Publication Information

{'id': 'https://openalex.org/W4239331730', 'doi': 'https://doi.org/10.1210/en.137.9.4046', 'title': 'Agonist-dependent regulation of cloned human somatostatin receptor types 1-5 (hSSTR1-5): subtype selective internalization or upregulation', 'display_name': 'Agonist-dependent regulation of cloned human somatostatin receptor types 1-5 (hSSTR1-5): subtype selective internalization or upregulation', 'publication_year': 1996, 'publication_date': '1996-09-01', 'ids': {'openalex': 'https://openalex.org/W4239331730', 'doi': 'https://doi.org/10.1210/en.137.9.4046'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/en.137.9.4046', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/137/9/4046/10640550/endo4046.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/endo/article-pdf/137/9/4046/10640550/endo4046.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5007287945', 'display_name': 'Nedim Hukovic', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210088756', 'display_name': 'Royal Victoria Hospital', 'ror': 'https://ror.org/00arwy491', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801766832', 'https://openalex.org/I4210088756']}, {'id': 'https://openalex.org/I5023651', 'display_name': 'McGill University', 'ror': 'https://ror.org/01pxwe438', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I5023651']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'N. Hukovic', 'raw_affiliation_strings': ['Fraser Laboratories, Department of Medicine, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Fraser Laboratories, Department of Medicine, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada.', 'institution_ids': ['https://openalex.org/I4210088756', 'https://openalex.org/I5023651']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5007287945'], 'corresponding_institution_ids': ['https://openalex.org/I4210088756', 'https://openalex.org/I5023651'], 'apc_list': {'value': 3400, 'currency': 'USD', 'value_usd': 3400, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.082, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 47, 'citation_normalized_percentile': {'value': 0.822885, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '137', 'issue': '9', 'first_page': '4046', 'last_page': '4049'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10754', 'display_name': 'Neuroendocrine Tumor Research Advances', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10754', 'display_name': 'Neuroendocrine Tumor Research Advances', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9922, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/internalization', 'display_name': 'Internalization', 'score': 0.97792304}, {'id': 'https://openalex.org/keywords/somatostatin-receptor-1', 'display_name': 'Somatostatin receptor 1', 'score': 0.42626587}], 'concepts': [{'id': 'https://openalex.org/C139770010', 'wikidata': 'https://www.wikidata.org/wiki/Q1339807', 'display_name': 'Internalization', 'level': 3, 'score': 0.97792304}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.8880336}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.8637515}, {'id': 'https://openalex.org/C80115893', 'wikidata': 'https://www.wikidata.org/wiki/Q2067077', 'display_name': 'Somatostatin receptor', 'level': 3, 'score': 0.7140997}, {'id': 'https://openalex.org/C2776297358', 'wikidata': 'https://www.wikidata.org/wiki/Q407166', 'display_name': 'Somatostatin', 'level': 2, 'score': 0.68145084}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.57234305}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.56767684}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5038392}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42677554}, {'id': 'https://openalex.org/C64980429', 'wikidata': 'https://www.wikidata.org/wiki/Q18031730', 'display_name': 'Somatostatin receptor 1', 'level': 5, 'score': 0.42626587}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39357167}, {'id': 'https://openalex.org/C150008808', 'wikidata': 'https://www.wikidata.org/wiki/Q18031731', 'display_name': 'Somatostatin receptor 2', 'level': 4, 'score': 0.3419717}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15471447}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.121467054}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.046813548}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/en.137.9.4046', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/137/9/4046/10640550/endo4046.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/en.137.9.4046', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/137/9/4046/10640550/endo4046.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.58, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 7, 'referenced_works': ['https://openalex.org/W1594960037', 'https://openalex.org/W1597750467', 'https://openalex.org/W1969253887', 'https://openalex.org/W2061342343', 'https://openalex.org/W2085643537', 'https://openalex.org/W4235673215', 'https://openalex.org/W4255736068'], 'related_works': ['https://openalex.org/W597918840', 'https://openalex.org/W2472221713', 'https://openalex.org/W2413517490', 'https://openalex.org/W2321353203', 'https://openalex.org/W2140741951', 'https://openalex.org/W2118631824', 'https://openalex.org/W2046702994', 'https://openalex.org/W2008562659', 'https://openalex.org/W2001169676', 'https://openalex.org/W1741250325'], 'abstract_inverted_index': {'Agonist': [0], 'regulation': [1], 'of': [2, 28, 44, 73, 75, 106], 'somatostatin': [3], 'receptors': [4], '(SSTRs)': [5], 'was': [6, 82, 111], 'investigated': [7], 'in': [8, 33], 'stable': [9], 'CHO-K1': [10], 'cells': [11], 'individually': [12], 'expressing': [13], 'the': [14, 76, 85, 109], '5': [15, 23, 125], 'human': [16], '(h)': [17], 'SSTR': [18], 'subtypes.': [19], 'hSSTR': [20], '2,3,4,': [21], 'and': [22, 36, 56, 90, 94, 99, 138], 'displayed': [24, 62], 'rapid': [25], 'agonist-dependent': [26], 'internalization': [27, 43, 131, 137], '[125I]': [29], 'LTT': [30], 'SST-28': [31], 'ligand': [32], 'a': [34], 'time-': [35], 'temperature-dependent': [37], 'manner': [38], 'over': [39], '60': [40], 'min.': [41], 'Maximum': [42], 'radioligand': [45], 'occurred': [46], 'with': [47, 115], 'hSSTR3': [48, 98], '(78%)': [49], 'followed': [50], 'by': [51, 87, 92, 113, 127], 'hSSTR5': [52, 100], '(66%),': [53], 'hSSTR4': [54, 91], '(29%)': [55], 'hSSTR2': [57, 89], '(20%).': [58], 'In': [59], 'contrast,': [60], 'hSSTR1': [61, 81, 107, 116], 'virtually': [63], 'no': [64], 'internalization.': [65], 'Prolonged': [66], 'agonist': [67], 'treatment': [68], 'led': [69], 'to': [70, 108], 'differential': [71, 128], 'upregulation': [72, 139], 'some': [74], 'SSTRs.': [77], 'After': [78], '22': [79], 'h,': [80], 'upregulated': [83], 'at': [84], 'membrane': [86, 110], '110%,': [88], '26%': [93], '22%': [95], 'respectively,': [96], 'whereas': [97], 'showed': [101], 'little': [102], 'change.': [103], 'Agonist-induced': [104], 'recruitment': [105], 'confirmed': [112], 'immunocytochemistry': [114], 'antibodies.': [117], 'These': [118], 'results': [119], 'show': [120], 'that': [121], 'SST': [122], 'regulates': [123], 'all': [124], 'hSSTRs': [126], 'subtype': [129], 'selective': [130], 'or': [132], 'upregulation.': [133], 'Subtype': [134], 'selectivity': [135], 'for': [136], 'is': [140], 'inversely': [141], 'related.': [142]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4239331730', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-19T18:12:50.820081', 'created_date': '2022-05-12'}