Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3009569511', 'doi': 'https://doi.org/10.4081/incontri.2019.607', 'title': 'THE PHYSIOPATHOLOGICAL ROLES OF ANDROGENS IN MOTONEURONS', 'display_name': 'THE PHYSIOPATHOLOGICAL ROLES OF ANDROGENS IN MOTONEURONS', 'publication_year': 2020, 'publication_date': '2020-03-04', 'ids': {'openalex': 'https://openalex.org/W3009569511', 'doi': 'https://doi.org/10.4081/incontri.2019.607', 'mag': '3009569511'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4081/incontri.2019.607', 'pdf_url': 'http://www.ilasl.org/index.php/Incontri/article/download/607/571', 'source': {'id': 'https://openalex.org/S4210173836', 'display_name': 'Istituto Lombardo - Accademia di Scienze e Lettere - Incontri di Studio', 'issn_l': '2279-5251', 'issn': ['2279-5251', '2384-9878'], 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310319913', 'host_organization_name': 'PAGEPress (Italy)', 'host_organization_lineage': ['https://openalex.org/P4310319913'], 'host_organization_lineage_names': ['PAGEPress (Italy)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.ilasl.org/index.php/Incontri/article/download/607/571', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059962048', 'display_name': 'Angelo Poletti', 'orcid': 'https://orcid.org/0000-0002-8883-0468'}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}, {'id': 'https://openalex.org/I189158943', 'display_name': 'University of Milan', 'ror': 'https://ror.org/00wjc7c48', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I189158943']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Angelo Poletti', 'raw_affiliation_strings': ['Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Dipartimento di Eccellenza 2018-2022, Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano. Centro InterUniversitario sulle Malattie Neurodegenerative, Università degli Studi di Firenze, Genova, Roma Tor Vergata e Milano'], 'affiliations': [{'raw_affiliation_string': 'Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Dipartimento di Eccellenza 2018-2022, Centro di Eccellenza sulle Malattie Neurodegenerative, Università degli Studi di Milano, Milano. Centro InterUniversitario sulle Malattie Neurodegenerative, Università degli Studi di Firenze, Genova, Roma Tor Vergata e Milano', 'institution_ids': ['https://openalex.org/I45084792', 'https://openalex.org/I189158943']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5059962048'], 'corresponding_institution_ids': ['https://openalex.org/I45084792', 'https://openalex.org/I189158943'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10949', 'display_name': 'Genetic Neurodegenerative Diseases', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10949', 'display_name': 'Genetic Neurodegenerative Diseases', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10441', 'display_name': 'Muscle Physiology and Disorders', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11585', 'display_name': 'Exercise and Physiological Responses', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/2742', 'display_name': 'Rehabilitation'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.58714324}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4178098}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31881523}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4081/incontri.2019.607', 'pdf_url': 'http://www.ilasl.org/index.php/Incontri/article/download/607/571', 'source': {'id': 'https://openalex.org/S4210173836', 'display_name': 'Istituto Lombardo - Accademia di Scienze e Lettere - Incontri di Studio', 'issn_l': '2279-5251', 'issn': ['2279-5251', '2384-9878'], 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310319913', 'host_organization_name': 'PAGEPress (Italy)', 'host_organization_lineage': ['https://openalex.org/P4310319913'], 'host_organization_lineage_names': ['PAGEPress (Italy)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4081/incontri.2019.607', 'pdf_url': 'http://www.ilasl.org/index.php/Incontri/article/download/607/571', 'source': {'id': 'https://openalex.org/S4210173836', 'display_name': 'Istituto Lombardo - Accademia di Scienze e Lettere - Incontri di Studio', 'issn_l': '2279-5251', 'issn': ['2279-5251', '2384-9878'], 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310319913', 'host_organization_name': 'PAGEPress (Italy)', 'host_organization_lineage': ['https://openalex.org/P4310319913'], 'host_organization_lineage_names': ['PAGEPress (Italy)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.72, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 89, 'referenced_works': ['https://openalex.org/W1502906763', 'https://openalex.org/W1598865329', 'https://openalex.org/W1601161972', 'https://openalex.org/W1606037334', 'https://openalex.org/W1813423898', 'https://openalex.org/W1965283193', 'https://openalex.org/W1972121275', 'https://openalex.org/W1972818610', 'https://openalex.org/W1974152852', 'https://openalex.org/W1975279744', 'https://openalex.org/W1975747878', 'https://openalex.org/W1985902870', 'https://openalex.org/W1986422550', 'https://openalex.org/W1987282399', 'https://openalex.org/W1987857828', 'https://openalex.org/W1990534307', 'https://openalex.org/W1996920204', 'https://openalex.org/W2002559713', 'https://openalex.org/W2003644831', 'https://openalex.org/W2013452556', 'https://openalex.org/W2019520565', 'https://openalex.org/W2023215532', 'https://openalex.org/W2024336151', 'https://openalex.org/W2024496930', 'https://openalex.org/W2026512028', 'https://openalex.org/W2035761264', 'https://openalex.org/W2042437056', 'https://openalex.org/W2043782933', 'https://openalex.org/W2044970885', 'https://openalex.org/W2046776107', 'https://openalex.org/W2050679356', 'https://openalex.org/W2054731798', 'https://openalex.org/W2063046277', 'https://openalex.org/W2065375787', 'https://openalex.org/W2069125659', 'https://openalex.org/W2069888159', 'https://openalex.org/W2077872467', 'https://openalex.org/W2080202166', 'https://openalex.org/W2080667282', 'https://openalex.org/W2082220526', 'https://openalex.org/W2084492223', 'https://openalex.org/W2090845446', 'https://openalex.org/W2094047861', 'https://openalex.org/W2100647214', 'https://openalex.org/W2100955793', 'https://openalex.org/W2108114401', 'https://openalex.org/W2108226812', 'https://openalex.org/W2108421300', 'https://openalex.org/W2108709235', 'https://openalex.org/W2109506725', 'https://openalex.org/W2113333419', 'https://openalex.org/W2115254311', 'https://openalex.org/W2116896548', 'https://openalex.org/W2119221350', 'https://openalex.org/W2121506107', 'https://openalex.org/W2124973113', 'https://openalex.org/W2125040888', 'https://openalex.org/W2125069527', 'https://openalex.org/W2128633219', 'https://openalex.org/W2130466887', 'https://openalex.org/W2131259023', 'https://openalex.org/W2132525296', 'https://openalex.org/W2132594134', 'https://openalex.org/W2133305808', 'https://openalex.org/W2143850427', 'https://openalex.org/W2146352944', 'https://openalex.org/W2148966536', 'https://openalex.org/W2149411724', 'https://openalex.org/W2154445158', 'https://openalex.org/W2155719261', 'https://openalex.org/W2157439375', 'https://openalex.org/W2158621084', 'https://openalex.org/W2159317313', 'https://openalex.org/W2161123101', 'https://openalex.org/W2165589182', 'https://openalex.org/W2166923441', 'https://openalex.org/W2167188607', 'https://openalex.org/W2241735356', 'https://openalex.org/W2262143804', 'https://openalex.org/W2296135919', 'https://openalex.org/W2318353205', 'https://openalex.org/W2319986175', 'https://openalex.org/W2345399459', 'https://openalex.org/W2607295011', 'https://openalex.org/W2752326209', 'https://openalex.org/W2885381221', 'https://openalex.org/W4214955261', 'https://openalex.org/W4249786873', 'https://openalex.org/W89892064'], 'related_works': ['https://openalex.org/W4391375266', 'https://openalex.org/W4387497383', 'https://openalex.org/W2948807893', 'https://openalex.org/W2899084033', 'https://openalex.org/W2778153218', 'https://openalex.org/W2748952813', 'https://openalex.org/W2527526854', 'https://openalex.org/W2078814861', 'https://openalex.org/W1976181487', 'https://openalex.org/W1531601525'], 'abstract_inverted_index': {'The': [0], 'androgen': [1, 30, 32, 77, 119, 154, 156, 168], 'receptor': [2, 21, 78, 120, 169], 'has': [3], 'been': [4], 'purified': [5], 'in': [6, 11, 31, 46, 55, 65, 72, 94, 98, 115, 132, 158, 174], 'the': [7, 12, 19, 25, 41, 47, 56, 66, 76, 99, 107, 110, 118, 133, 149, 159, 162, 166], '‘70s': [8], 'and': [9, 23, 50, 61, 123, 161, 176], 'cloned': [10], '‘80s.': [13], 'It': [14], 'is': [15, 63], 'a': [16, 89, 102, 128], 'member': [17], 'of': [18, 29, 40, 58, 68, 83, 88, 91, 101, 105, 109, 127, 130, 141, 153], 'steroid': [20], 'superfamily': [22], 'mediated': [24], 'most': [26, 150], 'important': [27, 151], 'effects': [28], 'dependent': [33], 'or': [34], 'sensitive': [35], 'tissues.': [36], 'Several': [37], 'physiological': [38], 'function': [39, 93], 'brain': [42, 160], 'are': [43], 'differentially': [44], 'controlled': [45], 'two': [48], 'sexes': [49], 'androgens': [51], 'play': [52], 'specific': [53], 'role': [54], 'processes': [57], 'sexual': [59], 'differentiation': [60], 'it': [62], 'involved': [64], 'maintenance': [67], 'male': [69], 'sex': [70], 'behaviour': [71], 'adulthood.': [73], 'When': [74], 'mutated,': [75], 'may': [79, 170], 'impact': [80], 'on': [81], 'many': [82], 'these': [84], 'androgen-regulated': [85], 'activities': [86], 'because': [87], 'loss': [90], 'androgenic': [92], 'target': [95], 'cells.': [96], 'However,': [97], 'case': [100], 'peculiar': [103], 'type': [104], 'mutation,': [106], 'elongation': [108], 'polyglutamine': [111], 'tract': [112], 'normally': [113], 'present': [114], 'its': [116], 'N-terminus,': [117], 'becomes': [121], 'neurotoxic': [122], 'induces': [124], 'cells': [125], 'death': [126], 'number': [129], 'motoneurons': [131], 'spinal': [134], 'cord,': [135], 'which': [136, 165], 'express': [137], 'very': [138], 'high': [139], 'level': [140], 'this': [142], 'protein.': [143], 'Here,': [144], 'we': [145], 'will': [146], 'briefly': [147], 'discuss': [148], 'actions': [152], 'receptor-mediated': [155], 'activity': [157], 'mechanisms': [163], 'by': [164], 'mutant': [167], 'lead': [171], 'to': [172], 'neurodegeneration': [173], 'Spinal': [175], 'Bulbar': [177], 'Muscular': [178], 'Atrophy': [179], '(SBMA).': [180]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3009569511', 'counts_by_year': [], 'updated_date': '2024-12-10T15:09:49.622763', 'created_date': '2020-03-13'}