Title: Catalytic Enantioselective Synthesis of Flavanones and Chromanones
Abstract: The enantioselective synthesis of flavanones and chromanones is described. Bifunctional thiourea catalysts promote an asymmetric oxo-conjugate addition to a β-ketoester alkylidene in high yields with excellent enantioselectivity (80−94% ee) for aryl and alkyl substrates. Decarboxylation of the β-ketoester proceeds smoothly in a one-pot procedure to afford the enantioenriched flavanones and chromanones.
Publication Year: 2007
Publication Date: 2007-03-10
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 275
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