Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4248291600', 'doi': 'https://doi.org/10.1385/0-89603-256-6:1', 'title': 'DNase I Footprinting', 'display_name': 'DNase I Footprinting', 'publication_year': 2003, 'publication_date': '2003-11-14', 'ids': {'openalex': 'https://openalex.org/W4248291600', 'doi': 'https://doi.org/10.1385/0-89603-256-6:1', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8004186'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1385/0-89603-256-6:1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306463399', 'display_name': 'Humana Press eBooks', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310315801', 'host_organization_name': 'Humana Press', 'host_organization_lineage': ['https://openalex.org/P4310315801'], 'host_organization_lineage_names': ['Humana Press'], 'type': 'ebook platform'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'book-chapter', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5104091954', 'display_name': 'Benoît Leblanc', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43406934', 'display_name': 'Université Laval', 'ror': 'https://ror.org/04sjchr03', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I43406934']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Benoît Leblanc', 'raw_affiliation_strings': ["Centre de Recherche en Cancérologie de I'Université Laval, Québec, Canada"], 'affiliations': [{'raw_affiliation_string': "Centre de Recherche en Cancérologie de I'Université Laval, Québec, Canada", 'institution_ids': ['https://openalex.org/I43406934']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5089829367', 'display_name': 'Tom Moss', 'orcid': 'https://orcid.org/0000-0003-2047-4783'}, 'institutions': [{'id': 'https://openalex.org/I43406934', 'display_name': 'Université Laval', 'ror': 'https://ror.org/04sjchr03', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I43406934']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Tom Moss', 'raw_affiliation_strings': ["Centre de Recherche en Cancérologie de I'Université Laval, Québec, Canada"], 'affiliations': [{'raw_affiliation_string': "Centre de Recherche en Cancérologie de I'Université Laval, Québec, Canada", 'institution_ids': ['https://openalex.org/I43406934']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.368749, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 81, 'max': 82}, 'biblio': {'volume': None, 'issue': None, 'first_page': '1', 'last_page': '10'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10432', 'display_name': 'DNA and Nucleic Acid Chemistry', 'score': 0.9883, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/footprinting', 'display_name': 'Footprinting', 'score': 0.92856145}, {'id': 'https://openalex.org/keywords/dna-footprinting', 'display_name': 'DNA footprinting', 'score': 0.81758213}, {'id': 'https://openalex.org/keywords/hypersensitive-site', 'display_name': 'Hypersensitive site', 'score': 0.63768744}], 'concepts': [{'id': 'https://openalex.org/C2778021871', 'wikidata': 'https://www.wikidata.org/wiki/Q648006', 'display_name': 'Footprinting', 'level': 4, 'score': 0.92856145}, {'id': 'https://openalex.org/C22427896', 'wikidata': 'https://www.wikidata.org/wiki/Q4493748', 'display_name': 'DNA footprinting', 'level': 5, 'score': 0.81758213}, {'id': 'https://openalex.org/C2779377703', 'wikidata': 'https://www.wikidata.org/wiki/Q14901483', 'display_name': 'Deoxyribonuclease I', 'level': 4, 'score': 0.65419364}, {'id': 'https://openalex.org/C58237431', 'wikidata': 'https://www.wikidata.org/wiki/Q5958570', 'display_name': 'Hypersensitive site', 'level': 5, 'score': 0.63768744}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.6220875}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5406283}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.53657115}, {'id': 'https://openalex.org/C182614070', 'wikidata': 'https://www.wikidata.org/wiki/Q17119065', 'display_name': 'DNase I hypersensitive site', 'level': 5, 'score': 0.48991412}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.3800246}, {'id': 'https://openalex.org/C94966510', 'wikidata': 'https://www.wikidata.org/wiki/Q2252764', 'display_name': 'DNA-binding protein', 'level': 4, 'score': 0.3346939}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.29791757}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.27995497}, {'id': 'https://openalex.org/C3017666073', 'wikidata': 'https://www.wikidata.org/wiki/Q1764062', 'display_name': 'Base sequence', 'level': 3, 'score': 0.08837849}], 'mesh': [{'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003850', 'descriptor_name': 'Deoxyribonuclease I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015336', 'descriptor_name': 'Molecular Probe Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014981', 'descriptor_name': 'Xenopus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029867', 'descriptor_name': 'Xenopus Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1385/0-89603-256-6:1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306463399', 'display_name': 'Humana Press eBooks', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310315801', 'host_organization_name': 'Humana Press', 'host_organization_lineage': ['https://openalex.org/P4310315801'], 'host_organization_lineage_names': ['Humana Press'], 'type': 'ebook platform'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8004186', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4248291600', 'https://openalex.org/W4232849376', 'https://openalex.org/W4206050837', 'https://openalex.org/W2280567170', 'https://openalex.org/W2140873593', 'https://openalex.org/W2079869065', 'https://openalex.org/W2069235651', 'https://openalex.org/W2047695266', 'https://openalex.org/W2024879439', 'https://openalex.org/W109287442'], 'abstract_inverted_index': {'DNase': [0, 50, 133, 166, 213], 'I': [1, 134, 167, 214], 'footprinting': [2, 142, 168, 176, 215, 224], 'was': [3], 'developed': [4], 'by': [5, 67, 78, 162, 188, 212, 222], 'Galas': [6], 'and': [7, 42, 80, 147], 'Schmitz': [8], 'in': [9, 90, 150], '1978': [10], 'as': [11, 87], 'a': [12, 27, 38, 88, 180], 'method': [13], 'to': [14, 21, 35, 108, 125, 140, 178], 'study': [15, 127], 'the': [16, 44, 56, 59, 68, 75, 83, 91, 110, 126, 132, 156, 170, 175, 192, 203], 'sequence-specific': [17, 116], 'binding': [18], 'of': [19, 58, 74, 85, 95, 112, 114, 128, 173], 'proteins': [20, 118], 'DNA': [22, 31, 60, 77, 157, 206], '(1).': [23], 'In': [24], 'this': [25, 151], 'technique': [26, 104], 'suitable': [28], 'uniquely': [29], 'end-labeled': [30], 'fragment': [32], 'is': [33, 46, 136, 158, 169, 185], 'allowed': [34], 'interact': [36], 'with': [37, 49, 61, 202], 'given': [39], 'DNA-binding': [40], 'protein': [41, 54], 'then': [43], 'complex': [45], 'partially': [47], 'digested': [48], '1.': [51], 'The': [52, 103, 199], 'bound': [53], 'protects': [55], 'region': [57, 84], 'which': [62], 'it': [63], 'interacts': [64], 'from': [65], 'attack': [66, 154], 'DNase.': [69], 'Subsequent': [70], 'molecular': [71], 'weight': [72], 'analysis': [73], 'degraded': [76], 'electrophoresis': [79], 'autoradiography': [81], 'identifies': [82], 'protection': [86], 'gap': [89], 'otherwise': [92], 'continuous': [93], 'background': [94], 'digestion': [96], 'products': [97], '(for': [98], 'examples,': [99], 'see': [100], 'Fig.': [101, 197], '1).': [102], 'can': [105, 208], 'be': [106, 209], 'used': [107], 'determine': [109], 'site': [111], 'interaction': [113, 201], 'most': [115, 122, 171], 'DNAbinding': [117], 'but': [119, 216], 'has': [120, 217], 'been': [121, 220], 'extensively': [123], 'applied': [124], 'transcription': [129, 193], 'factors.': [130], 'Since': [131], 'molecule': [135], 'relatively': [137], 'large': [138], 'compared': [139], 'other': [141, 223], 'agents': [143], '(see': [144, 196], 'Chapters': [145, 148], '3': [146], '7': [149], 'volume),': [152], 'its': [153], 'on': [155, 191], 'more': [159], 'readily': [160], 'prevented': [161], 'steric': [163], 'hindrance.': [164], 'Thus': [165], 'likely': [172], 'all': [174], 'techniques': [177], 'detect': [179], 'specific': [181], 'DNA-protein': [182], 'interaction.': [183], 'This': [184], 'clearly': [186], 'demonstrated': [187], 'our': [189], 'studies': [190], 'factor': [194], 'xUBF': [195, 200], '1B).': [198], 'xenopus': [204], 'ribosomal': [205], 'enhancer': [207], 'easily': [210], 'detected': [211, 221], 'not': [218], 'yet': [219], 'techniques.': [225]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4248291600', 'counts_by_year': [], 'updated_date': '2024-12-15T17:40:10.277701', 'created_date': '2022-05-12'}