Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4313345791', 'doi': 'https://doi.org/10.1016/j.ibmb.2022.103899', 'title': 'Role of neuronal and non-neuronal acetylcholine signaling in Drosophila humoral immunity', 'display_name': 'Role of neuronal and non-neuronal acetylcholine signaling in Drosophila humoral immunity', 'publication_year': 2022, 'publication_date': '2022-12-31', 'ids': {'openalex': 'https://openalex.org/W4313345791', 'doi': 'https://doi.org/10.1016/j.ibmb.2022.103899', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36596348'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ibmb.2022.103899', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S130917594', 'display_name': 'Insect Biochemistry and Molecular Biology', 'issn_l': '0965-1748', 'issn': ['0965-1748', '1879-0240'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.ibmb.2022.103899', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040756234', 'display_name': 'Giorgia Giordani', 'orcid': 'https://orcid.org/0000-0003-1826-7814'}, 'institutions': [{'id': 'https://openalex.org/I9360294', 'display_name': 'University of Bologna', 'ror': 'https://ror.org/01111rn36', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I9360294']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giorgia Giordani', 'raw_affiliation_strings': ['Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum Università di Bologna, Bologna, Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum Università di Bologna, Bologna, Italy', 'institution_ids': ['https://openalex.org/I9360294']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038044090', 'display_name': 'Giulia Cattabriga', 'orcid': 'https://orcid.org/0000-0001-5720-4555'}, 'institutions': [{'id': 'https://openalex.org/I9360294', 'display_name': 'University of Bologna', 'ror': 'https://ror.org/01111rn36', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I9360294']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giulia Cattabriga', 'raw_affiliation_strings': ['Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum Università di Bologna, Bologna, Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum Università di Bologna, Bologna, Italy', 'institution_ids': ['https://openalex.org/I9360294']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029663319', 'display_name': 'Andrea Becchimanzi', 'orcid': 'https://orcid.org/0000-0001-5117-0235'}, 'institutions': [{'id': 'https://openalex.org/I71267560', 'display_name': 'University of Naples Federico II', 'ror': 'https://ror.org/05290cv24', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Andrea Becchimanzi', 'raw_affiliation_strings': ['Dipartimento di Agraria, Laboratorio di Entomologia "E. Tremblay", Università degli Studi di Napoli "Federico II", Portici, Napoli, Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Agraria, Laboratorio di Entomologia "E. Tremblay", Università degli Studi di Napoli "Federico II", Portici, Napoli, Italy', 'institution_ids': ['https://openalex.org/I71267560']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009725341', 'display_name': 'Ilaria Di Lelio', 'orcid': 'https://orcid.org/0000-0001-8933-0919'}, 'institutions': [{'id': 'https://openalex.org/I71267560', 'display_name': 'University of Naples Federico II', 'ror': 'https://ror.org/05290cv24', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Ilaria Di Lelio', 'raw_affiliation_strings': ['Dipartimento di Agraria, Laboratorio di Entomologia "E. Tremblay", Università degli Studi di Napoli "Federico II", Portici, Napoli, Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Agraria, Laboratorio di Entomologia "E. Tremblay", Università degli Studi di Napoli "Federico II", Portici, Napoli, Italy', 'institution_ids': ['https://openalex.org/I71267560']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064967220', 'display_name': 'Giovanna De Leva', 'orcid': 'https://orcid.org/0000-0002-5199-5445'}, 'institutions': [{'id': 'https://openalex.org/I71267560', 'display_name': 'University of Naples Federico II', 'ror': 'https://ror.org/05290cv24', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giovanna De Leva', 'raw_affiliation_strings': ['Dipartimento di Agraria, Laboratorio di Entomologia "E. Tremblay", Università degli Studi di Napoli "Federico II", Portici, Napoli, Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Agraria, Laboratorio di Entomologia "E. Tremblay", Università degli Studi di Napoli "Federico II", Portici, Napoli, Italy', 'institution_ids': ['https://openalex.org/I71267560']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050568447', 'display_name': 'Silvia Gigliotti', 'orcid': 'https://orcid.org/0000-0002-1772-3825'}, 'institutions': [{'id': 'https://openalex.org/I4210108634', 'display_name': 'Institute of Biosciences and Bioresources', 'ror': 'https://ror.org/01gtsa866', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210108634', 'https://openalex.org/I4210155236']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Silvia Gigliotti', 'raw_affiliation_strings': ['Istituto di Bioscienze e Biorisorse, Consiglio Nazionale delle Ricerche, Napoli, Italy'], 'affiliations': [{'raw_affiliation_string': 'Istituto di Bioscienze e Biorisorse, Consiglio Nazionale delle Ricerche, Napoli, Italy', 'institution_ids': ['https://openalex.org/I4210108634']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009984296', 'display_name': 'S. Bradleigh Vinson', 'orcid': 'https://orcid.org/0000-0002-8794-9328'}, 'institutions': [{'id': 'https://openalex.org/I71267560', 'display_name': 'University of Naples Federico II', 'ror': 'https://ror.org/05290cv24', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I71267560']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Pennacchio', 'raw_affiliation_strings': ['Dipartimento di Agraria, Laboratorio di Entomologia "E. Tremblay", Università degli Studi di Napoli "Federico II", Portici, Napoli, Italy', 'Interuniversity Center for Studies on Bioinspired Agro-Environmental Technology (BATCenter), University of Napoli "Federico II", Portici, NA, Italy'], 'affiliations': [{'raw_affiliation_string': 'Interuniversity Center for Studies on Bioinspired Agro-Environmental Technology (BATCenter), University of Napoli "Federico II", Portici, NA, Italy', 'institution_ids': []}, {'raw_affiliation_string': 'Dipartimento di Agraria, Laboratorio di Entomologia "E. Tremblay", Università degli Studi di Napoli "Federico II", Portici, Napoli, Italy', 'institution_ids': ['https://openalex.org/I71267560']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005700993', 'display_name': 'Giuseppe Gargiulo', 'orcid': 'https://orcid.org/0000-0003-3974-2557'}, 'institutions': [{'id': 'https://openalex.org/I9360294', 'display_name': 'University of Bologna', 'ror': 'https://ror.org/01111rn36', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I9360294']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giuseppe Gargiulo', 'raw_affiliation_strings': ['Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum Università di Bologna, Bologna, Italy', 'Interuniversity Center for Studies on Bioinspired Agro-Environmental Technology (BATCenter), University of Napoli "Federico II", Portici, NA, Italy'], 'affiliations': [{'raw_affiliation_string': 'Interuniversity Center for Studies on Bioinspired Agro-Environmental Technology (BATCenter), University of Napoli "Federico II", Portici, NA, Italy', 'institution_ids': []}, {'raw_affiliation_string': 'Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum Università di Bologna, Bologna, Italy', 'institution_ids': ['https://openalex.org/I9360294']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5060988424', 'display_name': 'Valeria Cavaliere', 'orcid': 'https://orcid.org/0000-0002-3264-499X'}, 'institutions': [{'id': 'https://openalex.org/I9360294', 'display_name': 'University of Bologna', 'ror': 'https://ror.org/01111rn36', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I9360294']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Valeria Cavaliere', 'raw_affiliation_strings': ['Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum Università di Bologna, Bologna, Italy', 'Interuniversity Center for Studies on Bioinspired Agro-Environmental Technology (BATCenter), University of Napoli "Federico II", Portici, NA, Italy'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Farmacia e Biotecnologie, Alma Mater Studiorum Università di Bologna, Bologna, Italy', 'institution_ids': ['https://openalex.org/I9360294']}, {'raw_affiliation_string': 'Interuniversity Center for Studies on Bioinspired Agro-Environmental Technology (BATCenter), University of Napoli "Federico II", Portici, NA, Italy', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3750, 'currency': 'USD', 'value_usd': 3750, 'provenance': 'doaj'}, 'apc_paid': {'value': 3750, 'currency': 'USD', 'value_usd': 3750, 'provenance': 'doaj'}, 'fwci': 5.144, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.99979, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '153', 'issue': None, 'first_page': '103899', 'last_page': '103899'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10423', 'display_name': 'Neuroscience and Genetics of Drosophila Melanogaster', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10423', 'display_name': 'Neuroscience and Genetics of Drosophila Melanogaster', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11403', 'display_name': 'Invertebrate Immunity and Host Defense Mechanisms', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11641', 'display_name': 'Impact of Pesticides on Honey Bee Health', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/1109', 'display_name': 'Insect Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/insulin-signaling', 'display_name': 'Insulin Signaling', 'score': 0.461998}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.86563945}, {'id': 'https://openalex.org/C2775910092', 'wikidata': 'https://www.wikidata.org/wiki/Q180623', 'display_name': 'Acetylcholine', 'level': 2, 'score': 0.73280585}, {'id': 'https://openalex.org/C2780104201', 'wikidata': 'https://www.wikidata.org/wiki/Q130888', 'display_name': 'Drosophila melanogaster', 'level': 3, 'score': 0.7209275}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.66749763}, {'id': 'https://openalex.org/C80161118', 'wikidata': 'https://www.wikidata.org/wiki/Q408520', 'display_name': 'Acetylcholine receptor', 'level': 3, 'score': 0.64547986}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.61789864}, {'id': 'https://openalex.org/C22885893', 'wikidata': 'https://www.wikidata.org/wiki/Q4862743', 'display_name': 'Cholinergic', 'level': 2, 'score': 0.568661}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.54299414}, {'id': 'https://openalex.org/C2779570518', 'wikidata': 'https://www.wikidata.org/wiki/Q412256', 'display_name': 'Nicotinic acetylcholine receptor', 'level': 4, 'score': 0.50500256}, {'id': 'https://openalex.org/C545706735', 'wikidata': 'https://www.wikidata.org/wiki/Q9404', 'display_name': 'Nervous system', 'level': 2, 'score': 0.5008409}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.47705618}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.47388333}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.37725657}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2563434}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.24216032}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.1435372}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.08896732}], 'mesh': [{'descriptor_ui': 'D000109', 'descriptor_name': 'Acetylcholine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011978', 'descriptor_name': 'Receptors, Nicotinic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004330', 'descriptor_name': 'Drosophila', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004330', 'descriptor_name': 'Drosophila', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D056724', 'descriptor_name': 'Immunity, Humoral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011978', 'descriptor_name': 'Receptors, Nicotinic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ibmb.2022.103899', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S130917594', 'display_name': 'Insect Biochemistry and Molecular Biology', 'issn_l': '0965-1748', 'issn': ['0965-1748', '1879-0240'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36596348', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ibmb.2022.103899', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S130917594', 'display_name': 'Insect Biochemistry and Molecular Biology', 'issn_l': '0965-1748', 'issn': ['0965-1748', '1879-0240'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.56, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1511626298', 'https://openalex.org/W1511996564', 'https://openalex.org/W1594018550', 'https://openalex.org/W1829316027', 'https://openalex.org/W1885479805', 'https://openalex.org/W1977699952', 'https://openalex.org/W1992478688', 'https://openalex.org/W2007143131', 'https://openalex.org/W2010841889', 'https://openalex.org/W2016498619', 'https://openalex.org/W2018058864', 'https://openalex.org/W2053383171', 'https://openalex.org/W2055807373', 'https://openalex.org/W2058427270', 'https://openalex.org/W2076995634', 'https://openalex.org/W2077894786', 'https://openalex.org/W2082210532', 'https://openalex.org/W2094760990', 'https://openalex.org/W2097288065', 'https://openalex.org/W2102549002', 'https://openalex.org/W2115734610', 'https://openalex.org/W2124490218', 'https://openalex.org/W2127177111', 'https://openalex.org/W2142794903', 'https://openalex.org/W2148570600', 'https://openalex.org/W2155783580', 'https://openalex.org/W2166445583', 'https://openalex.org/W2166702964', 'https://openalex.org/W2169567979', 'https://openalex.org/W2268231674', 'https://openalex.org/W2507877237', 'https://openalex.org/W2740568419', 'https://openalex.org/W2766125113', 'https://openalex.org/W2790783879', 'https://openalex.org/W2802639922', 'https://openalex.org/W2937724109', 'https://openalex.org/W2983739733', 'https://openalex.org/W2990319247', 'https://openalex.org/W3104730270', 'https://openalex.org/W3144770029', 'https://openalex.org/W3159622633', 'https://openalex.org/W3210238462'], 'related_works': ['https://openalex.org/W81472463', 'https://openalex.org/W2417380356', 'https://openalex.org/W2354177325', 'https://openalex.org/W2072353469', 'https://openalex.org/W2053665683', 'https://openalex.org/W2026155884', 'https://openalex.org/W2005226742', 'https://openalex.org/W1966766929', 'https://openalex.org/W1958024232', 'https://openalex.org/W1129799796'], 'abstract_inverted_index': {'Acetylcholine': [0], '(ACh)': [1], 'is': [2, 22, 41], 'one': [3], 'the': [4, 18, 44, 47, 65, 105, 139, 145, 183, 188, 191], 'major': [5], 'neurotransmitters': [6], 'in': [7, 11, 17, 32, 43, 62, 76, 89, 101, 104, 128, 138, 151, 159, 187], 'insects,': [8], 'whose': [9], 'role': [10, 184], 'mediating': [12], 'synaptic': [13], 'interactions': [14], 'between': [15], 'neurons': [16, 63], 'central': [19], 'nervous': [20, 106], 'system': [21, 107], 'well': [23, 99], 'characterized.': [24], 'It': [25], 'also': [26], 'plays': [27], 'largely': [28], 'unexplored': [29], 'regulatory': [30], 'functions': [31], 'non-neuronal': [33, 129, 160], 'tissues.': [34], 'Here': [35], 'we': [36], 'demonstrate': [37], 'that': [38, 174], 'ACh': [39, 56, 59, 157], 'signaling': [40], 'involved': [42], 'modulation': [45], 'of': [46, 51, 55, 67, 113, 144, 156, 185, 190], 'innate': [48], 'immune': [49, 177, 193], 'response': [50, 123], 'Drosophila': [52, 90], 'melanogaster.': [53], 'Knockdown': [54], 'synthesis': [57, 158], 'or': [58], 'vesicular': [60], 'transport': [61], 'reduced': [64], 'activation': [66, 143], 'drosomycin': [68], '(drs),': [69], 'a': [70, 81, 108, 121], 'gene': [71, 147], 'encoding': [72], 'an': [73], 'antimicrobial': [74], 'peptide,': [75], 'adult': [77], 'flies': [78, 102], 'infected': [79], 'with': [80], 'Gram-positive': [82], 'bacterium.': [83], 'drs': [84, 146, 163], 'transcription': [85], 'was': [86, 126, 135], 'similarly': [87], 'affected': [88, 162], 'α7': [91], 'nicotinic': [92], 'acetylcholine': [93], 'receptor,': [94], 'nAChRalpha7': [95], '(Dα7)': [96], 'mutants,': [97], 'as': [98, 100], 'expressing': [103], 'dominant': [109], 'negative': [110], 'form': [111], '(Dα7DN)': [112], 'this': [114], 'specific': [115], 'receptor': [116], 'subunit.': [117], 'Interestingly,': [118], 'Dα7DN': [119], 'elicited': [120], 'comparable': [122], 'when': [124, 133], 'it': [125, 134], 'expressed': [127], 'tissues': [130], 'and': [131, 170, 179], 'even': [132], 'specifically': [136], 'produced': [137], 'hemocytes.': [140], 'Consistently,': [141], 'full': [142], 'required': [148], 'Dα7': [149], 'expression': [150], 'these': [152, 166], 'cells.': [153], 'Moreover,': [154], 'knockdown': [155], 'cells': [161], 'expression.': [164], 'Overall,': [165], 'findings': [167], 'uncover': [168], 'neural': [169], 'non-neural': [171], 'cholinergic': [172], 'signals': [173], 'modulate': [175], 'insect': [176], 'defenses': [178], 'shed': [180], 'light': [181], 'on': [182], 'hemocytes': [186], 'regulation': [189], 'humoral': [192], 'response.': [194]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4313345791', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 5}], 'updated_date': '2024-09-18T00:14:25.514049', 'created_date': '2023-01-06'}