Title: Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling
Abstract: European Journal of ImmunologyVolume 29, Issue 10 p. 3160-3167 ArticleFree Access Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling Anne-Renée Van der Vuurst de Vries, Anne-Renée Van der Vuurst de Vries Department of Immunology, University Hospital Utrecht, Utrecht, The NetherlandsSearch for more papers by this authorHans Clevers, Hans Clevers Department of Immunology, University Hospital Utrecht, Utrecht, The NetherlandsSearch for more papers by this authorTon Logtenberg, Ton Logtenberg Department of Immunology, University Hospital Utrecht, Utrecht, The NetherlandsSearch for more papers by this authorLinde Meyaard, Corresponding Author Linde Meyaard [email protected] Department of Immunology, University Hospital Utrecht, Utrecht, The NetherlandsDepartment of Immunology, University Hospital Utrecht, Heidelberglaan 100, Rm F03.821, 3584 CX Utrecht, The Netherlands Fax: + 31-30-2517107Search for more papers by this author Anne-Renée Van der Vuurst de Vries, Anne-Renée Van der Vuurst de Vries Department of Immunology, University Hospital Utrecht, Utrecht, The NetherlandsSearch for more papers by this authorHans Clevers, Hans Clevers Department of Immunology, University Hospital Utrecht, Utrecht, The NetherlandsSearch for more papers by this authorTon Logtenberg, Ton Logtenberg Department of Immunology, University Hospital Utrecht, Utrecht, The NetherlandsSearch for more papers by this authorLinde Meyaard, Corresponding Author Linde Meyaard [email protected] Department of Immunology, University Hospital Utrecht, Utrecht, The NetherlandsDepartment of Immunology, University Hospital Utrecht, Heidelberglaan 100, Rm F03.821, 3584 CX Utrecht, The Netherlands Fax: + 31-30-2517107Search for more papers by this author First published: 08 October 1999 https://doi.org/10.1002/(SICI)1521-4141(199910)29:10<3160::AID-IMMU3160>3.0.CO;2-SCitations: 66AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Leukocyte-associated Ig-like receptor-1 (LAIR-1) belongs to the growing family of immunoreceptor tyrosine-based inhibitory motif-bearing receptors and is expressed on the majority of peripheral mononuclear cells, including NK cells, T cells, B cells, monocytes, and dendritic cells. In this study, we investigated the distribution and the capacity of LAIR-1 to function as an inhibitory receptor on human B cells. LAIR-1 is expressed from early on during B cell differentiation, but is absent on approximately half of the memory B cells, and all germinal center B cells, plasmablasts, and terminally differentiated plasma cells. In vitro stimulation of naive B cells via the B cell receptor (BCR) or CD40, triggering proliferation and differentiation into Ig-producing plasma cells, is accompanied by loss of LAIR-1 expression. We previously reported that LAIR-1 can function as an inhibitory receptor on NK cells and T cells. Here, we demonstrate that it can also function as a negative regulator of BCR-mediated signaling, since simultaneous cross-linking of LAIR-1 and the BCR reduces the increase of intracellular Ca2+ evoked by BCR ligation. Taken together, this suggests that the inhibitory mechanism of LAIR-1 is functional in multiple components of the hematopoietic system. Citing Literature Volume29, Issue10October 1999Pages 3160-3167 ReferencesRelatedInformation