Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4247904703', 'doi': 'https://doi.org/10.1042/bj3510095', 'title': 'Specificity and mechanism of action of some commonly used protein kinase inhibitors', 'display_name': 'Specificity and mechanism of action of some commonly used protein kinase inhibitors', 'publication_year': 2000, 'publication_date': '2000-09-26', 'ids': {'openalex': 'https://openalex.org/W4247904703', 'doi': 'https://doi.org/10.1042/bj3510095'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj3510095', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5033866306', 'display_name': 'Stephen Davies', 'orcid': 'https://orcid.org/0000-0003-3659-0893'}, 'institutions': [{'id': 'https://openalex.org/I177639307', 'display_name': 'University of Dundee', 'ror': 'https://ror.org/03h2bxq36', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I177639307']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Stephen P. DAVIES', 'raw_affiliation_strings': ['Division of Signal Transduction Therapy, University of Dundee, Dundee DD1 5EH, Scotland, U.K.'], 'affiliations': [{'raw_affiliation_string': 'Division of Signal Transduction Therapy, University of Dundee, Dundee DD1 5EH, Scotland, U.K.', 'institution_ids': ['https://openalex.org/I177639307']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057473438', 'display_name': 'Helen Reddy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177639307', 'display_name': 'University of Dundee', 'ror': 'https://ror.org/03h2bxq36', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I177639307']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Helen REDDY', 'raw_affiliation_strings': ['Division of Signal Transduction Therapy, University of Dundee, Dundee DD1 5EH, Scotland, U.K.'], 'affiliations': [{'raw_affiliation_string': 'Division of Signal Transduction Therapy, University of Dundee, Dundee DD1 5EH, Scotland, U.K.', 'institution_ids': ['https://openalex.org/I177639307']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056050624', 'display_name': 'Matilde Caivano', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210110201', 'display_name': 'MRC Protein Phosphorylation and Ubiquitylation Unit', 'ror': 'https://ror.org/01zg1tt02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I177639307', 'https://openalex.org/I4210087105', 'https://openalex.org/I4210110201', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I177639307', 'display_name': 'University of Dundee', 'ror': 'https://ror.org/03h2bxq36', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I177639307']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Matilde CAIVANO', 'raw_affiliation_strings': ['MRC Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, Scotland, U.K.'], 'affiliations': [{'raw_affiliation_string': 'MRC Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, Scotland, U.K.', 'institution_ids': ['https://openalex.org/I4210110201', 'https://openalex.org/I177639307']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010890113', 'display_name': 'Philip Cohen', 'orcid': 'https://orcid.org/0000-0001-7632-9492'}, 'institutions': [{'id': 'https://openalex.org/I177639307', 'display_name': 'University of Dundee', 'ror': 'https://ror.org/03h2bxq36', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I177639307']}, {'id': 'https://openalex.org/I4210110201', 'display_name': 'MRC Protein Phosphorylation and Ubiquitylation Unit', 'ror': 'https://ror.org/01zg1tt02', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I177639307', 'https://openalex.org/I4210087105', 'https://openalex.org/I4210110201', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Philip COHEN', 'raw_affiliation_strings': ['Division of Signal Transduction Therapy, University of Dundee, Dundee DD1 5EH, Scotland, U.K.', 'MRC Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, Scotland, U.K.'], 'affiliations': [{'raw_affiliation_string': 'Division of Signal Transduction Therapy, University of Dundee, Dundee DD1 5EH, Scotland, U.K.', 'institution_ids': ['https://openalex.org/I177639307']}, {'raw_affiliation_string': 'MRC Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, Scotland, U.K.', 'institution_ids': ['https://openalex.org/I177639307', 'https://openalex.org/I4210110201']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 50.673, 'has_fulltext': False, 'cited_by_count': 3003, 'citation_normalized_percentile': {'value': 0.999974, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '351', 'issue': '1', 'first_page': '95', 'last_page': '105'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11533', 'display_name': 'Melanoma and MAPK Pathways', 'score': 0.9824, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11533', 'display_name': 'Melanoma and MAPK Pathways', 'score': 0.9824, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11075', 'display_name': 'Insect Resistance and Genetics', 'score': 0.9751, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11663', 'display_name': 'Viral Infectious Diseases and Gene Expression in Insects', 'score': 0.975, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/wortmannin', 'display_name': 'Wortmannin', 'score': 0.6674553}, {'id': 'https://openalex.org/keywords/c-raf', 'display_name': 'c-Raf', 'score': 0.48373035}], 'concepts': [{'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.74597096}, {'id': 'https://openalex.org/C2778308172', 'wikidata': 'https://www.wikidata.org/wiki/Q423565', 'display_name': 'Wortmannin', 'level': 4, 'score': 0.6674553}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.62824774}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49624163}, {'id': 'https://openalex.org/C99405784', 'wikidata': 'https://www.wikidata.org/wiki/Q410434', 'display_name': 'c-Raf', 'level': 5, 'score': 0.48373035}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.47218716}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.4720864}, {'id': 'https://openalex.org/C82495950', 'wikidata': 'https://www.wikidata.org/wiki/Q14911732', 'display_name': 'Cyclin-dependent kinase 2', 'level': 4, 'score': 0.46792173}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.44901463}, {'id': 'https://openalex.org/C132149769', 'wikidata': 'https://www.wikidata.org/wiki/Q899651', 'display_name': 'Mitogen-activated protein kinase', 'level': 3, 'score': 0.44145313}, {'id': 'https://openalex.org/C90934575', 'wikidata': 'https://www.wikidata.org/wiki/Q6593810', 'display_name': 'Mitogen-activated protein kinase kinase', 'level': 4, 'score': 0.44092977}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3473259}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31163305}, {'id': 'https://openalex.org/C2780610907', 'wikidata': 'https://www.wikidata.org/wiki/Q2273248', 'display_name': 'Phosphatidylinositol', 'level': 3, 'score': 0.29156616}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj3510095', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4241863761', 'https://openalex.org/W2151196184', 'https://openalex.org/W2090799728', 'https://openalex.org/W2075521983', 'https://openalex.org/W2064943475', 'https://openalex.org/W2061404590', 'https://openalex.org/W2037654470', 'https://openalex.org/W2033421786', 'https://openalex.org/W1999628035', 'https://openalex.org/W1997855401'], 'abstract_inverted_index': {'The': [0, 28, 107], 'specificities': [1, 187], 'of': [2, 13, 25, 153, 188, 215], '28': [3], 'commercially': [4], 'available': [5], 'compounds': [6, 29, 108], 'reported': [7], 'to': [8, 37, 61, 96, 103, 138], 'be': [9, 62, 193], 'relatively': [10], 'selective': [11, 79, 173], 'inhibitors': [12, 174, 191, 218], 'particular': [14], 'serine/threonine-specific': [15], 'protein': [16, 26, 40, 87, 142, 180, 189, 216], 'kinases': [17, 88, 201], 'have': [18], 'been': [19], 'examined': [20], 'against': [21], 'a': [22], 'large': [23], 'panel': [24], 'kinases.': [27], 'KT': [30], '5720,': [31], 'Rottlerin': [32], 'and': [33, 50, 66, 74, 126, 130, 157, 167], 'quercetin': [34], 'were': [35, 77, 115, 136], 'found': [36, 95, 137], 'inhibit': [38, 97], 'many': [39], 'kinases,': [41], 'sometimes': [42], 'much': [43], 'more': [44, 78, 86], 'potently': [45], 'than': [46], 'their': [47, 54, 198], 'presumed': [48], 'targets,': [49], 'conclusions': [51], 'drawn': [52], 'from': [53, 165], 'use': [55, 214], 'in': [56, 146, 206, 219], 'cell-based': [57, 147, 220], 'experiments': [58], 'are': [59, 203], 'likely': [60], 'erroneous.': [63], 'Ro': [64], '318220': [65], 'related': [67, 205], 'bisindoylmaleimides,': [68], 'as': [69, 71], 'well': [70], 'H89,': [72], 'HA1077': [73], 'Y': [75], '27632,': [76], 'inhibitors,': [80], 'but': [81], 'still': [82], 'inhibited': [83], 'two': [84], 'or': [85], 'with': [89, 100, 109], 'similar': [90, 101], 'potency.': [91], 'LY': [92], '294002': [93], 'was': [94], 'casein': [98], 'kinase-2': [99], 'potency': [102], 'phosphoinositide': [104], '(phosphatidylinositol)': [105], '3-kinase.': [106], 'the': [110, 140, 151, 171, 186, 213], 'most': [111, 172], 'impressive': [112], 'selectivity': [113], 'profiles': [114], 'KN62,': [116], 'PD': [117, 120, 131, 134, 168], '98059,': [118, 135], 'U0126,': [119], '184352,': [121, 132, 169], 'rapamycin,': [122], 'wortmannin,': [123], 'SB': [124, 127], '203580': [125], '202190.': [128], 'U0126': [129], 'like': [133], 'block': [139], 'mitogen-activated': [141], 'kinase': [143, 155, 190, 217], '(MAPK)': [144], 'cascade': [145], 'assays': [148], 'by': [149, 159, 196], 'preventing': [150], 'activation': [152], 'MAPK': [154], '(MKK1),': [156], 'not': [158], 'inhibiting': [160], 'MKK1': [161], 'activity': [162], 'directly.': [163], 'Apart': [164], 'rapamycin': [166], 'even': [170], 'affected': [175], 'at': [176], 'least': [177], 'one': [178], 'additional': [179], 'kinase.': [181], 'Our': [182], 'results': [183], 'demonstrate': [184], 'that': [185, 202], 'cannot': [192], 'assessed': [194], 'simply': [195], 'studying': [197], 'effect': [199], 'on': [200], 'closely': [204], 'primary': [207], 'structure.': [208], 'We': [209], 'propose': [210], 'guidelines': [211], 'for': [212], 'assays.': [221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4247904703', 'counts_by_year': [{'year': 2024, 'cited_by_count': 37}, {'year': 2023, 'cited_by_count': 52}, {'year': 2022, 'cited_by_count': 57}, {'year': 2021, 'cited_by_count': 68}, {'year': 2020, 'cited_by_count': 66}, {'year': 2019, 'cited_by_count': 88}, {'year': 2018, 'cited_by_count': 59}, {'year': 2017, 'cited_by_count': 83}, {'year': 2016, 'cited_by_count': 99}, {'year': 2015, 'cited_by_count': 93}, {'year': 2014, 'cited_by_count': 86}, {'year': 2013, 'cited_by_count': 101}, {'year': 2012, 'cited_by_count': 107}], 'updated_date': '2025-01-11T17:17:57.770235', 'created_date': '2022-05-12'}