Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain

Name: Work Video:
Duration: 3 min 30 s
Description: Brain metastases are a common cause of disabling neurologic complications and death in patients with metastatic melanoma. Previous studies of nivolumab combined with ipilimumab in metastatic melanoma have excluded patients with untreated brain metastases. We evaluated the efficacy and safety of nivolumab plus ipilimumab in patients with melanoma who had untreated brain metastases.
Hussein A. Tawbi; Peter Forsyth; Alain P. Algazi; Omid Hamid; F. Stephen Hodi; Stergios J. Moschos; Nikhil I. Khushalani; Karl D. Lewis; Christopher D. Lao; Michael A. Postow; Michael B. Atkins; Marc S. Ernstoff; David A. Reardon; Igor Puzanov; Ragini R. Kudchadkar; Reena Thomas; Ahmad A. Tarhini; Anna C. Pavlick; Joel Jiang; Alexandre Avila; Sheena Demelo; Kim Margolin
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Moschos', 'raw_affiliation_strings': ['University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill'], 'affiliations': [{'raw_affiliation_string': 'University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill', 'institution_ids': ['https://openalex.org/I4390039329', 'https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058902095', 'display_name': 'Nikhil I. Khushalani', 'orcid': 'https://orcid.org/0000-0002-3636-4143'}, 'institutions': [{'id': 'https://openalex.org/I3019308854', 'display_name': 'Moffitt Cancer Center', 'ror': 'https://ror.org/01xf75524', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019308854']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nikhil I. 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