Continuous signaling of <scp>CD</scp> 79b and <scp>CD</scp> 19 is required for the fitness of Burkitt lymphoma B cells

Name: Work Video:
Duration: 3 min 30 s
Xiaocui He; Kathrin Kläsener; Joseena Iype; Martin Becker; Palash Chandra Maity; Marco Cavallari; Peter Nielsen; Jianying Yang; Michael Reth
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'https://openalex.org/W2013243191', 'https://openalex.org/W1993764875', 'https://openalex.org/W1990804418', 'https://openalex.org/W1971568933'], 'abstract_inverted_index': {'Article18': [0], 'April': [1], '2018Open': [2], 'Access': [3], 'Transparent': [4], 'process': [5, 761], 'Continuous': [6], 'signaling': [7, 818, 868, 932, 938, 956, 969, 991, 1023, 1189, 1254, 1345, 1429, 1453, 1682, 1733, 1772, 1837, 1888, 1969, 2428, 2487, 2652, 3077, 3197, 3233, 3658, 3667, 3702, 3716, 3821, 4174, 4364], 'of': [8, 17, 34, 40, 43, 50, 75, 81, 84, 91, 117, 123, 126, 149, 155, 158, 182, 188, 191, 213, 219, 222, 242, 267, 273, 276, 283, 312, 318, 321, 328, 353, 359, 362, 369, 394, 400, 403, 410, 436, 442, 445, 468, 474, 477, 501, 507, 510, 532, 538, 541, 561, 586, 592, 595, 602, 631, 637, 640, 647, 692, 698, 701, 708, 747, 757, 785, 803, 865, 891, 928, 943, 975, 993, 1001, 1009, 1020, 1045, 1076, 1103, 1127, 1151, 1166, 1198, 1218, 1294, 1300, 1356, 1492, 1506, 1514, 1517, 1563, 1571, 1575, 1585, 1610, 1620, 1653, 1671, 1695, 1718, 1742, 1760, 1803, 1821, 1830, 1856, 1864, 1890, 1908, 1916, 1922, 1959, 1974, 1983, 1991, 1997, 2005, 2024, 2043, 2049, 2068, 2188, 2196, 2208, 2227, 2286, 2305, 2312, 2349, 2352, 2359, 2366, 2381, 2398, 2401, 2422, 2426, 2430, 2437, 2468, 2484, 2555, 2583, 2591, 2604, 2630, 2654, 2663, 2667, 2693, 2783, 2788, 2843, 2923, 2954, 2959, 2974, 2991, 2994, 3001, 3057, 3074, 3086, 3119, 3126, 3169, 3189, 3207, 3224, 3230, 3255, 3269, 3276, 3282, 3287, 3307, 3318, 3329, 3349, 3352, 3359, 3374, 3381, 3388, 3393, 3414, 3436, 3454, 3457, 3465, 3485, 3491, 3513, 3582, 3618, 3624, 3641, 3689, 3696, 3825, 3836, 3845, 3851, 3883, 3890, 3910, 3933, 3936, 3962, 3990, 4014, 4023, 4027, 4060, 4081, 4162, 4234, 4251, 4298, 4358, 4368, 4385, 4392, 4422, 4451, 4458, 4474, 4480, 4487, 4506, 4532, 4539, 4560, 4587, 4617, 4625], 'CD79b': [9], 'and': [10, 52, 93, 244, 285, 330, 371, 412, 563, 604, 649, 681, 710, 750, 768, 833, 845, 872, 879, 913, 924, 946, 960, 978, 1003, 1026, 1063, 1085, 1090, 1105, 1125, 1149, 1160, 1168, 1182, 1196, 1233, 1278, 1280, 1325, 1331, 1346, 1361, 1388, 1423, 1470, 1476, 1478, 1495, 1503, 1583, 1618, 1624, 1681, 1731, 1734, 1740, 1763, 1773, 1797, 1818, 1828, 1835, 1887, 1921, 1955, 1967, 1976, 2030, 2034, 2111, 2210, 2229, 2282, 2307, 2314, 2326, 2334, 2346, 2361, 2368, 2395, 2447, 2460, 2495, 2588, 2615, 2678, 2689, 2701, 2709, 2811, 2820, 2855, 2879, 2902, 2937, 2988, 3003, 3066, 3115, 3140, 3221, 3226, 3346, 3400, 3451, 3501, 3526, 3620, 3635, 3686, 3694, 3699, 3736, 3759, 3775, 3867, 3930, 3969, 3975, 3986, 4056, 4091, 4172, 4221, 4227, 4272, 4294, 4333, 4365, 4387, 4405, 4419, 4448, 4462, 4529, 4571, 4633], 'CD19': [11, 912, 925, 963, 1062, 1261, 1295, 1341, 1386, 1412, 1920, 1956, 4182, 4220, 4252, 4283, 4311, 4359, 4380, 4386, 4404, 4481, 4498, 4521, 4547, 4588, 4608, 4618, 4644, 4657], 'is': [12, 791, 825, 906, 1052, 1220, 1235, 1259, 1414, 1437, 1498, 1613, 1688, 1735, 1784, 1790, 1798, 1859, 1931, 1944, 2407, 2635, 2778, 3036, 3048, 3331, 3587, 3615, 3629, 3942, 4002, 4016, 4042, 4122, 4183, 4360, 4566, 4628], 'required': [13, 1236, 1499, 1614, 1690, 1736, 1860, 3049, 3630, 4044, 4123, 4184, 4361], 'for': [14, 57, 98, 131, 163, 196, 227, 249, 290, 335, 376, 417, 450, 482, 515, 546, 568, 609, 654, 717, 795, 800, 819, 876, 989, 1122, 1237, 1320, 1451, 1500, 1615, 1660, 1668, 1691, 1737, 1861, 1884, 1964, 2205, 2409, 2611, 2934, 3038, 3050, 3071, 3496, 3631, 3944, 4004, 4045, 4124, 4185, 4205, 4248, 4309, 4362, 4568], 'the': [15, 758, 786, 796, 801, 850, 863, 866, 873, 889, 901, 941, 961, 973, 997, 1010, 1018, 1021, 1027, 1039, 1043, 1055, 1077, 1091, 1123, 1152, 1154, 1163, 1179, 1184, 1193, 1221, 1229, 1260, 1269, 1274, 1281, 1305, 1321, 1327, 1359, 1362, 1371, 1389, 1411, 1420, 1449, 1504, 1518, 1530, 1564, 1569, 1572, 1589, 1607, 1611, 1616, 1630, 1654, 1669, 1684, 1692, 1738, 1761, 1804, 1808, 1819, 1826, 1854, 1857, 1862, 1876, 1885, 1891, 1894, 1906, 1909, 1914, 1917, 1923, 1938, 1972, 1988, 1995, 1998, 2003, 2010, 2025, 2041, 2044, 2057, 2089, 2142, 2145, 2155, 2159, 2166, 2193, 2197, 2203, 2206, 2221, 2243, 2283, 2310, 2344, 2364, 2382, 2388, 2393, 2420, 2427, 2431, 2434, 2438, 2485, 2509, 2524, 2534, 2542, 2558, 2566, 2581, 2586, 2597, 2617, 2628, 2631, 2650, 2661, 2664, 2668, 2691, 2694, 2712, 2720, 2750, 2758, 2768, 2775, 2781, 2786, 2816, 2822, 2841, 2860, 2875, 2894, 2906, 2921, 2931, 2948, 2957, 2975, 2986, 3010, 3072, 3075, 3084, 3117, 3120, 3124, 3127, 3145, 3154, 3187, 3195, 3205, 3218, 3227, 3253, 3267, 3274, 3285, 3316, 3344, 3372, 3391, 3449, 3498, 3502, 3514, 3522, 3528, 3548, 3579, 3583, 3608, 3616, 3622, 3632, 3636, 3665, 3670, 3679, 3683, 3692, 3697, 3727, 3732, 3748, 3756, 3765, 3780, 3794, 3800, 3818, 3837, 3863, 3918, 3928, 3984, 3987, 4017, 4024, 4058, 4093, 4112, 4136, 4160, 4168, 4186, 4195, 4202, 4210, 4222, 4232, 4235, 4249, 4299, 4305, 4314, 4323, 4331, 4356, 4366, 4390, 4416, 4420, 4423, 4429, 4439, 4446, 4485, 4497, 4520, 4527, 4584, 4596, 4603, 4607, 4623, 4629, 4643, 4652], 'fitness': [16, 878, 1008, 1617, 1863, 1907, 1982, 2436, 2629, 2922, 3053, 3085, 3188, 3254, 3275, 3581, 3654, 4161, 4188, 4367, 4378], 'Burkitt': [18, 812, 1012, 1781], 'lymphoma': [19, 813, 945, 977, 1013, 1782], 'B': [20, 805, 860, 944, 948, 976, 980, 1129, 1199, 1242, 1257, 1350, 1384, 1408, 1464, 1508, 1586, 1622, 1643, 1673, 1716, 1795, 1911, 1978, 2071, 2107, 2181, 2218, 2440, 2458, 2527, 2539, 2569, 2633, 2658, 2725, 2745, 2792, 2863, 2909, 2945, 3088, 3099, 3191, 3259, 3519, 3542, 3567, 3585, 3605, 3643, 3722, 3792, 4028, 4054, 4149, 4164, 4178, 4192, 4318, 4370], 'cells': [21, 861, 981, 1130, 1200, 1243, 1258, 1351, 1465, 1587, 1623, 1644, 1674, 1717, 1745, 1796, 1832, 1867, 1912, 1985, 2053, 2059, 2108, 2135, 2162, 2182, 2190, 2219, 2231, 2249, 2262, 2267, 2274, 2291, 2316, 2336, 2373, 2386, 2459, 2470, 2515, 2528, 2549, 2562, 2570, 2634, 2726, 2746, 2761, 2814, 2827, 2837, 2870, 2910, 2925, 2946, 2965, 2979, 3008, 3089, 3100, 3131, 3148, 3158, 3192, 3210, 3260, 3278, 3290, 3310, 3321, 3362, 3396, 3419, 3468, 3520, 3533, 3543, 3568, 3586, 3606, 3723, 3802, 3830, 3856, 3893, 3899, 3913, 4029, 4055, 4070, 4099, 4105, 4140, 4150, 4165, 4193, 4280, 4303, 4319, 4337, 4396, 4411, 4427, 4465, 4490, 4509, 4542, 4600, 4613, 4637, 4648], 'Xiaocui': [22, 24, 341, 343, 662], 'He': [23, 25, 342, 344], 'orcid.org/0000-0002-0106-057X': [26, 345], 'BIOSS': [27, 68, 110, 142, 175, 206, 260, 305, 346, 387, 429, 461, 494, 525, 579, 624], 'Centre': [28, 69, 111, 143, 176, 207, 261, 306, 347, 388, 430, 462, 495, 526, 580, 625, 686], 'For': [29, 70, 112, 144, 177, 208, 262, 307, 348, 389, 431, 463, 496, 527, 581, 626, 687, 1713, 2442], 'Biological': [30, 71, 113, 145, 178, 209, 263, 308, 349, 390, 432, 464, 497, 528, 582, 627, 688], 'Signaling': [31, 72, 114, 146, 179, 210, 264, 309, 350, 391, 433, 465, 498, 529, 583, 628, 689, 3265], 'Studies,': [32, 73, 115, 147, 180, 211, 265, 310, 351, 392, 434, 466, 499, 530, 584, 629, 690], 'Department': [33, 74, 116, 148, 181, 212, 266, 311, 352, 393, 435, 467, 500, 531, 585, 630, 691], 'Molecular': [35, 76, 118, 150, 183, 214, 268, 313, 354, 395, 437, 469, 502, 533, 587, 632, 693], 'Immunology,': [36, 77, 119, 151, 184, 215, 269, 314, 355, 396, 438, 470, 503, 534, 588, 633, 694, 718], 'Biology': [37, 78, 120, 152, 185, 216, 270, 315, 356, 397, 439, 471, 504, 535, 589, 634, 695], 'III,': [38, 79, 121, 153, 186, 217, 271, 316, 357, 398, 440, 472, 505, 536, 590, 635, 696], 'Faculty': [39, 80, 122, 154, 187, 218, 272, 317, 358, 399, 441, 473, 506, 537, 591, 636, 697], 'Biology,': [41, 82, 124, 156, 189, 220, 274, 319, 360, 401, 443, 475, 508, 539, 593, 638, 699], 'University': [42, 83, 125, 157, 190, 221, 275, 320, 361, 402, 444, 476, 509, 540, 594, 639, 700], 'Freiburg,': [44, 45, 54, 85, 86, 95, 127, 128, 159, 160, 192, 193, 223, 224, 246, 277, 278, 287, 322, 323, 332, 363, 364, 373, 404, 405, 414, 446, 447, 478, 479, 511, 512, 542, 543, 565, 596, 597, 606, 641, 642, 651, 702, 703, 712], 'Germany': [46, 55, 87, 96, 129, 161, 194, 225, 247, 279, 288, 324, 333, 365, 374, 406, 415, 448, 480, 513, 544, 566, 598, 607, 643, 652, 704, 713, 723, 730], 'Max': [47, 88, 239, 280, 325, 366, 407, 558, 599, 644], 'Planck': [48, 89, 240, 281, 326, 367, 408, 559, 600, 645, 706], 'Institute': [49, 90, 241, 282, 327, 368, 409, 560, 601, 646, 707, 716], 'Immunobiology': [51, 92, 243, 284, 329, 370, 411, 562, 603, 648, 709], 'Epigenetics,': [53, 94, 245, 286, 331, 372, 413, 564, 605, 650, 711], 'Search': [56, 97, 130, 162, 195, 226, 248, 289, 334, 375, 416, 449, 481, 514, 545, 567, 608, 653], 'more': [58, 99, 132, 164, 197, 228, 250, 291, 336, 377, 418, 451, 483, 516, 547, 569, 610, 655, 1661], 'papers': [59, 100, 133, 165, 198, 229, 251, 292, 337, 378, 419, 452, 484, 517, 548, 570, 611, 656], 'by': [60, 101, 134, 166, 199, 230, 252, 293, 338, 379, 420, 453, 485, 518, 549, 571, 612, 657, 827, 996, 1304, 1440, 1800, 2220, 2295, 2319, 2376, 2492, 2501, 2580, 2698, 2828, 2848, 2947, 2968, 3132, 3204, 3300, 3407, 3478, 3534, 3655, 3755, 3764, 3832, 3922, 3997, 4063, 4166, 4258, 4274, 4399, 4415, 4435, 4467, 4501, 4589], 'this': [61, 102, 135, 167, 200, 231, 253, 294, 339, 380, 421, 454, 486, 519, 550, 572, 613, 658, 2624, 2885, 3162, 3235, 3573, 3955, 4131], 'author': [62, 103, 136, 168, 201, 232, 254, 295, 340, 381, 422, 455, 487, 520, 551, 573, 614, 659, 769], 'Kathrin': [63, 65, 382, 384, 664], 'Kläsener': [64, 66, 383, 385], 'orcid.org/0000-0002-5969-2553': [67, 386], 'Joseena': [104, 107, 423, 426, 666], 'M': [105, 108, 424, 427, 667], 'Iype': [106, 109, 425, 428], 'Martin': [137, 139, 456, 458, 669], 'Becker': [138, 140, 457, 459], 'orcid.org/0000-0002-1751-1056': [141, 460], 'Palash': [169, 172, 488, 491, 671], 'C': [170, 173, 489, 492, 672], 'Maity': [171, 174, 490, 493, 1378, 1402], 'Marco': [202, 204, 521, 523, 674], 'Cavallari': [203, 205, 522, 524], 'Peter': [233, 236, 552, 555, 676], 'J': [234, 237, 553, 556, 677], 'Nielsen': [235, 238, 554, 557], 'Jianying': [255, 257, 574, 576, 679], 'Yang': [256, 258, 575, 577], 'orcid.org/0000-0001-8197-5413': [259, 578], 'Michael': [296, 300, 615, 619, 682], 'Reth': [297, 301, 616, 620, 683], 'Corresponding': [298, 617], 'Author': [299, 618, 660], '[email': [302, 621, 739], 'protected]': [303, 622, 740], 'orcid.org/0000-0002-1025-7198': [304, 623], 'Information': [661], 'He1,2,': [663], 'Kläsener1,2,': [665], 'Iype1,3,': [668], 'Becker1,4,': [670], 'Maity1,3,': [673], 'Cavallari1,': [675], 'Nielsen2,': [678], 'Yang1,2': [680], '*,1,2': [684], '1BIOSS': [685], '2Max': [705], '3Present': [714], 'address:': [715, 725], 'Uni': [719], 'Hospital': [720], 'Ulm,': [721, 722], '4Present': [724], 'Helmholtz': [726], 'Zentrum': [727], 'München,': [728, 729], '*Corresponding': [731], 'author.': [732], 'Tel:': [733], '+49': [734], '761': [735], '203': [736], '97663;': [737], 'E-mail:': [738], 'The': [741, 951, 1007, 1049, 1070, 1100, 1174, 1290, 1434, 1461, 1490, 1561, 1981, 2302, 2329, 2341, 2356, 2482, 2772, 2865, 2952, 2983, 3054, 3166, 3280, 3305, 3333, 3341, 3377, 3386, 3412, 3438, 3446, 3462, 3481, 3538, 3596, 3813, 3841, 3879, 3907, 3925, 3981, 4069, 4180, 4374, 4383, 4403, 4443, 4470, 4524, 4556, 4611], 'EMBO': [742], 'Journal': [743], '(2018)37:e97980https://doi.org/10.15252/embj.201797980': [744], 'PDFDownload': [745], 'PDF': [746], 'article': [748], 'text': [749], 'main': [751], 'figures.': [752], 'Peer': [753], 'ReviewDownload': [754], 'a': [755, 1266, 1480, 1493, 1496, 1512, 1526, 1592, 1634, 1801, 1844, 1848, 1934, 2095, 2115, 2339, 2350, 2399, 2463, 2601, 2699, 2702, 2853, 2890, 2992, 3338, 3350, 3443, 3455, 3656, 3761, 3859, 3934, 4021, 4078, 4101, 4142, 4261, 4275, 4343, 4590], 'summary': [756], 'editorial': [759, 763], 'decision': [760, 764], 'including': [762, 811], 'letters,': [765], 'reviewer': [766], 'comments': [767], 'responses': [770, 3000, 3358, 3464, 3824, 3850, 4457, 4538], 'to': [771, 774, 842, 911, 939, 1061, 1186, 1192, 1419, 1427, 1455, 1879, 1949, 2014, 2066, 2258, 2796, 2815, 2874, 2899, 3182, 3273, 3521, 3572, 3675, 3760, 3793, 3953, 4089, 4341, 4348, 4641], 'feedback.': [772], 'ToolsAdd': [773], 'favoritesDownload': [775], 'CitationsTrack': [776], 'CitationsPermissions': [777], 'ShareFacebookTwitterLinked': [778], 'InMendeleyWechatReddit': [779], 'Figures': [780], '&': [781, 1097, 1208, 1287, 1335, 1375, 1458, 1538, 1554, 1706, 4214], 'Info': [782], 'Abstract': [783], 'Expression': [784, 1679, 4479], 'B-cell': [787, 809, 846, 902, 931, 952, 968, 994, 1004, 1040, 1056, 1071, 1230, 1310, 1501, 1579, 1697, 1755, 1787, 1939, 2006, 2017, 3052, 4211, 4218], 'antigen': [788, 953, 1072, 1147, 1484], 'receptor': [789, 954, 1073, 1283, 1886, 1962, 3237], '(BCR)': [790, 955, 1074], 'essential': [792], 'not': [793, 1033, 2077, 2137, 2636, 2872, 3160, 3251, 3570, 3621], 'only': [794, 2541, 2612, 2757, 2905], 'development': [797, 1124, 1502], 'but': [798, 1032, 2641, 4284], 'also': [799, 1438, 1689, 2490, 3202, 3711, 4043, 4339], 'maintenance': [802, 1126, 1505, 1635], 'mature': [804, 1128, 1507, 1578, 1621, 1642, 4191], 'cells.': [806, 949, 1509, 1979, 2127, 2328, 2390, 2441, 2804, 2864, 2982, 3644, 3896, 3906, 3980, 4179, 4371], 'Similarly,': [807], 'many': [808], 'lymphomas,': [810, 2007], '(BL),': [814], 'require': [815, 862, 1833], 'continuous': [816, 936, 1693, 1729], 'BCR': [817, 844, 867, 894, 1002, 1022, 1047, 1180, 1185, 1452, 1497, 1612, 1632, 1647, 1687, 1762, 1858, 1892, 1918, 1924, 1999, 2027, 2124, 2140, 2198, 2264, 2288, 2369, 2383, 2432, 2486, 2640, 2683, 2696, 2939, 2961, 2976, 3004, 3076, 3672, 3680, 3698, 3715, 3820, 4236], 'their': [820, 877, 2080, 2148, 2477, 2733, 3425, 3739, 4289, 4515, 4551, 4620], 'tumor': [821, 1744, 1775, 1788, 1866, 1977], 'growth.': [822], 'This': [823, 2832, 3199, 3575, 3770, 4117, 4353], 'growth': [824, 881, 1694, 1902, 2004, 2083, 2096, 2156, 2244, 3242, 4143], 'driven': [826], 'immunoreceptor': [828, 1110], 'tyrosine-based': [829, 1111], 'activation': [830, 1112, 3695], 'motif': [831, 1113], '(ITAM)': [832, 1114], 'PI3': [834], 'kinase': [835, 1157, 1307, 1329, 3839], '(PI3K)': [836], 'signaling.': [837, 985, 3782, 4127], 'Here,': [838, 1872], 'we': [839, 885, 1873, 2008, 2103, 2444, 2595, 2892, 3094, 3718, 3785, 3797, 4048, 4133, 4256], 'employ': [840], 'CRISPR/Cas9': [841, 998, 1877, 2011, 2222, 2949, 4306, 4417], 'delete': [843, 1880], 'co-receptor': [847, 874, 962, 1005, 1028, 1262, 1919, 4181, 4196], 'genes': [848, 1524, 1881, 4407], 'in': [849, 882, 888, 908, 915, 1042, 1058, 1065, 1240, 1256, 1366, 1416, 1468, 1472, 1577, 1581, 1591, 1658, 1768, 1893, 1933, 1946, 2001, 2061, 2079, 2081, 2094, 2101, 2114, 2154, 2462, 2533, 2737, 2740, 2780, 2825, 2840, 2852, 2884, 3531, 3779, 3967, 4111, 4231, 4253, 4408, 4428, 4631, 4651], 'human': [851, 1011, 1895, 3058], 'BL': [852, 1831, 1849, 1896], 'cell': [853, 1014, 1897, 2092, 2149, 2478, 2659, 2685, 2734, 2793, 4290, 4377, 4653], 'line': [854, 1015, 1898, 2046], 'Ramos.': [855, 1899], 'We': [856, 1927, 1951, 2038, 2086, 2416, 2646, 2670, 2805, 3509, 3745, 4581, 4593], 'find': [857], 'that': [858, 887, 922, 934, 971, 1119, 1446, 1606, 1629, 1789, 1825, 1853, 1882, 1905, 1929, 1953, 1970, 2048, 2067, 2074, 2132, 2173, 2466, 2575, 2608, 2627, 2719, 2774, 2835, 2904, 3068, 3578, 3628, 3650, 3747, 3773, 3799, 4119, 4135, 4157, 4278, 4355, 4656], 'Ramos': [859, 1016, 1910, 1984, 2016, 2052, 2070, 2091, 2106, 2126, 2134, 2161, 2180, 2189, 2217, 2248, 2273, 2372, 2457, 2526, 2538, 2568, 2592, 2605, 2632, 2657, 2682, 2724, 2744, 2755, 2791, 2813, 2836, 2862, 2869, 2897, 2908, 2924, 2944, 2964, 3007, 3087, 3098, 3147, 3190, 3258, 3277, 3418, 3518, 3541, 3566, 3584, 3604, 3642, 3721, 3791, 3829, 3855, 3979, 4053, 4098, 4163, 4267, 4317, 4336, 4369, 4376, 4394, 4410], 'expression': [864, 1019, 1491, 1609, 1648, 1855, 1915, 1990, 2303, 2357, 2662, 2764, 2919, 2953, 3118, 3281, 3387, 3617, 4062, 4121, 4208, 4287, 4357, 4384, 4522, 4548, 4609, 4658], 'component': [869, 957, 1024, 2265, 2370, 2488, 2940, 2962, 2977, 3005, 4022], 'Igβ': [870, 896, 923, 958, 1025, 1031, 1051, 1106, 1169, 1523, 1930, 1954, 1992, 2194, 2448, 2543, 2644, 2655, 2730, 2763, 2776, 2839, 2918, 2955, 3031, 3059, 3113, 3121, 3170, 3225, 3246, 3271, 3283, 3296, 3330, 3368, 3389, 3402, 3474, 3546, 3561, 3619, 3651, 3663, 3710, 3804, 3815, 4046, 4126, 4158, 4254, 4286, 4363, 4388, 4483, 4627], '(CD79b),': [871], 'CD19,': [875, 4197], 'competitive': [880, 1901], 'culture.': [883], 'Furthermore,': [884, 1843, 4330], 'show': [886, 1605, 3161, 4141, 4156, 4614], 'absence': [890, 1044, 2782, 2842], 'any': [892, 1515, 2139], 'other': [893, 1046], 'component,': [895], 'can': [897, 1035, 1447, 2845], 'be': [898, 1036, 2846], 'expressed': [899, 1932, 2728, 2779, 3217], 'on': [900, 1038, 1054, 1268, 1370, 1847, 1937, 1987, 2147, 2192, 2309, 2363, 2476, 2656, 2732, 2785, 2956, 3091, 3123, 3194, 3284, 3390, 4209, 4288, 4389, 4484, 4619], 'surface,': [903], 'where': [904, 1942], 'it': [905, 1625, 1943, 3614], 'found': [907, 1053, 1415, 1928, 1945, 2903, 3746, 3798, 4134], 'close': [909, 1059, 1417, 1947], 'proximity': [910, 1060, 1418, 1948], 'signals': [914, 1064, 1667, 3816], 'an': [916, 929, 966, 1066, 1109, 1650, 1724, 1785, 1960, 2472, 2493, 3212, 3239, 3245, 3553, 3625], 'ITAM-dependent': [917, 1067], 'manner.': [918, 1068], 'These': [919, 1603], 'data': [920, 1604, 2342, 2984, 3342, 3378, 3447, 3482, 3842, 3880, 3926, 3982, 4444, 4471, 4525, 4557], 'suggest': [921, 1824, 1952, 3649], 'are': [926, 1120, 1302, 1392, 1957, 2175, 2578, 3069, 3379, 3483, 3777, 3843, 3881, 4472, 4558, 4574], 'part': [927, 1958, 2666], 'alternative': [930, 967, 1666, 1961], 'module': [933, 970, 1963], 'use': [935], 'ITAM/PI3K': [937, 984], 'promote': [940], 'survival': [942, 974, 1619, 1638, 1670, 1741, 1776, 1827, 1973], 'normal': [947, 979, 1975], 'Synopsis': [950], '(CD79b)': [959], 'act': [964], 'as': [965, 1317, 2338, 2451, 2453, 2498, 2500, 2521, 2523, 2674, 2676, 2881, 3337, 3442, 3669, 3877, 4176], 'promotes': [972, 1728, 1971, 3652, 4659], 'via': [982], 'integrated': [983], 'A': [986, 1215, 1900, 2128, 2199, 2240, 2927, 3045, 3489], 'new': [987, 2602], 'strategy': [988], 'functional': [990, 3046], 'studies': [992], 'lines': [995, 2093, 2686], 'mediated': [999], 'deletion': [1000, 1513, 1562, 1652], 'genes.': [1006], 'requires': [1017, 1913, 2660, 4199, 4379], 'CD19.': [1029, 1950], 'Only': [1030], 'Igα': [1034, 1104, 1167, 1576, 1655, 2033, 2446, 2559, 3024], 'transported': [1037], 'surface': [1041, 1057, 2150, 2311, 2365, 2479, 2735, 2787, 2958, 3125, 3286, 3392, 4212, 4291, 4315, 4391, 4486, 4621, 4626], 'components.': [1048], 'BCR-independent': [1050, 2917, 3270, 3814], 'Introduction': [1069], 'consists': [1075], 'membrane-bound': [1078], 'immunoglobulin': [1079], '(mIg)': [1080], 'comprising': [1081], 'two': [1082, 1086, 1116, 1353, 2090, 3061, 3492], 'heavy': [1083], '(H)': [1084], 'light': [1087], '(L)': [1088], 'chains': [1089], 'signal-transducing': [1092], 'Igα/Igβ': [1093, 2454, 2546, 3626], '(CD79a/CD79b)': [1094], 'heterodimer': [1095, 3627], '(Reth': [1096], 'Wienands,': [1098], '1997).': [1099, 4216], 'cytoplasmic': [1101, 3055], 'tails': [1102], 'each': [1107, 2410, 3039, 3945, 4005], 'contain': [1108, 3805], 'with': [1115, 1162, 1273, 1443, 1511, 2047, 2063, 2109, 2118, 2253, 2271, 2536, 2565, 2600, 2638, 2643, 2742, 2753, 2859, 3012, 3079, 3101, 3107, 3292, 3323, 3364, 3398, 3427, 3470, 3589, 3601, 3607, 3682, 3724, 3858, 3865, 3869, 3894, 3903, 4074, 4130, 4147, 4201, 4304, 4492, 4517, 4544, 4553, 4601], 'conserved': [1117, 3062], 'tyrosines': [1118, 1165, 1298, 1315, 1574, 3064, 3179], 'crucial': [1121], '(Reth,': [1131], '1989;': [1132], 'Torres': [1133, 1541], 'et': [1134, 1138, 1143, 1171, 1202, 1212, 1245, 1249, 1379, 1399, 1403, 1431, 1487, 1534, 1542, 1546, 1550, 1558, 1596, 1600, 1676, 1700, 1710, 1748, 1778, 1813, 1839, 1869, 3704, 4031, 4035, 4084, 4239, 4243], 'al,': [1135, 1139, 1144, 1172, 1203, 1213, 1246, 1250, 1380, 1400, 1404, 1432, 1488, 1535, 1543, 1547, 1551, 1559, 1597, 1601, 1677, 1701, 1711, 1749, 1779, 1814, 1840, 1870, 3705, 4032, 4036, 4085, 4240, 4244], '1996;': [1136, 1540, 1544], 'Kraus': [1137, 1599], '2001,': [1140], '2004;': [1141, 1210], 'Reichlin': [1142, 1549], '2001).': [1145], 'Upon': [1146, 3673, 4087, 4217], 'ligation': [1148], 'opening': [1150], 'BCR,': [1153, 1357, 1726], 'spleen': [1155], 'tyrosine': [1156], '(Syk)': [1158], 'phosphorylates': [1159], 'interacts': [1161, 3681], 'ITAM': [1164, 1428, 1573, 1730, 1834, 1966, 3047, 3063, 3092, 3178, 3196, 3232, 3268, 3661], '(Rolli': [1170], '2002).': [1173, 1560], 'resulting': [1175, 1767], 'ITAM/Syk': [1176], 'complex': [1177, 1267, 1387, 1391, 1413, 1436, 2000], 'amplifies': [1178], 'signal': [1181, 1765, 4189, 4237], 'connects': [1183], 'several': [1187, 1696], 'downstream': [1188, 3701], 'pathways,': [1190], 'leading': [1191], 'activation,': [1194, 4219], 'proliferation,': [1195], 'differentiation': [1197], '(Johnson': [1201], '1995;': [1204], 'Kurosaki,': [1205], '1999;': [1206, 1247, 1548], 'Deane': [1207], 'Fruman,': [1209], 'Werner': [1211], '2010).': [1214, 1780], 'prominent': [1216, 4012], 'substrate': [1217, 4013], 'Syk': [1219, 3733, 3757, 3774, 4015], 'SLP65/BLNK': [1222], 'adaptor': [1223, 1322, 4018], 'protein': [1224, 1368, 1396, 2731, 2777, 4019], 'which,': [1225], 'upon': [1226, 1309, 3009, 3371, 4346], 'phosphorylation,': [1227], 'organizes': [1228], 'calcium': [1231, 1238, 2823, 3463, 3529, 3555, 3639, 3740, 3749, 4025, 4102, 4113, 4344], 'signalosome': [1232, 4026], 'thus': [1234, 1342, 1424, 2806], 'mobilization': [1239, 2824, 3530, 3556], 'activated': [1241, 1407, 3671, 4177], '(Jumaa': [1244], 'Kulathu': [1248], '2008).': [1251], 'Another': [1252], 'important': [1253, 3070], 'hub': [1255], 'molecule,': [1263], 'which': [1264, 1301, 1364, 1645, 1727, 2102, 3216, 3690, 4198], 'forms': [1265, 3435], 'plasma': [1270, 1372, 1940], 'membrane': [1271, 1373, 1941], 'together': [1272, 2270, 3902, 4226], 'tetraspanners,': [1275], 'CD81': [1276, 4204, 4406], '(TAPA-1)': [1277], 'leu-13,': [1279], 'complement': [1282], 'CD21': [1284], '(CR2;': [1285], 'Fearon': [1286], 'Carroll,': [1288, 1336], '2000).': [1289, 1337], 'long': [1291], 'cytosolic': [1292, 3228], 'tail': [1293, 3056, 3214, 3229, 3247, 3550], 'contains': [1296], 'nine': [1297], 'most': [1299, 1715, 3752], 'phosphorylated': [1303], 'src-family': [1306], 'Lyn': [1308, 3685, 3728, 3766, 3776], 'activation.': [1311], 'Once': [1312], 'phosphorylated,': [1313], 'these': [1314, 1672, 1743, 1865, 2469, 2576, 2803, 2826, 3532, 3647, 3713, 4154, 4279], 'serve': [1316], 'binding': [1318], 'partners': [1319], 'proteins': [1323, 3114, 3122], 'Grb2': [1324], 'Vav,': [1326], 'phosphoinositide-3': [1328], '(PI3K),': [1330], 'phospholipase': [1332], 'C-γ': [1333], '(Fearon': [1334], 'Signal': [1338], 'transduction': [1339, 3317, 3339, 3426, 3444, 4516], 'from': [1340, 1588, 1792, 2165, 2214, 2767, 2942, 3234, 4322], 'involves': [1343], 'PI3K': [1344, 1732, 1836, 1968], 'cytoskeleton': [1347], 'rearrangements.': [1348], 'Mature': [1349], 'co-express': [1352], 'different': [1354, 1367, 2299, 2510, 2896, 2960, 3295, 3312, 3326, 3367, 3401, 3421, 3433, 3473, 4393, 4511], 'classes': [1355], 'namely': [1358], 'IgM-BCR': [1360, 1422, 2143, 2306, 2360, 2473, 4223], 'IgD-BCR,': [1363], 'reside': [1365], 'islands': [1369, 1397], '(Yang': [1374], 'Reth,': [1376], '2010;': [1377, 1708], '2015).': [1381, 1405], 'On': [1382, 1406], 'resting': [1383, 3968], 'cells,': [1385, 1409, 2072, 2540, 2756, 3144], 'CD81-tetraspanin': [1390], 'localized': [1393], 'inside': [1394], 'IgD-class-specific': [1395], '(Mattila': [1398], '2013;': [1401], 'however,': [1410, 3173], 'open': [1421], 'gains': [1425], 'access': [1426], '(Klasener': [1430, 3703], '2014).': [1433, 1842, 3706, 4245], 'IgM/CD19/CD81/CD21': [1435], 'stabilized': [1439], 'its': [1441, 1764, 3660, 3676, 4206], 'co-ligation': [1442], 'complement-bound': [1444], 'antigens': [1445], 'reduce': [1448], 'threshold': [1450], '10-': [1454], '100-folds': [1456], '(Carter': [1457], 'Fearon,': [1459], '1992).': [1460], 'mouse': [1462, 1850], 'CD19-deficient': [1463], 'have': [1466, 1479, 1874], 'defects': [1467], 'proliferation': [1469, 2042, 2225], 'maturation': [1471], 'peripheral': [1473], 'lymph': [1474], 'tissues': [1475], 'spleen,': [1477], 'defective': [1481, 4414], 'T-cell': [1482], 'dependent': [1483], 'response': [1485, 3741, 3750, 4345], '(Rickert': [1486], '1995).': [1489], 'pre-BCR': [1494, 1685], 'Mice': [1510], 'one': [1516, 2423, 3175], 'H': [1519, 1565, 1809, 2029], 'chain,': [1520], 'Igα,': [1521], 'or': [1522, 1568, 1636, 1686, 2022, 2123, 2424, 2474, 2512, 2545, 3106, 3111, 3176, 3294, 3325, 3366, 3432, 3472, 3547, 3560, 3731, 3788, 4263, 4312, 4425, 4482, 4496, 4519, 4546, 4606], 'display': [1525, 4108], 'developmental': [1527], 'block': [1528], 'at': [1529, 2275, 2279, 2298, 3311, 3420, 3917, 4438, 4510], 'pro-B-cell': [1531], 'stage': [1532], '(Kitamura': [1533], '1991;': [1536], 'Gong': [1537], 'Nussenzweig,': [1539, 1555], 'Minegishi': [1545], '2001;': [1552], 'Meffre': [1553], '2002;': [1556, 1702], 'Pelanda': [1557], 'chain': [1566, 1810], 'gene': [1567, 1656], 'mutation': [1570], 'results': [1580, 2577, 2619, 3610, 3648, 4155], 'apoptosis': [1582], 'disappearance': [1584], 'periphery': [1590], 'few': [1593], 'days': [1594, 2554, 2614, 4327], '(Lam': [1595], '1997;': [1598], '2004).': [1602], 'proper': [1608, 4125], 'was': [1626, 2292, 2489, 2966, 3171, 3201, 3298, 3405, 3599, 3751, 3914, 4397, 4433], 'therefore': [1627], 'suggested': [1628], 'unengaged': [1631], 'emits': [1633], 'tonic': [1637, 1965], 'signal.': [1639], 'However,': [1640, 2532], 'some': [1641, 2023, 2729, 3512], 'loose': [1646], 'after': [1649, 3315, 3424, 3742, 3834, 3862, 4514, 4550], 'inducible': [1651], 'survive': [1657], 'mice': [1659], 'than': [1662, 2178], '20': [1663], 'days,': [1664, 2170], 'suggesting': [1665, 2172], '(Levit-Zerdoun': [1675], '2016).': [1678], 'of,': [1680], 'from,': [1683], 'lymphomas': [1698, 1756], '(Gauld': [1699], 'Kuppers,': [1703], '2005;': [1704], 'Lenz': [1705], 'Staudt,': [1707], 'Stevenson': [1709], '2011).': [1712], 'instance,': [1714], 'chronic': [1719, 1769], 'lymphocytic': [1720], 'leukemia': [1721], '(B-CLL)': [1722], 'carry': [1723, 1758, 2138, 2471], 'auto-aggregated': [1725], 'expansion': [1739, 1829], '(Duhren-von': [1746], 'Minden': [1747], '2012).': [1750], 'Activated': [1751], 'B-cell-like': [1752], 'diffuse': [1753], 'large': [1754, 4615], '(ABC-DLBCL)': [1757], 'mutations': [1759], 'components,': [1766, 2028, 3717], 'active': [1770], 'NFκB': [1771], 'increased': [1774, 3554, 3580, 3590, 3633], '(Davis': [1777], '(BL)': [1783], 'aggressive': [1786], 'derived': [1791], 'germinal': [1793], 'center': [1794], 'transformed': [1799], 'translocation': [1802], 'c-Myc': [1805], 'oncogene': [1806], 'into': [1807], 'locus': [1811], '(Dalla-Favera': [1812], '1982).': [1815], 'Knock-down': [1816], 'experiments': [1817, 2599], 'application': [1820], 'specific': [1822], 'inhibitors': [1823], '(Schmitz': [1838], '2012,': [1841], 'recent': [1845], 'study': [1846, 1994], 'model': [1851], 'suggests': [1852, 2626], '(Varano': [1868], '2017).': [1871], 'used': [1875, 2009, 2408, 3037, 3495, 3876, 3943, 4003, 4567], 'method': [1878], 'code': [1883], 'components': [1889, 2212, 2289, 2384, 2429, 2697, 3078], 'assay': [1903, 2098, 2226, 2752, 3889], 'showed': [1904, 2718, 4100], 'subunit': [1925, 2195], 'Igβ.': [1926, 3437], 'mIg-independent': [1935, 1989], 'fashion': [1936], 'Results': [1980], 'depends': [1986, 2191, 3090, 3193], 'To': [1993, 2573, 3081, 3707, 4038, 4246], 'role': [1996, 4250, 4586], 'supporting': [2002], 'gene-editing': [2012], 'tool': [2013], 'generate': [2015], 'mutants': [2018, 3297], 'lacking': [2019, 2762, 3803, 4106], 'all': [2020], '(BCR-null)': [2021], 'four': [2026, 2895], 'L': [2031], 'chains,': [2032], 'Igβ,': [2035], '(Fig': [2036, 2054, 2084, 2099, 2151, 2183, 2480, 2571, 2687, 2747, 2770, 2830, 2887, 3134, 3164, 3184, 3261, 3536, 3611, 3768, 3809, 4115, 4151, 4292, 4328, 4351, 4638], '1A).': [2037], 'then': [2039, 2293, 3737, 3915, 4072], 'compared': [2040, 2088, 2858], 'BCR-null': [2045, 2058, 2133, 2160, 2439], 'wild-type': [2050, 2215], '(WT)': [2051, 2216], '1B).': [2055, 2085], 'Surprisingly,': [2056], 'expanded': [2060, 2520], 'culture': [2062, 2167, 2556, 2590, 2610, 2769, 4324], 'similar': [2064], 'kinetics': [2065], 'WT': [2069, 2105, 2122, 2179, 2228, 2247, 2261, 2313, 2333, 2367, 2525, 2537, 2567, 2743, 2754, 2861, 2907, 2943, 3002, 3110, 3293, 3324, 3365, 3399, 3431, 3471, 3545], 'indicating': [2073, 4655], 'they': [2075, 2174, 2519], 'were': [2076, 2250, 2268, 2317, 2374, 2516, 2550, 2609, 3149, 3180, 3494, 3875, 3900, 3995, 4071, 4338, 4412, 4649], 'compromised': [2078], 'vitro': [2082], 'next': [2087, 2417, 2647, 3510, 4582], 'competition': [2097, 2157, 2245, 2323, 2330, 2380, 2535, 2598, 2751, 2973, 3888], '1C)': [2100], 'labeled': [2104], 'GFP': [2110, 3336, 3441], 'mixed': [2112, 2269, 3901], 'them': [2113], '1:1': [2116, 2277], 'ratio': [2117, 2278], 'either': [2119, 3102, 3430, 3725, 4310, 4602], 'unstained': [2120], '(GFP−)': [2121], 'mutant': [2125, 2684, 3369, 3403, 3475, 4335], 'FACScan': [2129, 2464, 2497, 2700, 2713, 2829, 3133, 3535, 4276], 'analysis': [2130, 2465, 2504, 2625, 2705, 2714, 2833, 3206, 3576, 3598, 3961, 4277], 'verified': [2131, 2461, 2491, 2690, 3116, 4057, 4273, 4583], 'did': [2136, 2871, 3159, 3569], '(neither': [2141], 'nor': [2144], 'IgD-BCR)': [2146], '1D).': [2152], 'Interestingly,': [2153, 2711], 'assay,': [2158], 'gradually': [2163, 2765, 4320], 'disappear': [2164, 2766], 'within': [2168, 2552, 4325], '8': [2169, 2553], 'thereby': [2171], 'less': [2176], 'fit': [2177], '1E).': [2184], 'Figure': [2185, 2915, 3263, 3811, 3957, 4372], '1.': [2186], 'Fitness': [2187], 'schematic': [2200, 2928], 'diagram': [2201, 2241, 2929], 'showing': [2202, 2930], 'route': [2204, 2932, 4175], 'generation': [2207, 2582], 'single-': [2209, 2936], 'multi-BCR': [2211], 'KO': [2213, 2266, 2290, 2371, 2385, 2450, 2456, 2514, 2548, 2561, 2593, 2606, 2681, 2723, 2760, 2790, 2868, 2963, 2978, 3006, 3021, 3028, 3097, 3130, 3143, 3209, 3257, 3289, 3320, 3361, 3395, 3417, 3467, 3500, 3517, 3540, 3565, 3603, 3790, 3828, 3854, 3892, 3898, 3912, 3974, 3978, 4052, 4097, 4139, 4266, 4302, 4307, 4395, 4431, 4464, 4489, 4541, 4573, 4599, 4636, 4647], 'method.': [2223, 2950], 'Cell': [2224], 'Ramos-null': [2230, 2315, 2325], 'using': [2232, 2715], 'CytoTell™': [2233], 'UltraGreen.': [2234], 'Null': [2235], '=': [2236, 3016, 3022, 3029], 'HC/LC/Igα/Igβ': [2237], 'tetra': [2238], 'KO.': [2239, 3033, 3504], 'depicting': [2242], 'assay.': [2246, 4592], 'retrovirally': [2251, 4594], 'transduced': [2252, 3095, 3128, 3139, 3309, 3515, 4073, 4491, 4543, 4595], 'pMIG': [2254], 'empty': [2255, 3103, 4493], 'vector': [2256, 3104, 4308, 4494, 4499, 4549], '(EV)': [2257, 3105, 4495], 'create': [2259], 'GFP-labeled': [2260], '(gWT).': [2263], 'gWT': [2272, 2327, 2335, 2389, 2981], 'about': [2276], 'day': [2280], '0,': [2281], 'relative': [2284, 3908], 'amount': [2285, 3909, 4624], 'GFP−': [2287, 2332], 'measured': [2294, 2821, 3527, 3738, 3916, 4434, 4500], 'flow': [2296, 2320, 2377, 2969, 3301, 3408, 3923, 4400, 4436, 4502], 'cytometry': [2297, 3960, 4437], 'time': [2300, 3152, 3313, 3422, 3920, 4441, 4512], 'points.': [2301, 4442], 'levels': [2304, 2358, 3808, 3966], 'IgD-BCR': [2308, 2362, 2475], 'determined': [2318, 2375, 2967, 3299, 3406, 4398], 'cytometry.': [2321, 2378, 2970, 3302, 3409, 3924, 4401, 4503], 'Growth': [2322, 2379, 2972, 3887], 'between': [2324, 2331], 'serves': [2337], 'control.': [2340], 'represent': [2343, 2392, 2985, 3343, 3448, 3927, 3983, 4445, 4526], 'mean': [2345, 2394, 2987, 3345, 3450, 3929, 3985, 4447, 4528], 'standard': [2347, 2396, 2989, 3347, 3452, 3931, 3988, 4449, 4530], 'error': [2348, 2397, 2990, 3348, 3453, 3932, 4450, 4531], 'minimum': [2351, 2400, 2993, 3351, 3456, 3490, 3935], 'three': [2353, 2402, 2995, 3353, 3382, 3458, 3486, 3846, 3884, 3937, 3991, 4452, 4475, 4533, 4561], 'independent': [2354, 2403, 2996, 3354, 3383, 3459, 3487, 3847, 3885, 3938, 3992, 4453, 4476, 4534, 4562], 'experiments.': [2355, 2404, 2997, 3355, 3384, 3460, 3488, 3848, 3886, 3939, 3993, 4454, 4477, 4535, 4563], 'against': [2387, 2980], 'Data': [2391], 'One': [2405, 3034, 3940, 4000, 4011, 4564], 'clone': [2406, 3035, 3941, 4001, 4565], 'genotype.': [2411, 3040, 3946, 4006], 'Download': [2412, 2414, 3041, 3043, 3505, 3507, 3947, 3949, 4007, 4009, 4577, 4579], 'figure': [2413, 3042, 3506, 3948, 4008, 4578], 'PowerPoint': [2415, 3044, 3508, 3950, 4010, 4580], 'asked': [2418], 'whether': [2419, 2649, 2798, 3083, 3709, 4040], 'loss': [2421, 2483, 2692, 4059], 'both': [2425, 3177, 3497, 3688, 4228], 'caused': [2433], 'reduced': [2435, 2738, 2856, 3754, 3806], 'this,': [2443], 'generated': [2445, 2671, 4049, 4257], 'single': [2449, 2511, 2544, 2560], 'well': [2452, 2499, 2522, 2564, 2675], 'double': [2455, 2513, 2547, 2673, 3018, 3827, 3973, 4301], 'none': [2467], '1F).': [2481], 'intra-': [2494], 'extracellular': [2496, 3219], 'Western': [2502, 2703, 4064], 'blot': [2503, 2704, 4065], '(Appendix': [2505, 2529, 2620, 2706, 2912, 4066, 4269], 'Fig': [2506, 2530, 2621, 2707, 2913, 4067, 4270], 'S1).': [2507], 'When': [2508], 'cultured': [2517], 'separately,': [2518], 'S2).': [2531], 'lost': [2551, 4282], 'whereas': [2557, 3153, 3244, 3557, 4104], 'competed': [2563], '1G).': [2572], 'exclude': [2574], 'influenced': [2579], 'variants': [2584], 'during': [2585], 'selection': [2587], 'prolonged': [2589], 'clones,': [2594], 'repeated': [2596, 3600], 'set': [2603], 'clones': [2607, 2898, 3493], '14': [2613], 'obtained': [2616], 'same': [2618, 3609, 3666, 4169, 4630], 'S3).': [2622], 'Together,': [2623, 4153], 'associated': [2637], 'total': [2639], 'rather': [2642], 'expression.': [2645], 'analyzed': [2648], 'apparent': [2651], 'function': [2653], 'mIg': [2665, 2784, 2844], 'BCR.': [2669], 'HL': [2672, 3787, 3826, 3972, 4300], 'HLα': [2677, 2721, 2789, 3020], 'HLβ': [2679, 2759, 3027, 3096, 3129, 3142, 3208, 3256, 3288, 3319, 3360, 3499, 3516, 3539, 3564, 3789, 3976], 'triple': [2680, 2722, 2867, 3025, 3032, 3853, 3977, 4051, 4096, 4138, 4265, 4430, 4598], '2A)': [2688], 'corresponding': [2695], 'S1D': [2708], 'E).': [2710], 'anti-Igβ': [2716, 2799, 2818, 2849, 2876, 3013, 3375, 3479, 3524, 3593, 3637, 3743, 3833, 3866, 4090, 4349, 4468, 4554], 'antibodies': [2717, 2800, 2901, 4350], 'still': [2727], 'albeit': [2736, 2851], 'amounts': [2739, 4616], 'comparison': [2741], '2B).': [2748], 'In': [2749, 3136, 4128], '2C).': [2771], 'finding': [2773], 'prompted': [2794], 'us': [2795], 'test': [2797, 3082, 3708, 4039, 4247], 'could': [2801, 3250], 'stimulate': [2802], 'exposed': [2807, 2893, 3511, 3786], 'WT,': [2808], 'HL-KO,': [2809, 4459], 'HLα-KO,': [2810], 'HLβ-KO': [2812, 2866], 'monoclonal': [2817, 3523], 'antibody': [2819, 2877, 3525, 3594], '2D–G).': [2831], 'shows': [2834, 3577], 'expressing': [2838, 3211, 3544, 3563], 'stimulated': [2847, 3477, 3831, 4466], 'antibody,': [2850], 'delayed': [2854], 'manner': [2857], 'respond': [2873, 3571], 'treatment': [2878, 3835, 3868], 'served': [2880], 'negative': [2882], 'control': [2883, 3157, 3559, 4605], 'experiment': [2886], '2G).': [2888], 'As': [2889], 'control,': [2891], 'anti-Igα': [2900], 'responded': [2911], 'S4).': [2914], '2.': [2916], 'determines': [2920], 'A.': [2926, 3279], 'map': [2933], 'generating': [2935], 'multi-': [2938], 'KOs': [2941], 'B.': [2951, 4382], 'C.': [2971, 3304, 4402], 'D–G.': [2998], 'Calcium': [2999, 3357, 3823, 3849, 4456, 4537], 'stimulation': [3011, 3373, 3864, 4552], 'antibodies.': [3014, 3376, 3480, 4469, 4555], 'HL-KO': [3015, 3720, 3895, 3905, 4148, 4409], 'HC/LC': [3017], 'KO;': [3019, 3026], 'HC/LC,': [3023, 3030], 'Igβ-dependent': [3051, 4375], 'carries': [3060], '(Y196': [3065], 'Y207)': [3067], 'interaction': [3073], 'Syk.': [3080], 'signaling,': [3093, 4047, 4255], 'vectors': [3108, 3334, 3428, 3439], 'encoding': [3109, 3429, 4076], 'ITAM-mutated': [3112], '3A).': [3135], 'co-cultures': [3137], 'containing': [3138], 'non-transduced': [3141], 'Igβ-producing': [3146], 'enriched': [3150, 4650], 'over': [3151], 'EV': [3155, 3558, 4518, 4545, 4604, 4632], 'transfected': [3156], 'effect': [3163, 3168], '3B).': [3165], 'growth-promoting': [3167], 'abolished,': [3172], 'when': [3174, 3784, 4145], 'mutated': [3181, 3327, 3434], 'phenylalanine': [3183], '3C).': [3185, 3262], 'Thus,': [3186, 3613], 'mechanism.': [3198], 'conclusion': [3200], 'confirmed': [3203], 'Igβ-α': [3213, 3549], 'chimera,': [3215], 'portion': [3220], 'transmembrane': [3222], 'region': [3223], 'Igα.': [3231], 'chimeric': [3236], 'provided': [3238], 'even': [3240], 'higher': [3241], 'advantage,': [3243], 'truncation': [3248], '(Igβtl)': [3249], 'increase': [3252], '3.': [3264], 'through': [3266, 3659], 'contributes': [3272], 'reconstituted': [3291, 3322, 3363, 3397, 3469, 3857], 'B,': [3303], 'percentage': [3306, 4421], 'GFP-positive': [3308, 3415, 4507], 'points': [3314, 3423, 3921, 4513], 'form': [3328, 4080], 'shown.': [3332], 'express': [3335, 3440, 4194], 'marker.': [3340, 3445], 'D.': [3356, 4455], 'constructs': [3370, 3404, 3476], 'representative': [3380, 3484, 3844, 3882, 4473, 4559], 'E.': [3385, 4478], 'αβ': [3394, 3416, 3466, 3503, 3602], 'F,': [3410], 'G.': [3411, 4536], 'proportion': [3413], 'H.': [3461], '3D).': [3537], 'chimera': [3551], 'displayed': [3552], 'tail-less': [3562], 'stimulus.': [3574], 'correlated': [3588], 'responsiveness': [3591], 'toward': [3592], 'stimulation.': [3595, 3744], 'above': [3597], '3E–H).': [3612], 'formation': [3623], 'fitness,': [3634], 'induced': [3638], 'release': [3640], 'Taken': [3645], 'together,': [3646], 'cellular': [3653], 'constant': [3657], 'tyrosines.': [3662], 'employs': [3664], 'pathway': [3668, 3822], 'exposure': [3674, 4088, 4347], 'cognate': [3677], 'antigen,': [3678], 'kinases': [3684], 'Syk,': [3687, 4171], 'support': [3691], 'dissociation': [3693], 'mediate': [3700], 'uses': [3712], 'classical': [3714], 'pre-treated': [3719], 'DMSO,': [3726], 'inhibitor': [3729, 3734, 3758, 3767], 'PP2,': [3730], 'R406': [3735], 'strongly': [3753], 'lesser': [3762], 'extent': [3763], '4A).': [3769], 'result': [3771], 'demonstrates': [3772], 'involved': [3778], 'Igβ-mediated': [3781], 'Indeed': [3783], 'oxidant': [3795], 'pervanadate,': [3796], 'latter': [3801, 4612], 'pSyk': [3807], 'EV1).': [3810], '4.': [3812], 'though': [3817], 'canonical': [3819], 'indicated': [3838, 3919, 4440], 'inhibitors.': [3840], 'HLSLP65': [3852, 3891, 3897, 3911, 4050, 4095, 4137], 'tamoxifen-inducible': [3860, 4079], 'SLP65': [3861, 3873, 4041, 4061, 4082, 4120, 4173], '4-OHT.': [3870], 'Cells': [3871], 'without': [3872], 'production': [3874], 'controls.': [3878], 'GFP-expressing': [3904], 'Click': [3951], 'here': [3952], 'expand': [3954], 'figure.': [3956], 'EV1.': [3958], 'Flow': [3959], 'phosphoSykNormalized': [3963], 'intracellular': [3964], 'phosphoSyk': [3965], 'pervanadate': [3970], 'treated': [3971], 'deviation': [3989], 'P-values': [3994], 'calculated': [3996], 'paired': [3998], 't-test.': [3999], 'SLP65/BLNK,': [4020], '(Fu': [4030], '1998;': [4033], 'Wienands': [4034], '1998).': [4037], 'S5).': [4068], 'plasmids': [4075], 'SLP65ERT2,': [4077], '(Trageser': [4083], '2009).': [4086], 'tamoxifen,': [4092], 'SLP65ERT2-transduced': [4094], 'flux,': [4103], 'SLP65ERT2': [4107], 'no': [4109], 'change': [4110], 'level': [4114], '4B).': [4116], 'indicates': [4118, 4354], 'agreement': [4129], 'conclusion,': [4132], 'disadvantage': [4144], 'co-cultured': [4146], '4C).': [4152], 'improves': [4159], 'employing': [4167], 'Lyn,': [4170], 'Igβ-induced': [4187], 'All': [4190], 'association': [4200], 'tetraspanner': [4203], 'stable': [4207], '(Maecker': [4213], 'Levy,': [4215], 'move': [4224], 'closer': [4225], 'receptors': [4229], 'cooperate': [4230], 'amplification': [4233], '(Fujimoto': [4238], '2000;': [4241], 'Klasener': [4242], 'bulk': [4259], 'transfection': [4260, 4297], 'HLCD19': [4262, 4332, 4460, 4488, 4540, 4597, 4635, 4646], 'HLCD81': [4264, 4334, 4463, 4572], 'population': [4268, 4432], 'S6)': [4271], 'had': [4281], 'maintained': [4285], '5A': [4293], 'B).': [4295], 'After': [4296], 'CD81,': [4313], 'CD19-negative': [4316], 'disappeared': [4321], '12': [4326], '5C).': [4329], 'unable': [4340], 'mount': [4342], '5D).': [4352], '5.': [4373], 'A,': [4381], 'rendered': [4413], 'method,': [4418], 'CD19-': [4424], 'CD81-negative': [4426], 'KO,': [4461], 'F.': [4504], 'Percentage': [4505], 'HLCD19KO': [4508, 4570], 'vector.': [4523, 4610], 'HL-KO.': [4569], 'batch': [4575], 'sorted.': [4576], 'fitness-promoting': [4585], 'gain-of-function': [4591], 'while': [4622], 'CD19-transduced': [4634], '5E).': [4639], 'Compared': [4640], 'EV,': [4642], '(GFP+)-transduced': [4645], 'culture,': [4654], 'Ig': [4660]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2799959526', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2025-01-13T00:39:06.124813', 'created_date': '2018-05-17'}
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