Abstract 4607: Androgen signaling is essential for prostate cancer development initiated from prostatic basal cells

Name: Work Video:
Duration: 3 min 30 s
Yongfeng He; Erika Hooker; Eun-Jeong Yu; Gerald R. Cunha; Lan Liao; Jianming Xu; Andrew Earl; Huiqing Wu; Michael L. Gonzalgo; Zijie Sun
{'id': 'https://openalex.org/W4251812294', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-4607', 'title': 'Abstract 4607: Androgen signaling is essential for prostate cancer development initiated from prostatic basal cells', 'display_name': 'Abstract 4607: Androgen signaling is essential for prostate cancer development initiated from prostatic basal cells', 'publication_year': 2019, 'publication_date': '2019-07-01', 'ids': {'openalex': 'https://openalex.org/W4251812294', 'doi': 'https://doi.org/10.1158/1538-7445.am2019-4607'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-4607', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.1158/1538-7445.am2019-4607', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101200023', 'display_name': 'Yongfeng He', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210110459', 'display_name': 'City of Hope', 'ror': 'https://ror.org/01z1vct10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4210110459']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yongfeng He', 'raw_affiliation_strings': ['1City of Hope, Duarte, CA;'], 'affiliations': [{'raw_affiliation_string': '1City of Hope, Duarte, CA;', 'institution_ids': ['https://openalex.org/I4210110459']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089961911', 'display_name': 'Erika Hooker', 'orcid': 'https://orcid.org/0000-0002-4515-4041'}, 'institutions': [{'id': 'https://openalex.org/I4210110459', 'display_name': 'City of Hope', 'ror': 'https://ror.org/01z1vct10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4210110459']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Erika Hooker', 'raw_affiliation_strings': ['1City of Hope, Duarte, CA;'], 'affiliations': [{'raw_affiliation_string': '1City of Hope, Duarte, CA;', 'institution_ids': ['https://openalex.org/I4210110459']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101125936', 'display_name': 'Eun-Jeong Yu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210110459', 'display_name': 'City of Hope', 'ror': 'https://ror.org/01z1vct10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4210110459']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eun-Jeong Yu', 'raw_affiliation_strings': ['1City of Hope, Duarte, CA;'], 'affiliations': [{'raw_affiliation_string': '1City of Hope, Duarte, CA;', 'institution_ids': ['https://openalex.org/I4210110459']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065328069', 'display_name': 'Gerald R. Cunha', 'orcid': 'https://orcid.org/0000-0003-2361-370X'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gerald R. Cunha', 'raw_affiliation_strings': ['2University of California San Francisco, San Francisco, CA;'], 'affiliations': [{'raw_affiliation_string': '2University of California San Francisco, San Francisco, CA;', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101138114', 'display_name': 'Lan Liao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lan Liao', 'raw_affiliation_strings': ['3Baylor College of Medicine, TX;'], 'affiliations': [{'raw_affiliation_string': '3Baylor College of Medicine, TX;', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100569875', 'display_name': 'Jianming Xu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jianming Xu', 'raw_affiliation_strings': ['3Baylor College of Medicine, TX;'], 'affiliations': [{'raw_affiliation_string': '3Baylor College of Medicine, TX;', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032025076', 'display_name': 'Andrew Earl', 'orcid': 'https://orcid.org/0000-0002-5732-954X'}, 'institutions': [{'id': 'https://openalex.org/I4210110459', 'display_name': 'City of Hope', 'ror': 'https://ror.org/01z1vct10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4210110459']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew Earl', 'raw_affiliation_strings': ['1City of Hope, Duarte, CA;'], 'affiliations': [{'raw_affiliation_string': '1City of Hope, Duarte, CA;', 'institution_ids': ['https://openalex.org/I4210110459']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038450525', 'display_name': 'Huiqing Wu', 'orcid': 'https://orcid.org/0000-0003-4609-0323'}, 'institutions': [{'id': 'https://openalex.org/I4210110459', 'display_name': 'City of Hope', 'ror': 'https://ror.org/01z1vct10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4210110459']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Huiqing Wu', 'raw_affiliation_strings': ['1City of Hope, Duarte, CA;'], 'affiliations': [{'raw_affiliation_string': '1City of Hope, Duarte, CA;', 'institution_ids': ['https://openalex.org/I4210110459']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075901144', 'display_name': 'Michael L. Gonzalgo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145608581', 'display_name': 'University of Miami', 'ror': 'https://ror.org/02dgjyy92', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145608581']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael L. Gonzalgo', 'raw_affiliation_strings': ['4University of Miami, Miami, FL.'], 'affiliations': [{'raw_affiliation_string': '4University of Miami, Miami, FL.', 'institution_ids': ['https://openalex.org/I145608581']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064012830', 'display_name': 'Zijie Sun', 'orcid': 'https://orcid.org/0000-0002-6787-6272'}, 'institutions': [{'id': 'https://openalex.org/I4210110459', 'display_name': 'City of Hope', 'ror': 'https://ror.org/01z1vct10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4210110459']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zijie Sun', 'raw_affiliation_strings': ['1City of Hope, Duarte, CA;'], 'affiliations': [{'raw_affiliation_string': '1City of Hope, Duarte, CA;', 'institution_ids': ['https://openalex.org/I4210110459']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': '79', 'issue': '13_Supplement', 'first_page': '4607', 'last_page': '4607'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9839, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9839, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.7364757}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.7263166}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.6220794}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5817055}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.574998}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.54039025}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.509231}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5082969}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4498139}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3451055}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.32918048}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.2960056}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.27564663}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.23060489}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.063509315}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-4607', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2019-4607', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.44}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3009569511', 'https://openalex.org/W2365928272', 'https://openalex.org/W2327862400', 'https://openalex.org/W2169608764', 'https://openalex.org/W2104364640', 'https://openalex.org/W2095348706', 'https://openalex.org/W2051020921', 'https://openalex.org/W2033566079', 'https://openalex.org/W2012986564', 'https://openalex.org/W1967664125'], 'abstract_inverted_index': {'Abstract': [0], 'Emerging': [1], 'evidence': [2], 'has': [3], 'shown': [4], 'that': [5, 106], 'both': [6], 'prostatic': [7, 101, 116, 134, 149, 244], 'basal': [8, 55, 68, 245], 'and': [9, 35, 42, 59, 67, 81, 96, 125, 139, 161, 192, 208], 'luminal': [10, 165, 194], 'cells': [11, 29, 56, 118, 158, 189, 246], 'are': [12, 60, 153, 172, 190], 'able': [13, 61, 120], 'to': [14, 62, 85, 121, 159, 163], 'initiate': [15], 'oncogenic': [16, 94, 109], 'transformation.': [17], 'However,': [18], 'despite': [19, 143], 'the': [20, 31, 88, 126, 144, 185, 201, 251], 'diversity': [21], 'of': [22, 48, 77, 90, 128, 148, 187, 250], 'tumor': [23, 97, 188], 'initiating': [24], 'cells,': [25, 151], 'most': [26], 'prostate': [27, 52, 168, 181, 205, 239], 'cancer': [28, 206, 240], 'express': [30, 57], 'androgen': [32, 49, 91, 145], 'receptor': [33], '(AR)': [34], 'depend': [36], 'on': [37], 'androgens': [38, 152], 'for': [39, 156, 204, 238, 254], 'their': [40], 'growth': [41], 'expansion,': [43], 'implicating': [44], 'an': [45], 'essential': [46, 155, 237], 'role': [47], 'signaling': [50, 92, 110, 235], 'in': [51, 82, 93, 115, 132, 179, 183], 'tumorigenesis.': [53], 'Prostatic': [54], 'p63': [58], 'differentiate': [63], 'into': [64, 200], 'luminal,': [65], 'neuroendocrine,': [66], 'cells.': [69, 103], 'In': [70], 'this': [71], 'study,': [72], 'we': [73], 'used': [74], 'a': [75], 'variety': [76], 'relevant': [78], 'mouse': [79], 'models': [80], 'vivo': [83], 'systems': [84], 'directly': [86], 'address': [87], 'significance': [89], 'transformation': [95], 'development': [98, 241], 'initiated': [99, 242], 'from': [100, 243], 'p63-expressing': [102, 117, 150], 'We': [104], 'demonstrate': [105], 'activating': [107], 'Wnt': [108], 'by': [111], 'expressing': [112], 'stabilized': [113], 'b-catenin': [114], 'is': [119, 236], 'induce': [122], 'cell': [123, 130, 166, 195], 'proliferation': [124], 'formation': [127], 'atypical': [129], 'clusters': [131], 'different': [133], 'lobes': [135], 'at': [136], 'embryonic,': [137], 'prepubescent,': [138], 'adult': [140], 'stages.': [141], 'Intriguingly,': [142], 'insensitive': [146], 'nature': [147], 'still': [154], 'these': [157], 'grow': [160], 'develop': [162], 'androgen-dependent,': [164], 'type': [167], 'tumors.': [169], 'These': [170], 'findings': [171], 'consistent': [173], 'with': [174], 'what': [175], 'have': [176], 'been': [177], 'observed': [178], 'human': [180], 'cancers,': [182], 'which': [184], 'majority': [186], 'androgen-sensitive': [191], 'possess': [193], 'properties,': [196], 'providing': [197], 'new': [198], 'insight': [199], 'molecular': [202], 'mechanisms': [203], 'initiation': [207], 'progression.': [209], 'Citation': [210], 'Format:': [211], 'Yongfeng': [212], 'He,': [213], 'Erika': [214], 'Hooker,': [215], 'Eun-Jeong': [216], 'Yu,': [217], 'Gerald': [218], 'R.': [219], 'Cunha,': [220], 'Lan': [221], 'Liao,': [222], 'Jianming': [223], 'Xu,': [224], 'Andrew': [225], 'Earl,': [226], 'Huiqing': [227], 'Wu,': [228], 'Michael': [229], 'L.': [230], 'Gonzalgo,': [231], 'Zijie': [232], 'Sun.': [233], 'Androgen': [234], '[abstract].': [247], 'In:': [248], 'Proceedings': [249], 'American': [252], 'Association': [253], 'Cancer': [255, 269], 'Research': [256], 'Annual': [257], 'Meeting': [258], '2019;': [259], '2019': [260], 'Mar': [261], '29-Apr': [262], '3;': [263], 'Atlanta,': [264], 'GA.': [265], 'Philadelphia': [266], '(PA):': [267], 'AACR;': [268], 'Res': [270], '2019;79(13': [271], 'Suppl):Abstract': [272], 'nr': [273], '4607.': [274]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4251812294', 'counts_by_year': [], 'updated_date': '2024-12-12T17:37:49.566228', 'created_date': '2022-05-12'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
