Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4241093956', 'doi': 'https://doi.org/10.1158/2159-8290.cd-nb2015-058', 'title': 'Nivolumab + Ipilimumab Ups Melanoma Response', 'display_name': 'Nivolumab + Ipilimumab Ups Melanoma Response', 'publication_year': 2015, 'publication_date': '2015-06-01', 'ids': {'openalex': 'https://openalex.org/W4241093956', 'doi': 'https://doi.org/10.1158/2159-8290.cd-nb2015-058', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25898833'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/2159-8290.cd-nb2015-058', 'pdf_url': 'https://cancerdiscovery.aacrjournals.org/content/5/6.toc.pdf', 'source': {'id': 'https://openalex.org/S2486275289', 'display_name': 'Cancer Discovery', 'issn_l': '2159-8274', 'issn': ['2159-8274', '2159-8290'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://cancerdiscovery.aacrjournals.org/content/5/6.toc.pdf', 'any_repository_has_fulltext': False}, 'authorships': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.152, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.484757, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 66, 'max': 73}, 'biblio': {'volume': '5', 'issue': '6', 'first_page': 'OF2', 'last_page': 'OF2'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10158', 'display_name': 'Cancer Immunotherapy', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11491', 'display_name': 'Chimeric Antigen Receptor T Cell Therapy', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunobiology of Dendritic Cells', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/combination-therapies', 'display_name': 'Combination Therapies', 'score': 0.548839}], 'concepts': [{'id': 'https://openalex.org/C2781433595', 'wikidata': 'https://www.wikidata.org/wiki/Q2459042', 'display_name': 'Ipilimumab', 'level': 4, 'score': 0.9904282}, {'id': 'https://openalex.org/C2780030458', 'wikidata': 'https://www.wikidata.org/wiki/Q7041828', 'display_name': 'Nivolumab', 'level': 4, 'score': 0.97580415}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.7107593}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6558186}, {'id': 'https://openalex.org/C2994587330', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Metastatic melanoma', 'level': 3, 'score': 0.46277416}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.46029672}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.45621338}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.40865445}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.31987363}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.31277144}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.19754076}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.17784}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/2159-8290.cd-nb2015-058', 'pdf_url': 'https://cancerdiscovery.aacrjournals.org/content/5/6.toc.pdf', 'source': {'id': 'https://openalex.org/S2486275289', 'display_name': 'Cancer Discovery', 'issn_l': '2159-8274', 'issn': ['2159-8274', '2159-8290'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25898833', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/2159-8290.cd-nb2015-058', 'pdf_url': 'https://cancerdiscovery.aacrjournals.org/content/5/6.toc.pdf', 'source': {'id': 'https://openalex.org/S2486275289', 'display_name': 'Cancer Discovery', 'issn_l': '2159-8274', 'issn': ['2159-8274', '2159-8290'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.6, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4372049985', 'https://openalex.org/W4313890856', 'https://openalex.org/W4249156275', 'https://openalex.org/W4236421112', 'https://openalex.org/W3043703771', 'https://openalex.org/W2976744492', 'https://openalex.org/W2973740076', 'https://openalex.org/W2963333658', 'https://openalex.org/W2899127460', 'https://openalex.org/W2888298425'], 'abstract_inverted_index': {'Abstract': [0], 'For': [1], 'patients': [2], 'with': [3], 'advanced': [4], 'melanoma,': [5], 'the': [6, 19, 31], 'combination': [7, 21], 'of': [8], 'ipilimumab': [9, 16], 'and': [10], 'nivolumab': [11], 'yields': [12], 'better': [13], 'responses': [14], 'than': [15, 30], 'alone.': [17], 'However,': [18], 'two-drug': [20], 'is': [22], 'much': [23], 'more': [24], 'likely': [25], 'to': [26], 'cause': [27], 'side': [28], 'effects': [29], 'monotherapy.': [32]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4241093956', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-01T06:43:12.634108', 'created_date': '2022-05-12'}