Abstract: A novel bifunctional chiral Brønsted acid/base catalyst is reported. The authors applied the new catalyst 1 to the enantioselective desymmetrization of meso-anhydrides, and the products were obtained in good yields and high enantioselectivities (er up to 99:1). The synthetic utility of this methodology was demonstrated in the symmetric formal synthesis of (+)-grandisol.
Publication Year: 2010
Publication Date: 2010-06-22
Language: en
Type: article
Indexed In: ['crossref']
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