Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4285396457', 'doi': 'https://doi.org/10.17749/2313-7347/ob.gyn.rep.2022.301', 'title': 'Investigating genetic predisposition to premature decline in ovarian reserve', 'display_name': 'Investigating genetic predisposition to premature decline in ovarian reserve', 'publication_year': 2022, 'publication_date': '2022-07-12', 'ids': {'openalex': 'https://openalex.org/W4285396457', 'doi': 'https://doi.org/10.17749/2313-7347/ob.gyn.rep.2022.301'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.17749/2313-7347/ob.gyn.rep.2022.301', 'pdf_url': 'https://www.gynecology.su/jour/article/download/1358/1022', 'source': {'id': 'https://openalex.org/S2764951701', 'display_name': 'Obstetrics Gynecology and Reproduction', 'issn_l': '2313-7347', 'issn': ['2313-7347', '2500-3194'], 'is_oa': True, 'is_in_doaj': True, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.gynecology.su/jour/article/download/1358/1022', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5091890867', 'display_name': 'Е. V. Kudryavtseva', 'orcid': 'https://orcid.org/0000-0003-2797-1926'}, 'institutions': [{'id': 'https://openalex.org/I4210093938', 'display_name': 'Ural State Medical University', 'ror': 'https://ror.org/00fycgp36', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I4210093938']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'E. V. Kudryavtseva', 'raw_affiliation_strings': ['Ural State Medical University, Health Ministry of Russian Federation'], 'affiliations': [{'raw_affiliation_string': 'Ural State Medical University, Health Ministry of Russian Federation', 'institution_ids': ['https://openalex.org/I4210093938']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044820816', 'display_name': 'N. V. Kurbatova', 'orcid': 'https://orcid.org/0000-0002-5403-3153'}, 'institutions': [{'id': 'https://openalex.org/I4210114597', 'display_name': 'Medico', 'ror': 'https://ror.org/01z78yd74', 'country_code': 'CZ', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210114597']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'N. V. Kurbatova', 'raw_affiliation_strings': ['Medico-Pharmaceutical Center «Harmony» LLC'], 'affiliations': [{'raw_affiliation_string': 'Medico-Pharmaceutical Center «Harmony» LLC', 'institution_ids': ['https://openalex.org/I4210114597']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046182117', 'display_name': 'В. В. Ковалев', 'orcid': 'https://orcid.org/0000-0001-8640-8418'}, 'institutions': [{'id': 'https://openalex.org/I4210093938', 'display_name': 'Ural State Medical University', 'ror': 'https://ror.org/00fycgp36', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I4210093938']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'V. V. Кovalev', 'raw_affiliation_strings': ['Ural State Medical University, Health Ministry of Russian Federation'], 'affiliations': [{'raw_affiliation_string': 'Ural State Medical University, Health Ministry of Russian Federation', 'institution_ids': ['https://openalex.org/I4210093938']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019201976', 'display_name': 'Д. К. Исламиди', 'orcid': 'https://orcid.org/0000-0001-5561-3072'}, 'institutions': [{'id': 'https://openalex.org/I4210093938', 'display_name': 'Ural State Medical University', 'ror': 'https://ror.org/00fycgp36', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I4210093938']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'D. K. Islamidi', 'raw_affiliation_strings': ['Ural State Medical University, Health Ministry of Russian Federation;\r\nMedico-Pharmaceutical Center «Harmony» LLC'], 'affiliations': [{'raw_affiliation_string': 'Ural State Medical University, Health Ministry of Russian Federation;\r\nMedico-Pharmaceutical Center «Harmony» LLC', 'institution_ids': ['https://openalex.org/I4210093938']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 15000, 'currency': 'RUB', 'value_usd': 142, 'provenance': 'doaj'}, 'apc_paid': {'value': 15000, 'currency': 'RUB', 'value_usd': 142, 'provenance': 'doaj'}, 'fwci': 0.625, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.533855, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 70, 'max': 76}, 'biblio': {'volume': '16', 'issue': '3', 'first_page': '266', 'last_page': '276'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10364', 'display_name': 'Reproductive Biology and Fertility', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10364', 'display_name': 'Reproductive Biology and Fertility', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10390', 'display_name': 'Ovarian function and disorders', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11732', 'display_name': 'Assisted Reproductive Technology and Twin Pregnancy', 'score': 0.9896, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ovarian-reserve', 'display_name': 'Ovarian Reserve', 'score': 0.8588996}, {'id': 'https://openalex.org/keywords/premature-ovarian-insufficiency', 'display_name': 'Premature ovarian insufficiency', 'score': 0.8419098}, {'id': 'https://openalex.org/keywords/premature-ovarian-failure', 'display_name': 'Premature ovarian failure', 'score': 0.78771424}, {'id': 'https://openalex.org/keywords/genetic-predisposition', 'display_name': 'Genetic predisposition', 'score': 0.5325709}, {'id': 'https://openalex.org/keywords/live-birth', 'display_name': 'Live birth', 'score': 0.41487408}], 'concepts': [{'id': 'https://openalex.org/C2776600139', 'wikidata': 'https://www.wikidata.org/wiki/Q7113253', 'display_name': 'Ovarian reserve', 'level': 4, 'score': 0.8588996}, {'id': 'https://openalex.org/C2911206770', 'wikidata': 'https://www.wikidata.org/wiki/Q647630', 'display_name': 'Premature ovarian insufficiency', 'level': 2, 'score': 0.8419098}, {'id': 'https://openalex.org/C2777395788', 'wikidata': 'https://www.wikidata.org/wiki/Q647630', 'display_name': 'Premature ovarian failure', 'level': 2, 'score': 0.78771424}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.74770534}, {'id': 'https://openalex.org/C2777688143', 'wikidata': 'https://www.wikidata.org/wiki/Q179399', 'display_name': 'Infertility', 'level': 3, 'score': 0.58848685}, {'id': 'https://openalex.org/C67636389', 'wikidata': 'https://www.wikidata.org/wiki/Q784237', 'display_name': 'Genetic predisposition', 'level': 3, 'score': 0.5325709}, {'id': 'https://openalex.org/C2776210078', 'wikidata': 'https://www.wikidata.org/wiki/Q351870', 'display_name': 'Reproductive medicine', 'level': 3, 'score': 0.5030524}, {'id': 'https://openalex.org/C72563966', 'wikidata': 'https://www.wikidata.org/wiki/Q1303415', 'display_name': 'Cohort', 'level': 2, 'score': 0.47227606}, {'id': 'https://openalex.org/C2779234561', 'wikidata': 'https://www.wikidata.org/wiki/Q11995', 'display_name': 'Pregnancy', 'level': 2, 'score': 0.42625302}, {'id': 'https://openalex.org/C2778279030', 'wikidata': 'https://www.wikidata.org/wiki/Q1543380', 'display_name': 'Live birth', 'level': 3, 'score': 0.41487408}, {'id': 'https://openalex.org/C201903717', 'wikidata': 'https://www.wikidata.org/wiki/Q1778788', 'display_name': 'Cohort study', 'level': 2, 'score': 0.41149005}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.39263427}, {'id': 'https://openalex.org/C29456083', 'wikidata': 'https://www.wikidata.org/wiki/Q1221899', 'display_name': 'Gynecology', 'level': 1, 'score': 0.35855088}, {'id': 'https://openalex.org/C42407357', 'wikidata': 'https://www.wikidata.org/wiki/Q521', 'display_name': 'Physiology', 'level': 1, 'score': 0.35238892}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.32009572}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.22718504}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.15579295}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.17749/2313-7347/ob.gyn.rep.2022.301', 'pdf_url': 'https://www.gynecology.su/jour/article/download/1358/1022', 'source': {'id': 'https://openalex.org/S2764951701', 'display_name': 'Obstetrics Gynecology and Reproduction', 'issn_l': '2313-7347', 'issn': ['2313-7347', '2500-3194'], 'is_oa': True, 'is_in_doaj': True, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/9537106d6a40415b88f16fb8f266bcf8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.17749/2313-7347/ob.gyn.rep.2022.301', 'pdf_url': 'https://www.gynecology.su/jour/article/download/1358/1022', 'source': {'id': 'https://openalex.org/S2764951701', 'display_name': 'Obstetrics Gynecology and Reproduction', 'issn_l': '2313-7347', 'issn': ['2313-7347', '2500-3194'], 'is_oa': True, 'is_in_doaj': True, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.45, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W2090387565', 'https://openalex.org/W2108264404', 'https://openalex.org/W2109446581', 'https://openalex.org/W2123901876', 'https://openalex.org/W2134128777', 'https://openalex.org/W2146295943', 'https://openalex.org/W2169919403', 'https://openalex.org/W2170617449', 'https://openalex.org/W2287315831', 'https://openalex.org/W2416496765', 'https://openalex.org/W2548900876', 'https://openalex.org/W2780310383', 'https://openalex.org/W2945770443', 'https://openalex.org/W2964956788', 'https://openalex.org/W2991104636', 'https://openalex.org/W3004503534', 'https://openalex.org/W3011082140', 'https://openalex.org/W3011739252', 'https://openalex.org/W3114480102', 'https://openalex.org/W3121918846', 'https://openalex.org/W3184138858', 'https://openalex.org/W3216482673', 'https://openalex.org/W3217393839', 'https://openalex.org/W4255268892'], 'related_works': ['https://openalex.org/W4312920393', 'https://openalex.org/W4224101605', 'https://openalex.org/W4212805473', 'https://openalex.org/W3009704512', 'https://openalex.org/W2977457118', 'https://openalex.org/W2944776654', 'https://openalex.org/W2941059461', 'https://openalex.org/W2793258156', 'https://openalex.org/W2412519933', 'https://openalex.org/W1781570'], 'abstract_inverted_index': {'Introduction': [0], '.': [1, 138, 192], 'Normal': [2], 'ovarian': [3, 8, 163, 184], 'reserve': [4], '(OR)': [5], 'determining': [6], 'the': [7, 45, 129, 157, 172], 'response': [9, 185], 'to': [10, 53, 57, 156, 181, 223], 'follicle': [11], 'development': [12], 'containing': [13], 'fully-featured': [14], 'oocytes': [15], 'is': [16, 143, 196], 'an': [17], 'important': [18], 'factor': [19], 'in': [20, 162], 'pregnancy,': [21], 'including': [22, 204], 'assisted': [23], 'reproductive': [24], 'technology': [25], '(ART)': [26], 'programs.': [27, 233], 'The': [28, 36, 93, 139], 'causes': [29], 'of': [30, 38, 44, 82, 113, 128, 159, 167, 188, 226], 'premature': [31, 46, 58, 107, 160, 206, 227], 'OR': [32, 47, 59, 108, 202, 228], 'decrease': [33, 48, 60, 161, 229], 'are': [34], 'multifactorial.': [35], 'study': [37, 68, 77], 'gene': [39, 219], 'polymorphism': [40], 'as': [41, 186], 'a': [42, 63, 106, 117, 182, 197, 211], 'cause': [43], 'deserves': [49], 'attention.': [50], 'Aim': [51], ':': [52], 'determine': [54], 'genetic': [55, 124, 149, 153, 194], 'predisposition': [56], 'and': [61, 71, 150, 169, 179, 210, 230], 'create': [62], 'prognostic': [64, 212], 'model': [65, 213], 'based': [66, 214], 'on': [67, 215], 'results.': [69], 'Materials': [70], 'Methods.': [72], 'A': [73, 80], 'retrospective': [74], 'comparative': [75], 'cohort': [76], 'was': [78], 'conducted.': [79], 'total': [81], '200': [83], 'reproductively': [84], 'active': [85], 'patients': [86, 94, 104, 115, 121], 'with': [87, 105, 116], 'infertility': [88], 'underwent': [89, 122], 'ART': [90, 232], 'were': [91, 95, 135], 'examined.': [92], 'divided': [96], 'into': [97], '2': [98, 111], 'groups:': [99], 'Group': [100, 110], '1': [101], 'included': [102], '100': [103, 114], 'decrease;': [109], 'consisted': [112], 'normal': [118], 'OR.': [119], 'All': [120], 'molecular': [123], 'study.': [125], 'Genetic': [126], 'polymorphisms': [127], 'genes': [130], 'ESR1,': [131], 'ESR2,': [132], 'FSHR,': [133], 'CYP19A': [134], 'studied.': [136], 'Results': [137], 'final': [140], 'clinical': [141], 'phenotype': [142], 'shaped': [144], 'by': [145], 'multiple': [146], 'factors': [147], '–': [148], 'environmental.': [151], 'Several': [152], 'variants': [154, 220], 'contribute': [155], 'formation': [158], 'reserve.': [164], 'Gene': [165], 'combination': [166], 'CYP19A1': [168], 'FSHR': [170], 'displayed': [171], 'greatest': [173], 'synergistic': [174], 'effect,': [175], 'potentiating': [176], 'each': [177], 'other': [178], 'predisposing': [180], 'poor': [183], 'part': [187], 'stimulated': [189], 'superovulation.': [190], 'Conclusion': [191], 'Identifying': [193], 'markers': [195], 'promising': [198], 'method': [199], 'for': [200], 'individual': [201], 'evaluation,': [203], 'its': [205], 'decline.': [207], 'Multilocus': [208], 'analysis': [209], 'combining': [216], 'several': [217], 'polymorphic': [218], 'will': [221], 'allow': [222], 'assess': [224], 'risks': [225], 'individualize': [231]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4285396457', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}], 'updated_date': '2024-12-10T09:53:50.243003', 'created_date': '2022-07-14'}