Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4308507738', 'doi': 'https://doi.org/10.1128/aac.00992-22', 'title': 'Pseudomonas aeruginosa Phosphate Transporter PitA (PA4292) Controls Susceptibility to Aminoglycoside Antibiotics by Regulating the Proton Motive Force', 'display_name': 'Pseudomonas aeruginosa Phosphate Transporter PitA (PA4292) Controls Susceptibility to Aminoglycoside Antibiotics by Regulating the Proton Motive Force', 'publication_year': 2022, 'publication_date': '2022-11-08', 'ids': {'openalex': 'https://openalex.org/W4308507738', 'doi': 'https://doi.org/10.1128/aac.00992-22', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/36346250'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.00992-22', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765264', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068010403', 'display_name': 'Xinrui Zhao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205237279', 'display_name': 'Nankai University', 'ror': 'https://ror.org/01y1kjr75', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I205237279']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xinrui Zhao', 'raw_affiliation_strings': ['State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China', 'institution_ids': ['https://openalex.org/I205237279']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050482950', 'display_name': 'Yongxin Jin', 'orcid': 'https://orcid.org/0000-0002-1449-6735'}, 'institutions': [{'id': 'https://openalex.org/I205237279', 'display_name': 'Nankai University', 'ror': 'https://ror.org/01y1kjr75', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I205237279']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yongxin Jin', 'raw_affiliation_strings': ['State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China', 'institution_ids': ['https://openalex.org/I205237279']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046277831', 'display_name': 'Fang Bai', 'orcid': 'https://orcid.org/0000-0003-0639-8104'}, 'institutions': [{'id': 'https://openalex.org/I205237279', 'display_name': 'Nankai University', 'ror': 'https://ror.org/01y1kjr75', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I205237279']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fang Bai', 'raw_affiliation_strings': ['State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China', 'institution_ids': ['https://openalex.org/I205237279']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101102358', 'display_name': 'Zhihui Cheng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205237279', 'display_name': 'Nankai University', 'ror': 'https://ror.org/01y1kjr75', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I205237279']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhihui Cheng', 'raw_affiliation_strings': ['State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China', 'institution_ids': ['https://openalex.org/I205237279']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034471224', 'display_name': 'Weihui Wu', 'orcid': 'https://orcid.org/0000-0002-9017-0091'}, 'institutions': [{'id': 'https://openalex.org/I205237279', 'display_name': 'Nankai University', 'ror': 'https://ror.org/01y1kjr75', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I205237279']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weihui Wu', 'raw_affiliation_strings': ['State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China', 'institution_ids': ['https://openalex.org/I205237279']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019852661', 'display_name': 'Xiaolei Pan', 'orcid': 'https://orcid.org/0000-0003-0907-2177'}, 'institutions': [{'id': 'https://openalex.org/I205237279', 'display_name': 'Nankai University', 'ror': 'https://ror.org/01y1kjr75', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I205237279']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Xiaolei Pan', 'raw_affiliation_strings': ['State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China'], 'affiliations': [{'raw_affiliation_string': 'State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China', 'institution_ids': ['https://openalex.org/I205237279']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5019852661'], 'corresponding_institution_ids': ['https://openalex.org/I205237279'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.462, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.303167, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 78, 'max': 82}, 'biblio': {'volume': '66', 'issue': '12', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10147', 'display_name': 'Global Challenge of Antibiotic Resistance in Bacteria', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10147', 'display_name': 'Global Challenge of Antibiotic Resistance in Bacteria', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10120', 'display_name': 'Bacterial Physiology and Genetics', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/antimicrobial-resistance-genes', 'display_name': 'Antimicrobial Resistance Genes', 'score': 0.490693}], 'concepts': [{'id': 'https://openalex.org/C2777787772', 'wikidata': 'https://www.wikidata.org/wiki/Q45355603', 'display_name': 'Aminoglycoside', 'level': 3, 'score': 0.8785368}, {'id': 'https://openalex.org/C2777637488', 'wikidata': 'https://www.wikidata.org/wiki/Q31856', 'display_name': 'Pseudomonas aeruginosa', 'level': 3, 'score': 0.76628506}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.6782073}, {'id': 'https://openalex.org/C2778974779', 'wikidata': 'https://www.wikidata.org/wiki/Q1758380', 'display_name': 'Tobramycin', 'level': 4, 'score': 0.6714514}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.66761404}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.6252256}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.50357336}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.4909137}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45599008}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39117903}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.3828145}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.33350092}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.20244226}, {'id': 'https://openalex.org/C2775832221', 'wikidata': 'https://www.wikidata.org/wiki/Q422482', 'display_name': 'Gentamicin', 'level': 3, 'score': 0.14414638}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.093729794}], 'mesh': [{'descriptor_ui': 'D018892', 'descriptor_name': 'Proton-Motive Force', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011550', 'descriptor_name': 'Pseudomonas aeruginosa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000617', 'descriptor_name': 'Aminoglycosides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000617', 'descriptor_name': 'Aminoglycosides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000617', 'descriptor_name': 'Aminoglycosides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D028061', 'descriptor_name': 'Phosphate Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010710', 'descriptor_name': 'Phosphates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011550', 'descriptor_name': 'Pseudomonas aeruginosa', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011550', 'descriptor_name': 'Pseudomonas aeruginosa', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047090', 'descriptor_name': 'beta-Lactams', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.00992-22', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765264', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/36346250', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765264', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.65}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '31870130'}, {'funder': 'https://openalex.org/F4320335777', 'funder_display_name': 'National Key Research and Development Program of China', 'award_id': '82061148018'}, {'funder': 'https://openalex.org/F4320335787', 'funder_display_name': 'Fundamental Research Funds for the Central Universities', 'award_id': '63223030'}], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1489326505', 'https://openalex.org/W1509512816', 'https://openalex.org/W1901312711', 'https://openalex.org/W1972241490', 'https://openalex.org/W1972448472', 'https://openalex.org/W1999063954', 'https://openalex.org/W2006342320', 'https://openalex.org/W2007296377', 'https://openalex.org/W2042684319', 'https://openalex.org/W2046385870', 'https://openalex.org/W2054564555', 'https://openalex.org/W2059167716', 'https://openalex.org/W2067753843', 'https://openalex.org/W2075287054', 'https://openalex.org/W2077225298', 'https://openalex.org/W2102279893', 'https://openalex.org/W2102672963', 'https://openalex.org/W2104587686', 'https://openalex.org/W2106359046', 'https://openalex.org/W2117064229', 'https://openalex.org/W2144954424', 'https://openalex.org/W2149407025', 'https://openalex.org/W2167788763', 'https://openalex.org/W2179324586', 'https://openalex.org/W2411159413', 'https://openalex.org/W2416290591', 'https://openalex.org/W2524034808', 'https://openalex.org/W2573117263', 'https://openalex.org/W2763539803', 'https://openalex.org/W2793325503', 'https://openalex.org/W2943205553', 'https://openalex.org/W3000074066', 'https://openalex.org/W3011397444', 'https://openalex.org/W3047076834', 'https://openalex.org/W3050771491', 'https://openalex.org/W3099789223', 'https://openalex.org/W3113307687', 'https://openalex.org/W3136759802', 'https://openalex.org/W3162115681', 'https://openalex.org/W3197844376', 'https://openalex.org/W4206111934', 'https://openalex.org/W4206914089', 'https://openalex.org/W4282583686'], 'related_works': ['https://openalex.org/W2559770681', 'https://openalex.org/W2417348294', 'https://openalex.org/W2101246301', 'https://openalex.org/W2098041361', 'https://openalex.org/W2097236266', 'https://openalex.org/W2089376663', 'https://openalex.org/W2067849157', 'https://openalex.org/W2036491572', 'https://openalex.org/W2004603709', 'https://openalex.org/W2000314844'], 'abstract_inverted_index': {'Pseudomonas': [0], 'aeruginosa': [1, 26], 'is': [2], 'an': [3], 'opportunistic': [4], 'Gram-negative': [5], 'bacterium': [6], 'that': [7, 31], 'causes': [8], 'nosocomial': [9], 'infections': [10], 'in': [11, 21, 33], 'immunocompromised': [12], 'patients.': [13], 'β-lactam': [14, 41], 'and': [15], 'aminoglycoside': [16], 'antibiotics': [17], 'are': [18], 'commonly': [19], 'used': [20], 'the': [22], 'treatment': [23], 'of': [24], 'P.': [25], 'infections.': [27], 'Previously,': [28], 'we': [29], 'found': [30], 'mutation': [32], 'a': [34], 'PA4292': [35], 'gene': [36], 'increases': [37], 'bacterial': [38], 'resistance': [39], 'to': [40], 'antibiotics.': [42]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4308507738', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}], 'updated_date': '2024-09-19T03:35:35.953851', 'created_date': '2022-11-12'}