 'display_name': 'Institute of Medical Sciences', 'ror': 'https://ror.org/04y75dx46', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I51317819', 'https://openalex.org/I91357014']}, {'id': 'https://openalex.org/I91357014', 'display_name': 'Banaras Hindu University', 'ror': 'https://ror.org/04cdn2797', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I91357014']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Khushbu Sharma', 'raw_affiliation_strings': ['Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India', 'institution_ids': ['https://openalex.org/I51317819', 'https://openalex.org/I91357014']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069318560', 'display_name': 'Jyotsana Pandey', 'orcid': 'https://orcid.org/0000-0002-0606-6903'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}, {'id': 'https://openalex.org/I99364266', 'display_name': 'Academy of Scientific and Innovative Research', 'ror': 'https://ror.org/053rcsq61', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I99364266']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Jyotsana Pandey', 'raw_affiliation_strings': ['Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India', 'Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India', 'institution_ids': ['https://openalex.org/I185249246']}, {'raw_affiliation_string': 'Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India', 'institution_ids': ['https://openalex.org/I99364266']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100784636', 'display_name': 'Kapil Dev', 'orcid': 'https://orcid.org/0000-0002-3995-2370'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Kapil Dev', 'raw_affiliation_strings': ['Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India'], 'affiliations': [{'raw_affiliation_string': 'Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062137268', 'display_name': 'Sleman Kadan', 'orcid': 'https://orcid.org/0000-0002-0631-0435'}, 'institutions': [{'id': 'https://openalex.org/I119057318', 'display_name': 'Al-Qasemi Academic College of Education', 'ror': 'https://ror.org/00e9cav63', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I119057318']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Sleman Kadan', 'raw_affiliation_strings': ['Qasemi Research Center, Al-Qasemi Academic College, P.O. Box 124, Baqa El-Gharbia 30100, Israel'], 'affiliations': [{'raw_affiliation_string': 'Qasemi Research Center, Al-Qasemi Academic College, P.O. Box 124, Baqa El-Gharbia 30100, Israel', 'institution_ids': ['https://openalex.org/I119057318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086436975', 'display_name': 'Mahendra Sahai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I91357014', 'display_name': 'Banaras Hindu University', 'ror': 'https://ror.org/04cdn2797', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I91357014']}, {'id': 'https://openalex.org/I51317819', 'display_name': 'Institute of Medical Sciences', 'ror': 'https://ror.org/04y75dx46', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I51317819', 'https://openalex.org/I91357014']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Mahendra Sahai', 'raw_affiliation_strings': ['Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India', 'institution_ids': ['https://openalex.org/I91357014', 'https://openalex.org/I51317819']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051790226', 'display_name': 'Ishbal Ahmad', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Ishbal Ahmad', 'raw_affiliation_strings': ['Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India', 'institution_ids': ['https://openalex.org/I185249246']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020817270', 'display_name': 'Arvind K. Srivastava', 'orcid': 'https://orcid.org/0000-0001-8406-4535'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}, {'id': 'https://openalex.org/I99364266', 'display_name': 'Academy of Scientific and Innovative Research', 'ror': 'https://ror.org/053rcsq61', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I99364266']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Arvind K. Srivastava', 'raw_affiliation_strings': ['Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India', 'Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India', 'institution_ids': ['https://openalex.org/I185249246']}, {'raw_affiliation_string': 'Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India', 'institution_ids': ['https://openalex.org/I99364266']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042783687', 'display_name': 'Akhilesh K. Tamrakar', 'orcid': 'https://orcid.org/0000-0003-0554-3779'}, 'institutions': [{'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}, {'id': 'https://openalex.org/I99364266', 'display_name': 'Academy of Scientific and Innovative Research', 'ror': 'https://ror.org/053rcsq61', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I99364266']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'Akhilesh K. Tamrakar', 'raw_affiliation_strings': ['Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India', 'Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India'], 'affiliations': [{'raw_affiliation_string': 'Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India', 'institution_ids': ['https://openalex.org/I185249246']}, {'raw_affiliation_string': 'Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India', 'institution_ids': ['https://openalex.org/I99364266']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087955502', 'display_name': 'Hilal Zaid', 'orcid': 'https://orcid.org/0000-0002-1411-8953'}, 'institutions': [{'id': 'https://openalex.org/I119057318', 'display_name': 'Al-Qasemi Academic College of Education', 'ror': 'https://ror.org/00e9cav63', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I119057318']}, {'id': 'https://openalex.org/I53620714', 'display_name': 'Arab American University', 'ror': 'https://ror.org/04jmsq731', 'country_code': 'PS', 'type': 'education', 'lineage': ['https://openalex.org/I53620714']}], 'countries': ['IL', 'PS'], 'is_corresponding': True, 'raw_author_name': 'Hilal Zaid', 'raw_affiliation_strings': ['Faculty of Medicine, Arab American University, Jenin P.O. Box 240, Palestine', 'Qasemi Research Center, Al-Qasemi Academic College, P.O. Box 124, Baqa El-Gharbia 30100, Israel'], 'affiliations': [{'raw_affiliation_string': 'Qasemi Research Center, Al-Qasemi Academic College, P.O. Box 124, Baqa El-Gharbia 30100, Israel', 'institution_ids': ['https://openalex.org/I119057318']}, {'raw_affiliation_string': 'Faculty of Medicine, Arab American University, Jenin P.O. Box 240, Palestine', 'institution_ids': ['https://openalex.org/I53620714']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5020426573', 'display_name': 'Rakesh Maurya', 'orcid': 'https://orcid.org/0000-0002-6170-2714'}, 'institutions': [{'id': 'https://openalex.org/I99364266', 'display_name': 'Academy of Scientific and Innovative Research', 'ror': 'https://ror.org/053rcsq61', 'country_code': 'IN', 'type': 'education', 'lineage': ['https://openalex.org/I99364266']}, {'id': 'https://openalex.org/I185249246', 'display_name': 'Central Drug Research Institute', 'ror': 'https://ror.org/04t8qjg16', 'country_code': 'IN', 'type': 'facility', 'lineage': ['https://openalex.org/I185249246', 'https://openalex.org/I2799351866', 'https://openalex.org/I4210134808', 'https://openalex.org/I66760702']}], 'countries': ['IN'], 'is_corresponding': True, 'raw_author_name': 'Rakesh Maurya', 'raw_affiliation_strings': ['Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India', 'Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India'], 'affiliations': [{'raw_affiliation_string': 'Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India', 'institution_ids': ['https://openalex.org/I99364266']}, {'raw_affiliation_string': 'Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India', 'institution_ids': ['https://openalex.org/I185249246']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5087955502', 'https://openalex.org/A5020426573'], 'corresponding_institution_ids': ['https://openalex.org/I119057318', 'https://openalex.org/I53620714', 'https://openalex.org/I99364266', 'https://openalex.org/I185249246'], 'apc_list': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'apc_paid': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'fwci': 0.552, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.706866, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 71, 'max': 82}, 'biblio': {'volume': '28', 'issue': '2', 'first_page': '483', 'last_page': '483'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11914', 'display_name': 'Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11914', 'display_name': 'Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Role of AMP-Activated Protein Kinase in Cellular Metabolism', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12298', 'display_name': 'Therapeutic Potential of Ayurvedic Medicine', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glut4', 'display_name': 'GLUT4', 'score': 0.7886938}, {'id': 'https://openalex.org/keywords/tinospora-cordifolia', 'display_name': 'Tinospora cordifolia', 'score': 0.74972856}, {'id': 'https://openalex.org/keywords/wortmannin', 'display_name': 'Wortmannin', 'score': 0.65914977}, {'id': 'https://openalex.org/keywords/amp-activated-protein-kinase', 'display_name': 'AMP-activated protein kinase', 'score': 0.5509264}, {'id': 'https://openalex.org/keywords/phosphoinositide-3-kinase', 'display_name': 'Phosphoinositide 3-kinase', 'score': 0.5062453}, {'id': 'https://openalex.org/keywords/insulin-signaling', 'display_name': 'Insulin Signaling', 'score': 0.474339}], 'concepts': [{'id': 'https://openalex.org/C2780124434', 'wikidata': 'https://www.wikidata.org/wiki/Q12357464', 'display_name': 'AMPK', 'level': 4, 'score': 0.86337423}, {'id': 'https://openalex.org/C2776188179', 'wikidata': 'https://www.wikidata.org/wiki/Q24768727', 'display_name': 'GLUT4', 'level': 4, 'score': 0.7886938}, {'id': 'https://openalex.org/C2779959927', 'wikidata': 'https://www.wikidata.org/wiki/Q1048687', 'display_name': 'Skeletal muscle', 'level': 2, 'score': 0.7574623}, {'id': 'https://openalex.org/C2778523797', 'wikidata': 'https://www.wikidata.org/wiki/Q3595912', 'display_name': 'Tinospora cordifolia', 'level': 2, 'score': 0.74972856}, {'id': 'https://openalex.org/C2778308172', 'wikidata': 'https://www.wikidata.org/wiki/Q423565', 'display_name': 'Wortmannin', 'level': 4, 'score': 0.65914977}, {'id': 'https://openalex.org/C161573976', 'wikidata': 'https://www.wikidata.org/wiki/Q420277', 'display_name': 'Glucose transporter', 'level': 3, 'score': 0.6500827}, {'id': 'https://openalex.org/C2777866211', 'wikidata': 'https://www.wikidata.org/wiki/Q5572349', 'display_name': 'Glucose uptake', 'level': 3, 'score': 0.6230396}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.5602447}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5521582}, {'id': 'https://openalex.org/C2776780712', 'wikidata': 'https://www.wikidata.org/wiki/Q295240', 'display_name': 'AMP-activated protein kinase', 'level': 5, 'score': 0.5509264}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5269193}, {'id': 'https://openalex.org/C2781322055', 'wikidata': 'https://www.wikidata.org/wiki/Q423725', 'display_name': 'Phosphoinositide 3-kinase', 'level': 4, 'score': 0.5062453}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46854055}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.45401564}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.43937123}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3471378}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.33891422}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.30476844}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.2943889}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.27623844}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.25231928}, {'id': 'https://openalex.org/C556039675', 'wikidata': 'https://www.wikidata.org/wiki/Q771035', 'display_name': 'Traditional medicine', 'level': 1, 'score': 0.11411682}], 'mesh': [{'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D031610', 'descriptor_name': 'Tinospora', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D055372', 'descriptor_name': 'AMP-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D055372', 'descriptor_name': 'AMP-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051275', 'descriptor_name': 'Glucose Transporter Type 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051275', 'descriptor_name': 'Glucose Transporter Type 4', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018485', 'descriptor_name': 'Muscle Fibers, Skeletal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D058539', 'descriptor_name': 'Phosphatidylinositol 3-Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D058539', 'descriptor_name': 'Phosphatidylinositol 3-Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/molecules28020483', 'pdf_url': 'https://www.mdpi.com/1420-3049/28/2/483/pdf?version=1672826599', 'source': {'id': 'https://openalex.org/S108911230', 'display_name': 'Molecules', 'issn_l': '1420-3049', 'issn': ['1420-3049', '1433-1373'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864719', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36677541', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/molecules28020483', 'pdf_url': 'https://www.mdpi.com/1420-3049/28/2/483/pdf?version=1672826599', 'source': {'id': 'https://openalex.org/S108911230', 'display_name': 'Molecules', 'issn_l': '1420-3049', 'issn': ['1420-3049', '1433-1373'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1849821171', 'https://openalex.org/W1972011552', 'https://openalex.org/W2003032553', 'https://openalex.org/W2026067359', 'https://openalex.org/W2030137409', 'https://openalex.org/W2031546726', 'https://openalex.org/W2034377789', 'https://openalex.org/W2049383509', 'https://openalex.org/W2049561654', 'https://openalex.org/W2057478539', 'https://openalex.org/W2062787370', 'https://openalex.org/W2064701412', 'https://openalex.org/W2078374645', 'https://openalex.org/W2100512139', 'https://openalex.org/W2124485965', 'https://openalex.org/W2129284446', 'https://openalex.org/W2141885300', 'https://openalex.org/W2145566259', 'https://openalex.org/W2156090275', 'https://openalex.org/W2170764780', 'https://openalex.org/W2504442040', 'https://openalex.org/W2622101734', 'https://openalex.org/W2781136666', 'https://openalex.org/W2909496783', 'https://openalex.org/W2924395156', 'https://openalex.org/W2939633281', 'https://openalex.org/W2972733442', 'https://openalex.org/W2980639864', 'https://openalex.org/W3023653620', 'https://openalex.org/W3123732616', 'https://openalex.org/W3139422999', 'https://openalex.org/W3147245769', 'https://openalex.org/W3157862982', 'https://openalex.org/W3159059369', 'https://openalex.org/W3165207916', 'https://openalex.org/W3175585930', 'https://openalex.org/W3186406587', 'https://openalex.org/W3197813197', 'https://openalex.org/W3200836713', 'https://openalex.org/W4200215705', 'https://openalex.org/W4210258733', 'https://openalex.org/W4220765579'], 'related_works': ['https://openalex.org/W2070682152', 'https://openalex.org/W2063117678', 'https://openalex.org/W2050658441', 'https://openalex.org/W2033844313', 'https://openalex.org/W2032434538', 'https://openalex.org/W2028365267', 'https://openalex.org/W2008679478', 'https://openalex.org/W1997470922', 'https://openalex.org/W1993071508', 'https://openalex.org/W1568711262'], 'abstract_inverted_index': {'The': [0, 167], 'stem': [1, 45], 'of': [2, 13, 22, 46, 86, 108, 127, 134, 153, 156, 180], 'Tinospora': [3], 'cordifolia': [4], 'has': [5], 'been': [6], 'traditionally': [7], 'used': [8], 'in': [9, 57, 69, 92, 124, 163, 183], 'traditional': [10], 'Indian': [11], 'systems': [12], 'medicine': [14], 'for': [15, 30, 51, 98], 'blood': [16], 'sugar': [17], 'control,': [18], 'without': [19], 'the': [20, 23, 31, 36, 44, 66, 84, 89, 106, 125, 128, 154, 178], 'knowledge': [21], 'underlying': [24], 'mechanism': [25], 'and': [26, 113, 130, 142, 151, 160, 189], 'chemical': [27], 'constitution': [28], 'responsible': [29], 'observed': [32], 'anti-diabetic': [33], 'effect.': [34], 'In': [35], 'present': [37], 'study,': [38], 'Tinosporaside,': [39], 'a': [40], 'diterpenoid': [41], 'isolated': [42], 'from': [43], 'T.': [47], 'cordifolia,': [48], 'was': [49, 62], 'investigated': [50], 'its': [52, 173], 'effects': [53, 121], 'on': [54], 'glucose': [55, 80, 140, 181], 'utilization': [56, 182], 'skeletal': [58, 164, 184], 'muscle': [59, 165], 'cells,': [60], 'which': [61], 'followed': [63], 'by': [64, 82, 176, 187], 'determining': [65], 'anti-hyperglycemic': [67], 'efficacy': [68, 175], 'our': [70], 'diabetic': [71], 'db/db': [72, 137], 'mice': [73, 138], 'model.': [74], 'We': [75], 'found': [76], 'that': [77, 170], 'tinosporaside': [78, 102, 135, 171], 'augmented': [79], 'uptake': [81], 'increasing': [83], 'translocation': [85], 'GLUT4': [87], 'to': [88, 136], 'plasma': [90], 'membrane': [91], 'L6': [93], 'myotubes,': [94], 'upon': [95], 'prolonged': [96], 'exposure': [97], '16': [99], 'h.': [100], 'Moreover,': [101], 'treatment': [103], 'significantly': [104], 'increased': [105, 148], 'phosphorylation': [107, 152], 'protein': [109, 116], 'kinase': [110, 117], 'B/AKT': [111], '(Ser-473)': [112], "5'": [114], 'AMP-activated': [115], '(AMPK,': [118], 'Thr-172).': [119], 'These': [120], 'were': [122], 'abolished': [123], 'presence': [126], 'wortmannin': [129], 'compound': [131], 'C.': [132], 'Administration': [133], 'improved': [139], 'tolerance': [141], 'peripheral': [143], 'insulin': [144], 'sensitivity': [145], 'associated': [146], 'with': [147], 'gene': [149], 'expression': [150], 'markers': [155], 'phosphoinositide': [157], '3-kinases': [158], '(PI3Ks)': [159], 'AMPK': [161], 'signaling': [162, 191], 'tissue.': [166], 'findings': [168], 'revealed': [169], 'exerted': [172], 'antidiabetic': [174], 'enhancing': [177], 'rate': [179], 'muscle,': [185], 'mediated': [186], 'PI3K-': [188], 'AMPK-dependent': [190], 'mechanisms.': [192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4313500299', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2024-09-18T17:28:43.688938', 'created_date': '2023-01-06'}